scholarly journals Asymmetric dimethylarginine and the effect of folate substitution in children with familial hypercholesterolemia and diabetes mellitus type 1

2009 ◽  
pp. 179-184
Author(s):  
P Jehlička ◽  
F Stožický ◽  
O Mayer ◽  
J Varvařovská ◽  
J Racek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Folic Acid ◽  
Endothelial Dysfunction ◽  
Familial Hypercholesterolemia ◽  
Asymmetric Dimethylarginine ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Healthy Children

A recently discussed cardiovascular risk factor, asymmetric dimethylarginine (ADMA), is known to act as an endogenous inhibitor of endothelial nitric oxide synthase. The aim of this study was to establish 1) the relationship between ADMA and ultrasonographically or biochemically determined endothelial dysfunction in children, and 2) the effect of folate supplementation on these parameters. The study cohort included 32 children with familial hypercholesterolemia (FH), 30 with diabetes mellitus type 1 (DM1) and 30 age-matched healthy children as the control group. Furthermore, twenty-eight randomly selected FH and DM1 children were re-examined after 3-months supplementation with folic acid. Baseline levels of ADMA and oxidized low density lipoproteins (oxLDL) were significantly higher in FH group than in DM1 and healthy children. Children in DM1 group had significantly lower concentration of homocysteine, but ADMA levels were normal. Folic acid supplementation significantly lowered homocysteine and hsCRP levels in both FH and DM1 group; however, ADMA and oxLDL concentrations remained unaltered. In conclusion, ADMA and oxLDL appear to be associated with endothelial dysfunction in children with FH. Administration of folic acid did not influence these markers in both FH and DM1 children.

scholarly journals Assessment of the functional state of the microvasculature in children with diabetes mellitus type 1

2020 ◽  
Vol 11 (2) ◽  
pp. 71-80
Author(s):  
N. V. Malyuzhinskaya ◽  
K. V. Stepanenko ◽  
E. I. Volchansky
Keyword(s):  
Diabetes Mellitus ◽  
Functional State ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Healthy Children ◽  
Regulation Mechanisms ◽  
Glycated Hemoglobin Level ◽  
Type 1 Dm

Objective: to assess the functional state of the microvasculature in children with diabetes mellitus type 1 (DM type 1).Materials and methods: 63 children with a verifi ed diagnosis of diabetes mellitus type 1 were examined. Th e control group consisted of 30 practically healthy children. Methods: clinical, paraclinical (determination of glycated hemoglobin level, study of microcirculation indicators using laser Doppler fl owmetry (LDF), statistical.Results: microcirculatory disorders accompanying the course of diabetes mellitus type 1 depending on the length of illness were identifi ed. In children with diabetes mellitus type 1 with standing less than 3 years an increase in the average modulation of blood fl ow mainly due to passive regulation mechanisms and the predominance of hypera adaptation in assessing the functional states of microcirculation of varying severity with an increase in the energy of oscillatory processes were observed. Signs of non-nutritive hyperemia in the zone rich in arteriovenous anastamoses and a decrease in perfusion due to an increase in perfusion fl uctuations and coeffi cient of variation in the distal extremities, as well as a decrease in amplitudes in the active tone-forming range, a gradual decrease in the energy of oscillations and randomness criteria were diagnosed with standing in the duration of the disease.Conclusions: disorders in children with diabetes mellitus type 1 microcirculatory detected using LDF are staged. Th e contribution of non-nutritive blood fl ow to microcirculation increases as the disease progresses, which leads to tissue hypoxia. Evaluation of the combination of energy, information and non-linear parameters of the oscillatory component of the blood flow allows you to identify the type of functional state in the microcirculation system.

scholarly journals Vliyanie narusheniya kostnogo metabolizma na sostoyanie tkaney parodonta u muzhchin reproduktivnogo vozrasta s sakharnym diabetom 1 tina i puti korrektsii

2006 ◽  
Vol 9 (3) ◽  
pp. 14-22
Author(s):  
K R Grigoryan ◽  
O R Grigoryan ◽  
T V Nikonova ◽  
V A Gorelysheva ◽  
G M BARER
Keyword(s):  
Diabetes Mellitus ◽  
Bone Metabolism ◽  
Biochemical Parameters ◽  
Optimal Algorithm ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Childbearing Age ◽  
Second Stage

The aims of this study were to investigate the influence of alterations in bone metabolism and in hormonal and biochemical parameters on periodontium tissue as well as to estimate the optimal algorithm of investigation and treatment in men with diabetes mellitus type 1. During the first stage (12 months) the comparative analysis of conditions of pariodontium tissue was conducted in 60 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group. During the second stage (12 months) the markers of bone metabolism and the conditions of paradontium tissue were studied in 26 men of childbearing age with diabetes mellitus type 1 and in 25 men of the control group. The marker of bone resorption (CTX) was significantly lower (372,7 pkg/ml versus 473,0 pkg/ml; p= 0,006) and the marker of bone formation (OK) was significantly higher (27,6 ng/ml compared to 21,42 ng/ml; p< 0,005) in the group of patients who received ALPHA D3-TEVA (alfacalcidol 0,75mkg/day) and 2 tab CALCEMIN ADVANCE (calcium 1000 mg, cholecalciferol 400 UI) in comparison with the control group. Conclusion: the treatment with Calcium and Vitamin D is effective for prevention of bone resorbtion, particularly in jaws.

scholarly journals THE LYMPH NODES IN RATS WITH EXPERIMENTAL TYPE 1 DIABETES MELLITUS (DM-1)

2017 ◽  
Vol 2 ◽  
pp. 9-13
Author(s):  
Margaryta Khomenko ◽  
Iurii Gavrylenko
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Lymph Nodes ◽  
Lymphoid Tissue ◽  
Experimental Diabetes ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Experimental Type

The aim is to study morphofunctional structure of NALT (nasal associated lymphoid tissue) and visceral lymph nodes of rats with experimental type 1 diabetes mellitus (DM-1) and to define the effectiveness of the treatment with herbal drug “Imupret”. Materials and methods: The experiment involved 20 animals, divided into 4 groups: the 1st group was the control group of healthy rats, the 2nd group was the control group subject to prophylactic treatment with “Imupret, the 3rd group included rats with experimental diabetes, and the 4th group included rats with experimental diabetes subject to treatment with “Imupret. Functional changes in immune organs were evaluated by the results of morphometric analysis; morphological pattern was evaluated by histostructural changes. Results. The research revealed that under conditions of diabetes mellitus type 1, the volume, area and density of the lymphoid tissue decreased, and only its "fine" cell was detected. The paper demonstrates the development of relative immune deficiency in immunocompetent organs in rats with diabetes mellitus type 1. The use of drug "Imupret" demonstrated its immunomodulatory function, which is especially important in terms of immunosuppression in patient with DM-1. Conclusion. The received results are of a great clinical significance, and show the necessity of early prevention and treatment of immunity disorders under conditions of diabetes mellitus type 1.

scholarly journals Renal dysfunction markers in patients with diabetes mellitus type 1 after kidney or simultaneous kidney-pancreas transplantation

2016 ◽  
Vol 62 (5) ◽  
pp. 14-16
Author(s):  
Alexandra M. Glazunova ◽  
Larisa V. Nikankina ◽  
Alexandr V. Ilin ◽  
Minara S. Shamkhalova ◽  
Gulya M. Musaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Transplant ◽  
Renal Dysfunction ◽  
Cystatin C ◽  
Pancreas Transplantation ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Patients With Diabetes

Objective. To examine kidney transplant dysfunction markers in patients with diabetes mellitus type 1 (T1DM) after kidney transplantation (KT) and simultaneous kidney-pancreas transplantation (SPK).Materials and methods. The study included 20 patients after successful SPK (group 1) and 41 patients after KT (21 received insulin pump therapy (group 2), 20 –multiple daily injections of insulin (group 3). Post transplantation period at the time of inclusion in the KT group was 8 months [7;8], in SPK-11 months [8;18]. The control group consisted of 15 patients with DM1 without diabetic nephropathy (group 4). Sex, age and duration of T1DM were comparable. Donors of SPK were younger than KT: 29 [25; 33] vs 46[30; 51] years p<0,01 and transplant cold ischemia time was less 8[7;10] vs 11,5 [1; 17] hours respectively, p<0,01. After 9 months of observation biomarkers of dysfunction of renal transplant: Cystatin C (serum, urine); NGAL, KIM-1, podocin, nephrin, IL-18, IP-10 (urine), TGF-β1, MMP-9, VEGF-A, Osteopontin – (OPN) (serum) were defined.Results. the level of GFR in patients after transplantation was C2 stage, albuminuria A1 of chronic kidney disease. In the group of patients with T1DM after successful SPK and KT revealed a significant increase in markers of renal dysfunction (cystatin C (serum), NGAL, Podocin, OPN) compared with the control group despite of carbohydrate metabolism compensation (Tabl.1). High level and a negative associated of blood cystatin C with GFR (r = - 0,36, p<0.05) and positive with albuminuria (r=0,40, p<0,05), as well as a direct link of podocin urine-with blood creatinine (r = 0,35, p<0.05) and NGAL with albuminuria (r = 0,35, p<0.05) in recipients after transplantation were defined. Association between podocin with MMP-9 (r = 0,46, p<0,05) and NGAL (r = 0,33, p<0,05) indicated correlation of stress factors of renal microstructures in posttransplantation patients.Conclusion. High levels of renal graft dysfunction biomarkers in the examined patients (including those after SPK) show the persistence of damage to the microstructures with stable graft function and demonstrate the need to control all factors in the preservation of renal function.Table 1. Renal transplant dysfunction markersParametrsGroup 1Group 2Group 3Group 4TGF b1 (serum, pg/ml)32999[24514;3917]24473[21752;33330]25139[11367;2862]26986[17347;4266]VEGF A (serum, pg/ml)471,9[296;530,6]#407,6[301,6;522,2] #226,6[177,8;367,4]467,4[288,3;474,8]CYS C, (serum, ng/ml)1047[985;1295]*∞1252,9[1151;1540]#∞1113,32[986;1257] §728,8[592,9;765,3]Osteopontin (serum, ng/ml)3,51[2,7;4,9] #∞4,28[2,8;8,2] ∞4,71[3,6;12,7] §2,86[2,2;3,1]MMP-9 (urine, ng/ml)1,15[1,1;1,7]1,30[1,2;1,9] #1,10[0,9;1,3]1,22[1,0;1,3]IP-10 (urine, ng/ml)17,83[17,32;18,36]17,83[17,32;18,36]18,36[17,83;18,90]18,36[17,83;18,90]CYS C (urine, ng/ml)10407[5812;16306]15574[7518;28397]13329[7006;24624]14701[3643;26666]Podocin (urine, ng/ml)0,41[0,18;0,51] #0,49[0,26;0,69]0,56[0,38;0,79]§0,36[0,1;0,51]Nephrin (urine, ng/ml)0,0[0,0;0,1]0,0[0,0;01]0,0[0,0;0,07]0,07[0,0;0,1]KIM-1 (urine, ng/ml)211,8[83,3;368,4]314,9[152,1;508,6]338,7[191,3;594,0]359,2[204,4;494,5]NGAL (urine, ng/ml)2,4[1,7;6,7] *7,8[2,8;14,5] ∞2,9[1,8;12,0]§2,3[1,7;7,3]* р<0,01 (1-2); # р<0,01 (1,2-3); ∞ р<0,01 (1,2-4); § р<0,01 (3–4)

scholarly journals Diabetes and family hypercholesterolemia in a child: is it real?

2019 ◽  
Vol 64 (4) ◽  
pp. 88-91
Author(s):  
L. F. Galimova ◽  
D. I. Sadykova ◽  
I. V. Leontyeva ◽  
E. S. Slastnikova ◽  
M. R. Shaidullina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Familial Hypercholesterolemia ◽  
Clinical Case ◽  
Receptor Gene ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetes Mellitus Type 1 ◽  
Diabetes Mellitus Type ◽  
Target Tissue

Diabetes mellitus type 1 is one of the most common chronic diseases among children. It is a pathology of carbohydrate, fat and protein metabolism caused by insulin deficiency in the target tissue. Changes in the lipid profile can be both secondary and primary. The article describes a clinical case of a combination of diabetes mellitus type 1 and family hypercholesterolemia in a child. It presents the clinical and laboratory results of the examination of the child and his parents. Familial hypercholesterolemia is confirmed by mutation of the low density lipoprotein receptor gene (LDLR) in the heterozygous state. In addition, the proband has a polymorphism of the SLCO1B1 gene, which should be considered when prescribing therapy. The demonstrated clinical case shows that familial hypercholesterolemia can be an independent disease, aggravating the course of diabetes mellitus and requiring correction of the therapy.

scholarly journals Hypertension and endothelial dysfunction in comorbid pathology: diabetes mellitus and primary hypothyriodism

2016 ◽  
Vol 24 (4) ◽  
pp. 42-55
Author(s):  
I I Dubinina ◽  
O M Uryasev ◽  
S V Berstneva ◽  
A A Nikiforov
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Endothelial Dysfunction ◽  
Pressure Profile ◽  
Diabetes Mellitus Type 1 ◽  
Primary Hypothyroidism ◽  
Diabetes Mellitus Type ◽  
High Prevalence ◽  
Patients With Diabetes

The article presents the results of studying the characteristics of arterial hypertension and endothelial dysfunction in patients with diabetes mellitus type 1 and diabetes mellitus-type 2 in combination with primary hypothyroidism. We revealed the increased time index of diastolic blood pressure and disorders circadian blood pressure profile with high prevalence of non-dippersrate. Decrease of endothelium-dependent vasodilation and increased concentration of endothelin-1 were diagnosed. The analysis showed the correlation of endothelial function parameters with carbohydrate and lipid metabolism, blood pressure, insulin resistance, TSH level in patients with combined pathology.

scholarly journals Bone metabolism assessment in diabetes mellitus type 1

2018 ◽  
Vol 99 (2) ◽  
pp. 201-207
Author(s):  
S S Safarova
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Bone Mineral ◽  
Diabetes Mellitus Type 1 ◽  
Serum Markers ◽  
Diabetes Mellitus Type ◽  
Control Group ◽  
Mineral Density

Aim. To evaluate the effect of changes occuring in the organism in diabetes mellitus type 1 on the state of bone mineral density and its metabolism parameters; to determine the changes in serum markers of bone remodeling and bone mineral density in this disease. Methods. Bone mineral density (by dual-energy X-ray absorptiometry) and serum markers of bone remodeling (total alkaline phosphatase activity, level of aminoterminal propeptide of type 1 procollagen and C-terminal telopeptide) were examined in 98 patients with diabetes mellitus type 1 and in the control group consisting of 82 subjects. Results. The average concentration of C-terminal telopeptide in the blood serum of patients with type 1 diabetes (0.525±0.03 ng/ml) was significantly higher in comparison to the control group (0.424±0.02 ng/ml; p <0.01). Proximal femoral T-score in type 1 diabetes was significantly lower than the average value in the control group: -1.44±0.15 and -0.49±0.17 (p <0.001). In the femoral neck it was -1.68±0.14 and -0.64±0.18 (p <0.001), in LI-IV zone -2.04±0.16 and -0.73±0.19, respectively (p <0.001). Moderate negative significant correlation was found between T-score (LI-IV) and level of C-terminal telopeptide (r=-0.431, p=0.000). Conclusion. In patients with diabetes mellitus osteopenia is a relatively frequent complication, but bone loss increases with duration and decompensation of the disease; evaluation of bone mineral density and C-terminal telopeptide level (bone resorption marker) promotes detection of bone metabolism abnormalities at any stage of the disease, especially in the long-term course of type 1 diabetes.

scholarly journals Зміни вмісту метаболітів азоту та ендотеліну-1 в ротовій рідині хворих на генералізований пародонтит на тлі цукрового діабету 1 типу з кардіоміопатією

2017 ◽  
Author(s):  
R. Yu. Shkrebnyuk ◽  
Yu. L. Bandrivskyі
Keyword(s):  
Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Comparative Evaluation ◽  
Diabetes Mellitus Type 1 ◽  
Main Group ◽  
Diabetes Mellitus Type ◽  
Endothelin 1 ◽  
Comparative Group ◽  
Somatic Diseases

The work adduces the parameters of endothelial dysfunction according to indices (NO2+NO3) and endothelin-1 (ET–1) in оral serum in patients with generalized parodontitis on the backdround of diabetes mellitus type 1 with  cardiomiopathy (main group) and in persons with GP without general somatic diseases (comparative group). When comparative evaluation of frequency of change of ET-1, NO2+NO3 it was established that patients with GP on the background of diabetes mellitus type 1 with cardiomiopathy differs from patients with GP without general somatic diseases more significant changes of metabolites of nitrogen and endothelin-1, where when intensifying of processes in examined patients’ parodontium the meaning of analyzed indices characterized more pronocenced disbalance.

Psychological problems in children with diabetes mellitus type 1

2015 ◽  
Author(s):  
Anzhalika Solntsava ◽  
Olga Zagrebaeva ◽  
Nadeya Peskavaya ◽  
Viktoryia Kozel ◽  
Hanna Mikhno
Keyword(s):  
Diabetes Mellitus ◽  
Diabetes Mellitus Type 1 ◽  
Psychological Problems ◽  
Diabetes Mellitus Type
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