Preserved immune parameters in peripheral blood and gastrointestinal mucosa is a characteristic of spontaneous HIV controllers

The object of research: the state of chronic periodontitis among servicemen of the Armed Forces of Ukraine remains extremely urgent. Therefore a group of servicemen with chronic periodontitis and its complications was taken. In addition, a control group of servicemen was used to compare the results. Investigated problem: in this article, the diagnosis was considered due to the use of immunological studies of peripheral blood of sick servicemen of the Armed Forces of Ukraine with chronic periodontitis, as well as its complications. The study of the features of immunological parameters in peripheral blood was performed. The main scientific results: according to the obtained data, there is a relative suppression of immunity among servicemen with chronic periapical infection compared with servicemen of the control group. According to our data, the main lymphocyte subpopulation of peripheral blood are CD8 and CD4 / CD8; CD19+(B-lymphocytes) and CD3-HLA+; CD4 and CD4 / CD8, which reflect inflammatory processes in the body. These indicators are closely interrelated. The area of practical use of the research results: these results of research can be applied to students’ training at stomatology faculties, in stomatology practice, to research into the immunological status of patients with chronic periodontitis and its complications. Innovative technological product: it is the first time the study of the immunological status of peripheral blood during chronic periapical infections among servicemen has been performed. Scope of the innovative technological product: this study can be used in the diagnosis and treatment of chronic periodontitis in dental practice, as well as in the research to compare the results of the immunological state of peripheral blood.

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Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

Cancers ◽

10.3390/cancers11091324 ◽

2019 ◽

Vol 11 (9) ◽

pp. 1324 ◽

Cited By ~ 7

Author(s):

Balázs ◽

Kis ◽

Badie ◽

Bogdándi ◽

Candéias ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Peripheral Blood ◽

Blood Cells ◽

Local Therapy ◽

Peripheral Blood Cells ◽

Immune Parameters ◽

Induced Changes

Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important consequences in the long-term prognosis and therapy individualization. Our objective was to investigate immune and inflammation-related changes in the peripheral blood of head and neck cancer patients treated with radiotherapy. Peripheral blood cells, plasma and blood cell-derived RNA were isolated from 23 patients before and at two time points after radiotherapy and cellular immune parameters, plasma protein changes and gene expression alterations were studied. Increased regulatory T cells and increased CTLA4 and PD-1 expression on CD4 cells indicated an immune suppression induced by the malignant condition, which was accentuated by radiotherapy. Circulating dendritic cells were strongly elevated before treatment and were not affected by radiotherapy. Decreased endoglin levels in the plasma of patients before treatment were further decreased by radiotherapy. Expression of the FXDR, SESN1, GADD45, DDB2 and MDM2 radiation-response genes were altered in the peripheral blood cells of patients after radiotherapy. All changes were long-lasting, detectable one month after radiotherapy. In conclusion we demonstrated radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients and proposed markers suitable for patient stratification worth investigating in larger patient cohorts.

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Effects of substitution of dietary fish oil with a blend of vegetable oils on liver and peripheral blood leucocyte fatty acid composition, plasma prostaglandin E2and immune parameters in three strains of Atlantic salmon (Salmo salar)

Aquaculture Nutrition ◽

10.1111/j.1365-2095.2008.00627.x ◽

2009 ◽

Vol 15 (6) ◽

pp. 596-607 ◽

Cited By ~ 26

Author(s):

I.K. PETROPOULOS ◽

K.D. THOMPSON ◽

A. MORGAN ◽

J.R. DICK ◽

D.R. TOCHER ◽

...

Keyword(s):

Fatty Acid Composition ◽

Fatty Acid ◽

Atlantic Salmon ◽

Fish Oil ◽

Salmo Salar ◽

Vegetable Oils ◽

Peripheral Blood ◽

Peripheral Blood Leucocyte ◽

Immune Parameters ◽

Dietary Fish

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Insulin Resistance Adversely Affect IVF Outcomes in Lean Women Without PCOS

Frontiers in Endocrinology ◽

10.3389/fendo.2021.734638 ◽

2021 ◽

Vol 12 ◽

Author(s):

Haoyu Wang ◽

Yu Zhang ◽

Xuhui Fang ◽

Joanne Kwak-Kim ◽

Li Wu

Keyword(s):

Insulin Resistance ◽

Peripheral Blood ◽

Egg Quality ◽

Formation Rate ◽

Blastocyst Formation ◽

Cumulative Live Birth Rate ◽

Ivf Outcomes ◽

Immune Parameters ◽

Cell Immunity ◽

The University

ObjectiveTo investigate the effects of insulin resistance (IR) on IVF outcomes and a potential underlying mechanism in lean women without PCOS.DesignA prospective cohort study at the University Clinic.SettingIVF center at the University setting.PatientsA total of 155 lean women (body mass index <25) without PCOS undergoing IVF cycle.InterventionPatients were allocated to IR and non-IR groups based on HOMA-M120.Main Outcome Measure(s)IVF outcomes, including egg quality, the percentage of mature oocytes, fertilization rate, blastocyst formation rate, advanced embryo rate, and cumulative live birth rate were investigated. Auto-immune parameters, peripheral blood immunophenotypes, thyroid hormone, homocysteine, and 25-OH-vitamin D3 (25-OH-VD3) levels were analyzed.ResultsThe percentage of mature oocytes and blastocyst formation rate were significantly lower in the IR group as compared with those of the non-IR group (p<0.05, respectively). The proportion of peripheral blood CD19+ B cells was significantly higher in the IR group than those of the non-IR group (p<0.05). Homocysteine, 25-OH-VD3, and auto-immune parameters were the same between the two groups.ConclusionIn lean infertile women without PCOS, IR is associated with the decreased percentage of mature eggs and poor embryo quality in which B cell immunity may play a role.

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