scholarly journals Influence of Gender on Ischemia-Reperfusion Injury in Lungs in an Animal Model

2016 ◽  
pp. 953-958 ◽  
Author(s):  
H. MRAZKOVA ◽  
R. LISCHKE ◽  
J. HERGET

As with other organ transplants even lung transplantation raises the question of the possibility of the influence of gender on ischemia-reperfusion injury. This is a current topic especially for increasingly utilized method of lung transplantation from non-heart-beating donors, where reperfusion preceded by a period of warm and cold ischemia with subsequent treatment options for lung graft reperfusion. For measurements we used our laboratory previously created and validated animal model for ex vivo lung transplantation. As with other organ systems of our monitoring resulted protective effect of female sex on ischemia reperfusion lung injury. In two of the three parameters that were monitored, we found a significant difference. In females, higher oxygen transfer ability after reperfusion was manifested as well as lower perfusion pressure (vascular compliance). Conversely, weight gain (the development of pulmonary edema) in males was not significant difference from the females. These conclusions could cause further studies leading to influence the selection of appropriate donor grafts.

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1333
Author(s):  
Toyofumi Fengshi Chen-Yoshikawa

Lung transplantation has been established worldwide as the last treatment for end-stage respiratory failure. However, ischemia–reperfusion injury (IRI) inevitably occurs after lung transplantation. The most severe form of IRI leads to primary graft failure, which is an important cause of morbidity and mortality after lung transplantation. IRI may also induce rejection, which is the main cause of mortality in recipients. Despite advances in donor management and graft preservation, most donor grafts are still unsuitable for transplantation. Although the pulmonary endothelium is the primary target site of IRI, the pathophysiology of lung IRI remains incompletely understood. It is essential to understand the mechanism of pulmonary IRI to improve the outcomes of lung transplantation. Therefore, we reviewed the state-of-the-art in the management of pulmonary IRI after lung transplantation. Recently, the ex vivo lung perfusion (EVLP) system has been clinically introduced worldwide. Various promising therapeutic strategies for the protection of the endothelium against IRI, including EVLP, inhalation therapy with therapeutic gases and substances, fibrinolytic treatment, and mesenchymal stromal cell therapy, are awaiting clinical application. We herein review the latest advances in the field of pulmonary IRI in lung transplantation.


2011 ◽  
Vol 165 (2) ◽  
pp. 331
Author(s):  
R.G. Nava ◽  
A.C. Bribriesco ◽  
W. Li ◽  
A.E. Gelman ◽  
A.S. Krupnick ◽  
...  

2008 ◽  
Vol 74 (8) ◽  
pp. 1009-1016 ◽  
Author(s):  
Atsunori Nakao ◽  
Gaetano Faleo ◽  
Hiroko Shimizu ◽  
Kiichi Nakahira ◽  
Junichi Kohmoto ◽  
...  

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