CHOOSING OF SOME BLOOD PARAMETERS AND HEPATIC ENZYMES AS INDICATORS FOR RADIATION EXPOSURE IN EXPERIMENTAL RABBITS

ObjectiveBiochemical changes in treatment of schizophrenic and bipolar disorders, in Albanian patients, with atypical antipsychotic and anti-depressive drugs. Some of the adverse effects related to their use are hyperlipidemia, hepatic enzymes, type 2 diabetes and CK level, which may result in development of metabolic syndrome. This study aimed to investigate a possible increase of biochemical parameters, in patients with schizophrenia and bipolar disorders treated with atypical antipsychotic and antidepressive drugs (Olanzapin, Risperidon, Clozapin, Antidepresiv triciclik, SSRI, SNRI).MethodsForty subjects with schizophrenia and bipolar disorders were evaluated, 12 women and 28 men, aged between 17 and 72 years. Blood collection of the patients was taken in our laboratory and this values were measure in long treatment patients, after years of treatment. Analyses were perform in our laboratory with autoanalysator SAT 450.ResultsEvaluation after measurements showed significant differences when comparing the mean values obtained in each patients. The biochemical indicators of development of metabolic syndrome measured in our study, show that is an increasement of lipids panel, specially triglycerides and total cholesterol, also in glucose, CK level and hepatic enzymes, presenting statistically significant changes (P < 0.05) for prolong treatment.ConclusionWe conclude that the treatment with atypical antipsychotic and antidepressive drugs, promoted a substantial increasing of biochemical blood parameters. Lipids panel, hepatic enzymes, type 2 diabetes, CK levels are observed in among subjects evaluated.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Efficiency of savory (Satureja Khuzestanica Jamzad) essential oil on performance, carcass traits, some blood parameters and immune function of Male Ross 308 heat stressed broiler chicks

Ukrainian Journal of Ecology ◽

10.15421/2019_783 ◽

2019 ◽

Vol 9 (4) ◽

pp. 515-520 ◽

Cited By ~ 1

Author(s):

Y. Mohammad ◽

G. Hasan ◽

D. Mohsen

Keyword(s):

Essential Oil ◽

Broiler Chickens ◽

Body Weight Gain ◽

Relative Weight ◽

Blood Parameters ◽

Serum Glucose ◽

The Body ◽

Broiler Chicks ◽

Hepatic Enzymes ◽

Feed Conversion

To investigate the efficiency of savory essential oil on performance, organs relative weight, some blood parameters, immune response and hepatic enzymes of broiler chickens, a total 320 male Ross 308 chicks were allocated to four treatments and four replicates of twenty birds as a completely randomized design from. The varidifferent levels savory oil. The body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR) was recorded at continues weeks of the experiment. Relative weight of visceral organs was determined and blood serum glucose and activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured after blood sampling at 42 days old and plasma IgG immunoglobulin was quantified. Data showed that BW and FI increased with savory oil inclusion (p≤0.05). Besides, the savory oil decreased the plasma glucose, AST and ALT and serum blood Ig G of heat stressed broilers, increased significantly (p?0.05) instead. In conclusion we may suggested that, the savory oil at 0.4 ml/L could improve economic proficiency in broiler flocks due to accumulation of minute advantages in greater BWG, FI, and improved immune system and lowered hepatic enzymes under heat stress condition.

Download Full-text

Combined Efficacy of Cinnamomum Zeylanicum And Doxorubicin Against Leukemia Through Regulation of TRAIL And NF-Kappa B Pathways In Rat Model

10.21203/rs.3.rs-478779/v1 ◽

2021 ◽

Author(s):

Sidra Bukhari ◽

Anum Naeem ◽

Inam Ullah Khan ◽

Muhammad Hamid Siddique ◽

Zain Ali ◽

...

Keyword(s):

Cancer Therapeutics ◽

Blood Parameters ◽

Hepatic Enzymes ◽

Sprague Dawley ◽

Nf Kappa B ◽

Cinnamomum Zeylanicum ◽

Inhibition Of Proliferation ◽

Organ Weights ◽

Cell Counts ◽

Haematological Profile

Abstract Background: Recent discoveries in cancer therapeutics have proven combination therapies more effective than individual drugs. This study describes the efficacy of Cinnamomum zeylanicum and doxorubicin combination against benzene-induced leukemia. Methods and Results: Brine shrimp assay was used to assess the cytotoxicity of Cinnamomum zeylanicum, doxorubicin and their combination. After AML induction in Sprague Dawley rats, the same drugs were given to rat groups. Changes in organ weights, haematological profile, and hepatic enzymes were determined. Real-time PCR was used to elucidate the effect on the expression of STMN1, GAPDH, P53 and various TRAIL and NF-kappa B components. Cinnamomum zeylanicum reduced the cytotoxicity of doxorubicin. The combination treatment showed better anti-leukemic potential than any of the individual drugs as evident from STMN1 expression (p<0.001). It was particularly useful in reducing total white blood cell counts and recovering lymphocytes, monocytes and eosinophils along with hepatic enzymes ALT and AST (p<0.001). All doses recovered relative organ weights and improved blood parameters. The combination therapy was particularly effective in the inhibition of proliferation marker GAPDH (p<0.001) and NF-kappa B pathway components Rel-A (p<0.001) and Rel-B (p<0.05). Expressions of TRAIL components c-FLIP (p<0.001), TRAIL ligand (p<0.001) and caspase 8 (p<0.05) were also altered. Conclusion: Cinnamomum zeylanicum in combination with doxorubicin helps to counter benzene-induced cellular and hepatic toxicity and improve haematological profile. The anti-leukemic effects are potentially mediated through inhibition of GAPDH and NF-kappa B pathway and regulation of TRAIL pathway. Our data suggest the use of Cinnamomum zeylanicum with doxorubicin to improve anti-leukemic therapeutic regimes.

Download Full-text

Effect of dental base metal alloys on IgE levels and some blood parameters

Journal of Oral Rehabilitation ◽

10.1046/j.1365-2842.1997.00549.x ◽

1997 ◽

Vol 24 (10) ◽

pp. 749-754 ◽

Cited By ~ 6

Author(s):

Y. KULAK ◽

A. ARIKAN

Keyword(s):

Base Metal ◽

Blood Parameters ◽

Metal Alloys

Download Full-text

Radiation Exposure

Rheumatology News ◽

10.1016/s1541-9800(07)70634-8 ◽

2007 ◽

Vol 6 (11) ◽

pp. 35

Author(s):

WILLIAM E. GOLDEN ◽

ROBERT H. HOPKINS

Keyword(s):

Radiation Exposure

Download Full-text

Nutrient pattern of unsaturated fatty acids and vitamin E increase resting metabolic rate of overweight and obese women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000664 ◽

2020 ◽

pp. 1-9

Author(s):

Habib Yarizadeh ◽

Leila Setayesh ◽

Caroline Roberts ◽

Mir Saeed Yekaninejad ◽

Khadijeh Mirzaei

Keyword(s):

Vitamin E ◽

Metabolic Rate ◽

Unsaturated Fatty Acids ◽

Resting Metabolic Rate ◽

Blood Parameters ◽

Cross Sectional Study ◽

Obese Women ◽

Cross Sectional ◽

Dietary Nutrients ◽

Nutrient Patterns

Abstract. Objectives: Obesity plays an important role in the development of chronic diseases including cardiovascular disease and diabetes. A low resting metabolic rate (RMR) for a given body size and composition is a risk factor for obesity, however, there is limited evidence available regarding the association of nutrient patterns and RMR. The aim of this study was to determine the association of nutrient patterns and RMR in overweight and obese women. Study design: This cross-sectional study was conducted on 360 women who were overweight or obese. Method: Dietary intake was assessed using a semi-quantitative standard food frequency questionnaire (FFQ). Nutrient patterns were also extracted by principal components analysis (PCA). All participants were evaluated for their body composition, RMR, and blood parameters. Result: Three nutrient patterns explaining 64% of the variance in dietary nutrients consumption were identified as B-complex-mineral, antioxidant, and unsaturated fatty acid and vitamin E (USFA-vit E) respectively. Participants were categorized into two groups based on the nutrient patterns. High scores of USFA-vit E pattern was significantly associated with the increase of RMR (β = 0.13, 95% CI = 0.79 to 68.16, p = 0.04). No significant associations were found among B-complex-mineral pattern (β = −0.00, 95% CI = −49.67 to 46.03, p = 0.94) and antioxidant pattern (β = 0.03, 95% CI −41.42 to 22.59, p = 0.56) with RMR. Conclusion: Our results suggested that the “USFA-vit E” pattern (such as PUFA, oleic, linoleic, vit.E, α-tocopherol and EPA) was associated with increased RMR.

Download Full-text