scholarly journals Comparison of Delayed-Onset Glaucoma and Early-Onset Glaucoma after Infantile Cataract Surgery

2006 ◽  
Vol 20 (1) ◽  
pp. 41 ◽  
Author(s):  
Kui Dong Kang ◽  
Hye Bin Yim ◽  
Albert W Biglan
Keyword(s):  
Cataract Surgery ◽  
Early Onset ◽  
Delayed Onset

Early Neuromotor Behavior in Craniosynostotic Rabbits

2003 ◽  
Vol 40 (5) ◽  
pp. 486-492 ◽  
Author(s):  
Ronal L. Mitchell ◽  
Timothy E. Barbano ◽  
H. Wolfgang Losken ◽  
Michael I. Siegel ◽  
Mark P. Mooney
Keyword(s):  
Early Onset ◽  
Rabbit Model ◽  
Zealand White Rabbit ◽  
Psychomotor Development ◽  
Activity Levels ◽  
Coronal Suture ◽  
Wild Type ◽  
Significant Group ◽  
Delayed Onset ◽  
Neuromotor Development

Objective Clinical studies have shown both abnormal and normal mental and psychomotor development in patients with craniosynostosis. However, a number of confounding variables make study comparisons difficult. For these reasons, the present study describes early neuromotor development in an homogeneous rabbit model of craniosynostosis. Design Fifty-three newborn New Zealand white rabbit kits were used: 13 were wild-type, normal control rabbits; 23 had delayed-onset coronal suture synostosis (onset is approximately 57 to 74 days post conception); and 17 had early-onset coronal suture synostosis (onset is approximately 21 to 25 days post conception). All rabbits were observed individually and blindly in an open field, daily for 2 minutes, from birth through the first 14 days of life. The first day of emergence of 10 different mature behaviors and developmental events (in developmental order of appearance: falling, righting, cliff avoidance, first sign of fur, body elevation, head elevation, circling, dragging, eye opening, and hopping) was recorded for each kit. Daily activity levels (grid crossing), and body weights were also recorded. Results Significant group (p < .05) differences were observed in 9 of 11 measures. Both synostosed groups had significantly (p < .05) accelerated onset of behavior in 8 of 9 measures, compared with wild-type controls. The early-onset synostosis group had significantly (p < .05) accelerated onset in five of eight measures, compared with wild-type controls, and three of eight measures, compared with the delayed-onset synostosis group. Conclusions Synostotic rabbits showed precocious neuromotor development possibly through frontal lobe constrictions and altered brain activity from increased intracranial pressure, although primary genetic effects cannot be ruled out.

An Outbreak of Early-Onset Endophthalmitis Caused byFusariumSpecies following Cataract Surgery

2009 ◽  
Vol 34 (11) ◽  
pp. 988-995 ◽  
Author(s):  
Mehmet Çakır ◽  
Serhat İmamoğlu ◽  
Osman Çekiç ◽  
Ercüment Bozkurt ◽  
Neşe Alagöz ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Early Onset

Comparison of Prognostic Impact Between Early-onset and Delayed-onset Cytomegalovirus Replication in Heart Transplant Recipients

2018 ◽  
Vol 37 (4) ◽  
pp. S354-S355
Author(s):  
A. Rodriguez Chaverri ◽  
I. Ponz de Antonio ◽  
M. Garcia-Cosio ◽  
C. Ortiz Bautista ◽  
L. Moran Fernandez ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Early Onset ◽  
Prognostic Impact ◽  
Transplant Recipients ◽  
Delayed Onset ◽  
Heart Transplant Recipients

Abstract TP144: Mechanisms And Prognosis Of Acute Ischemic Stroke Related To Acute Aortic Dissection

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Seung-Jae Lee ◽  
Dong-Suk Shim ◽  
Si-Ryung Han
Keyword(s):  
Ischemic Stroke ◽  
Aortic Dissection ◽  
Early Onset ◽  
Acute Aortic Dissection ◽  
Type A ◽  
Posterior Circulation ◽  
Type B ◽  
Delayed Onset ◽  
Bilateral Carotid ◽  
Type B Dissection

Background: Acute aortic dissection (AD) is one of the lethal cardiac diseases involving the aorta. Although pain is a typical symptom, stroke may not rarely occur with the occlusive dissection of aortic branches or hypotension under the condition of AD. We attempted to explores the clinical features, possible mechanisms and prognosis of acute ischemic stroke (AIS) related to AD Method: Medical records of 278 consecutive patients with AD (165 with type A and 113 with type B dissection) over 11.5 years were retrospectively analyzed for clinical history, CT or MRI findings and outcome. AIS were categorized into early- or delayed-onset stroke. Early-onset stroke was defined as an AIS presented at admission, and delayed-onset stroke was an AIS which were developed during the two months after the first admission. Results: 26 (9.4%) patients experienced an ischemic stroke, which included 22 with type A and 4 with type B dissection. 8 patients (2.9%) including a case of TIA had an early-onset stroke, whereas delayed-onset stroke occurred in 18 patients (6.5%) postoperatively or under medical treatment. Early-onset stroke was all referable to the anterior circulation, predominantly right-sided (87.5%). One or more main branches of the aortic arch were involved in 6 out of 8 patients (75%) with early-onset stroke. Innominate artery was most frequently involved (75.0%). In contrast, delayed-onset stroke affected similarly bilateral carotid territories, and also included lesions in bilateral carotid, posterior-circulation and anterior/posterior-circulation territories. Among the 26 patients, 8 patients (30.8%) expired within 6 months of the disease onset (3 cases from hemispheric stroke with brain herniation, 2 cases from aortic rupture, 2 cases from sepsis with multiple organ failure and a case from mesentery ischemia and renal failure). Additionally, 9 patients (34.6%) remained functionally dependent six months later. Conclusion: AD not infrequently causes AIS with grave prognosis, especially in patients with type A dissection. The presumed mechanisms were aortic branch dissection causing luminal occlusion and emboli from thrombosed vascular lumen and hypotension under the condition of AD.

scholarly journals DGAT1 mutations leading to delayed chronic diarrhoea: a case report

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Luojia Xu ◽  
Weizhong Gu ◽  
Youyou Luo ◽  
Jingan Lou ◽  
Jie Chen
Keyword(s):  
Early Onset ◽  
Failure To Thrive ◽  
Nutritional Therapy ◽  
Congenital Disorder ◽  
Nutrition Status ◽  
Chronic Diarrhoea ◽  
Compound Heterozygous ◽  
Case Presentation ◽  
Delayed Onset ◽  
Restriction Diet

Abstract Background Early-onset chronic diarrhoea often indicates a congenital disorder. Mutation in diacylglycerol o-acyltransferase 1 (DGAT1) has recently been linked to early-onset chronic diarrhoea. To date, only a few cases of DGAT1 deficiency have been reported. Diarrhoea in those cases was severe and developed in the neonatal period or within 2 months after birth. Case presentation Here, we report a female patient with DGAT1 mutations with delayed-onset chronic diarrhoea. The patient had vomiting, hypoalbuminemia, hypertriglyceridemia, and failure to thrive at early infancy. Her intractable chronic diarrhoea occurred until she was 8 months of age. A compound heterozygous DGAT1 mutation was found in the patient, which was first found in the Chinese population. Her symptoms and nutrition status improved after nutritional therapy, including a fat restriction diet. Conclusions This case expanded our knowledge of the clinical features of patients with DGAT1 mutations. Intractable diarrhoea with delayed onset could also be a congenital disorder.

scholarly journals Hearing Trajectory in Children with Congenital Cytomegalovirus Infection

2018 ◽  
Vol 158 (4) ◽  
pp. 736-744 ◽  
Author(s):  
Tatiana M. Lanzieri ◽  
Winnie Chung ◽  
Jessica Leung ◽  
A. Chantal Caviness ◽  
Jason L. Baumgardner ◽  
...  
Keyword(s):  
White Matter ◽  
Early Onset ◽  
Cytomegalovirus Infection ◽  
Cox Regression ◽  
Hearing Threshold ◽  
Congenital Cytomegalovirus Infection ◽  
Congenital Cytomegalovirus ◽  
Delayed Onset ◽  
Hearing Thresholds ◽  
Asymptomatic Case

Objectives To compare hearing trajectories among children with symptomatic and asymptomatic congenital cytomegalovirus infection through age 18 years and to identify brain abnormalities associated with sensorineural hearing loss (SNHL) in asymptomatic case patients. Study Design Longitudinal prospective cohort study. Setting Tertiary medical center. Subjects and Methods The study included 96 case patients (4 symptomatic and 92 asymptomatic) identified through hospital-based newborn cytomegalovirus screening from 1982 to 1992 and 72 symptomatic case patients identified through referrals from 1993 to 2005. We used growth curve modeling to analyze hearing thresholds (0.5-8 kHz) by ear with increasing age and Cox regression to determine abnormal findings on head computed tomography scan associated with SNHL (hearing threshold ≥25 dB in any audiometric frequency) among asymptomatic case patients. Results Fifty-six (74%) symptomatic and 20 (22%) asymptomatic case patients had SNHL: congenital/early-onset SNHL was diagnosed in 78 (51%) and 10 (5%) ears, respectively, and delayed-onset SNHL in 25 (17%) and 20 (11%) ears; 49 (32%) and 154 (84%) ears had normal hearing. In affected ears, all frequency-specific hearing thresholds worsened with age. Congenital/early-onset SNHL was significantly worse (severe-profound range, >70 dB) than delayed-onset SNHL (mild-moderate range, 26-55 db). Frequency-specific hearing thresholds were significantly different between symptomatic and asymptomatic case patients at 0.5 to 1 kHz but not at higher frequencies (2-8 kHz). Among asymptomatic case patients, white matter lucency was significantly associated with SNHL by age 5 years (hazard ratio, 4.4; 95% CI, 1.3-15.6). Conclusion Congenital/early-onset SNHL frequently resulted in severe to profound loss in symptomatic and asymptomatic case patients. White matter lucency in asymptomatic case patients was significantly associated with SNHL by age 5 years.

scholarly journals Should You Follow the Better-Hearing Ear for Congenital Cytomegalovirus Infection and Isolated Sensorineural Hearing Loss?

2019 ◽  
Vol 162 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Vanessa Torrecillas ◽  
Chelsea M. Allen ◽  
Tom Greene ◽  
Albert Park ◽  
Winnie Chung ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Early Onset ◽  
Medical Center ◽  
Antiviral Treatment ◽  
Sensorineural Hearing ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus ◽  
Delayed Onset ◽  
Hearing Thresholds

Objective To describe the progression of sensorineural hearing loss (SNHL) in the better- and poorer-hearing ears in children with asymptomatic congenital cytomegalovirus (CMV) infection with isolated SNHL. Study Design Longitudinal prospective cohort study. Setting Tertiary medical center. Subjects and Methods We analyzed hearing thresholds of the better- and poorer-hearing ears of 16 CMV-infected patients with isolated congenital/early-onset or delayed-onset SNHL identified through hospital-based CMV screening of >30,000 newborns from 1982 to 1992. Results By 12 months of age, 4 of 7 patients with congenital/early-onset SNHL developed worsening thresholds in the poorer-hearing ear, and 1 had an improvement in the better-hearing ear. By 18 years of age, all 7 patients had worsening thresholds in the poorer-hearing ear and 3 patients had worsening thresholds in the better-hearing ear. Hearing loss first worsened at a mean age of 2 and 6 years in the poorer- and better-hearing ears, respectively. Nine patients were diagnosed with delayed-onset SNHL (mean age of 9 years vs 12 years for the poorer- and better-hearing ears), 6 of whom had worsening thresholds in the poorer-hearing ear and 1 in both ears. Conclusion In most children with congenital CMV infection and isolated SNHL, the poorer-hearing ear worsened earlier and more precipitously than the better-hearing ear. This study suggests that monitoring individual hearing thresholds in both ears is important for appropriate interventions and future evaluation of efficacy of antiviral treatment.

Early-onset drug-induced parkinsonism after exposure to offenders implies nigrostriatal dopaminergic dysfunction

2017 ◽  
Vol 89 (2) ◽  
pp. 169-174 ◽  
Author(s):  
Seok Jong Chung ◽  
Han Soo Yoo ◽  
Hyojeong Moon ◽  
Jungsu S Oh ◽  
Jae Seung Kim ◽  
...  
Keyword(s):  
Early Onset ◽  
Drug Exposure ◽  
Onset Time ◽  
Individual Variability ◽  
Short Exposure ◽  
Drug Induced ◽  
Delayed Onset ◽  
Natural Logarithm ◽  
Dopaminergic Dysfunction ◽  
Onset Group

ObjectivesThe onset of parkinsonism in patients with drug-induced parkinsonism (DIP) exhibits extensive individual variability following exposure to offending drugs. We investigated whether the individual variations in the onset time of parkinsonism reflected the underlying subtle dopaminergic dysfunction in DIP.MethodsWe enrolled 71 patients with DIP who had visually normal striatal dopamine transporter (DAT) availability in 18F-FP-CIT positron emission tomography scans. According to their exposure durations to the offending drugs prior to onset of the parkinsonism, the patients were divided into the early-onset group (duration ≤6 months; n=35) and delayed-onset group (duration >6 months; n=36). We performed the quantitative analysis of the DAT availability in each striatal subregion between the groups.ResultsNo patients with DIP had DAT availability that was more than 2 SD below the normal mean of DAT availability. Compared with the delayed-onset group, the early-onset DIP group had decreased DAT availability in the striatal subregions including the posterior putamen (p=0.018), anterior putamen (p=0.011), caudate (p=0.035) and ventral striatum (p=0.027). After adjusting for age, sex and cross-cultural smell identification test scores, a multivariate analysis revealed that the DAT availability in the striatal subregions of the patients with DIP was significantly and positively associated with the natural logarithm of the duration of drug exposure.ConclusionsThese results suggest that a short exposure to the offending drugs before the development of parkinsonism would be associated with subtle nigrostriatal dopaminergic dysfunction in patients with DIP.

scholarly journals High Rate of Early Posterior Capsule Opacification following Femtosecond Laser-Assisted Cataract Surgery

2016 ◽  
Vol 7 (3) ◽  
pp. 491-495 ◽  
Author(s):  
Benjamin Rostami ◽  
Jack Tian ◽  
Nicholas Jackson ◽  
Rustum Karanjia ◽  
Kenneth Lu
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Postoperative Complication ◽  
Retrospective Review ◽  
Early Onset ◽  
Posterior Capsule Opacification ◽  
High Rate ◽  
Posterior Capsule ◽  
Time Period

Purpose: To compare the rates of rapid posterior capsule opacification (PCO) formation in the first 3 months following femtosecond laser-assisted cataract surgery (FLACS) to manual anterior capsulorhexis. Methods: Retrospective review of 29 cases of FLACS, comparing the rates of PCO in the first 3 months following surgery to 50 consecutive cases of manual anterior capsulorhexis. Results: Seven of the 29 FLACS cases developed PCO requiring capsulotomy at 3 months, while none of the control cases required a capsulotomy over the same time period (p < 0.05). Conclusion: There is an increased incidence of early-onset PCO following the use of femtosecond laser in cataract surgery that is otherwise unfounded in manual capsulorhexis. This suggests that the use of a femtosecond laser could increase the risk of this novel postoperative complication.

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