scholarly journals FACTORS INFLUENCING THE OCCURRENCE OF HYPERTROPHIC SCARS AMONG POSTOPERATIVE PATIENTS IN GARUT, INDONESIA

2017 ◽  
Vol 3 (1) ◽  
pp. 23-31
Author(s):  
Andri Nugraha ◽  
Rizal Chaidir ◽  
Urip Rahayu ◽  
Santi Rinjani
Keyword(s):  
Family History ◽  
Influencing Factors ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Dominant Factor ◽  
Hypertrophic Scars ◽  
Surgical Wound ◽  
Polyglactin 910 ◽  
Significant Relationships ◽  
Hypertrophic Scar Tissue

Background: Hypertrophic scar causes physical and psychological problems. Thus understanding the factors related to the occurrence of hypertrophic scar tissue is needed. Little is known about its influencing factors in Indonesia, especially in Garut.Objective: This study aims to examine the relationships between hypertrophic scar and its influencing factors, and identify the most dominant factor of the occurrence of hypertrophic scars.Methods: This was an observational case control study using retrospective approach in Polyclinic of Surgery of Regional Public Hospital of dr. Slamet of Garut Regency. There were 40 samples recruited in this study by purposive sampling, which was divided to be case group (20 patients) and control group (20 patients). Data were collected using Stony Brook Scar Evaluation Scale by observation and documentation of the medical records of patients. Data were analyzed using logistic regression analysisResults: Findings indicated that there were significant relationships between the surgical wound infection (p = 0.02), family history (p = 0.026), and type of suture (p = 0.043) with the occurrence of hypertrophic scars. The most dominant factor on the occurrence of hypertrophic scars was type of suture, acid polyglactin 910. The variables that had no significant relationships with the occurrence of hypertrophic scar tissue were age (p = 0.34), area of surgical wound (p = 0.177), and smoking habit (p = 0.479).Conclusion: There were significant relationships between infection of surgical wound, genetic history, the type of suture, and the occurrence of hypertrophic scar tissue. The most dominant factor that influenced the occurrence of hypertrophic scar tissue was the type of suture. Therefore, it is suggested to health professionals to modify the using of acid polyglactin 910 sutures, and nurses particularly need to provide the information regarding the family history and genetic-related hypertrophic scar, and prevent the infection of surgical wound after operation. 

scholarly journals Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway

2015 ◽  
Vol 37 (2) ◽  
pp. 666-676 ◽  
Author(s):  
Ting He ◽  
Xiaozhi Bai ◽  
Longlong Yang ◽  
Lei Fan ◽  
Yan Li ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Ex Vivo ◽  
Scar Tissue ◽  
Scar Formation ◽  
Jnk Pathway ◽  
Protein Levels ◽  
Mapk Inhibitors ◽  
Hypertrophic Scar Tissue ◽  
Loureirin B ◽  
Tgf Β1

Background/Aims: Our previous study confirmed that Loureirin B (LB) can inhibit hypertrophic scar formation. However, the mechanism of LB-mediated inhibition of scar formation is still unknown. Methods: Immunohistochemistry was used to detect expression of Col1, FN and TGF-β1 in skin and scar tissue. Fibroblasts were stimulated with TGF-β1 to mimic scar formation. LB or MAPK inhibitors were used to study the pathways involved in the process. Western blotting was used to evaluate the expression of p-JNK, p-ERK, p-p38, Col1 and FN. The contractile capacity of fibroblasts was evaluated using a gel contraction assay. Tissues were cultured ex vivo with LB to further investigate the participation of ERK and JNK in the LB-mediated inhibition of scar formation. Results: FN and Col1 were up regulated in hypertrophic scars. LB down regulated p-ERK and p-JNK in TGF-β1-stimulated fibroblasts, while levels of phosphorylated p38 did not change. The down regulation of p-ERK and p-JNK was associated with a reduction of Col1 and FN. Similarly, inhibition of ERK and JNK down regulated the expression of Col1 and FN in TGF-β1-stimulated fibroblasts. LB down regulated protein levels of p-ERK and p-JNK in cultured hypertrophic scar tissue ex vivo. Conclusions: This study suggests that LB can inhibit scar formation through the ERK/JNK pathway.

Enhanced expression of mRNA for insulin-like growth factor-1 in post-burn hypertrophic scar tissue and its fibrogenic role by dermal fibroblasts

1995 ◽  
Vol 148 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Aziz Ghahary ◽  
You J. Shen ◽  
Bernadette Nedelec ◽  
Paul G. Scott ◽  
Edward E. Tredget
Keyword(s):  
Growth Factor ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Dermal Fibroblasts ◽  
Insulin Like Growth Factor ◽  
Enhanced Expression ◽  
Hypertrophic Scar Tissue

scholarly journals 5-Fluorouracil-Loaded Transfersome as Theranostics in Dermal Tumor of Hypertrophic Scar Tissue

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Z. Zhang ◽  
X. Wang ◽  
X. Chen ◽  
Y. Wo ◽  
Y. Zhang ◽  
...  
Keyword(s):  
High Performance ◽  
Scar Tissue ◽  
Hypertrophic Scars ◽  
Transdermal Drug Delivery System ◽  
Permeation Studies ◽  
Fluorescent Agent ◽  
Hypertrophic Scar Tissue ◽  
Laser Confocal Microscope

To investigate the ability of transfersomal gel carrying the antiscarring agent (5-FU) to permeate hypertrophic scarsin vivoandin vitro, scar permeation studies were performed after the agent was labeled with the fluorescent agent, rhodamine 6GO. Laser confocal microscope was employed to dynamically observe the effects of transfersomal gel carrying 5-FU at different time points. High-performance liquid chromatography (HPLC) was used to analyze the contents of the agent in the scar tissues at different hours after administration. Scar elevation index (SEI) was used to evaluate the changes of the ear scar models in rabbits. Compared with the PBS gel of 5-FU, the transfersomal gel displayed greater permeation rate and depth, as well as a higher content retention of the agent in scar tissues. Local administrations of the agent for some certain periods effectively inhibited the hyperplasia of ear scars in rabbits. Transfersomes can be chosen as a potential transdermal drug delivery system.

The Use of Silicone Gel Sheets in the Control of Hypertrophic Scar Tissue

1988 ◽  
Vol 51 (7) ◽  
pp. 248-249 ◽  
Author(s):  
Rosemary Gollop
Keyword(s):  
Retrospective Study ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
City Hospital ◽  
Hypertrophic Scarring ◽  
The Past ◽  
Silicone Gel ◽  
Clinical Observations ◽  
Hypertrophic Scar Tissue ◽  
Indications For Use

For the past 3 years, Nottingham City Hospital Burns and Plastic Surgery Unit have been using silicone gel in addition to, or as an alternative to, accepted methods of treating hypertrophic scarring. This paper outlines the history, properties and indications for use of silicone gel. Its findings result from a retrospective study based largely on clinical observations.

In vitro study of ethosome penetration in human skin and hypertrophic scar tissue

2012 ◽  
Vol 8 (6) ◽  
pp. 1026-1033 ◽  
Author(s):  
Zhen Zhang ◽  
Yan Wo ◽  
Yixin Zhang ◽  
Danru Wang ◽  
Rong He ◽  
...  
Keyword(s):  
Human Skin ◽  
Hypertrophic Scar ◽  
In Vitro Study ◽  
Scar Tissue ◽  
Vitro Study ◽  
Hypertrophic Scar Tissue

Reduced collagenase gene expression in fibroblasts from hypertrophic scar tissue

1996 ◽  
Vol 134 (5) ◽  
pp. 863-868 ◽  
Author(s):  
M. ARAKAWA ◽  
A. HATMOCHI ◽  
Y. MORI ◽  
K. MORI ◽  
H. UEKI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue ◽  
Collagenase Gene

scholarly journals High-Efficiency Expression of TAT-bFGF Fusion Protein in Escherichia coli and the Effect on Hypertrophic Scar Tissue

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117448 ◽  
Author(s):  
Xuechao Jia ◽  
Haishan Tian ◽  
Lu Tang ◽  
Long Zheng ◽  
Lulu Zheng ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Fusion Protein ◽  
Hypertrophic Scar ◽  
High Efficiency ◽  
Scar Tissue ◽  
Hypertrophic Scar Tissue

scholarly journals Nitric Oxide Synthase Expression and Nitric Oxide Production Are Reduced in Hypertrophic Scar Tissue and Fibroblasts

1997 ◽  
Vol 108 (4) ◽  
pp. 438-444 ◽  
Author(s):  
Rijian Wang ◽  
Aziz Ghahary ◽  
You J Shen ◽  
Paul G Scott ◽  
Edward E Tredget
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Hypertrophic Scar Tissue ◽  
Oxide Synthase

scholarly journals Mechanical Analysis of Hypertrophic Scar Tissue: Structural Basis for Apparent Increased Rigidity

1985 ◽  
Vol 84 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Michael G. Dunn ◽  
Frederick H. Silver ◽  
David A. Swann
Keyword(s):  
Hypertrophic Scar ◽  
Scar Tissue ◽  
Mechanical Analysis ◽  
Structural Basis ◽  
Hypertrophic Scar Tissue
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