scholarly journals Enhancing osseointegration by site-specific laser modification of titanium implants: comparative and correlative analyses of different parameters of bone-implant integration

2016 ◽  
Vol 4 ◽  
Author(s):  
Omar Omar ◽  
Johansson Martin ◽  
Shah Furqan ◽  
Simonsson Hanna ◽  
Emanuelsson Lena ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Site Specific ◽  
Bone Implant ◽  
Laser Modification ◽  
Implant Integration ◽  
Modification Of Titanium

scholarly journals Macrophagic Inflammatory Response Next to Dental Implants with Different Macro- and Micro-Structure: An In Vitro Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5324
Author(s):  
Maria Menini ◽  
Francesca Delucchi ◽  
Domenico Baldi ◽  
Francesco Pera ◽  
Francesco Bagnasco ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Implants ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone Implant ◽  
Optimal Outcomes ◽  
Negative Controls ◽  
Inflammatory Effect

(1) Background: Intrinsic characteristics of the implant surface and the possible presence of endotoxins may affect the bone–implant interface and cause an inflammatory response. This study aims to evaluate the possible inflammatory response induced in vitro in macrophages in contact with five different commercially available dental implants. (2) Methods: one zirconia implant NobelPearl® (Nobel Biocare) and four titanium implants, Syra® (Sweden & Martina), Prama® (Sweden & Martina), 3iT3® (Biomet 3i) and Shard® (Mech & Human), were evaluated. After 4 h of contact of murine macrophage cells J774a.1 with the implants, the total RNA was extracted, transcribed to cDNA and the gene expression of the macrophages was evaluated by quantitative PCR (qPCR) in relation to the following genes: GAPDH, YWHAZ, IL1β, IL6, TNFα, NOS2, MMP-9, MMP-8 and TIMP3. The results were statistically analyzed and compared with negative controls. (3) Results: No implant triggered a significant inflammatory response in macrophages, although 3iT3 exhibited a slight pro-inflammatory effect compared to other samples. (4) Conclusions: All the samples showed optimal outcomes without any inflammatory stimulus on the examined macrophagic cells.

scholarly journals Osseointegration: Switching On and Off Macrophages by a “Bridge‐Burning” Coating Improves Bone‐Implant Integration under Osteoporosis (Adv. Funct. Mater. 7/2021)

2021 ◽  
Vol 31 (7) ◽  
pp. 2170043
Author(s):  
Zhenzhen Wang ◽  
Yiming Niu ◽  
Xuejiao Tian ◽  
Na Yu ◽  
Xiaoyu Yin ◽  
...  
Keyword(s):  
Bone Implant ◽  
Implant Integration

Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone

2018 ◽  
Vol 6 (15) ◽  
pp. 2274-2288 ◽  
Author(s):  
Xiao-Fan Hu ◽  
Ya-Fei Feng ◽  
Geng Xiang ◽  
Wei Lei ◽  
Lin Wang
Keyword(s):  
Lactic Acid ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Bone Implant ◽  
3D Printed

PLGA-coating on 3D-printed porous titanium implants promoted the angiogenesis and osteointegration at bone-implant interface in diabetes by releasing lactic acid.

scholarly journals Selected Physicochemical Properties of Diamond Like Carbon (DLC) Coating on Ti-13Nb-13Zr Alloy Used for Blood Contacting Implants

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5077
Author(s):  
Magdalena Antonowicz ◽  
Roksana Kurpanik ◽  
Witold Walke ◽  
Marcin Basiaga ◽  
Jozef Sondor ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Physicochemical Properties ◽  
Fundamental Problem ◽  
Circulatory System ◽  
Titanium Implants ◽  
Diamond Like Carbon ◽  
Dlc Coating ◽  
13Zr Alloy ◽  
Artificial Plasma ◽  
Modification Of Titanium

Despite high interest in the issues of hemocompatibility of titanium implants, particularly those made of the Ti-13Nb-13Zr alloy, the applied methods of surface modification still do not always guarantee the physicochemical properties required for their safe operation. The factors that reduce the efficiency of the application of titanium alloys in the treatment of conditions of the cardiovascular system include blood coagulation and fibrous proliferation within the vessel’s internal walls. They result from their surfaces’ physicochemical properties not being fully adapted to the specifics of the circulatory system. Until now, the generation and development mechanics of these adverse processes are not fully known. Thus, the fundamental problem in this work is to determine the correlation between the physicochemical properties of the diamond like carbon (DLC) coating (shaped by the technological conditions of the process) applied onto the Ti-13Nb-13Zr alloy designed for contact with blood and its hemocompatibility. In the paper, microscopic metallographic, surface roughness, wettability, free surface energy, hardness, coating adhesion to the substrate, impendence, and potentiodynamic studies in artificial plasma were carried out. The surface layer with the DLC coating ensures the required surface roughness and hydrophobic character and sufficient pitting corrosion resistance in artificial plasma. On the other hand, the proposed CrN interlayer results in better adhesion of the coating to the Ti-13Nb-13Zr alloy. This type of coating is an alternative to the modification of titanium alloy surfaces using various elements to improve the blood environment’s hemocompatibility.

scholarly journals Antibacterial surface modification of titanium implants in orthopaedics

2018 ◽  
Vol 9 ◽  
pp. 204173141878983 ◽  
Author(s):  
Wich Orapiriyakul ◽  
Peter S Young ◽  
Laila Damiati ◽  
Penelope M Tsimbouri
Keyword(s):  
Titanium Implants ◽  
Implant Design ◽  
Material Surface ◽  
Bacterial Interaction ◽  
Biomaterial Surface ◽  
Antibacterial Surface ◽  
Production Research ◽  
The Cost ◽  
Modification Of Titanium ◽  
Review Current

The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity. With the increasing burden of infection, it is vitally important that we consider the bacterial interaction with the biomaterial and the host when designing and manufacturing future implants. During this review, we will elucidate the interaction between patient, biomaterial surface and bacteria. We aim to review current and developing surface modifications with a view towards antibacterial orthopaedic implants for clinical applications.

Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9908-9918 ◽  
Author(s):  
Elisabeth Rieger ◽  
Agnès Dupret-Bories ◽  
Laetitia Salou ◽  
Marie-Helene Metz-Boutigue ◽  
Pierre Layrolle ◽  
...  
Keyword(s):  
Surface Modification ◽  
Soft Tissue ◽  
Surface Modifications ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Tissue Response ◽  
Soft Tissue Response ◽  
Modification Of Titanium

Nanoscale surface modification of titanium microbeads can control the soft tissue response in vitro and in vivo.

scholarly journals On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic

2004 ◽  
Vol 222 (1-4) ◽  
pp. 33-42 ◽  
Author(s):  
Guerric Vrillet ◽  
Soo Keun Lee ◽  
Daniel McStay ◽  
Peter K.J Robertson
Keyword(s):  
Titanium Dioxide ◽  
Second Harmonic ◽  
Optical Surface ◽  
Laser Modification ◽  
On Line ◽  
Modification Of Titanium

scholarly journals Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Warwick J. Duncan ◽  
Min-Ho Lee ◽  
Tae-Sung Bae ◽  
Sook-Jeong Lee ◽  
Jennifer Gay ◽  
...  
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Stability ◽  
Bone Implant ◽  
Implant Stability Quotient ◽  
Phosphate Ions ◽  
Surface Control ◽  
Bone Implant Contact ◽  
The Subject ◽  
Clinically Significant

Spark discharge anodic oxidation forms porous TiO2films on titanium implant surfaces. This increases surface roughness and concentration of calcium and phosphate ions and may enhance early osseointegration. To test this, forty 3.75 mm × 13 mm titanium implants (Megagen, Korea) were placed into healed mandibular postextraction ridges of 10 sheep. There were 10 implants per group: RBM surface (control), RBM + anodised, RBM + anodised + fluoride, and titanium alloy + anodised surface. Resonant frequency analysis (RFA) was measured in implant stability quotient (ISQ) at surgery and at sacrifice after 1-month unloaded healing. Mean bone-implant contact (% BIC) was measured in undemineralised ground sections for the best three consecutive threads. One of 40 implants showed evidence of failure. RFA differed between groups at surgery but not after 1 month. RFA values increased nonsignificantly for all implants after 1 month, except for controls. There was a marked difference in BIC after 1-month healing, with higher values for alloy implants, followed by anodised + fluoride and anodised implants. Anodisation increased early osseointegration of rough-surfaced implants by 50–80%. RFA testing lacked sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically significant is the subject of future experiments.

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