scholarly journals Funisitis as a Risk Factor for Adverse Neonatal Outcomes in Twin Neonates with Spontaneous Preterm Birth: A Retrospective Cohort Study

2021 ◽  
Vol 62 (9) ◽  
pp. 822
Author(s):  
Subeen Hong ◽  
Mina Jeong ◽  
Sohee Oh ◽  
Jeong Won Oh ◽  
Chan-Wook Park ◽  
...  
2020 ◽  
Vol 9 (4) ◽  
pp. 1108 ◽  
Author(s):  
Jessica M. Turner ◽  
Sailesh Kumar

The aim of this study was to assess if women with a low first trimester maternal pregnancy-associated plasma protein-A (PAPP-A) level are at increased risk of emergency cesarean (EmCS) for intrapartum fetal compromise (IFC) and/or adverse neonatal outcomes. This was a retrospective cohort study performed at Mater Mother’s Hospital, Brisbane, Australia, between 2016 and 2018. All women with a singleton, euploid, non-anomalous fetus with a documented PAPP-A level measured between 10 +0 and 13 +6 weeks gestation during the study period were included. Data were extracted from the institution’s perinatal database and dichotomized according to PAPP-A level (≤0.4 Multiples of Medium (MoM) vs. >0.4 MoM). The primary outcomes were EmCS-IFC and a composite of severe adverse neonatal outcomes (SCNO). Nine thousand sixty-one pregnancies were included, 3.3% with a PAPP-A ≤ 0.4 MoM. Low maternal PAPP-A was not associated with an increased risk of EmCS-IFC (adjusted odds ratio (aOR) 0.77, 95% confidence interval (CI) 0.24–2.46, p = 0.66) or SCNO (aOR 0.65, 95% CI 0.39–1.07, p = 0.09). Low PAPP-A was associated with increased odds of pre-eclampsia, preterm birth and birthweight < 10th centile. In conclusion, low maternal PAPP-A level is not associated with an increased risk of EmCS IFC or adverse neonatal outcomes despite greater odds of low-birthweight infants and preterm birth.


Neonatology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Emily J.J. Horn-Oudshoorn ◽  
Marijn J. Vermeulen ◽  
Kelly J. Crossley ◽  
Suzan C.M. Cochius-den Otter ◽  
J. Marco Schnater ◽  
...  

<b><i>Introduction:</i></b> The oxygenation index (OI) is a marker for respiratory disease severity and adverse neonatal outcomes. The oxygen saturation index (OSI) is an alternative that allows for continuous noninvasive monitoring, but evidence for clinical use in critically ill neonates is scarce. The aim of this study was to evaluate the OSI as compared to the OI in term neonates with a congenital diaphragmatic hernia (CDH). <b><i>Methods:</i></b> A single-center retrospective cohort study was conducted including all live-born infants with an isolated CDH between June 2017 and December 2020. Paired values of the OI and OSI in the first 24 h after birth were collected. The relation between OI and OSI measurements was assessed, taking into account arterial pH, body temperature, and preductal versus postductal location of oxygen saturation measurement or arterial blood sampling. The predictive values for pulmonary hypertension, need for extracorporeal membrane oxygenation therapy, and survival at discharge were evaluated. <b><i>Results:</i></b> Of 33 subjects included, 398 paired values of the OI (median 5.8 [3.3–17.2]) and OSI (median 7.3 [3.6–14.4]) were collected. The OI and OSI correlated strongly (<i>r</i> = 0.77, <i>p</i> &#x3c; 0.001). The OSI values corresponding to the clinically relevant OI values (10, 15, 20, and 40) were 8.9, 10.9, 12.9, and 20.9, respectively. The predictive values of the OI and OSI were comparable for all adverse neonatal outcomes. No difference was found in the area under the receiver operating characteristic curves for the OI and the OSI for adverse neonatal outcomes. <b><i>Conclusions:</i></b> The OSI could replace the OI in clinical practice in infants with a CDH.


2015 ◽  
Vol 41 (11) ◽  
pp. 1708-1714 ◽  
Author(s):  
Michiko Yamashita ◽  
Shusaku Hayashi ◽  
Masayuki Endo ◽  
Kentaro Okuno ◽  
On Fukui ◽  
...  

2012 ◽  
Vol 50 (5) ◽  
pp. 390-395 ◽  
Author(s):  
David N. Juurlink ◽  
Tara Gomes ◽  
Astrid Guttmann ◽  
Chelsea Hellings ◽  
Marco L. A. Sivilotti ◽  
...  

2016 ◽  
Vol 34 (02) ◽  
pp. 174-182 ◽  
Author(s):  
Esme Kamphuis ◽  
Michel Hof ◽  
Sarah Robertson ◽  
Eva Pajkrt ◽  
Christianne de Groot ◽  
...  

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Kristjana Einarsdóttir ◽  
Fatima A Haggar ◽  
Amanda T Langridge ◽  
Anthony S Gunnell ◽  
Helen Leonard ◽  
...  

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