Osteoporosis in rheumatic diseases

2021 ◽  
pp. 64-75
Author(s):  
L. P. Evstigneeva
Keyword(s):  
Rheumatic Diseases ◽  
Systemic Vasculitis ◽  
Connective Tissue Diseases ◽  
Epidemiological Studies ◽  
Treatment Of Osteoporosis ◽  
High Prevalence ◽  
Term Administration ◽  
Prevalence Of Osteoporosis ◽  
Reduce Bone Loss

The article presents a review of studies that have examined osteoporosis in rheumatic diseases, including rheumatoid arthritis, spondylarthritis, psoriatic arthritis, systemic connective tissue diseases, and systemic vasculitis. The review discusses the pathogenesis, diagnosis and treatment of osteoporosis in these diseases, presents the results of epidemiological studies assessing the risk factors and the prevalence of osteoporosis in rheumatic diseases. There was a high prevalence of osteoporosis and fractures in rheumatic diseases, exceeding the population, associated primarily with systemic and local inflammation, as well as with the intake of glucocorticoids. It is indicated that the existing strategies for the treatment of rheumatic diseases may partially reduce bone loss, but long-term administration of glucocorticoids, on the contrary, increase bone resorption. The review presents data on the medications for the treatment of osteoporosis and approaches to the treatment of glucocorticoid osteoporosis.

scholarly journals Glucocorticoid-induced osteoporosis in systemic lupus erythematosus

2018 ◽  
Vol 3 ◽  
pp. 205990211880251
Author(s):  
Kee Fong Phang ◽  
Jiacai Cho ◽  
Weixian Lee ◽  
Anselm Mak
Keyword(s):  
Bone Mineral Density ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Bone Health ◽  
Mineral Density ◽  
Systemic Lupus ◽  
Treatment Of Osteoporosis ◽  
Improvement In Survival ◽  
Prevalence Of Osteoporosis

Improvement in survival of systemic lupus erythematosus has been brought about with new advancement in treatment. However, glucocorticoids remain the sole cornerstone and as patients live longer, there is a need to address long-term complications brought by long-term glucocorticoid use such as osteoporosis. In this review, glucocorticoid-induced osteoporosis in systemic lupus erythematosus will be extensively discussed. This would include prevalence of osteoporosis in systemic lupus erythematosus patients, the difficulties in measuring fracture risk and pitfalls in using conventional methods such as bone mineral density. In addition, the mechanism of actions of glucocorticoids and evidence for glucocorticoids in the treatment of specific systemic lupus erythematosus manifestations would be explored and we also discussed specific pathophysiological mechanisms in the development of glucocorticoid-induced osteoporosis in systemic lupus erythematosus. We also reviewed the latest guidelines in the treatment of glucocorticoid-induced osteoporosis and the evidence for various osteoporosis medications. Finally, we recommend an approach in monitoring bone health and the treatment of osteoporosis specifically in systemic lupus erythematosus patients.

scholarly journals Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

2021 ◽  
Author(s):  
Laura Andreoli ◽  
Cecilia Nalli ◽  
Maria Grazia Lazzaroni ◽  
Chiara Carini ◽  
Francesca Dall’Ara ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Connective Tissue Diseases ◽  
Nationwide Survey ◽  
Chronic Arthritis ◽  
Childbearing Age ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Increased Risk ◽  
Italian Women

Abstract The concern about the offspring’s health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children. By surveying 398 patients who received their diagnosis of RD during childbearing age (before the age of 45), information about the offspring were obtained from 230 women who declared to have had children. A total of 148 (64.3%) patients were affected by connective tissue diseases (CTD) and 82 (35.7%) by chronic arthritis. Data on 299 children (156 males, 52.1%; mean age at the time of interview 17.1 ± 9.7 years) were collected. Twelve children (4.0%), who were born to patients with CTD in 75% of the cases, were affected by AD (8 cases of celiac disease). Eleven children had a certified diagnosis of ND (3.6%; 6 cases of learning disabilities); 9 of them were born to mothers with CTD (5 after maternal diagnosis). No association was found between ND and prenatal exposure to either maternal autoantibodies or anti-rheumatic drugs. Absolute numbers of offspring affected by AD and ND were low in a multicentre cohort of Italian women with RD. This information can be helpful for the counselling about reproductive issues, as the health outcomes of the offspring might not be an issue which discourage women with RD from having children.

RARE RHEUMATIC DISEASES. RELAPSING POLYCHONDRITIS: A CLINICAL CASE

2019 ◽  
Vol 57 (4) ◽  
pp. 478-481
Author(s):  
I. V. Semizarova ◽  
L. N. Eliseeva ◽  
A. F. Davydova ◽  
Z. A. Baste ◽  
Zh. A. Kisian
Keyword(s):  
Rheumatic Diseases ◽  
Structural Changes ◽  
Clinical Laboratory ◽  
Systemic Vasculitis ◽  
Connective Tissue Diseases ◽  
Clinical Manifestations ◽  
Relapsing Polychondritis ◽  
Diagnostic Algorithm ◽  
Cartilage Tissue ◽  
Systemic Inflammatory Disease

The diagnosis of a disease accompanied by febrile syndrome presents special problems in clinical practice. The traditional diagnostic algorithm in this case involves the exclusion of infections, cancer, and rheumatic diseases. The causes of fever can be severe types of rheumatoid arthritis, systemic vasculitis, and diffuse connective tissue diseases, as well as rare diseases, the difficulty of diagnosis of which is due to low awareness of the disease and the absence of specific clinical, laboratory, and instrumental signs. These also include relapsing polychondritis (RPC) in particular. RPC is a rare systemic inflammatory disease of cartilage tissue, which leads to its structural changes resulting in complete destruction. Cartilages of the acoustic apparatus, nose, trachea, and joints are mainly affected. The severity of cardiovascular injury in RPC has recently been emphasized. This disease is observed with equal frequency in men and women, primarily at the age of 40–60 years, predominantly in white people, but it also occurs in other populations. The etiology of RPC is unknown. There are no pathognomonic laboratory and instrumental tests for the diagnosis of RPC. A unified approach to treating this condition has not been elaborated. The available data on the pathogenesis, various clinical manifestations and treatment options of the disease are analyzed. The authors’ own observations of RPC are depicted.

scholarly journals Panorama Des Maladies Rhumatismales A Conakry

2018 ◽  
Vol 14 (24) ◽  
pp. 422
Author(s):  
Kamissoko Aly Badra ◽  
Diallo Mamadou Lamine ◽  
Traoré Marie ◽  
Diallo Alhassane ◽  
Yombouno Emmanuel ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Relative Frequency ◽  
Connective Tissue Diseases ◽  
Epidemiological Studies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
National Hospital ◽  
Cross Sectional ◽  
The Mean ◽  
Epidemiological Profile

Objective: To determine the epidemiological profile of rheumatic diseases in hospital consultation at the Ignace Deen National Hospital in Conakry (Guinea). Patients and methods: We used a cross-sectional study of participant seen in rheumatologic consultation between November 1, 2016 and November 30, 2017 at the Rheumatology Department of the Ignace Deen National Hospital in Conakry (Guinea). Rheumatic diseases were diagnosed according to the rigorous criteria. Results: We collected 1038 patients including 679 women (65.41%). The mean age of the patients was 49.88 ± 17.47 years with range of 5 and 93 years. Degenerative pathology (644 cases, 62.04%), chronic inflammatory rheumatism and connective tissue diseases (252 cases, 24.27%), periarticular pathology and canal syndromes (91 cases, 8.76%), microcrystalline arthropathies (49 cases, 4.72%), osteopathies (45 cases, 4.33%), and infectious diseases (16 cases, 1.54%) were the main disorders observed during study period. Conclusion: Most of the rheumatic diseases described in the literature have been found. The particuliarity was the relative frequency of inflammatory rheumatism and fracture osteoporosis. However, the further epidemiological studies would be needed to confirm these data.

The efficacy and safety of long-term administration of alpha-interferon and lamivudine in patients with chronic hepatitits B

2001 ◽  
Vol 120 (5) ◽  
pp. A572-A572
Author(s):  
F JABOLI ◽  
E RODA ◽  
C FABBRI ◽  
S MARCHETTO ◽  
F FERRARA ◽  
...  
Keyword(s):  
Alpha Interferon ◽  
Efficacy And Safety ◽  
Term Administration

STUDIES IN THE SUPPOSED GOITROGENOUS EFFECT OF TAP WATER IN HELSINKI

1960 ◽  
Vol XXXIII (IV) ◽  
pp. 630-636
Author(s):  
F.-E. Krusius ◽  
P. Peltola
Keyword(s):  
Tap Water ◽  
Physiological Saline ◽  
Normal Weight ◽  
The Body ◽  
Iodine Uptake ◽  
Redistilled Water ◽  
Detectable Difference ◽  
Term Administration ◽  
Long Term Experiment

ABSTRACT The study reported here was performed in order to examine the tap water of Helsinki for its alleged goitrogenous effect. In a short-term, 24-hour experiment with rats, kept on an iodine-poor diet, we noticed no inhibition of the 4-hour 131I uptake, as compared with that of animals receiving physiological saline instead of tap water. Two similar groups of rats receiving 1 and 2 mg of mercazole in redistilled water showed a distinct blockage of the 4-hour uptake, which proved the effect of this substance. In a long-term experiment of 5 weeks' duration there was no detectable difference in the body weight, thyroid weight and the 4-hour 131I uptake when the rats receiving tap water or distilled water to which 0.45 per cent of sodium chloride was added were compared with each other. Replacement of tap water by a 10 mg per cent solution of mercazole in redistilled water enlarged the thyroid to double its normal weight and increased the 131I uptake to approximately five times that of the controls. Thus our experiments failed to demonstrate any goitrogenous effect in the tap water of Helsinki. Changes similar to those produced by a long-term administration of mercazole, i. e. an enlargement of the thyroid and an increased thyroidal iodine uptake, have been shown to be due to milk collected from goitrous areas. The observations here reported confirm the importance of milk in the genesis of the goitre endemia of Helsinki. Attention is further called to the fact that a thyroidal enlargement combined with an increased thyroidal iodine uptake cannot always be taken as a sign of iodine deficiency because similar changes may be produced by the administration of goitrogens.

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