scholarly journals Morbidities of preterm VLBW neonates and the bacteriological profile of sepsis cases

Pulse ◽  
2011 ◽  
Vol 4 (1) ◽  
pp. 5-9
Author(s):  
MM Hoque ◽  
ASMNU Ahmed ◽  
SK Halder ◽  
MFH Khan ◽  
MAKA Chowdhury
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Tertiary Care ◽  
Developed Countries ◽  
Normal Weight ◽  
Suspected Sepsis ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
Increased Risk

Background: Preterm very low birth weight babies are at increased risk of perinatal, neonatal and postnatal mortality and morbidity, mainly due to infections and complications of prematurity. Mortality of VLBW neonates is 30 times more than that of normal weight. Outcomes of such infants have been reported extensively from developed countries, but less is known from developing countries like Bangladesh though prematurity is very common.Objective: To determine the morbidities associated with preterm VLBW neonates with particular emphasis on sepsis. Methods: A prospective cohort study was done in Special Care Baby Unit of a tertiary care teaching hospital from July 2009 to December 2009. Preterm VLBW neonates admitted within 7 days of age comprised the cohort for the study. Detailed physical findings and information on pregnancy, delivery and immediate postnatal period were recorded on enrolment. Sepsis workup was done whenever sepsis was suspected clinically. Daily follow-up was given till discharge/death and relevant clinical findings recorded. Data were analyzed using SPSS 12.    Results: A total of 738 neonates were admitted during study period, 92 were preterm VLBW and enrolled in the cohort. Fifty-two (56.5%) of the enrolled cases were male and 40 (43.5%) female, male female ratio of 1.3:1. Mean gestational age was 30.8±2.4 weeks and mean birth weight 1,320±133 grams. Eight cases (8.7%) had features of septicaemia on admission and 49 (53.2%) neonates subsequently developed nosocomial infections. Other morbidities were jaundice (34.8%), RDS (8.7%), NEC (4.3%), TTN (3.3%), IVH (2.2%) and PDA (1.1%). Blood culture was positive in 29.8% among 57 suspected sepsis cases; Acinetobacter (41.2%) was the most common organism, followed by Klebsiella pneumoniae (23.5%), Escherichia coli (23.5%) and Pseudomonas sp. (11.8%). Sixty (62.5%) preterm VLBW neonates were improved and discharged, 3 (3.3%) cases were discharged on risk bond and 29 (31.5%) died.Conclusions: Preterm VLBW neonates are at increased risk of morbidity and mortality. Septicemia is the most common and devastating morbidity, most infections are hospital acquired. Therefore strict protocol for asepsis in neonatal units must be adhered to when handling these high risk infants. Key words: Preterm; very low birth weight; septicaemia; morbidity; mortalityDOI: http://dx.doi.org/10.3329/pulse.v4i1.6955Pulse Vol.4 January 2010 p.5-9

scholarly journals Clinical profile and factors determining outcome of intramural very low birth weight babies in a tertiary care centre: a retrospective study

2017 ◽  
Vol 5 (2) ◽  
pp. 520
Author(s):  
Devi Meenakshi K. ◽  
Arasar Seeralar A. T. ◽  
Srinivasan Padmanaban
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Logistic Regression Analysis ◽  
Very Low Birth Weight ◽  
Tertiary Care ◽  
P Value ◽  
Increased Risk

Background: Very low birth weight (VLBW) babies are at increased risk of a number of complications both immediate and late. Worldwide it has been observed that these babies contribute to a significant extent to neonatal mortality and morbidity. Aim of the study was to study the risk factors contributing to mortality in VLBW babies and to evaluate the morbidity pattern in these infants.Methods: A retrospective analysis of data retrieved from the case records of VLBW babies admitted in the NICU of Kilpauk Medical College between January 2015 to December 2015. Out of the 2360 intramural babies admitted during the study period, 99 babies were less than 1500 gms. The risk factors for these babies were analyzed for their association with the outcome. Data were statistically analyzed.Results: In present study, we found that sex of the baby, gestational age, obstetric score, birth asphyxia, pulmonary haemorrhage, ROP and presence of shock were found to be associated with increased mortality. By logistic regression analysis it was observed that birth weight of the baby (p value 0.002), duration of stay (p value 0.0006), presence of shock (p<0.0001), were the risk factors significantly associated with poor outcome.Conclusions: Among the maternal and neonatal factors analyzed in the study using logistic regression analysis, birth weight, duration of hospital stay and presence of shock were significantly related to poor outcome. Of these presence of shock was the single most important factor that predicted increased mortality.

scholarly journals Morbidity profile and immediate outcome of low birth weight neonates in a rural tertiary care hospital of Gujarat, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1272
Author(s):  
Manish Rasania ◽  
Sunil Pathak ◽  
Prerna Dogra ◽  
Ayushi Jain ◽  
Neil Shah ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Tertiary Care ◽  
Normal Weight ◽  
Health Improvement ◽  
Care Hospital ◽  
Normal Birth Weight ◽  
Mortality And Morbidity ◽  
Normal Birth ◽  
Partnership Model

Background: Low birth weight (LBW) has been defined as a birth weight of <2.5 kilogram regardless of gestational age. In India, every 3rd born child is of LBW. LBW is associated with increased neonatal mortality and morbidity, compromised growth and cognitive development.Methods: This is a retrospective cohort study using previously collected data from January 2015 to December 2015.Results: Out of 1238 live births, 485 (39.17%) were LBW. 456(94.01%) were LBW weighing >1500 grams (LBW), 22(4.53%) were VLBW, and 07(1.44%) were ELBW. 361(74.43%) were LBW2 (birth weight ≥2000 - <2500 grams), 95(19.58%) were LBW1 (birth weight ≥1500 - <2000 grams). 289(59.58%) of LBW neonates were full term. SNCU admission is significantly higher in LBW neonates (25.8% vs 9.61%). Morbidities were higher in LBW neonates compared to normal birth weight neonates. Difference was more significant in incidence of sepsis (3.72% vs 0.83%), RDS (2.19% vs 0%), TTN (5.48% vs 2.36%), hypoglycemia (1.31% vs 0%), feed intolerance (1.09% vs 0%) and risk of major congenital malformation (1.97% vs 0.27%). Need for respiratory support was 4.82% in LBW vs 2.36% in normal birth weight neonates. Morbidities were significantly higher in VLBW and ELBW neonates. Immediate poor outcome was in 3.92% in LBW neonates, while it was 0.56% in normal weight neonates. Poor immediate outcome was 1.11% in LBW2, 2.10% in LBW1, 10% in VLBW1, 41.66% IN VLBW2, and 100% in ELBW.Conclusions: LBW neonates are at higher risk of morbidities and mortalities. The major determinant for mortality in LBW babies is the birth weight. The best option to prevent LBW is by improving maternal health. Improvement of perinatal and neonatal services   in government sector and public private partnership model of free neonatal care can help to achieve the INAP goal of NMR <10 by 2030. 

Prevalence and predictors of adverse outcomes in neonatal seizures

2021 ◽  
pp. 1-7
Author(s):  
K. Famra ◽  
P. Barta ◽  
A. Aggarwal ◽  
B.D. Banerjee
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Birth Asphyxia ◽  
Adverse Outcomes ◽  
Neonatal Seizures ◽  
Clinical Practices ◽  
Inborn Errors ◽  
Mortality And Morbidity ◽  
Low Birth Weight Babies

OBJECTIVES: Neonatal seizures are significant cause of neonatal mortality and morbidity. Current study was planned to study prevalence of adverse outcomes in neonatal seizures and identify its predictors. METHODS: This observational descriptive study was carried out on 220 neonates with seizures. Neonates who succumbed to illness/ death before investigations, or whose maternal records were incomplete were excluded. Blood sugar, serum calcium, serum electrolytes, and USG skull were done in all patients. CT scan, MRI and inborn errors of metabolism profile were done as and when indicated. Adverse outcomes were defined as death, phenobarbitone non responders, or abnormal examination at discharge. Antenatal, perinatal and neonatal predictors of adverse outcomes in neonatal seizures were evaluated. RESULTS: Out of 220 neonates with seizures 76(34.5%) had adverse outcomes. Very low birth weight babies (≤1500 gm) [OR 1.27(CI 0.57–2.84)], microcephaly [OR 5.93 (CI 0.55–64.41)], Apgar score≤3 at 5 minutes [OR 11.28(CI 14.18–30.45)], seizure onset within 24 hours [OR 5.99(CI 12.43–14.78)], meningitis [OR 2.63(CI 0.08–6.39)], septicemia [OR1.22(CI 0.45–3.31)] and abnormal cranial USG [OR 7.95(CI 12.61–24.22)] were significant predictors of adverse outcomes in neonates with seizures. CONCLUSION: Prematurity, very low birth weight, birth asphyxia, meningitis, septicemia and abnormal USG could predict adverse outcomes in neonatal seizures. Improved antenatal and neonatal clinical practices may help reduce adverse outcomes in these patients.

scholarly journals Current obesity was associated with hypertension in children born very low birth weight

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Chompoonut Limratchapong ◽  
Pracha Nuntnarumit ◽  
Wischuri Paksi ◽  
Kwanchai Pirojsakul
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Blood Pressure Monitoring ◽  
Developed Countries ◽  
Masked Hypertension ◽  
Normal Birth ◽  
The Developed Countries ◽  
Hypertension In Children

Abstract Objectives Previous studies from the developed countries showed that children born very low birth weight have a higher risk of hypertension compared with that of the normal birth weight controls. However, studies regarding the prevalence of hypertension in such children from the developing countries are scarce. This study aimed to identify the perinatal and postnatal factors associated with hypertension in children born very low birth weight. Results Forty-six children aged ≥ 6 years from the VLBW cohort of Ramathibodi Hospital, Bangkok, Thailand underwent the ambulatory blood pressure monitoring. The prevalence of hypertension was 15.2% (7/46). The hypertension group had a significant higher BMI z-score at 3 years of age (0.90 ± 1.44 vs − 0.45 ± 1.47, p = 0.045) and a greater proportion of current obesity (42% vs 2.5%, p < 0.01) compared to those in the normotensive group. Multivariate analysis revealed that current obesity was associated with hypertension (OR 34.77, 95%CI 1.814–666.5). Among 36 children with normal office blood pressure, four children (11.1%) had high blood pressure uncovered by ABPM, called “masked hypertension”. Office systolic blood pressure at the 85th percentile was the greatest predictor for masked hypertension with a sensitivity of 75% and a specificity of 81.2%.

Comparison of Mortality and Morbidity of Very Low Birth Weight Infants Between Canada and Japan

PEDIATRICS ◽  
2012 ◽  
Vol 130 (4) ◽  
pp. e957-e965 ◽  
Author(s):  
T. Isayama ◽  
S. K. Lee ◽  
R. Mori ◽  
S. Kusuda ◽  
M. Fujimura ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Mortality And Morbidity

A meta-analysis of neonatal health outcomes from oocyte donation

2015 ◽  
Vol 7 (3) ◽  
pp. 257-272 ◽  
Author(s):  
D. H. Adams ◽  
R. A. Clark ◽  
M. J. Davies ◽  
S. de Lacey
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Health Outcomes ◽  
Very Low Birth Weight ◽  
Meta Analysis ◽  
Oocyte Donation ◽  
Donor Oocyte ◽  
Cochrane Reviews ◽  
Increased Risk ◽  
Weight Outcomes

Donated oocytes are a treatment modality for female infertility which is also associated with increased risks of preeclampsia. Subsequently it is important to evaluate if there is concomitant increased risks for adverse neonatal events in donated oocyte neonates. A structured search of the literature using PubMed, EMBASE and Cochrane Reviews was performed to investigate the perinatal health outcomes of offspring conceived from donor oocytes compared with autologous oocytes. Meta-analysis was performed on comparable outcomes data. Twenty-eight studies were eligible and included in the review, and of these, 23 were included in a meta-analysis. Donor oocyte neonates are at increased risk of being born with low birth weight (<2500 g) [risk ratio (RR): 1.18, 95% confidence interval (CI): 1.14–1.22, P-value (P)<0.00001], very low birth weight (<1500 g) (RR: 1.24, CI: 1.15–1.35, P<0.00001), preterm (<37 weeks) (RR: 1.26, CI: 1.23–1.30, P<0.00001), of lower gestational age (mean difference −0.3 weeks, CI: −0.35 weeks to −0.25 weeks, P<0.00001), and preterm with low birth weight (RR: 1.24, CI: 1.19–1.29, P<0.00001), when compared with autologous oocyte neonates. Conversely, low birth weight outcomes were improved in term donor oocyte neonates (RR: 0.86, CI: 0.8–0.93, P=0.0003). These negative outcomes remained significant when controlling for multiple deliveries. The donor oocyte risk rates are higher than those found in general ART outcomes, are important considerations for the counselling of infertile patients and may also influence the long term health of the offspring.

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