scholarly journals Design and Optimization of Lactic Acid Purification Process by Reactive Distillation with Isoamyl Alcohol

2021 ◽  
pp. 29-42
Author(s):  
Ying Wang ◽  
Jumei Xu ◽  
Zuoxiang Zeng ◽  
Weilan Xue ◽  
Zhijie Mao
Keyword(s):  
Lactic Acid ◽  
Process Parameters ◽  
Annual Cost ◽  
Reactive Distillation ◽  
Fermentation Broth ◽  
Isoamyl Alcohol ◽  
Total Annual Cost ◽  
Operating Pressure ◽  
Feed Composition ◽  
Yield And Purity

The purpose of this study was to investigate a continuous process for the recovery of lactic acid from fermentation broth. A reactive distillation process to purify lactic acid by esterification with isoamyl alcohol and hydrolysis was designed and simulated by Aspen. Five columns were included in the process: esterification column, purification column, hydrolysis column, dehydration column and recovery column. Effects of process parameters (operating pressure, feed composition, feed position, number of reaction and separation stages, and reboiler duty) of the esterification column on the yield and purity of lactic ester was evaluated. Further evaluation was carried out to reveal the effects of process parameters of the hydrolysis column on the yield and purity of lactic acid. The total annual cost of the whole process was calculated. Simulation studies are carried out using Aspen Plus RADFRAC module. It was shown that under the optimized condition, the concentration of lactic acid can reach up to 82.4 wt%, and the organic acid impurities were less than 3 ppm. Compared with the traditional usage of methanol and butanol, the isoamyl alcohol process can save about 20% of the total annual cost at the same output of lactic acid. Results obtained in this work can be used for scale-up study of an industrial reactive distillation operation as an efficient and economical alternative to recover lactic acid from fermentation broth.

scholarly journals Statistical Optimization of Lactic Acid Extraction Using Green Solvent and Mixed Extractants (TOA and TOMAC)

2020 ◽  
Vol 21 (1) ◽  
pp. 20-35
Author(s):  
Anil Kumar ◽  
Avinash Thakur
Keyword(s):  
Lactic Acid ◽  
Distribution Coefficient ◽  
Process Parameters ◽  
Chemical Engineering ◽  
Fermentation Broth ◽  
Mutual Effect ◽  
Reactive Extraction ◽  
Acid Extraction ◽  
Green Solvent ◽  
Separation And Purification

Since some previous years, reactive extraction has become more attractive and competitive technique for the separation and purification of lower carboxylic acids from fermentation broth as well as from dilute aqueous streams. This paper shows the results of investigation of reactive extraction of lactic acid (LA) from an aqueous solution using the synergistic mixture of the extractants (TOA (tri-n-octylamine) and TOMAC (Tri-n-octylmethylammonium chloride)) and a non-toxic and biocompatible green solvent (soybean oil). Three-level Box-Behnken design (BBD) under response surface methodology (RSM) was opted for the experimental design and to interpret the mutual effect of seven independent process parameters on the LA distribution coefficient (KD). The maximum values of LA distribution coefficient (KD=2.51) and its extraction efficiency (ηη=71.5%) were obtained for the optimum values of various process parameters such as 0.02 [M] initial LA concentration (CC1), 0.5 (v/v) extractant ratio (α), 28.66% (v/v) mixed extractants concentration (ψ), 2 (v/v) phase ratio (φ), 270C temperature (T), 102 rpm stirring speed (ω), and 63 mincontact time (τ). This present investigation will provide a noble discussion on LA reactive extraction using green solvent and on various influencing process parameters for gaining the enhanced value of LA distribution coefficient (KD). Chemical Engineering Research Bulletin 21(2019) 20-35

Energy-saving investigation of vacuum reactive distillation for the production of ethyl acetate

2022 ◽  
Vol 0 (0) ◽  
Author(s):  
Ganesh N. Patil ◽  
Nirmala Gnanasundaram
Keyword(s):  
Ethyl Acetate ◽  
Reactive Distillation ◽  
Cooling Water ◽  
Design Parameters ◽  
Total Annual Cost ◽  
Operating Pressure ◽  
Cooling Water Temperature ◽  
Pressure Swing ◽  
The Impact ◽  
Better Than

Abstract Ethyl acetate (EtAc) reactive distillation (RD) configurations often use atmospheric pressure, and this operating pressure can be reduced further to conserve energy based on the condenser cooling water temperature. Using the Aspen Plus simulator, two proposed configurations, RD column with stripper and pressure swing reactive distillation (PSRD), were simulated at lower operating pressure. The impact of RD column operating pressure on total energy usage and total annual cost (TAC) was studied. All design parameters were optimized using sequential iterative optimization procedures and sensitivity analysis to minimize the energy cost while maintaining the required product purity at 99.99%. The simulation results showed that the RD column with a stripper is better than PSRD with a saving of 23.17% in TAC and 31.53% in the specific cost of EtAc per kg. Compared to literature results, the proposed configurations have lower reboiler duty requirements and lower cost per kg of EtAc.

scholarly journals Alternative reverse osmosis to purify lactic acid from a fermentation broth

2018 ◽  
Vol 24 (2) ◽  
pp. 179-190
Author(s):  
Natnirin Phanthumchinda ◽  
Tanapawarin Rampai ◽  
Budsabathip Prasirtsak ◽  
Sitanan Thitiprasert ◽  
Somboon Tanasupawat ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Reverse Osmosis ◽  
Fermentation Broth ◽  
Feed Solution ◽  
Sodium Lactate ◽  
Calcium Lactate ◽  
Operating Pressure ◽  
Two Stage ◽  
Ammonium Lactate ◽  
Monovalent Ions

Brackish water reverse osmosis (BWRO) and seawater reverse osmosis (SWRO) membranes were used in a two-stage reverse osmosis (RO) unit to recover, pre-purify, and pre-concentrate lactic acid. Calcium lactate, sodium lactate, and ammonium lactate were used as model feed solutions. The operating pressure showed a pronounced effect on lactate passage through the first BWRO unit, and the Donnan exclusion effect and hydrogen bonding were responsible for cation rejection. Calcium ions were rejected at the BWRO unit because of low diffusion rate and charge interaction at the surface. However, monovalent ions formed hydrogen bonds with the carbonyl group of the membrane that allowed passage across the membrane. The second SWRO unit was for pre-concentrating lactic acid. A high lactate purity of 99.2% with a total recovery of 50.5% was acquired from calcium lactate feed solution. Lower purity with higher lactate recovery was obtained when the feed solution was sodium lactate and ammonium lactate. When the actual fermentation broth was used in the two-stage RO unit, a slightly lower recovery and purity of lactic acid were obtained. It was claimed that the total ions present in the fermentation broth were responsible for the low efficiency of the two-stage RO unit.

Recent advances in the separation and purification of lactic acid from fermentation broth

2021 ◽  
Vol 104 ◽  
pp. 142-151
Author(s):  
Chenglong Li ◽  
Ming Gao ◽  
Wenbin Zhu ◽  
Nuohan Wang ◽  
Xiaoyu Ma ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fermentation Broth ◽  
Separation And Purification ◽  
Recent Advances

Optimizing and scale-up strategy of molecular distillation for the purification of lactic acid from fermentation broth

2015 ◽  
pp. 150623131312002 ◽  
Author(s):  
Jiang Yu ◽  
Aiwu Zeng ◽  
Xigang Yuan ◽  
Xinyu Zhang ◽  
Ji Ju
Keyword(s):  
Lactic Acid ◽  
Molecular Distillation ◽  
Fermentation Broth ◽  
Scale Up

scholarly journals Development of Kefir beverages: Standardization of process parameters

2016 ◽  
Vol 7 (2) ◽  
pp. 80
Author(s):  
Jaqueline Gilmara Barboza Januário ◽  
Tailana Marin de Lima ◽  
Daiane Aparecida Camargo Portella ◽  
Caroline Barboza Januário ◽  
Suellen Jensen Klososki ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Factorial Design ◽  
Process Parameters ◽  
Titratable Acidity ◽  
Central Point ◽  
Sensory Characteristics ◽  
Acidic Ph ◽  
Fermentation Time ◽  
23 Factorial Design ◽  
Kefir Grains

This study aimed to characterize physico-chemically Kefir grains and standardize the process parameters of the beverages, in order to obtain an optimum product. Kefir grains consisted basically of water (85.61 ± 0.41%) and had an acidic pH (4.45) and low acidity (0.44 ± 0.09% lactic acid). To determine the process parameters, it was used a 23 factorial design with three replications at the central point, being evaluated the amount of grain (2-6%), amount of sugar (10-14%) and fermentation time (18-24 hours) at 25oC. The amount of sugar or grains had no influence on the pH and titratable acidity. A longer fermentation time (24 hours) resulted in products with pH and acidity within the recommended values, while fewer grains (2%) did not result in too firm beverages. The formulation with the best physicochemical and sensory characteristics had 2% grain, 10% sugar and 24 hours of fermentation, being described as creamy, slightly acidic and with intermediate sweetness.

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