scholarly journals Relationship between Cognition, levels of PTX-3, MBL and their polymorphisms: A systematic review

2020 ◽  
Vol 9 (10) ◽  
pp. e8749109215
Author(s):  
Tatiana Lins Carvalho ◽  
Taciana Furtado de Mendonça Belmont ◽  
Andreia Soares da Silva ◽  
Kleyton Palmeira do Ó ◽  
Lucas de Lucena Simões e Silva ◽  
...  

Introduction: Studies have suggested that pentraxin 3 (PTX3) and Mannose Binding Lectin (MBL) may interfere with cognitive processes. Objective: Identify data reported in the literature involving cognition, PTX3 and MBL. Materials and Methods: The research was done in five databases and the selection of studies was performed in two stages. The first involved review of titles and abstracts. Then the full articles were read and those that did not meet the eligibility criteria were excluded. Results: A total of 3,097 titles and abstracts were selected, but 3,089 were excluded. Finally, 8 articles were included in the review. The articles pointed out that high levels of PTX-3 could be predictors of cognitive impairment while high levels of MBL could have a protective effect on cognition. Conclusion: The current studies are still contradictory and inconclusive, but they lead us to reflect on possible genetic influences of innate immunity in the Central Nervous System. Further research involving the effects of PTX-3 and MBL and its variants on cognition are necessary.

2016 ◽  
Vol 38 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Tatiana Lins Carvalho ◽  
Lilian Maria Sanguinett de Almeida ◽  
Camila Maria Araújo Lorega ◽  
Mirella Francyne Oliveira Barata ◽  
Maria Lúcia Brito Ferreira ◽  
...  

Introduction Studies assessing symptoms of depression and anxiety in individuals with amyotrophic lateral sclerosis (ALS) have reported contradictory results. The objective of this systematic review is to identify the prevalence of these mood disorders in the literature. Methods We searched the PubMed, HighWire, MEDLINE, SciELO, LILACS and ScienceDirect databases. Literature was selected for review in two stages, according to eligibility criteria. The first stage involved searching databases and checking titles and abstracts. The second step consisted of reading complete articles and excluding those that did not meet the inclusion criteria. The inclusion criteria were articles written in Portuguese, English or Spanish, published in the last five years and involving people with ALS diagnosed according to the El Escorial criteria. Results The database searches returned a total of 1,135 titles and abstracts and then 1,117 of these were excluded. Eighteen articles were selected for review. The 12-item Amyotrophic Lateral Sclerosis Depression Inventory (ADI-12) was the only instrument designed specifically to assess depression in ALS, but it was only used in three studies. No instruments specifically designed for anxiety in ALS were used. A large number of studies found presence and slight increase of anxiety disorders. There was considerable large variation in the results related to depressive disorders, ranging from moderate depression to an absence of symptoms. Conclusions Patients with ALS may exhibit symptoms of depression and anxiety at different levels, but there is a need for studies using specific instruments with larger samples in order to ascertain the prevalence of symptoms in ALS and the factors associated with it.


2010 ◽  
Vol 95 (6) ◽  
pp. F452-F461 ◽  
Author(s):  
J. Israels ◽  
F. N. J. Frakking ◽  
L. C. M. Kremer ◽  
M. Offringa ◽  
T. W. Kuijpers ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Bojan Nedovic ◽  
Brunella Posteraro ◽  
Emanuele Leoncini ◽  
Alberto Ruggeri ◽  
Rosarita Amore ◽  
...  

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in theMBL2gene, particularly at codon 54 (variant alleleB; wild-type allele designated asA), impact upon host susceptibility toCandidainfection. This systematic review and meta-analysis were performed to assess the association betweenMBL2codon 54 genotype and vulvovaginal candidiasis (VVC) or recurrent VVC (RVVC). Studies were searched in MEDLINE, SCOPUS, and ISI Web of Science until April 2013. Five studies including 704 women (386 cases and 318 controls) were part of the meta-analysis, and pooled ORs were calculated using the random effects model. For subjects with RVVC, ORs ofABversusAAand ofBBversusAAwere 4.84 (95% CI 2.10–11.15;Pfor heterogeneity=0.013;I2=68.6%) and 12.68 (95% CI 3.74–42.92;Pfor heterogeneity=0.932,I2=0.0%), respectively. For subjects with VVC, OR ofABversusAAwas 2.57 (95% CI 1.29–5.12;Pfor heterogeneity=0.897;I2=0.0%). This analysis indicates that heterozygosity for theMBL2alleleBincreases significantly the risk for both diseases, suggesting that MBL may influence the women’s innate immunity in response toCandida.


2010 ◽  
Vol 38 (1) ◽  
pp. 49-62 ◽  
Author(s):  
Rik Crutzen ◽  
Jascha de Nooijer ◽  
Wendy Brouwer ◽  
Anke Oenema ◽  
Johannes Brug ◽  
...  

The Internet is considered to be a promising delivery channel of interventions aimed at promoting healthful behaviors, especially for adolescents and young adults. Exposure to these interventions, however, is generally low. A more extensive exploration of methods, strategies, and their effectiveness with regard to facilitating exposure is therefore timely, because this knowledge is crucial to improve the use of such interventions and, subsequently, to increase behavioral change. Therefore, a systematic review of the literature was conducted, resulting in 838 studies based on title selection, of which 26 studies met the eligibility criteria. The systematic review resulted in an overview of methods and strategies that have been used to facilitate exposure. Patterns of effective strategies could be observed, such as the combination of tailored communication and the use of reminders and incentives. Nevertheless, exposure-specific theories need to be developed and objective exposure measures should be tracked and reported in future studies.


2017 ◽  
Vol 2 ◽  
pp. 13 ◽  
Author(s):  
Mary A. Bitta ◽  
Symon M. Kariuki ◽  
Clifford Mwita ◽  
Samson Gwer ◽  
Leah Mwai ◽  
...  

Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association between anti-malarial drugs and mental and neurological impairment in humans. Methods: We systematically searched online databases, including Medline/PubMed, PsychoInfo, and Embase, for articles published up to 14th July 2016. Pooled prevalence, heterogeneity and factors associated with prevalence of mental and neurological manifestations were determined using meta-analytic techniques. Results: Of the 2,349 records identified in the initial search, 51 human studies met the eligibility criteria. The median pooled prevalence range of mental and neurological manifestations associated with antimalarial drugs ranged from 0.7% (dapsone) to 48.3% (minocycline) across all studies, while it ranged from 0.6% (pyrimethamine) to 42.7% (amodiaquine) during treatment of acute malaria, and 0.7% (primaquine/dapsone) to 55.0% (sulfadoxine) during prophylaxis. Pooled prevalence of mental and neurological manifestations across all studies was associated with an increased number of antimalarial drugs (prevalence ratio= 5.51 (95%CI, 1.05-29.04); P=0.045) in a meta-regression analysis. Headaches (15%) and dizziness (14%) were the most common mental and neurological manifestations across all studies. Of individual antimalarial drugs still on the market, mental and neurological manifestations were most common with the use of sulphadoxine (55%) for prophylaxis studies and amodiaquine (42.7%) for acute malaria studies. Mefloquine affected more domains of mental and neurological manifestations than any other antimalarial drug. Conclusions: Antimalarial drugs, particularly those used for prophylaxis, may be associated with mental and neurological manifestations, and the number of antimalarial drugs taken determines the association. Mental and neurological manifestations should be assessed following the use of antimalarial drugs.


2021 ◽  
Vol 12 ◽  
Author(s):  
Yasmin Notarbartolo di Villarosa do Amaral ◽  
Jocieli Malacarne ◽  
Paloma Glauca Brandão ◽  
Patrícia Brasil ◽  
Karin Nielsen-Saines ◽  
...  

Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age.Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021.Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations.Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children.Systematic Review Registration: PROSPERO REGISTER: CRD42020205947.


2021 ◽  
pp. 104945
Author(s):  
Rodrigo Feliciano do Carmo ◽  
Jaime Rangel Leal Neves ◽  
Pablo Rafael Silveira Oliveira ◽  
Luydson Richardson Silva Vasconcelos ◽  
Carlos Dornels Freire de Souza

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Ida Envall ◽  
Jan Bengtsson ◽  
Simon Jakobsson ◽  
Maj Rundlöf ◽  
Charlotte Åberg ◽  
...  

Abstract Background Semi-natural pastures are unfertilized grasslands with a long history of traditional low-input grazing management. This kind of pastures are recognized for their high species richness. However, as a consequence of modernization of agriculture, many of the semi-natural pastures have been lost during the last century, leading to a serious threat to farmland biodiversity. Semi-natural pastures are relatively low in productivity. Hence, to increase profitability, farmers may want to give the grazing animals access to additional nutrient sources. This can be done either as supplementary feeding, or by fencing the semi-natural pastures into the same enclosure as improved, more nutrient-rich, pastures. These practices are, however, controversial. It is argued that since semi-natural pastures are species-rich partly because they are nutrient-poor, introducing additional nutrients into the system should be avoided. Accordingly, in Sweden, these interventions are often prohibited while receiving financial subsidies for management of semi-natural pastures. However, since many farmers are dependent on such support to maintain their pastures, these prohibitions often cause problems. The question has been raised whether giving the grazers access to additional nutrient sources really affect the biodiversity in semi-natural pastures, as is assumed. The primary aim of the proposed systematic review is to answer this question. Method Peer-reviewed and grey literature will be searched for using bibliographic databases, search engines, specialist websites and stakeholder contacts. The references will be screened for relevance according to a predefined set of eligibility criteria. The criteria will be tested and clarified iteratively, until consistency in interpretations is achieved. Thereafter, the literature will be screened in two stages, first based upon title and abstract and then by examining full texts. Full text screening will be performed with blinded decisions by two independent reviewers. Each relevant study will then be critically appraised, based on a set of predefined validity criteria. A narrative synthesis will be provided, outlining the evidence base in terms of bibliographic information and study metadata. If possible, quantitative syntheses based on meta-analyses will be performed. Identified relevant knowledge gaps will be highlighted and discussed.


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