scholarly journals Tongue disorders due to megaloblastic anaemia and its management: A case report.

2021 ◽  
Vol 11 (1) ◽  
pp. 26-28
Author(s):  
Md Ashif Iqbal ◽  
Rina Niroula ◽  
Prima Singh ◽  
Mehnaz Khan
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Signs And Symptoms ◽  
Folic Acid Supplementation ◽  
Megaloblastic Anaemia ◽  
Burning Sensation ◽  
Blood Picture ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
Dietary Deficiency

The presence of megaloblasts and macrocytes in the bone marrow characterizes megaloblastic anaemia. Megaloblastic anaemia is the result of folate and vitamin B12 deficiency in more than 95% of cases. We hereby report a case of megaloblastic anaemia in a 23-year old female having glossitis and a burning sensation on the tongue. The blood picture showed megaloblastic anaemia and haematological tests confirmed the diagnosis. The patient positively responded to vitamin B12 and folic acid supplementation. The presence of oral signs and symptoms offer the dentist an opportunity to participate in the diagnosis of this condition. Early diagnosis is important to prevent deficiency. This paper explains the oral changes induced by dietary deficiency of cobalamin or folate in a patient with megaloblastic anaemia. Update Dent. Coll. j: 2021; 11 (1): 26-28

scholarly journals Parkinson’s Disease and Homocysteine: A Community-Based Study in a Folate and Vitamin B12 Deficient Population

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Zhang Wei ◽  
Wang Tiandong ◽  
Li Yang ◽  
Meng Huaxing ◽  
Min Guowen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Community Based ◽  
Current Smoking ◽  
Blood Samples ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
The Relationship

Background. Homocysteine (Hcy) levels were higher in patients with Parkinson’s disease (PD). This could be partially explained by levodopa treatment. Whether untreated PD patients have higher Hcy levels is contradictory.Methods.A community-based study was conducted using a two-stage approach for subjects ≥ 55 years to find PD patients in 3 towns of Lüliang City. Blood samples were collected. Serum Hcy, folate, and vitamin B12 concentrations were measured. For each untreated PD patient, 5 controls were selected matched with age and sex to evaluate the relationship between Hcy levels and PD.Results. Of 6338 eligible residents, 72.7% participated in the study. 31 PD cases were identified. The crude prevalence of PD for people ≥ 55 years was 0.67%. Blood samples were collected from 1845 subjects, including 17 untreated PD patients. There was no difference for concentrations of serum Hcy, folate, and vitamin B12 between cases and controls (P>0.05). In univariate and multivariate analysis, there was significant inverse relation between PD and current smoking (P<0.05). No other factor was significant statistically.Conclusions. The prevalence of PD was comparable to earlier studies in China. Hyperhomocysteinemia was not a risk factor of PD, as well as folate and vitamin B12 deficiency.

Oral signs and symptoms in patients with undiagnosed vitamin B12 deficiency

1995 ◽  
Vol 24 (10) ◽  
pp. 468-470 ◽  
Author(s):  
E. Anne Field ◽  
Janet A. Speechley ◽  
F. R. Rugman ◽  
E. Varga ◽  
W. R. Tyldesley
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Signs And Symptoms ◽  
B12 Deficiency

An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease

2017 ◽  
Vol 35 (5) ◽  
pp. 463-471
Author(s):  
Shuzi Zheng ◽  
Chaoqun Wu ◽  
Wei Yang ◽  
Xuanping Xia ◽  
Xiuqing Lin ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Vitamin B12 ◽  
Mutant Allele ◽  
Vitamin B12 Deficiency ◽  
Folate Deficiency ◽  
Serum Homocysteine ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
Transcobalamin Ii

Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B12 levels. Methods:TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B12 levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. Results: Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p < 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p < 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p < 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B12 levels were reduced in CD patients (both p < 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency was higher in CD patients than in controls (all p < 0.01). Both folate deficiency and vitamin B12 deficiency were independently related to risk of CD (both p < 0.01). Conclusion:TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with CD.

scholarly journals Questionable Reliability Of Homocysteine As The Metabolic Marker For Folate And Vitamin B12 Deficiency In Patients With Chronic Obstructive Pulmonary Disease

2015 ◽  
Vol 34 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Anđelo Beletić ◽  
Duško Mirković ◽  
Aleksandra Dudvarski-Ilić ◽  
Branislava Milenković ◽  
Ljudmila Nagorni-Obradović ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Chronic Obstructive ◽  
Vitamin B ◽  
Obstructive Pulmonary Disease ◽  
Metabolic Marker ◽  
Copd Patients ◽  
B12 Deficiency ◽  
Folate And Vitamin B12

SummaryBackground:An increased homocysteine (Hcy) concentration may represent a metabolic marker of folate and vitamin B12deficiency, both significant public health problems. For different reasons, patients with chronic obstructive pulmonary disease (COPD) are prone to these deficiencies. The study evaluates the reliability of Hcy concentration in predicting folate or vitamin B12deficiency in these patients.Methods:A group of 50 COPD patients (28 males/22 females, age$({\rm{\bar x}} \pm {\rm{SD}} = 49.0 \pm 14.5)$years was enrolled. A chemiluminescent microparticle immunoassay was applied for homocysteine, folate and vitamin B12concentration. Kolmogorov-Smirnov, Mann-Whitney U and χ2tests, Spearman’s correlation and ROC analysis were included in the statistical analysis, with the level of significance set at 0.05.Results:Average (SD) concentrations of folate and vitamin B12were 4.13 (2.16) μg/L and 463.6 (271.0) ng/L, whereas only vitamin B12correlated with the Hcy level (P=−0.310 (R=0.029)). Gender related differences were not significant and only a borderline significant correlation between age and folate was confirmed (R=0.279 (P=0.047)). The incidence of folate and vitamin B12 deficiency differed significantly (P=0.000 and P<0.000 for folate and vitamin B12respectively), depending on the cut-off used for classification (4.4, 6.6 and 8.0 μg/L – folate; 203 and 473 ng/L – vitamin B12). ROC analyses failed to show any significance of hyperhomocysteinemia as a predictor of folate or vitamin B12deficiency.Conclusion:Reliability of the Hcy concentration as a biomarker of folate or vitamin B12depletion in COPD patients is not satisfactory, so their deficiency cannot be predicted by the occurrence of HHcy.

scholarly journals OVERCOMING VITAMIN B12 DEFICIENCY IN VEGAN DIET

2014 ◽  
Vol 04 (01) ◽  
pp. 104-105
Author(s):  
Prassanna Baby ◽  
Keyword(s):  
Vitamin B12 ◽  
Higher Plants ◽  
Vitamin B12 Deficiency ◽  
Vegan Diet ◽  
Vitamin B ◽  
Daily Diet ◽  
B12 Deficiency ◽  
Vitamin B 12 ◽  
Micro Organisms ◽  
Dietary Deficiency

Abstract:Vitamin B12 is a crystalline compound essential to a number of micro-organisms and animals, including humans. So far as is known it is not present in higher plants. Pure vegetarian food is nearly free from vit. B12. It is a nutrient that needs attention in vegan diet. Vegetarians are at risk for vitamin B(12) (B12) deficiency due to suboptimal intake. Dietary deficiency of vitamin B12 due to vegetarianism is increasing and causes hyperhomocysteinemia Areas for research include intermittent vitamin B12 supplement dosing and better measurements of the bioavailability of B12 in fermented vegetarian foods and algae. The goal of the present literature review was to create an awareness among the vegans to identify the vegetarian sources of Vitamin B12 and to incorporate them into their daily diet.

Folate and vitamin B12 deficiency and hyperhomocysteinemia promote oxidative stress in adult type 2 diabetes

Nutrition ◽  
2012 ◽  
Vol 28 (7-8) ◽  
pp. e23-e26 ◽  
Author(s):  
Masoud Y. Al-Maskari ◽  
Mostafa I. Waly ◽  
Amanat Ali ◽  
Yusra S. Al-Shuaibi ◽  
Allal Ouhtit
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Adult Type ◽  
B12 Deficiency ◽  
Folate And Vitamin B12

scholarly journals Severe Anaemia during Late Pregnancy

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mahenaz Akhtar ◽  
Ismail Hassan
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Late Pregnancy ◽  
Severe Anaemia ◽  
Blood Transfusions ◽  
Deficiency Anaemia ◽  
History Of ◽  
B12 Deficiency ◽  
Folate And Vitamin B12 ◽  
In Pregnancy

Vitamin B12 deficiency is uncommon in pregnancy, it occurs in 10–28% of uncomplicated pregnancies, and is associated with a few complications. We present a case report of a 21-year-old patient with severe anaemia during late pregnancy caused by vitamin B12 deficiency. At 38 weeks gestation and with a BMI of 48.9, a history of rupture of membranes was given but not confirmed. On examination, she appeared pale and therefore full blood counts were done. Interestingly her haemoglobin (Hb) levels were 3.7 g/dL. Folate and vitamin B12 levels were also found to be low, and the diagnosis of anaemia caused by vitamin B12 deficiency was made. After treatment with vitamin B12 injections, folic acid and blood transfusions, the patient’s haemoglobin levels improved from 3.7 g/dL to 10.7 g/dL. The conclusion is that effective history taking, diagnosis, and management can prevent many complications that are usually associated with vitamin B12 deficiency anaemia.

Sign in / Sign up

Export Citation Format

Share Document