A Pilot Study on the Association between SLCO1B1 rs4363657 Polymorphism and Muscle Adverse Events in Adults with Newly Diagnosed Dyslipidaemia who were Prescribed a Statin: The Malaysian Primary Health Care Cohort

Abstract Background Patient-centered care and patient involvement have been increasingly recognized as crucial elements of patient safety. However, patient safety has rarely been evaluated from the patient perspective with a quantitative approach aiming at making patient safety and preventable adverse events measurable. Objectives The objectives of this study were to develop and evaluate the psychometric properties of a questionnaire assessing patient safety by perceived triggers of preventable adverse events among patients in primary health-care settings while considering mental health. Methods Two hundred and ten participants were recruited through various digital and print channels and asked to complete an online survey between November 2019 and April 2020. Exploratory factor analysis was performed to identify domains of triggers of preventable adverse events affecting patient safety. Furthermore, a multi-trait scaling analysis was performed to evaluate internal reliability as well as item-scale convergent–discriminant validity. A multivariate analysis of covariance evaluated whether individuals below and above the symptom threshold for depression and generalized anxiety perceive triggers of preventable adverse events differently. Results The five factors determined were information and communication with patients, time constraints of health-care professionals, diagnosis and treatment, hygiene and communication among health-care professionals, and knowledge and operational procedures. The questionnaire demonstrated a good total and subscale internal consistency (α = 0.90, range = 0.75–0.88), good item-scale convergent validity with significant correlations between 0.57 and 0.78 (P < 0.05; P < 0.01) for all items with their associated subscales, and satisfactory item-scale discriminant validity between 0.14 and 0.55 (P > 0.05) with no significant correlations between the items and their competing subscales. The questionnaire further revealed to be a generic measure irrespective of patients’ mental health status. Patients older than 50 years of age perceived a significantly greater threat to their own safety compared to patients below that age. Conclusion The developed Perceptions of Preventable Adverse Events Assessment Tool (PPAEAT) exhibits good psychometric properties, which supports its use in future research and primary health-care practice. Further validation of the PPAEAT in different settings, languages and larger samples is needed. The results of this study need to be considered when assessing patient safety in the context of health-care research.

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The prevalence of Behçet’s disease above the age of 10 years The results of a pilot study conducted at the Park Primary Health Care Center in Ankara, Turkey

Ophthalmic Epidemiology ◽

10.1076/opep.9.5.325.10338 ◽

2002 ◽

Vol 9 (5) ◽

pp. 325-331 ◽

Cited By ~ 60

Author(s):

A. Idil ◽

A. Gürler ◽

A. Boyvat ◽

D. Çaliskan ◽

Ö. Özdemir ◽

...

Keyword(s):

Health Care ◽

Primary Health Care ◽

Pilot Study ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Care Center ◽

Primary Health Care Center ◽

Behcet's Disease ◽

Health Care Center ◽

Primary Health

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P0047 Epidemiology of restless legs syndrome in a Georgian primary health care setting: a pilot study

Sleep Medicine ◽

10.1016/s1389-9457(07)70306-4 ◽

2007 ◽

Vol 8 ◽

pp. S81

Author(s):

G. Kuchukhidze ◽

I. Toidze ◽

I. Khatiashvili ◽

M. Eliosishvili ◽

L. Maisuradze ◽

...

Keyword(s):

Health Care ◽

Primary Health Care ◽

Pilot Study ◽

Restless Legs Syndrome ◽

Care Setting ◽

Health Care Setting ◽

Primary Health Care Setting ◽

Restless Legs ◽

Primary Health

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Consultation skills of last semester medical students in Sweden: video-recorded real-patient consultations in primary health care assessed by Calgary-Cambridge Global Consultation Rating Scale, a pilot study

MedEdPublish ◽

10.15694/mep.2019.000088.1 ◽

2019 ◽

Vol 8 (2) ◽

Author(s):

Sven-Olof Andersson ◽

Annika Bardel ◽

Malin André ◽

Per Kristiansson

Keyword(s):

Health Care ◽

Primary Health Care ◽

Medical Students ◽

Pilot Study ◽

Rating Scale ◽

Real Patient ◽

Primary Health ◽

Consultation Skills

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MUSCLE ADVERSE EVENTS AMONG USERS OF SIMVASTATIN IN PRIMARY HEALTH CARE: COLLABORATIVE DRUG THERAPY MANAGEMENT

Saúde e Pesquisa ◽

10.17765/1983-1870.2018v11n1p99-106 ◽

2018 ◽

Vol 11 (1) ◽

pp. 99

Author(s):

Marcos Francisco Pereira Lobrigatte ◽

Glauco de Mello Nogueira ◽

Vinícius João Navarini ◽

Márcia Terezinha Lonardoni Crozatti ◽

Jorge Juarez Vieira Teixeira

Keyword(s):

Health Care ◽

Creatine Kinase ◽

Primary Health Care ◽

Drug Therapy ◽

Adverse Events ◽

Thyroid Stimulating Hormone ◽

Therapy Management ◽

Drug Therapy Management ◽

Primary Health ◽

One Year

Collaborative drug therapy management in primary health care involves communication among the physician, pharmacist and user of simvastatin and can result in safer results regarding patient wellbeing. The aim of the study was to investigate muscle adverse events and risk factors related to simvastatin. For patients who developed muscle adverse events, collaborative drug therapy management was performed in an attempt to resolve the symptoms. A non-randomized case study was conducted at the single basic health unit in the city of Peabiru, Parana, Brazil, for a period of one year. Patients were interviewed using a structured form. To confirm muscle adverse events, the patient was referred to a physician and submitted to the suspension and return to treatment. Thyroid-stimulating hormone, creatine kinase and alanine aminotransferase exams were performed. A sample of 148 users of simvastatin was selected. Eleven patients had some type of simvastatin-associated muscle adverse event (myopathy), among whom seven had muscle symptoms (myalgia) and four had elevated creatine kinase, but were asymptomatic (asymptomatic myopathy). Collaborative drug therapy management focused on simvastatin for five patients with myalgia led to improvements in the quality of life of two patients. EVENTOS ADVERSOS MUSCULARES ENTRE USUÁRIOS DE SINVASTATINA NA ATENÇÃO PRIMÁRIA EM SAÚDE: MANEJO COLABORATIVO DE TERAPIA MEDICAMENTOSA Resumo: O manejo colaborativo de tratamento medicamentoso em atenção primária envolve a comunicação entre o médico, farmacêutico e o usuário de sinvastatina e pode levar a resultados mais seguros, favorecendo o bem-estar do paciente. O objetivo do estudo foi investigar eventos adversos musculares e fatores de risco para tais eventos, relacionados à sinvastatina. Para os pacientes que desenvolveram eventos adversos musculares, o manejo colaborativo foi realizada de forma a resolver os sintomas. Um estudo de caso não randomizado foi realizado na única unidade básica de saúde na cidade de Peabiru, Paraná, Brasil, por um período de um ano. Os pacientes foram entrevistados por meio de um formulário estruturado. Para confirmar os eventos adversos musculares, o paciente era encaminhado ao médico, sendo submetido à suspensão e retorno da sinvastatina. Foram realizadas dosagens do hormônio tireoestimulante, creatina quinase e alanina aminotransferase. Uma amostra de 148 usuários de simvastatina foi selecionada. Do grupo estudado, 11 pacientes tiveram algum tipo de evento adverso muscular (miopatia) associada à sinvastatina, entre os quais sete tiveram sintomas musculares (mialgia) e quatro apresentaram elevação da creatina quinase, mas eram assintomáticos (miopatia assintomática). O manejo colaborativo de terapia medicamentosa focada na sinvastatina para cinco pacientes com mialgia levou a melhoria na qualidade de vida de dois pacientes. Palavras-chave: Evento adverso; Manejo da terapia medicamentosa; Doença muscular; Atenção primária em saúde; Sinvastatina.

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