scholarly journals Formulation and Evaluation of Orodispersible Tablet of Domperidone

2012 ◽  
Vol 10 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Ashiqul Islam ◽  
Syed Shabbir Haider ◽  
Md Selim Reza
Keyword(s):  
Physical Stability ◽  
Disintegration Time ◽  
Drug Content ◽  
Sodium Starch Glycolate ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Orodispersible Tablet ◽  
Saccharin Sodium ◽  
Time Required ◽  
Mouth Feel

The aim of the present study was to develop and evaluate orodispersible tablets of domperidone by  direct compression method. Sodium starch glycolate ( SCG ), Kollidone CLSF and sodium bicarbonate were used as  disintegrants to achieve the desired disintegration time required for orodispersible tablets. To mask the bitter taste of  drug, impart sweetness and to offer a better feeling in mouth, saccharin sodium, aspartame, citric acid, menthol and  lemon flavor were also added. Mannitol and lactose were used as sugar based multifunctional diluents. The prepared  tablets were evaluated for their physical (hardness, friability, weight variation), organoleptic (taste, mouth-feel, color)  and functional (disintegration time) properties and for the drug content. The excipients were used in various  concentrations in order to optimize the desired properties. SCG and Kollidone CLSF, used in 5.5% and 4%  respectively, gave satisfactory disintegration time using BP instrument and within the mouth. Combination of  saccharin sodium (1.5%) and aspartame (3%) along with mannitol (40%) and other excipients effectively masked the  bitterness and provided satisfactory sweetness level. Incorporation of 0.05% menthol provided excellent mouth  feeling as assessed by a panel of volunteers. Hardness and friability values were also optimized in the formulations to  produce tablets of acceptable physical stability and mechanical strength. Weight variation and drug content of all  formulations fully complied with the official specifications.   DOI: http://dx.doi.org/10.3329/dujps.v10i2.11791   Dhaka Univ. J. Pharm. Sci. 10(2): 117-122, 2011 (December)    

PREPARATION & EVALUATION OF ORODISPERSIBLE TABLET CONTAINING ASPIRIN BY SUBLIMATION METHOD

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (12) ◽  
pp. 60-62
Author(s):  
P. Jain ◽  
◽  
A Mishra ◽  
A. Pathak
Keyword(s):  
Content Uniformity ◽  
Disintegration Time ◽  
Sodium Starch Glycolate ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Orally Disintegrating Tablets ◽  
Orodispersible Tablet ◽  
Sublimation Method ◽  
Dispersing Ability

Orodispersible tablets are uncoated tablets which when taken into the mouth, get easily dispersed within 3 min before swallowing. they are also known as orally disintegrating tablets, mouth-dissolving tablets, rapid dissolving tablets fast-disintegrating tablets, fast-dissolving tablets. In this work, sublimation process was used to prepare orodispersible tablets of aspirin by formulating various batches using different concentration of sodium starch glycolate, camphor and cross povidone. An effort was made by using two modes, first, to increase water uptake for the fast dispersion by creating pores by sublimation methods in tablets and second, use of super disintegrantes like sodium starch glycolate to minimise disintegration time and promote fast dispersing ability. Prepared formulations were evaluated for weight variation, content uniformity, friability, hardness, wetting time, disintegration time, in vitro drug release and interaction study by differential scanning calorimetery. The best formulation was selected on the basis of evaluation results.

scholarly journals Development of Tropisetron Hydrochloride Orodispersible Tablet using Natural Superdisintigrants

2021 ◽  
pp. 191-210
Author(s):  
Rupalben K. Jani ◽  
Gohil Krupa ◽  
Aanal Gandhi ◽  
Vijay Upadhye ◽  
Roshani Pragnesh Amin
Keyword(s):  
Drug Candidate ◽  
Antiemetic Drug ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Cassia Tora ◽  
Weight Variation ◽  
Orodispersible Tablet ◽  
Value Loss ◽  
Time Required

The foremost objective of this research was to compare and evaluate natural super disintegrants with synthetic super disintegrants for the preparation of the orodispersible tablet. Tropisetron hydrochloride is widely used as an antiemetic drug, which is a potential drug candidate for developing an orodispersible tablet for quick onset of action. Various formulations were prepared using different concentrations (5%, 7.5%, and 10%) by direct compression method of natural super disintegrants (Banana power and Cassia tora powder) and synthetic super disintegrants (Croscarmellose sodium, Crospovidone, and Sodium starch glycolate). The compatibility studies between the drug and excipients were carried out using FTIR spectroscopy before tablet formulation. The pre-compression parameters were evaluated for additive properties. Standardization of banana powder was done by various parameters like extractive value, ash value, loss on drying, TLC identification test, etc. Post-compression parameters like hardness, weight variation, friability, thickness, the time required for disintegration, wetting time, the release of drug in-vitro, and in-vitro dispersion time of the tablets were evaluated. The disintegration time and in-vitro drug release of optimized formulation (F2) were found to be 4.66±1.15 secs and 99.25±0.15%. The optimized formulation (F2) was subjected to stability studies (40 C& 75 % RH) for one month. The results were shown that natural super disintegrants require less disintegration time as compared to synthetic super disintegrants. Hence present study reveals that the orodispersible tablets prepared using Banana powder and Cassia tora powder is super disintegrants that shown better appearance and rapid disintegration time.

scholarly journals Formulation design, optimization & in vitro evaluation of novel orodissolving tablets of efavirenz for hiv infections

2015 ◽  
Vol 49 (3) ◽  
pp. 173-180
Author(s):  
T Ayyappan ◽  
C Poojitha ◽  
T Vetrichelvan
Keyword(s):  
Drug Release ◽  
In Vitro Dissolution ◽  
Dissolution Time ◽  
Disintegration Time ◽  
In Vitro Drug Release ◽  
Drug Content ◽  
Sodium Starch Glycolate ◽  
Weight Variation ◽  
Wetting Time

In the present work, orodissolving tablets of Efavirenz were prepared by direct compression method with a view to enhance patient compliance. A 23 full factorial design was applied to investigate the combined effect of three formulation variables. Amount of crospovidone, croscarmellose sodium and sodium starch glycolate were used as superdisintegrant material along with direct compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration time, wetting time, drug content and in-vitro dissolution studies. Based on wetting time, disintegration time, the formulation containing crospovidone (5% w/v), carscarmellose sodium (5% w/v) and sodium starch glycolate (8% w/v) was found to be promising and tested for in-vitro drug release pattern (in 0.1 N HCl), short term stability and drug- superdisintegrants interaction. Surface response plots are presented to graphically represent the effect of independent variables (conc. of superdisintegrants) on the in-vitro dissolution time. The validity of the generated mathematical model was tested by preparing extra-design check point formulation. The formulation showed nearly faster drug release compared to the conventional commercial tablet formulation. Stability studies on the optimized formulation indicated that there was no significant change found in physical appearance, hardness, disintegration time, drug content and in-vitro drug release. DOI: http://dx.doi.org/10.3329/bjsir.v49i3.22131 Bangladesh J. Sci. Ind. Res. 49(3), 173-180, 2014

scholarly journals Formulation and Evaluation of Fast Dissolving Film of Losartan Potassium

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
Bhageerathy A ◽  
Sandhya Murali ◽  
eny Sara Thomas ◽  
Sigi Vasanthkumar ◽  
Prasanth V V
Keyword(s):  
Drug Release ◽  
Physical Stability ◽  
Losartan Potassium ◽  
In Vivo Studies ◽  
Disintegration Time ◽  
Drug Content ◽  
Weight Variation ◽  
Significant Difference

A total of nine formulations of fast dissolving films of Losartan Potassium were developed by solvent casting method using film forming polymers such as HPMC E5, E15 and E50 and other film modifiers. The appearances of films were transparent, thin, flexible, elastic, smooth and transparent. The weight variation ranged between 16.14 ± 0.192 and 17.31 ± 0.313 and showed that there was no significant difference in the weight of individual formulations. All the formulations showed more than 150 of folding endurance. The drug content was found to be in an acceptable range for all the formulations which indicated uniform distribution of drug. A rapid dissolution of all the film was observed by the dissolution test, in which above 90% of Losartan Potassium was released within 5 min. The formulation F1 showed maximum drug release (98.73) within 5 minutes. Based on the in vitro drug release, drug content and in vitro disintegration time it is found that F1 was selected as the best formulation. The formulations showed satisfactory physical stability at 40°C at 75 % RH. Losartan Potassium (LOSAR-25) is shown in Figure 4. From the results of comparative studies of marketed product and it found that F1 showed 98.73% release within 5 min and LOSAR 25 showed 90.76% release in 30 min. In vitro studies indicate that this potential drug delivery system has considerably good stability and release profile. Nevertheless, further in vivo studies are warranted to confirm these results.

scholarly journals Formulation and Evaluation of Oral dispersible Tablet of Paroxetine Hydrochloride

2021 ◽  
Vol 11 (4) ◽  
pp. 41-47
Author(s):  
Ria Shah ◽  
Disha Patel ◽  
Dhruvanshi Kothari ◽  
Hetvi Shah ◽  
Aishwarya Chavda ◽  
...  
Keyword(s):  
Self Administration ◽  
Drug Release Profile ◽  
Onset Of Action ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Novel Approach ◽  
Orodispersible Tablet ◽  
Sodium Saccharin ◽  
Paroxetine Hydrochloride

Orodispersible tablets (ODTs) is one such novel approach which helps to increase user acceptance by virtue of rapid disintegration, self-administration without water or chewing. ODTs are solid unit dosage forms like the conventional tablets containing super disintegrants, which help them to disintegrate and/or disperse rapidly in the mouth within few seconds. The orodispersible tablet of Paroxetine hydrochloride was prepared by using direct compression method and the tablet were formulated using various concentration of Kyron T-314 as disintegrating agent, PVP K-30 as binder, F melt Type C as diluent, Sodium Saccharin as sweetening agent, talc as lubricant and Aerosil as glidant respectively. All the batches were prepared according to Factorial design. The prepared tablets were evaluated for various parameters like hardness, dissolution, friability, weight variation, disintegration time. Batch F5 was found to be the best batch as the disintegration time is minimum (26seconds) and better drug release profile. Orodispersible tablets of Paroxetine Hydrochloride were successfully formulated by which first pass metabolism could be avoided and faster onset of action could be achieved.

Formulation and Evaluation of Orally Disintegrating Tablets of Lamotrigine

2015 ◽  
Vol 8 (2) ◽  
pp. 2881-2888
Author(s):  
Sudarshan Singh ◽  
S S Shyale ◽  
P Karade
Keyword(s):  
Drug Release ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Disintegration Time ◽  
Orally Disintegrating Tablet ◽  
Drug Content ◽  
Weight Variation ◽  
Wetting Time ◽  
Croscarmellose Sodium

The aim of this study was to design orally disintegrating tablet (ODT) of Lamotrigine. It is an Antiepileptic drug which is widely used in epilepsy. It is also used in simple and complex partial seizures and secondary generalized tonic-clonic seizures. It is poorly water soluble drug (0.46 mg/ml). Thus, an attempt was made to enhance the water solubility by complexation with β-cyclodextrin (1:1 molar ratios). The orally disintegrating tablet of lamotrigine was prepared by direct compression method using different concentration of superdisintegrants such as Sodium starch glycollate, croscarmellose sodium by sublimating agent such as camphor. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro disintegration time and in vitro dissolution studies. The prepared tablets were characterized by Fourier transform infrared spectroscopy and differential scanning calorimetry. The disintegration time for the complexed tablets prepared by different concentration of superdisintegrants was found to be in range of 32.54 ± 0.50 to 55.12 ± 0.57 sec and wetting time of the formulations was found to be in range of 28.47 ± 0.67 to 52.19 ± 0.72 sec. All the formulation showed almost 100 percent of drug release within 15 min. Among all the formulation F6 and F7 prepared with 18% croscarmellose sodium and camphor shows faster drug release, respectively 10 min, F6 gives good result for disintegration time, drug release, wetting time and friability. Further formulations were subjected to stability testing for 30 days at temperature of 40 ± 5 ºC/75 ± 5 %RH. Tablets showed no appreciable changes with respect to physical appearance, drug content, disintegration time and dissolution profiles. Results were statistically analyzed by one-way ANOVA at a p < 0.05. It was found that, the data at any point of time are significant at p < 0.05.

Quality Evaluation of Generic Products of Metformin and Vildagliptin Tablets

2021 ◽  
pp. 255-258
Author(s):  
Bhavana Habib ◽  
Jyoti Mittha
Keyword(s):  
Quality Control ◽  
Quality Evaluation ◽  
Indian Market ◽  
Disintegration Time ◽  
Innovator Product ◽  
Drug Content ◽  
Weight Variation ◽  
Generic Products

The aim of the present study was the evaluation and comparison between four different Metformin and Vildagliptin tablets which are commercially available in Indian market. These tablets were assessed for various pharmacopoeial quality control tests. Parameters including weight variation, hardness, friability, drug content, and disintegration time were evaluated. Results were within acceptable limits for all selected products (three generic and an innovator). These results show that the tested generic products were biopharmaceutically similar to the innovator formulation. Therefore, the consumer can select any one of these equivalent products as a substitute for innovator product in case of cost concern or unavailability.

Formulation and Evaluation of Orodispersible Tablets Containing Taste Masked Mirabegron Resinate

2021 ◽  
pp. 4736-4742
Author(s):  
Sarika S. Malode ◽  
Milind P. Wagh
Keyword(s):  
Overactive Bladder ◽  
Bitter Taste ◽  
In Vitro Release ◽  
In Vitro Dissolution ◽  
Dissolution Time ◽  
Disintegration Time ◽  
Orodispersible Tablets ◽  
Weight Variation

The objective of present work was to develop taste masked orodispersible tablets of mirabegron. Mirabegron is beta 3 adrenoceptor agonist used to treat overactive bladder. Overactive bladder (OAB) is defined as a symptom syndrome showing feeling of urgency to urinate, typically accompanied by frequent daytime and nocturnal urination, in the absence of proven infection or other obvious pathology. Over active bladders are generally common in geriatrics. Moreover, this drug has a very strong bitter taste. Frequent dosing requires frequent water intake, which further aggregates the condition of over active bladder and bitter taste of drug affects patient compliance. Hence a need arises to mask the bitter taste for development of an ODT which does not require consuming water with every dosage. In this work, the bitter taste of mirabegron was masked by forming a complex with an ion exchange resin tulsion 344. The drug resin complexation process was optimized for resin activation, drug: resin ratio, soaking time and stirring time. In –vitro release studies revealed complete drug elution from the complex within 10 minutes in pH 1.2 buffer. The taste-masked complex was then formulated into palatable orodispersible tablets using a direct compression approach by use of superdisintegrants to achieve a rapid disintegration. The tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, In- vivo disintegration time and in-vitro dissolution time.

scholarly journals An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Mohammed Ghazwani ◽  
Umme Hani ◽  
Riyaz Ali M. Osmani ◽  
Mohamed Rahamathulla ◽  
M. Yasmin Begum ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Side Effects ◽  
Drug Release ◽  
Cancer Patients ◽  
Poloxamer 407 ◽  
Vaginal Candidiasis ◽  
Disintegration Time ◽  
Drug Content ◽  
Vaginal Suppository ◽  
Weight Variation

Aim. The study is aimed at developing curcumin suppositories as a promising approach for natural antifungal management of vaginal candidiasis in cervical cancer patients to eradicate side effects produced by current antifungal drugs. The objective of the study was to optimize the suppositories using optimal (custom) design employing Design-Expert 13 software to recognize the concentration of polyethylene glycols (PEG) and Poloxamer 407 and obtain a stable suppository. Methodology. Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. Results. Suppositories were devoid of holes and cracks, with a characteristic odor and a dark yellowish-orange color. All formulations passed the weight variation test. Formulations exhibited pH ranging from 5.5 to 6.5. Drug content was observed to be 98.65 ± 0.041 % – 99.85 ± 0.041 % . The hardness of the formulation was between 2.9 and 4.2 kg/cm2. The disintegration time ranged from 11 ± 0.052   min to 20 ± 0.011   min . The melting point was between 41 ± 0 . 31 ° C and 58 ± 0 . 62 ° C . Deformation time ranged from 10 ± 0.45 to 35 ± 0.52   min . Most of the formulations resulted in 90% of drug release at 40 min, and the zone of inhibition noted was 19.6 ± 0.4   mm . All the selected factors have a significant effect on the response chosen for the study. Conclusion. The optimized curcumin vaginal suppository formulation can be an efficient herbal treatment devoid of side effects to treat vaginal candidiasis in cervical cancer patients.

Evaluation of the disintegrant property of co-processed sorghum starch-silicon dioxide excipient in chlorpheniramine orodispersible tablets

2020 ◽  
Vol 1 (3) ◽  
pp. 1-10
Author(s):  
S.T. Noma ◽  
◽  
B.A. Tytler ◽  
A.K. Olowosulu ◽  
Z.S. Yahaya ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
In Vitro Dissolution ◽  
Average Weight ◽  
Chlorpheniramine Maleate ◽  
Differential Scanning Calorimetry Study ◽  
Sodium Starch Glycolate ◽  
Orodispersible Tablets ◽  
Weight Variation ◽  
Study Results ◽  
Croscarmellose Sodium

Background: Fast dissolving or orodispersible tablets are highly desirablein groups such as children, uncooperative, nauseated, or those on reduced water intake to ease the difficulties associated with swallowing the conventional solid dosage forms. Objectives: The work aimed to evaluate the disintegrant property of sorghum starch-silicon dioxide co-processed mixture in the formulation of chlorpheniramine orodispersible tablets. Method: Different batches of orodispersible tablets of chlorpheniramine maleate (4 mg) were prepared by direct compression method using Avicel® as a bulking agent and four different types of disintegrants (sorghum starch, co-processed sorghum starch-colloidal silicon dioxide, sodium starch glycolate and croscarmellose sodium) at varying concentrations (5, 10 and 20 %). The formulated tablets were subjected to weight variation test, thickness, crushing strength, friability test, wetting time, water absorption ratio, disintegration test and in-vitro dissolution study. Results: For tablets above 250 mg, it is expected that not more than two tablets should deviate from the average weight by 5% and none should deviate by more than 10%, all the formulations yielded tablets within this specification. The disintegration time of tablets containing 10% of disintegrants was all less than 60 s except those containing sorghum starch (SS) which took a long time. Similarly, the time taken to release 50 % of the drug (t50%) for tablets containing 10% sorghum starch was 25 s, 5 s for tablets containing 10% sorghum starch-colloidal silicon dioxide excipient and 8 s for tablets containing 10% of either croscarmellose sodium or sodium starch glycolate. The differential scanning calorimetry study results suggested that the drug and the excipient are compatible. Conclusion: The results show that sorghum starch-silicon dioxide co-processed mixture can be used as an alternative to croscarmellose sodium and sodium starch glycolate in orodispersible tablet formulations.

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