Case of penile cancer in patient with scleroatrophic lichen

2021 ◽  
pp. 52-54
Author(s):  
A. V. Ignatovskiy ◽  
Yu. R. Lasareva
Keyword(s):  
Primary Care ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Primary Care Physicians ◽  
Penile Cancer ◽  
Clinical Case ◽  
Previous Therapy ◽  
History Of ◽  
Penile Squamous Cell Carcinoma

Purpose. To describe a clinical case of penile cancer in a patient with sclerotrophic lichen. Material and methods. Data of anamnesis, medical clinical, histological and instrumental examination. Results. A case of rapidly progressing penile squamous cell carcinoma in a patient with a long history of sclerotrophic lichen and no previous therapy was described. Conclusions.The low level of awareness of primary care physicians about the manifestations of CSAL, as a consequence, the lack of treatment and progression of the disease, expressed in urethral stenosis and malignant transformation draws attention.

scholarly journals Penile squamous cell carcinoma :a three-year study at BP Koirala Memorial Cancer Hospital

2019 ◽  
Vol 2 (3) ◽  
pp. 149-153
Author(s):  
Shankar Bastakoti ◽  
Ranjan Raj Bhatta ◽  
Nandita Jha ◽  
Sadina Shrestha ◽  
Amrita Paudel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
The Elderly ◽  
Prognostic Indicator ◽  
Study Data ◽  
Cancer Hospital ◽  
Well Differentiated ◽  
Penile Squamous Cell Carcinoma

Background: Penile cancer is an aggressive and mutilating disease which deeply affects self-esteem and daily life of the patient. Penile cancer mostly affects the elderly, seen in people in their sixties and seventies. Occurrence in younger age is a need of research of penile neoplasia in young non-circumcised patients. Materials and Method: This is a three-year retrospective study. Data was extracted from the Department of Pathology and Medical Record section of B.P. Koirala Memorial Cancer Hospital. All histologically proven cases were included. The objective of this study was to assess clinical histopathological profile of penile carcinoma. Results. A total of 114 malignant cases were included out of which most common age group involved was 50-60 years with mean age of presentation being 51.6 years. Glans was the commonest site of involvement in 59 cases (51.7%). Well-differentiated squamous cell carcinoma was the most common type (71%). Forty nine patients (43%) presented when the mass size was 4-6 cm and 44 (39%) came with 2-4cm and rest less than 2 cm. Lymphvascular invasion was seen in 15 (13%) out of 114 cases and perineural invasion was seen only in 5 (4.3%) cases. 20 cases (17.5%) had lymphnodes positive which are less than 5 lymphnode positive and five (4.3%) had more than 5 lymphnodes positive. Conclusion. Early diagnosis and intervention of the patient ensure high probability of getting cured because the stage at presentation appears to be the most vital prognostic indicator for survival.  

Metastatic penile squamous cell carcinoma with dramatic response to combined checkpoint blockade with ipilimumab and nivolumab

2020 ◽  
pp. 107815522092260
Author(s):  
Abinav Baweja ◽  
Nataliya Mar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Checkpoint Inhibitors ◽  
Papilloma Virus ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Penile Squamous Cell Carcinoma

Introduction Prognosis for patients with lymph node positive or metastatic penile squamous cell carcinoma remains poor. Chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP regimen) is recommended as a first-line option in this cohort of patients. No standard preferred subsequent-line therapy exists for patients with relapsed or refractory penile carcinoma following TIP chemotherapy. Molecular pathogenesis of penile cancer can be subdivided into human papilloma virus-dependent and human papilloma virus-independent pathways. Recent studies have demonstrated increased expression of programmed death ligand-1 in some penile tumors, commonly those that are human papilloma virus-negative. Given the rarity of penile carcinoma in industrialized countries and lack of effective therapies, checkpoint inhibitors may be an attractive treatment option for this subset of patients. Case report We report a case of metastatic penile cancer refractory to TIP chemotherapy, with a dramatic treatment response to ipilimumab and nivolumab. Molecular profiling of this tumor showed a high programmed death ligand-1 expression, high tumor mutational burden, high microsatellite instability, and alterations in DNA mismatch repair genes. Discussion This case highlights another dimension of information that may be gained with molecular genomic profiling of penile tumors, providing insight into the biologic behavior of this neoplasm and assessing for predictive biomarkers of response to immune checkpoint inhibitors.

scholarly journals Imaging for the Initial Staging and Post-Treatment Surveillance of Penile Squamous Cell Carcinoma

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 170
Author(s):  
Samuel J. Galgano ◽  
John C. Norton ◽  
Kristin K. Porter ◽  
Janelle T. West ◽  
Soroush Rais-Bahrami
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
The United States ◽  
Positron Emission ◽  
Ultrasound Computed Tomography ◽  
Penile Squamous Cell Carcinoma ◽  
Almost All ◽  
Initial Staging

Although relatively rare in the United States, penile squamous cell carcinoma is encountered worldwide at a higher rate. Initial diagnosis is often made on clinical exam, as almost all of these lesions are externally visible and amenable to biopsy. In distinction to other types of malignancies, penile cancer relies heavily on clinical nodal staging of the inguinal lymph node chains. As with all cancers, imaging plays a role in the initial staging, restaging, and surveillance of these patients. The aim of this manuscript is to highlight the applications, advantages, and limitations of different imaging modalities in the evaluation of penile cancer, including ultrasound, computed tomography, magnetic resonance imaging, and positron emission tomography.

scholarly journals Hidden penile squamous cell carcinoma: A case report

2014 ◽  
Vol 8 (5-6) ◽  
pp. 433
Author(s):  
Sam Neufeld ◽  
Tadeusz Kroczak ◽  
Darrel Drachenberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Interesting Case ◽  
Rare Malignancy ◽  
Penile Squamous Cell Carcinoma

Penile cancer is a rare malignancy that typically presents as a superficial lesion. We present an interesting case of subepithelial penile cancer presenting without superficial manifestation.

scholarly journals Erythroplasia of Queyrat

2012 ◽  
Vol 2 (3) ◽  
pp. 63 ◽  
Author(s):  
Deirdre Mary Fanning ◽  
Hugh Flood
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Cell Cancer ◽  
Skin Grafting ◽  
Invasive Squamous Cell Carcinoma ◽  
Erythroplasia Of Queyrat ◽  
Penile Squamous Cell Carcinoma

A 58-year-old Caucasian male presented to the urology clinic reporting an approximate one-year history of a persistent irritating, slowly progressive, glans penis redness. Biopsy revealed penile squamous cell carcinoma <em>in situ</em>. He underwent a partial glansectomy with circumcision and skin grafting. At three months follow-up there is no evidence of local disease recurrence. In western countries, primary malignant penile cancer is uncommon, with an incidence of less than 1 per 100,000 males. Squamous cell cancer accounts for more than 95% of cases of penile cancer. Squamous cell carcinoma <em>in situ</em> on the penile mucosa or transitional surfaces is also known as Erythroplasia of Queyrat. In the region, one third of penile squamous cell carcinoma <em>in situ </em>cases progress to invasive squamous cell carcinoma.

scholarly journals Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care

2021 ◽  
Author(s):  
Luiza Dorofte ◽  
Diane Grélaud ◽  
Michelangelo Fiorentino ◽  
Francesca Giunchi ◽  
Costantino Ricci ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Histological Grade ◽  
Significant Risk ◽  
Tumor Grade ◽  
Patient Treatment ◽  
Histological Subtype ◽  
Penile Squamous Cell Carcinoma

AbstractDifferentiation between penile squamous cell carcinoma patients who can benefit from limited organ-sparing surgery and those at significant risk of lymph node metastasis is based on histopathological prognostic factors including histological grade and tumor histological subtype. We examined levels of interobserver and intraobserver agreement in assessment of histological subtype and grade in 207 patients with penile squamous cell carcinoma. The cases were assessed by seven pathologists from three hospitals located in Sweden and Italy. There was poor to moderate concordance in assessing both histological subtype and grade, with Fleiss kappas of 0.25 (range: 0.02–0.48) and 0.23 (range: 0.07–0.55), respectively. When choosing HPV-associated and non-HPV-associated subtypes, interobserver concordance ranged from poor to good, with a Fleiss kappa value of 0.36 (range: 0.02–0.79). A re-review of the slides by two of the pathologists showed very good intraobserver concordance in assessing histological grade and subtype, with Cohen’s kappa values of 0.94 and 0.91 for grade and 0.95 and 0.84 for subtype. Low interobserver concordance could lead to undertreatment and overtreatment of many patients with penile cancer, and brings into question the utility of tumor histological subtype and tumor grade in determining patient treatment in pT1 tumors.

scholarly journals Total Penectomy and Perineal Urethrostomy Management of Penile Squamous Cell Carcinoma with Paraffinoma in Single Center Hospital: A Rare Case Report

2021 ◽  
Vol 9 (C) ◽  
pp. 55-58
Author(s):  
Syaeful Agung Wibowo ◽  
Suharto Wijanarko ◽  
Erwin Aritama Ismail ◽  
Muhammad David Perdana Putra
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Previous History ◽  
Surrounding Tissue ◽  
Male Population ◽  
Surgical Specimen ◽  
History Of

BACKGROUND: Penile cancer is a rare condition, affecting less than 1% of the adult male population [1]. The risk of penile cancer increases significantly with age, poor hygiene, and the presence of the prepuce. The most common type encountered is squamous cell carcinoma (SCC). Clinically penile cancer appears as small lesions with induration and erythema or as large infiltrative ulcerative lesions. As the disease progresses, complaints such as itching, bleeding, discharge, foul odor, and pain occurred. CASE REPORT: A 63-year-old man with poor hygiene and has a history of diabetes mellitus had penis ulcers since 5 years ago. On physical examination, an ulcer with the size of 12 × 12 × 10 cm was found growing pus (-). Biopsy had done and confirmed SCC as a result. Pelvic multiple slice CT shows growth covering the entire shaft of the penis down to the base. The patient had a previous history of using silicone injection 35 years ago and causing Sclerofibromatosis. The patient was planned to undergo surgery with clinical diagnosis T4N0M0. Total penectomy was performed with an elliptical incision around the base with a margin of 2 cm. Sclerofibromatosis and the surrounding tissue were excised to the base of the penis followed by perineal urethrostomy. There was no problem postoperatively. The patient went home after staying in the hospital for 96 h. The surgical specimen revealed SCC with free of tumor excision margin. CONCLUSIONS: Injections with silicone to enlarge the penis cannot be justified. The process can trigger a chronic inflammatory reaction associated with penile malignancy. Total penectomy and wide excision with urethral perineostomy could be optimal initial treatment.

scholarly journals Pain: More than Meets the Eye, an Atypical Case of Ocular Squamous Cell Carcinoma

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Jasmin Hundal ◽  
Madiha Ali ◽  
Kyle Ferguson ◽  
Norman Saffra ◽  
Benson Babu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Care Physicians ◽  
Excisional Biopsy ◽  
Eye Pain ◽  
History Of ◽  
Refractory Case ◽  
Hispanic Male

Introduction  Eye pain is common and initially managed by primary care physicians. In the rare refractory case or atypical appearance, consultation with ophthalmology is needed. Case presentationA 35-year-old Hispanic male patient with a history of pterygium presented with complaints of worsening left eye pain for months .Over the past two weeks, the patient had also noticed more redness and soreness that occurred all day.  He noticed darkening in the medial vision of his left eye, persistence of left eye pain and visual changes. An excisional biopsy of the lesion was performed.  The final biopsy reports revealed an ocular surface squamous cell carcinoma in situ arising from pterygium.DiscussionTopical application and injections of immunotherapy such as mitomycin C and 5-fluorouracil have been shown to be effective.  Recurrence is high and follow-up examination by ophthalmology is essential. 

scholarly journals Novel presentation of intraocular metastases in a patient with penile squamous cell carcinoma: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Shanshan Li ◽  
Haifeng Zhao ◽  
Cui Qiu ◽  
Changfan Wu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Penile Cancer ◽  
Histopathological Analysis ◽  
Resonance Imaging ◽  
Choroidal Metastasis ◽  
Penile Squamous Cell Carcinoma ◽  
The Right

Abstract Background The choroid is the most common site for intraocular tumor metastasis because of its abundant vascular supply. However, choroidal metastasis in penile cancer is highly unusual. Here, we report the first case of diagnosis of choroidal metastasis at presentation in a patient with penile squamous cell carcinoma. Case presentation A 43-year-old Asian man with a 3-year history of penile cancer presented with metastasis in the right intraocular sites. Magnetic resonance imaging showed hyperintensity in the T1-weighted images and hypointensity in the T2-weighted images of the right eye. After enucleation of his right eye, histopathological analysis led to a diagnosis of metastatic, moderately differentiated penile squamous cell carcinoma. Conclusions Penile cancer typically occurs as penile squamous cell carcinoma, and its most common metastatic sites are the inguinal lymph nodes. Hemorrhagic transfer of tumor cells is extremely rare, especially to intraocular sites. Intraocular metastatic tumors have a unique presentation on imaging, as observed on magnetic resonance imaging and histopathological analysis. This novel finding of intraocular metastasis in penile squamous cell carcinoma is of great significance to optic surgeons and oncologists as it has new implications in the diagnosis of and timely intervention for penile cancer metastasis.

scholarly journals Long-term follow-up of a Patient with Malignant Transformation of Inverted Papilloma into Sinonasal Undifferentiated Carcinoma

2017 ◽  
Vol 8 (3) ◽  
pp. ar.2017.8.0209 ◽  
Author(s):  
Carolyn A. Orgain ◽  
Terry Y. Shibuya ◽  
Lester D. Thompson ◽  
David B. Keschner ◽  
Rohit Garg ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Undifferentiated Carcinoma ◽  
Sinonasal Undifferentiated Carcinoma ◽  
Postnasal Drip ◽  
Nasal Tumors ◽  
History Of

Introduction Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5–4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5–15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC). Methods A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined. Results A 62-year-old man presented with a 3-month history of nasal airway obstruction, rhinorrhea, and postnasal drip refractory to medical therapy. He had a long history of exposure to fumes, chemicals, dusts, and solvents as a professional painter as well as a 45 pack-year history of smoking and alcohol abuse. The patient was ultimately found to have a left ethmoidal IP with a focus of malignant transformation into SNUC. Endoscopic resection was performed, followed by concurrent chemoradiation and adjuvant chemotherapy. After surgery, he had no evidence of recurrent disease after 9 years of follow-up. Conclusions IP is known to transform into squamous cell carcinoma. Here we report a rare case of malignant transformation into SNUC, a much more uncommon and aggressive lesion. Although traditionally associated with a poorer prognosis, the positive outcome for SNUC observed in this patient may potentially be attributed to early detection and timely therapeutic intervention.

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