Efficacy of Combined Administration of Cinnamon and Curcumin on Acute Orofacial Inflammatory Pain Enhanced by Xerostomia

2021 ◽  
Vol 9 (4) ◽  
pp. 40-46
Author(s):  
Ja-Hyeong Choi ◽  
Seoul-Hee Nam ◽  
Min-Kyung Lee
Keyword(s):  
Inflammatory Pain ◽  
Combined Administration

scholarly journals Antinociceptive and Anti-inflammatory Effects of Combined Administration of a-Tocopherol and Morphine in Acetic Acid Induced Writhing Test

2017 ◽  
Vol 7 (2) ◽  
pp. 20-24 ◽  
Author(s):  
Tamanna Habib ◽  
Shelina Begum ◽  
Taskina Ali ◽  
Masud Imtiaz ◽  
Shahriar Masood
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Inflammatory Pain ◽  
Morphine Sulphate ◽  
Control Group ◽  
Writhing Test ◽  
Medical College ◽  
Combined Administration ◽  
Anti Inflammatory ◽  
Experimental Group

Background: Morphine represents the front line therapy for the clinical management of acute and chronic pain but has a number of side effects. So, to minimize the side effect of this tradition analgesic, this study is aimed to explore that combination of morphine and a-tocopherol (?T) are better analgesic as well as anti-inflammatory effect than that of morphine alone.Objective: to assess the effects of combination of morphine with a-tocopherol against nociceptive and inflammatory pain.Methods: This prospective experimental study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from January 2013 to December 2013. For this purpose, 15 male Long Evans rats were studied. On the basis of vitamin and drug administrations, the rats were divided into three (3) groups (5 rats in each). Control group received normal saline, one experimental group received morphine sulphate (MS) at a dose of 3 mg/kg body weight and another experimental group received combination of DS with ?T at a dose of 3 mg/kg body weight and 500 mg/kg body weight, respectively. All the groups received single dose and equal volume (1 ml) through intraperitoneal route 1 hour before the test. Just one hour after administrations, they were subjected to acetic acid induced writhing test . The data were statistically analyzed by ANOVA followed by Bonferroni Post Hoc test.Results: combined administration of MS and ?T significantly lowered (p 0.05) the variables for visceral nociceptive pain and inflammatory pain than individual administration of MS. Conclusion: from this study it may be concluded that combined administration of morphine sulphate and a-tocopherol were more effective in lowering the nociceptive and inflammatory pain than individual administration of morphine.Anwer Khan Modern Medical College Journal Vol. 7, No. 2: Jul 2016, P 20-24

The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

2020 ◽  
Vol 82 (6) ◽  
pp. 64-73
Author(s):  
O.H. Korotkyi ◽  
◽  
T.V. Luhovska ◽  
T.M. Serhiychuk ◽  
K.O. Dvorshchenko ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Chondroitin Sulfate ◽  
Joint Inflammation ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Quantitative Composition ◽  
Combined Administration ◽  
Osteoarthritis Progression ◽  
Experimental Osteoarthritis ◽  
Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

PROTECTIVE EFFECT OF POLYPEPTIDE AND AMINO ACIDS ON THE DEVELOPMENT OF THE NERVOUS TISSUE CULTURE IN THE PRESENCE OF CYCLOPHOSPHAMIDE

2017 ◽  
pp. 22-26
Author(s):  
V. B. Dolgo-Saburov ◽  
N. I. Chalisova ◽  
L. V. Lyanginen ◽  
E. S. Zalomaeva
Keyword(s):  
Amino Acids ◽  
Cell Proliferation ◽  
Tissue Culture ◽  
Protective Effect ◽  
Organotypic Culture ◽  
Inhibitory Effect ◽  
Mustard Gas ◽  
Synthesis Inhibitor ◽  
Combined Administration ◽  
The Central Nervous System

In an organotypic culture, an investigation was conducted into combined effects of cyclophosphamide DNA as synthesis inhibitor used to model a resorptive action of mustard gas, and cortexin polypeptide or each of 20 encoded amino acids on the development of cell proliferation in cerebral cortex explants of the rat. The combined administration of cyclophosphamide together with cortexin or with each of the 20 encoded amino acids, except glycine, showed suppression of the cytostatic agent inhibitory effect. Thus, cortexin and amino acids have a protective effect on cell proliferation in the tissue culture of the central nervous system under the action of mustardlike substances.

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