Parasites in the Tropic - A New Paradigm Shift

2017 ◽  
Keyword(s):  
Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2822
Author(s):  
Arnaud Martel ◽  
Sandra Lassalle ◽  
Alexandra Picard-Gauci ◽  
Lauris Gastaud ◽  
Henri Montaudie ◽  
...  

The management of periocular skin malignant tumours is challenging. Surgery remains the mainstay of treatment for localised eyelid cancers. For more locally advanced cancers, especially those invading the orbit, orbital exenteration has long been considered the gold standard; however, it is a highly disfiguring and traumatic surgery. The last two decades have been marked by the emergence of a new paradigm shift towards the use of ‘eye-sparing’ strategies. In the early 2000s, the first step consisted of performing wide conservative eyelid and orbital excisions. Multiple flaps and grafts were needed, as well as adjuvant radiotherapy in selected cases. Although being incredibly attractive, several limitations such as the inability to treat the more posteriorly located orbital lesions, as well as unbearable diplopia, eye pain and even secondary eye loss were identified. Therefore, surgeons should distinguish ‘eye-sparing’ from ‘sight-sparing’ strategies. The second step emerged over the last decade and was based on the development of targeted therapies and immunotherapies. Their advantages include their potential ability to treat almost all tumours, regardless of their locations, without performing complex surgeries. However, several limitations have been reported, including their side effects, the appearance of primary or secondary resistances, their price and the lack of consensus on treatment regimen and exact duration. The aim of this article was to review the evolution of the management of locally advanced periocular malignant tumours over the last three decades and highlight the new paradigm shift towards the use of ‘eye-sparing’ strategies.


2019 ◽  
Vol 14 (3) ◽  
pp. 497-506 ◽  
Author(s):  
J. N. Bhagwan ◽  
S. Pillay ◽  
D. Koné

Abstract The toilet-wastewater-pollution nexus – the provision of safe, hygienic and appropriate sanitation solutions – is an emerging, priority issue world-wide. Developed nations have followed a linear design approach to achieve their sanitation needs, with conventional waterborne systems continuously improved to meet more stringent control and pollution regulations while minimising the load on the natural environment. Developing countries, on the other hand, continue to struggle to implement such systems, due to a myriad of factors associated with financing, affordability and revenue, and thus rely heavily on on-site systems. On-site systems pose a different set of technical challenges related to their management, which is often overlooked in the developing world. Whereas, while technology strides increase in conventional sanitation processes towards zero-effluent, these come at a significant cost and energy requirement. Further, climate variability and water security put added pressure on the resources available for flushing and transporting human waste. A new paradigm for sanitation, proposed in this paper, introduces and is based on technology disrupters that can safely treat human excreta, and matches user preferences without the need for sewers, or reliance on large quantities of water and/or energy supplies. Through innovation and smart-chain supply, universal access can be achieved sustainably, and linked to water security and business opportunities. The opportunity arises for leapfrogging these solutions in growing cities in the developing world, reducing water consumption and eliminating pollutant pathways.


2012 ◽  
Vol 11 (1-2) ◽  
pp. 219-246 ◽  
Author(s):  
Ahmad Noor Sulastry Yurni

Abstract Abstract The Malays, Chinese and Indian community in Malaysia have been homogenized since British colonialism. The existence of Indian Muslims’ identity caused a new paradigm shift in Malaysia involving the racial discussion. This paper traces the difference in Indian Muslims’ identities from Indian and the Hindus. I argued that Indian Muslims share Islam as their religion and faith, while maintaining a Malay way of life and custom in their daily practices. In Malaysia, the Indian Muslim community struggled to place their future in terms of social, economic allocation and political justification among the other communities. However, the strength of ethnic politics clearly charted out their involvement in the political base and moved them to fight for their cause and rights. Hence, today’s Indian Muslim community has caused an Islamic resurgence, which has brought a new Indian dimension as a whole.


Author(s):  
H. Jurgens Hendriks

The article describes a theological paradigm shift taking place in congregations in South Africa that empower them to become involved in development work as a way of serving their neighbor. It also opens the possibility of working interdisciplinary without compromising theological and faith values. The perspectives and assumptions of the new paradigm are outlined and the basic methodology of doing theology is described. The new paradigm is a missional one, taking the focus on God as its point of departure and describing the identity and purpose of the church by looking at God’s identity and plan or mission with creation and humankind. Social development is seen as being in line with God’s mission and as such the church should not have difficulty in working with those who pursue the same goals.


2021 ◽  
Vol 236 ◽  
pp. 05059
Author(s):  
Xian Li ◽  
Eakachat Joneurairatana ◽  
Veerawat Sirivesmas

Architects and designers realize that new buildings cannot completely replace old buildings in the process of urbanization in the world. To establish a method of the new building and the old building coexist and to create the new paradigm of the new building construction in the old district is the responsibility faced by the contemporary architects. This paper first analyzes the old building renovation projects in Berlin and Paris in the 1980s and puts forward the symbiotic relationship between the old and the new buildings in the new era, thus obtaining the research objectives, trying to redefine new buildings and old districts, and creating the new paradigm of contemporary building construction in old districts. Using workshop as an exploration method, this paper conducts data research and sampling analyses on the Chinatown area in Bangkok, and explores the combination mode and paradigm transformation of new buildings and old districts in the city, aiming to seek solutions utilizing art exploration.


October ◽  
2021 ◽  
pp. 109-144
Author(s):  
Alexander Miller ◽  
Catherine Malabou ◽  
Emily Apter ◽  
Peter Szendy ◽  
Emanuela Bianchi ◽  
...  

Abstract “On Epigenesis” consists of a series of interrelated short articles examining the philosophical concept of epigenesis, with a particular focus on Catherine Malabou's development of it in contemporary thought. Alexander Miller introduces the topic of epigenesis and considers its significance as a new paradigm. He also presents the reader with an overview of Malabou's work on the topic: Drawing from recent advances in the life sciences as well as the Western philosophical tradition, he claims, Malabou has proposed “an epigenetic paradigm for rationality” for the 21st century. Catherine Malabou explains that when, in 2001, the scientific journal Nature published virtually the entire sequence of three billion bases that make up the human genome, people were surprised: Only five percent of the sequence turned out to actually be genes. Assembled in bunches and clusters, they are separated by vast expanses of so-called gene deserts made up of DNA characterized as “junk” or “repetitive,” which is to say, non-coding. The sequencing of the genome did not offer the revelations that people had expected, marking the end of the “everything is genetic” creed and announcing the rise of the “epigenetic paradigm.” The present article analyzes the implications of this new paradigm in biology, philosophy, and hermeneutics. Emily Apter situates Catherine Malabou's theory of epigenesis within a broader disciplinary context of Continental philosophy, the cognitive turn, and what a brain does or “is” as an object of aesthetic representation. Peter Szendy argues that even if they are not the central focus of her philosophical work, media and medial metaphors play a key role in Catherine Malabou's understanding of epigenetics. Indeed, her views on the epigenetic paradigm shift could lead to a rethinking of mediality. A medium, according to such an epigenetic approach, would be neither simply a storage space nor a carrier: It would be what happens along with the events (whether they involve works or data) that it hosts or transports. Emanuela Bianchi asks whether the epigenesis of “pure reason” can in any sense be “pure,” since epigenesis necessarily involves empirical processes. Foregrounding the topological involvement of the developing organism in its environment in both biological and psychoanalytic registers, she suggests a way forward can be found in thinking of the genesis of reason as both empirical and rational. Alexander R. Galloway traces an etymological path from “epigenetic” back to the Greek verb “gignomai,” meaning “to be born” or “to become.” But what is becoming? And why is becoming better than (mere) being? One answer is that becoming helps one to escape the confines of identity and rote determination. But what happens when the epigenetic paradigm becomes dominant, when contingency, evolution, and becoming prevail over essence, stasis, and determinism?


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