scholarly journals Evaluation of lipid profile among children and adolescents with type 1 diabetes mellitus in Bangladesh

Mediscope ◽  
2018 ◽  
Vol 5 (1) ◽  
pp. 15-21
Author(s):  
M Parveen ◽  
MA Muttalib ◽  
ST Huq ◽  
N Nazneen ◽  
MA Kabir ◽  
...  

The study, a cross-sectional survey, was carried out at the Department of Biochemistry in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) General Hospital from July 2015 to June 2016. A total of 576 clinically diagnosed children and adolescents with type 1 diabetes mellitus (T1DM) aged 10-18 years attending in ‘Changing Diabetes in Children’ clinic, BIRDEM-2, Dhaka were selected according to appropriate inclusion and exclusion criteria. The study subjects underwent detailed medical history and examination. Fasting blood samples were drawn from the participants for biochemical assays such as fasting blood sugar (FBS), glycated haemoglobin (HbA1c), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides. Anthropometric data and blood pressures both systolic and diastolic were measured. Student unpaired t-test and Chi-square test were used to determine the association between different groups. Out of 576 T1DM patients, 45.0% (259) were male and 55.0% (317) were female. Of the 576 T1DM patients, 35.1% were without dyslipidemia (DLP) and 64.9% were with DLP. Study revealed that the patients with DLP were more likely to have higher values of HbA1c (10.1±2.2% vs 9.4±1.9%, p < 0.001) and FBS (13.0±4.4 mmol/L vs 10.2±2.9 mmol/L, p < 0.001). A substantial proportion of children and adolescents with T1DM had DLP. We found an association between poor glycemic control and abnormal lipid profiles in those patients. Mediscope Vol. 5, No. 1: Jan 2018, Page 15-21

Author(s):  
Nosaiba Ahmed Hussein Abdelseed

Purpose: The aim of this study is to evaluate the long-term glycemic control by glycosylated hemoglobin level (HbA1c) and to assess knowledge about the diabetic regimen. The results of glycemic control in this study were compared with the results of a study conducted in 2018 that targeted almost a similar population. Study Design: A Cross-Sectional Study. Subjects and Methods: The study was conducted in October 2012 to December 2012 in a major referral Diabetic Centre. Diabetic children aged 8 to 18 years old who were attending the referral diabetic clinics were included in the study (n = 90). Knowledge of diabetes management was evaluated by using a semi-structured questionnaire and HbA1c results were obtained from medical records, available for only 71. Later, these Glycated Hemoglobin HbA1c results were compared with the results of a recent study carried out among Sudanese diabetic children and adolescents in 2018. Results: Out of 71 diabetic children 78.9% were of poor glycemic control with mean HbA1c 10.36±2.14. On the other hand, the majority had good knowledge about the diabetic treatment including insulin administration, its storage conditions, and also the effect of exercise on blood glucose. However, almost 18.8% of studied participants did not know hypoglycemia symptoms, and about 11% of these patients were unaware of hypoglycemia management. Conclusion: The study has indicated that a significant percentage of studied diabetic children and adolescents had poor glycemic control. Although children’s knowledge about insulin therapy was good, further study must be conducted to investigate factors related to glycemic control among children with type 1 diabetes mellitus (T1DM).  


2020 ◽  
Author(s):  
Leen Jamel Doya ◽  
Naya Talal Hassan ◽  
Entessar Nasser ◽  
Muhammad Imad Khayat

Abstract Background: Type 1 diabetes mellitus (T1DM) and dyslipidemia (DLP) are serious metabolic disorders, and its coexistence has been associated with dangerous outcomes. The purpose of the present study is to investigate dyslipidemia and their relationship with glycosylated hemoglobin (HbA1c) in Type 1 diabetes mellitus patients.Methods: In a cross-sectional study design included 118 patients with Type 1 diabetes mellitus aged between 5 and 13 years, who had referred to the outpatient pediatric clinic of endocrinology at Tishreen University Hospital and the Diabetic Center of Latakia, Syria, over 1 year period from October 2018 to November 2019. Anthropometric measurements; serum glycosylated hemoglobin (HbA1C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL), and triglycerides(TG) were measured.Results: The results showed that there was a significant relationship between dyslipidemia with a higher mean HbA1C (p=0.0001). Also, a significant relationship was found between all lipid profiles expect HDL-C and poor glycemic control. There was no statistical relationship between dyslipidemia and age, gender, body mass index (BMI), or diabetic durationConclusion: Glycemic control plays a role as a risk factor for the development of dyslipidemia in children with Type 1 diabetes mellitus.


2013 ◽  
Author(s):  
Parthasarathy Lavanya ◽  
Khadilkar Anuradha ◽  
Ekbote Veena ◽  
Chiplonkar Shashi ◽  
Mughal Zulf ◽  
...  

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