Vaccination Schedules

2021 ◽  
Author(s):  
Adam Ahmed ◽  
Rachel Chihana ◽  
Heinz-Josef Schmitt
Keyword(s):  
Phase 1 ◽  
Primary Vaccination ◽  
New Product ◽  
Trial And Error ◽  
Development Programs ◽  
Live Vaccines ◽  
Before School ◽  
Immunocompromised Hosts ◽  
Optimal Protection

First vaccines and vaccination schedules were based on “trial and error” and on immunogenicity data (serology). Latest since the 1990s, vaccination schedules are based on well-defined phase 1–3 development programs as basis for licensure of any new product. Vaccination schedules must bear in mind the epidemiology of the targeted disease; the biology of available vaccine product(s); local opportunities to vaccinate; monitoring for the desired outcome. There are 4 basic primary vaccination schedules for children, based on historical development and local needs. Birth doses are recommended with BCG and hepatitis B vaccine. Dosing in the 2nd year of life is usually needed for long term-protection induced by polysaccharide-conjugate vaccines. Live vaccines (MMR, VZV) are usually given as of 9 months of age – later dosing may induce improved immune responses; a second dose is needed before school entry for optimal protection. In addition to “general regular schedules” vaccines and schedules emerge for pregnant women, international travelers, persons above 60 or 65 years, immunocompromised hosts.

647 PHASE 1–2 STUDY OF MDV3100 IN PRE- AND POST-DOCETAXEL ADVANCED PROSTATE CANCER: LONG-TERM EFFICACY RESULTS

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Celestia Higano ◽  
Tomasz Beer ◽  
Evan Yu ◽  
Mary-Ellen Taplin ◽  
Eleni Efstathiou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Advanced Prostate Cancer ◽  
Phase 1 ◽  
Term Efficacy

FC 096THE EFFECT OF INCREMENTAL START OF HAEMODIALYSIS ON BLOOD PRESSURE AND INTERDIALYTIC WEIGHT GAIN: PRELIMINARY FINDINGS FROM THE ENDURE STUDY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Adil Hazara ◽  
Victoria Allgar ◽  
Maureen Twiddy ◽  
Sunil Bhandari
Keyword(s):  
Blood Pressure ◽  
Propensity Scores ◽  
Phase 1 ◽  
Tertiary Care ◽  
Residual Renal Function ◽  
Care Hospital ◽  
Interdialytic Weight Gain ◽  
Matching Criteria ◽  
The Impact

Abstract Background and Aims Mortality rates are high in patients starting haemodialysis/haemodiafiltration (HD) therapy. Incremental HD may help reduce this risk by reducing the burden of early treatment whilst patients are still adapting to long-term HD therapy. A feasibility study (ENDURE study – Clinical trials ID: NCT04268264) is being conducted with the primary objectives of evaluating the acceptability and tolerance of a new incremental HD regime. Its secondary aims are to evaluate the impact of this form of incremental HD on indicators of patient safety and wellbeing. These indicators include blood pressure (BP) control and interdialytic weight gains (IDWG) which are independently associated with adverse cardiovascular outcomes in patients on long-term HD. We present preliminary findings from the study related to systolic BP and IDWG. Method The ENDURE study is being carried out at a tertiary care hospital in the United Kingdom. Patients aged > 18 years known to renal services for at least 90 days, referred for start of HD, were eligible for participation. Following approved consenting procedures, they are started on a new regime of incremental HD starting dialysis twice weekly with progressive increases in the duration and frequency of sessions over 15 weeks. This period is split in to four phases; phase 1 representing the first two days of dialysis (baseline) whereas phases 2 – 4 representing the pre-specified incremental steps. Propensity scores were calculated to match each participant (incremental HD group) with two controls from a database of patients who previously started HD at our centres using the standard protocol of 3 times weekly, 4hr long sessions. The matching criteria accounted for 14 key demographic, clinical and laboratory characteristics. Results were analysed as intention to treat. In comparing BP and IDWG between the two groups, only readings taken pre-dialysis at the first session of the week was considered. This study has been approved by the West of Scotland Research Ethics committee-4 (Ref: 19/WS/0019). Results Baseline characteristics of the first 15 participants (target 20) and their matched controls are presented in table 1. The proportion of females and duration of previous specialist input was higher in the incremental HD group. Conclusion The ENDURE study tests the feasibility of starting patients on a novel incremental HD regime. Early data suggest that control of systolic BP and IDWG are comparable to patients who start dialysis at 3 times weekly. Further work is needed to understand the impact of reducing dialysis frequency on BP control correlating the findings with changes residual renal function and objective measures of fluid overload.

Abstract P290: Short-term Weight Change and Long-term Mortality in the Trials of Hypertension Prevention

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Nancy R Cook ◽  
Lawrence J Appel ◽  
Paul K Whelton
Keyword(s):  
Weight Loss ◽  
Weight Change ◽  
Phase 1 ◽  
Total Mortality ◽  
Weight Loss Intervention ◽  
Phase 2 ◽  
Short Term ◽  
Hypertension Prevention ◽  
Long Term Mortality

Introduction: Although weight loss has favorable effects on intermediate outcomes, such as blood pressure and insulin resistance, few studies have examined its effects on long-term outcomes including total mortality. Methods: In the Trials of Hypertension Prevention (TOHP) individuals aged 30-54 years with high normal BP were randomized to a weight loss intervention, to one of several other lifestyle or dietary supplement interventions, or to usual care. All participants from Phase 1 (1987-90) and Phase 2 (1990-5) were followed for mortality through 2013. The association of weight change during any of the interventions with long-term mortality up to 18-24 years after the trial periods was examined among 3828 participants who fell into a high baseline weight stratum, defined as body mass index at least 26 kg/m2 in men and 24 kg/m2 in women. Results and Conclusions: There were 1477 high-weight participants in Phase 1 and 2351 in Phase 2, of whom 21% and 50%, respectively, were assigned to a weight loss intervention. Overall, mean weight change during the trial period was -1.8 lbs (-0.8% of baseline body weight) over 1.5 years in Phase 1 and 1.6 lbs (0.8%) over 3-4 years in Phase 2. A total of 556 (15%) lost > 5%, 1,101 (29%) lost <=5%, 1,567 (41%) gained less than 5%, and 604 (16%) gained > 5% in body weight. Corresponding hazard ratios (HRs) for total mortality were 0.82 (95% confidence interval (CI)=0.57-1.18), 0.94 (95% CI=0.72-1.23), 1.00 (reference), and 1.29 (95% CI=0.92-1.80) (p-trend = 0.046). There was a direct linear relationship with percent change in weight during the trial period and later mortality (HR=1.14 per 5% change, 95% CI=1.02-1.28, p=0.019). This association persisted throughout the course of mortality follow-up (Figure). In these healthy individuals taking part in lifestyle and nutrition supplement trials , short-term weight change was directly associated with mortality about two decades later. These results are consistent with a long-term beneficial effect of presumed intentional weight loss on total mortality.

scholarly journals A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

Blood ◽  
2014 ◽  
Vol 123 (15) ◽  
pp. 2308-2316 ◽  
Author(s):  
David H. McDermott ◽  
Qian Liu ◽  
Daniel Velez ◽  
Lizbeeth Lopez ◽  
Sandra Anaya-O’Brien ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Low Dose ◽  
Phase 1 ◽  
Cxcr4 Antagonist ◽  
Phase 1 Clinical Trial ◽  
Dose Treatment ◽  
Whim Syndrome ◽  
Key Points

Key Points Plerixafor can be given safely to WHIM syndrome patients twice daily for a 6-month period and appears promising as a treatment.

Embedding Training Within Warnings Improves Skills of Identifying Phishing Webpages

2018 ◽  
Vol 61 (4) ◽  
pp. 577-595 ◽  
Author(s):  
Aiping Xiong ◽  
Robert W. Proctor ◽  
Weining Yang ◽  
Ninghui Li
Keyword(s):  
Phase 1 ◽  
Phase 2 ◽  
Long Term Effect ◽  
Security Training ◽  
Potential Applications ◽  
Effectiveness Of Training ◽  
Test Use ◽  
Click Through Rate ◽  
Complementary Strategy

Objective: Evaluate the effectiveness of training embedded within security warnings to identify phishing webpages. Background: More than 20 million malware and phishing warnings are shown to users of Google Safe Browsing every week. Substantial click-through rate is still evident, and a common issue reported is that users lack understanding of the warnings. Nevertheless, each warning provides an opportunity to train users about phishing and how to avoid phishing attacks. Method: To test use of phishing-warning instances as opportunities to train users’ phishing webpage detection skills, we conducted an online experiment contrasting the effectiveness of the current Chrome phishing warning with two training-embedded warning interfaces. The experiment consisted of three phases. In Phase 1, participants made login decisions on 10 webpages with the aid of warning. After a distracting task, participants made legitimacy judgments for 10 different login webpages without warnings in Phase 2. To test the long-term effect of the training, participants were invited back a week later to participate in Phase 3, which was conducted similarly as Phase 2. Results: Participants differentiated legitimate and fraudulent webpages better than chance. Performance was similar for all interfaces in Phase 1 for which the warning aid was present. However, training-embedded interfaces provided better protection than the Chrome phishing warning on both subsequent phases. Conclusion: Embedded training is a complementary strategy to compensate for lack of phishing webpage detection skill when phishing warning is absent. Application: Potential applications include development of training-embedded warnings to enable security training at scale.

scholarly journals Tilt and strain change during the explosion at Minami-dake, Sakurajima, on November 13, 2017

2021 ◽  
Author(s):  
Kohei Hotta ◽  
Masato Iguchi
Keyword(s):  
Ground Deformation ◽  
Large Strain ◽  
Phase 1 ◽  
Small Strain ◽  
Phase 2 ◽  
The North ◽  
Strombolian Eruption ◽  
Strain Change ◽  
Tilt Change

Abstract We herein propose an alternative model for deformation caused by an eruption at Sakurajima, which have been previously interpreted as being due to a Mogi-type spherical point source beneath Minami-dake. On November 13, 2017, a large explosion with a plume height of 4,200 m occurred at Minami-dake. During the three minutes following the onset of the explosion (November 13, 2017, 22:07–22:10 (Japan standard time (UTC+9); the same hereinafter), phase 1, a large strain change was detected at the Arimura observation tunnel (AVOT) located approximately 2.1 km southeast from the Minami-dake crater. After the peak of the explosion (November 13, 2017, 22:10–24:00), phase 2, a large deflation was detected at every monitoring station due to the continuous Strombolian eruption. Subsidence toward Minami-dake was detected at five out of six stations whereas subsidence toward the north of Sakurajima was detected at the newly installed Komen observation tunnel (KMT), located approximately 4.0 km northeast from the Minami-dake crater. The large strain change at AVOT as well as small tilt changes of all stations and small strain changes at HVOT and KMT during phase 1 can be explained by a very shallow deflation source beneath Minami-dake at 0.1 km below sea level (bsl). For phase 2, a deeper deflation source beneath Minami-dake at a depth of 3.3 km bsl was found in addition to the shallow source beneath Minami-dake which turned inflation after the deflation obtained during phase 1. However, this model cannot explain the tilt change of KMT. Adding a spherical deflation source beneath Kita-dake at a depth of 3.2 km bsl can explain the tilt and strain change at KMT and the other stations. The Kita-dake source was also found in a previous study of long-term ground deformation. Not only the deeper Minami-dake source MD but also the Kita-dake source deflated due to the Minami-dake explosion.

Sign in / Sign up

Export Citation Format

Share Document