scholarly journals T-cell Lymphoblastic Leukaemia/Lymphoma Presenting as Bilateral Renal Enlargement and Arthritis: A Rare Case Report

2020 ◽  
Vol 21 (2) ◽  
pp. 109-112
Author(s):  
Md Minhaj Uddin Bhuiyan ◽  
Rajib Bhowmic ◽  
Md Shahriar Siddiki ◽  
Md Kamrul Hasan Patwari ◽  
Sarmistha Biswas
Keyword(s):  
T Cell ◽  
Lymphoblastic Leukaemia ◽  
Clinical Suspicion ◽  
Flank Pain ◽  
Diagnostic Challenge ◽  
Rare Case Report ◽  
Night Sweats ◽  
Renal Enlargement ◽  
Systemic Symptoms ◽  
Histopathological Evidence

Lymphoma usually presents as painless enlargement of lymph nodes with or without systemic symptoms like fever, weight loss, night sweats, itching and hepatosplenomegaly. But renal enlargement and arthritis as initial manifestations of lymphoma are very uncommon and poses a potential diagnostic challenge. Renal manifestations of lymphoma are usually nonspecific hematuria, fever, flank pain and oliguria. Pathological data are scanty in this regard; few reports indicate that it has a very poor prognosis. Here we described a case of lymphoma presented with bilateral palpable kidneys, pyrexia and arthritis. Initially diagnosis was confused as renal dysfunction was absent and also the condition is rare. However, strong clinical suspicion along with radiological and histopathological evidence as well as immunophenotyping tests helped to diagnose the case as T-cell lymphoblastic leukaemia/lymphoma. J MEDICINE JUL 2020; 21 (2) : 109-112

scholarly journals T cell acute lymphoblastic leukaemia presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and cerebrospinal fluid studies

2012 ◽  
Vol 2012 (mar26 1) ◽  
pp. bcr0120125685-bcr0120125685
Author(s):  
V. R. Bhatt ◽  
M. Naqi ◽  
R. Bartaula ◽  
S. Murukutla ◽  
S. Misra ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Nerve Palsy ◽  
Sudden Onset ◽  
Oculomotor Nerve ◽  
Oculomotor Nerve Palsy

scholarly journals P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature

2021 ◽  
pp. 1040-1050
Author(s):  
Samah Kohla ◽  
Sarah EL Kourashy ◽  
Zafar Nawaz ◽  
Reda Youssef ◽  
Ahmad Al-Sabbagh ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Rare Case ◽  
De Novo ◽  
Lymphoblastic Leukemia ◽  
Prognostic Significance ◽  
Philadelphia Chromosome ◽  
Cytogenetic Abnormality ◽  
Rare Case Report ◽  
Philadelphia Chromosome Positive

T-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL). Ph+ T-ALL is exceeding rare and has a therapeutic and prognostic significance. The incidence and outcome of Ph+ T-ALL are unknown. Differentiation between Ph+ T-ALL/LBL and T-cell lymphoblastic crises of CML may be difficult. We report a rare case of adult de novo T-ALL with significant monocytosis, having Ph+ with (P190 <i>BCR-ABL1</i>) as a cytogenetic abnormality. He was treated with ALL induction chemotherapy and imatinib and achieved complete remission, then relapsed twice and expired shortly after the last CNS relapse.

scholarly journals PF163 TARGETING LYSOSOMES AS A POTENTIAL THERAPEUTIC APPROACH FOR T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 33-34
Author(s):  
A. Banus Mulet ◽  
J.M. Cornet-Masana ◽  
J.M. Carbó ◽  
L. Cuesta-Casanovas ◽  
F. Guijarro ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Therapeutic Approach
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