Morphofunctional changes of the rat skin in application of iron nanoparticles (Fe2O3) on the intact surface

Although fluoride levels become elevated in sound enamel following a topical fluoride treatment, the caries-preventive effect of fluoride is thought to be due primarily to the role of fluoride in remineralization of clinically undetectable enamel lesions and hypomineralized enamel. During lesion formation, redistribution of fluoride from the enamel surface to the subsurface demineralized enamel occurs. This results in a surface zone with a relatively low fluoride content. In order to maintain an intact surface zone over a carious lesion, it may be necessary to replenish the fluoride levels with an exogenous fluoride source. By acid-etching the lesion surface, a more reactive surface is made available for fluoride interaction. In addition, porosities and etching patterns may be created, allowing for bonding of a caries-resistant resin material to the lesion surface. The purpose of this study was to determine the integrity of the caries-like lesion surface following acid-etching and subsequent stannous fluoride treatment (SnF2).

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Prolongation and control of mouse-to-rat skin xenograft survival by malononitrilamides

Immunology Letters ◽

10.1016/s0165-2478(97)88840-2 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 490

Author(s):

H Schorlemmer

Keyword(s):

Rat Skin ◽

And Control ◽

Skin Xenograft

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A 3.5-Second Phenomenon in Haemostasis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649086 ◽

1973 ◽

Vol 30 (02) ◽

pp. 363-370

Author(s):

D Thilo ◽

E Böhm

Keyword(s):

Bleeding Time ◽

Rat Skin ◽

Fibrin Formation ◽

Bleeding Area ◽

Platelet Thrombus ◽

Platelet Aggregates ◽

Primary Platelet ◽

System Mechanism

SummaryExperiments with injury of the abdominal rat skin were carried out to examine the haemostatic system mechanism in vivo after zero to 30 seconds bleeding time. In the bleeding area only a few platelet aggregates could be found with no primary platelet thrombus. After 3.5 second bleeding time the first fibrin strands have been observed at the site of injury. The hypothesis is put forward that there is a very fast reacting haemostatic mechanism which results in the fibrin formation already at 3.5 seconds.

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Formulation and Evaluation of Carbopol Gel Containing Liposomes of Ketoconazole. (Part-II)

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v1i2.8839 ◽

2009 ◽

Vol 1 (2) ◽

Cited By ~ 1

Author(s):

Rakesh Patel ◽

Hardik Patel ◽

Ashok Baria

Keyword(s):

Antifungal Activity ◽

Rat Skin ◽

Albino Rat ◽

In Vitro Drug Release ◽

Carbopol Gel ◽

Liposomal Formulations ◽

Release Drug ◽

In Vitro Permeation ◽

In Vitro Antifungal Activity

The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Ketoconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were incorporated into 1% carbopol gel, and the systems were evaluated for in-vitro drug release, drug retention into skin and in-vitro antifungal activity. The in-vitro permeation of ketoconazole using wistar albino rat skin from liposomal gel was compared with that of plain drug gel and also with plain drug cream containing 2% w/w of ketoconazole. The release of ketoconazole from liposomal gel was much slower than from non liposomal formulations. Gel containing liposomal ketoconazole showed maximum antifungal activity after 30 hours over plain ketoconazole gel and cream formulations.

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Green synthesis of iron nanoparticles using flower extract of Piliostigma thonningii and their antibacterial activity evaluation

10.31221/osf.io/57zrj ◽

2019 ◽

Author(s):

Chem Int

Keyword(s):

Antibacterial Activity ◽

Environmental Remediation ◽

Iron Nanoparticles ◽

Reduction Process ◽

Xrd Analysis ◽

Visible Range ◽

Magnetic Storage ◽

Ferrous Chloride ◽

Flower Extract ◽

Piliostigma Thonningii

Iron nanoparticles have gained tremendous attention due to their application in magnetic storage media, ferrofluids, biosensors, catalysts, separation processes, environmental remediation and antibacterial activity. In the present paper, iron nanoparticles were synthesized using aqueous flower extract of Piliostigma thonningii, a natural nontoxic herbal infusion. Iron nanoparticles were generated by reaction of ferrous chloride solution with the flower extract. The reductants present in the flower extract acted as reducing and stabilizing agents. UV-vis analysis of the iron nanoparticles showed continuous absorption in the visible range suggesting the iron nanoparticles were amorphous. This was confirmed by X-ray diffraction (XRD) analysis which did not have distinct diffraction peaks. Scanning electron microscopy (SEM) analysis revealed that the synthesized iron nanoparticles were aggregated as irregular clusters with rough surfaces. FT-IR studies showed the functional groups that participated in the bio-reduction process to include a C-H stretch (due to alkane CH3, CH2 or CH), C=O stretch (due to aldehydes), O-H bend (due to tert-alcohol or phenol), C-O stretch (due to aldehydes or phenols) and C-O stretch (due to alcohols) corresponding to absorptions at 2929.00, 1721.53, 1405.19, 1266.31 and 1030.02 cm-1 respectively. The iron nanoparticles showed significant antibacterial activity against Escharichia coli and Staphylococcus aureus suggesting potential antibacterial application.

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