scholarly journals Development of Composition and Technology of Resveratrol Capsules

2019 ◽  
Vol 8 (4) ◽  
pp. 16-19
Author(s):  
M. S. Sokurenko ◽  
S. P. Krechetov ◽  
S. A. Olifer ◽  
I. I. Krasnyuk ◽  
N. L. Solovyova ◽  
...  
Keyword(s):  
Active Substance ◽  
Dosage Form ◽  
Biological Effects ◽  
Tween 80 ◽  
The State ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Wide Range ◽  
Ascorbic Acids

Introduction. Resveratrol is of scientific interest as a substance with a wide range of biological effects. However, its low bioavailability leads to limited use when administered orally. Therefore, the objective was to increase its solubility using various groups of excipients and create a solid dosage form. As a result of research, a group of twins was selected and the technology of manufacturing capsules containing 40 mg of resveratrol as a active substance was developed.Aim. The development of a solid dosage form – capsules containing resveratrol, tween 80 as a solubilizer and other excipients.Materials and methods. A composition with resveratrol, tween 80, glycerin, citric and ascorbic acids as stabilizers was developed. Methanol was used as a common solvent and was distilled off after complete dissolution of all components and obtaining a homogeneous mass. After adding olive oil (as a filler) to the resulting composition and a mixture of nipazole and nipagin (0.03 % by weight of the contents), the composition was manually mixed and poured into subsequently gelatin coated capsules for tightness. The quality indicators of the obtained capsules were studied in accordance with the requirements of the State pharmacopoeia XIV of Russian Federation (description, disintegration, dissolution, uniformity of dosage, residual organic solvents), as well as oxidation indicators.Results and discussion. During the research it was found that the obtained samples of capsules containing resveratrol 40 mg/caps. as an active substance, and tween 80 as a solubilizer, had a good disintegration. The substance is well soluble in hydrochloric acid condition, which indicates its high bioavailability.Conclusion. To produce capsules with resveratrol (40 mg/caps.) containing tween 80, glycerin, citric and ascorbic acids, excipients were selected according to studies that confirm the improvement of resveratrol bioavailability. The quality of the dosage form was assessed in accordance with the State Pharmacopoeia XIVth edition: it was shown that the use of Tween 80 as a solubilizer increases the release of resveratrol in the environment of gastric juice. 

THE VALUE OF LOVE IN THE SYSTEM OF FORMATION OF THE PROFESSIONAL MATURITY OF THE EDUCATOR

2020 ◽  
Vol 1 (10(79)) ◽  
pp. 12-18
Author(s):  
G. Bubyreva
Keyword(s):  
Russian Federation ◽  
The State ◽  
Educational Process ◽  
Wide Range ◽  
The Family ◽  
The Russian Federation ◽  
The Government ◽  
The Individual ◽  
The Right

The existing legislation determines the education as "an integral and focused process of teaching and upbringing, which represents a socially important value and shall be implemented so as to meet the interests of the individual, the family, the society and the state". However, even in this part, the meaning of the notion ‘socially significant benefit is not specified and allows for a wide range of interpretation [2]. Yet the more inconcrete is the answer to the question – "who and how should determine the interests of the individual, the family and even the state?" The national doctrine of education in the Russian Federation, which determined the goals of teaching and upbringing, the ways to attain them by means of the state policy regulating the field of education, the target achievements of the development of the educational system for the period up to 2025, approved by the Decree of the Government of the Russian Federation of October 4, 2000 #751, was abrogated by the Decree of the Government of the Russian Federation of March 29, 2014 #245 [7]. The new doctrine has not been developed so far. The RAE Academician A.B. Khutorsky believes that the absence of the national doctrine of education presents a threat to national security and a violation of the right of citizens to quality education. Accordingly, the teacher has to solve the problem of achieving the harmony of interests of the individual, the family, the society and the government on their own, which, however, judging by the officially published results, is the task that exceeds the abilities of the participants of the educational process.  The particular concern about the results of the patriotic upbringing served as a basis for the legislative initiative of the RF President V. V. Putin, who introduced the project of an amendment to the Law of RF "About Education of the Russian Federation" to the State Duma in 2020, regarding the quality of patriotic upbringing [3]. Patriotism, considered by the President of RF V. V. Putin as the only possible idea to unite the nation is "THE FEELING OF LOVE OF THE MOTHERLAND" and the readiness for every sacrifice and heroic deed for the sake of the interests of your Motherland. However, the practicing educators experience shortfalls in efficient methodologies of patriotic upbringing, which should let them bring up citizens, loving their Motherland more than themselves. The article is dedicated to solution to this problem based on the Value-sense paradigm of upbringing educational dynasty of the Kurbatovs [15].

scholarly journals Evaluation of Tropaeolin 000-1 as a Colorimetric Reagent for Assay of Duloxetine and Escitalopram in Solid Dosage Form

2016 ◽  
Vol 15 (3) ◽  
pp. 613
Author(s):  
Mani Ganesh ◽  
Abidov Sh Aziz ◽  
Mei Mei Peng ◽  
Ramaswamy Ravikumar ◽  
Kalaimani Sakthimanigandan ◽  
...  
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Colorimetric Reagent

scholarly journals Apiaceae as an Important Source of Antioxidants and Their Applications

Cosmetics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Punniamoorthy Thiviya ◽  
Ashoka Gamage ◽  
Dinushika Piumali ◽  
Othmane Merah ◽  
Terrence Madhujith
Keyword(s):  
Oxidative Stress ◽  
Biological Effects ◽  
Natural Antioxidants ◽  
Herbal Products ◽  
Oxidative Balance ◽  
Therapeutic Value ◽  
Wide Range ◽  
Ascorbic Acids ◽  
Beauty Care ◽  
And Oxidative Stress

The excess level of reactive oxygen species (ROS) disturbs the oxidative balance leading to oxidative stress, which, in turn, causes diabetes mellites, cancer, and cardiovascular diseases. These effects of ROS and oxidative stress can be balanced by dietary antioxidants. In recent years, there has been an increasing trend in the use of herbal products for personal and beauty care. The Apiaceae (previously Umbelliferae) family is a good source of antioxidants, predominantly phenolic compounds, therefore, widely used in the pharmaceutical, cosmetic, cosmeceutical, flavor, and perfumery industries. These natural antioxidants include polyphenolic acids, flavonoids, carotenoids, tocopherols, and ascorbic acids, and exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis, and anticancer. This review discusses the Apiaceae family plants as an important source of antioxidants their therapeutic value and the use in cosmetics.

scholarly journals Comparison of UV-spectrophotometric and RP-HPLC methods for estimation of deflazacort in solid dosage form

2020 ◽  
Author(s):  
Puranik Manisha ◽  
Shambharkar Samta ◽  
Nimbalkar Shantanu ◽  
Mahapatra Debarshi Kar
Keyword(s):  
Dosage Form ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Rp Hplc

scholarly journals Interaction between Polyethylene Films and BromhexineHCl in Solid Dosage Form. III. Prevention of Drug Sorption by Improving Manufacturing Processes.

1991 ◽  
Vol 39 (5) ◽  
pp. 1287-1291 ◽  
Author(s):  
Takuya KUKITA ◽  
Akemi YAMAGUCHI ◽  
Akihiko OKAMOTO ◽  
Masami NEMOTO ◽  
Hiroshi YAMAGUCHI ◽  
...  
Keyword(s):  
Dosage Form ◽  
Manufacturing Processes ◽  
Polyethylene Films ◽  
Solid Dosage Form ◽  
Solid Dosage
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