scholarly journals Nanosuspension: A Novel Drug Delivery System

2013 ◽  
Vol 2 (4) ◽  
pp. 179-196 ◽  
Author(s):  
Bhatt Ganesh ◽  
Raturi Ankita ◽  
Kothiyal Preeti
Keyword(s):  
Matrix Material ◽  
Poorly Soluble Drugs ◽  
Wet Milling ◽  
Essential Factor ◽  
Nonaqueous Media ◽  
Poorly Soluble ◽  
Emulsification Solvent Evaporation ◽  
Novel Drug ◽  
Vehicle Size ◽  
As Solubility

Low bioavailability is the major problem associated with poorly soluble drugs. The problem is more complex for drugs which are poorly soluble in both aqueous and nonaqueous media, as solubility is an essential factor for drug absorption, independent of the route of administration. Nanosuspensions have emerged as an attractive and promising approach to improve stability and bioavailability of poorly soluble drugs. These are very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1?m, without any matrix material, stabilized by surfactants and polymers. Techniques such as wet milling, high-pressure homogenization, emulsification-solvent evaporation and supercritical fluid have been used in the preparation of nanosuspension. Nanosuspension can be delivered by oral, parenteral, pulmonary and ocular routes. DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17117 International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 179-196

Nanosuspensions: Recent Patents and Pharmaceutical Aspects as Drug Delivery Systems

2017 ◽  
Vol 10 (2) ◽  
pp. 3631-3644
Author(s):  
Vikram S Gharge ◽  
Mukesh B Shinde ◽  
Bipin D Pustake ◽  
Krishna B Kinage ◽  
Anup A Kulkarni
Keyword(s):  
Drug Delivery ◽  
Pharmaceutical Preparation ◽  
Aqueous Media ◽  
Poorly Soluble Drugs ◽  
Wet Milling ◽  
Drug Effectiveness ◽  
Pharmaceutical Application ◽  
Poorly Soluble ◽  
Emulsification Solvent Evaporation ◽  
Biphasic Systems

Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-aqueous media. Nanosuspension technology can be used to improve the stability as well as the bioavailability of poorly soluble drugs. Nanosuspensions are biphasic systems consisting of pure drug particles dispersed in an aqueous vehicle, stabilized by surfactants. These are simple to prepare and are more advantageous than other approaches. Techniques such as wet milling, high-pressure homogenization, emulsification–solvent evaporation and super critical fluid have been used in the preparation of nanosuspensions. It has the advantage of delivery by various routes, including oral, parenteral, pulmonary and ocular routes. The present article reviews the current methods used to prepare nanosuspensions and their application in drug delivery. More than 100 patents have been published on nanosuspensions in the recent days. This patent reviews covers different methods of pharmaceutical preparation and applications in drug delivery as well as the recent marketed published or granted patent surveys. This patent review is useful in enhanceing the knowledge of pharmaceutical application in drug delivery.

scholarly journals Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

2019 ◽  
Vol 9 (2) ◽  
pp. 574-582
Author(s):  
Stanekzai Azimullah ◽  
, Vikrant ◽  
CK Sudhakar ◽  
Pankaj Kumar ◽  
Akshay Patil ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Water Soluble ◽  
Wet Milling ◽  
Poorly Water Soluble Drugs ◽  
Limited Applicability ◽  
Water Soluble Drugs ◽  
Poorly Soluble ◽  
Poorly Water Soluble ◽  
Emulsification Solvent Evaporation ◽  
Biphasic Systems

Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Techniques like high-pressure homogenization, wet milling, emulsification, solvent evaporation, bottom up technology and top down technology have been applicable in the fabrication of nanosuspensions. Nanosuspension delivery is possible by several routes, such as oral, pulmonary, parenteral and ocular routes. Nanosuspension not only solves solubility and bioavailability issue, but improve drug safety and efficacy. In this context, we reviewed the current techniques used to develop nanosuspensions and their recents studies application in drug delivery system. Keywords : Solubility, fabrication, Characterization, Applications, Nanosuspension.

Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling

2011 ◽  
Vol 411 (1-2) ◽  
pp. 215-222 ◽  
Author(s):  
Peng Liu ◽  
Xinyu Rong ◽  
Johanna Laru ◽  
Bert van Veen ◽  
Juha Kiesvaara ◽  
...  
Keyword(s):  
Poorly Soluble Drugs ◽  
Wet Milling ◽  
Poorly Soluble

Enhancement the Dissolution Rate and Solubility of Poorly Soluble Drugs: Review

2013 ◽  
Vol 701 ◽  
pp. 234-238 ◽  
Author(s):  
Mubarak Abdullah Saleh ◽  
Salam A. Mohammed ◽  
Ezzat C Abdullah ◽  
Laith A. Hashim
Keyword(s):  
Drug Delivery ◽  
Chemical Composition ◽  
Active Pharmaceutical Ingredient ◽  
Nucleation Mechanism ◽  
Rapid Freezing ◽  
Poorly Soluble Drugs ◽  
Pharmaceutical Development ◽  
Drug Products ◽  
Poorly Soluble ◽  
As Solubility

The use of reduction and nucleation technologies in nanosize active pharmaceutical ingredient (API) is as an enabling to bring improved drug products to the marketplace demand as well as for improved drug delivery. nanoPharmaceutical field represents a hopeful set of pharmaceutical materials offering the prospect of better alternatives to optimize drug physical properties and biopharmaceutical issues such as solubility, stability and bioavailability in pharmaceutical development without changing the chemical composition of the API, thereby, giving new patentable solid forms. With physically improved solid API may impact the the pharmaceutical intellectual property landscape. Nanoparticle formation is achievable in many ways, although primarily through particle reduction or through manipulation of the nucleation mechanism. Keywords: active pharmaceutical ingredient; drug delivery; ultra rapid freezing.

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

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