scholarly journals Flexible Biosensors Based on Colorimetry, Fluorescence, and Electrochemistry for Point-of-Care Testing

2021 ◽  
Vol 9 ◽  
Author(s):  
Tingyi Yan ◽  
Guangyao Zhang ◽  
Huining Chai ◽  
Lijun Qu ◽  
Xueji Zhang
Keyword(s):  
High Efficiency ◽  
Point Of Care ◽  
Wearable Devices ◽  
Practical Significance ◽  
Point Of Care Testing ◽  
User Friendliness ◽  
Feature Article ◽  
Sensing Platforms ◽  
Simple Detection

With the outbreak and pandemic of COVID-19, point-of-care testing (POCT) systems have been attracted much attention due to their significant advantages of small batches of samples, user-friendliness, easy-to-use and simple detection. Among them, flexible biosensors show practical significance as their outstanding properties in terms of flexibility, portability, and high efficiency, which provide great convenience for users. To construct highly functional flexible biosensors, abundant kinds of polymers substrates have been modified with sufficient properties to address certain needs. Paper-based biosensors gain considerable attention as well, owing to their foldability, lightweight and adaptability. The other important flexible biosensor employs textiles as substrate materials, which has a promising prospect in the area of intelligent wearable devices. In this feature article, we performed a comprehensive review about the applications of flexible biosensors based on the classification of substrate materials (polymers, paper and textiles), and illustrated the strategies to design effective and artificial sensing platforms, including colorimetry, fluorescence, and electrochemistry. It is demonstrated that flexible biosensors play a prominent role in medical diagnosis, prognosis, and healthcare.

scholarly journals Point-of-care testing (POCT) and IT security concepts

2020 ◽  
Vol 44 (2) ◽  
pp. 107-111 ◽  
Author(s):  
Wibke Johannis ◽  
Andreas Bietenbeck ◽  
Gebhart Malchau ◽  
Thomas Streichert
Keyword(s):  
Secure Communication ◽  
Point Of Care ◽  
Quality Criteria ◽  
Round Table ◽  
It Security ◽  
Point Of Care Testing ◽  
User Friendliness ◽  
Continuous Training ◽  
Network Connections ◽  
User Data

AbstractPoint-of-care testing (POCT) has been an essential service in hospitals for many years with a main focus on reliability, classical laboratory quality criteria and easy handling. Hospital information technology (IT) security regulations, however, have not yet been adapted to the specificities of POCT. Following the POCT Symposium in Munich, the “1st Round Table POCT-IT-Security Meeting” held in October 2019 in Cologne addressed these issues and managed to establish first consensus results in the essential fields of user, data and update management, as well as network connections and user-friendliness. First practical steps include optimizing the user management by connection to a directory service and definition of access control (including emergency authorization). Patient data economy on analyzers in combination with data and data transmission encryption as well as technically secure communication protocols are relevant steps in the fields of data management and network connections. An update management needs to be contractually defined for remote services and generally includes testing in a protocol-based scenario. Providing an organizational structure for POCT-IT security is a necessary prerequisite, as are continuous training and awareness for this topic with a strong focus on usability.

scholarly journals Analytical performance, agreement and user-friendliness of six point-of-care testing urine analysers for urinary tract infection in general practice

BMJ Open ◽  
2015 ◽  
Vol 5 (5) ◽  
pp. e006857-e006857 ◽  
Author(s):  
M. J. C. Schot ◽  
S. van Delft ◽  
A. M. J. Kooijman-Buiting ◽  
N. J. de Wit ◽  
R. M. Hopstaken
Keyword(s):  
General Practice ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Point Of Care ◽  
Analytical Performance ◽  
Point Of Care Testing ◽  
User Friendliness

Basis of Image Analysis for Evaluating Cell Biomaterial Interaction Using Brightfield Microscopy

2021 ◽  
pp. 1-28
Author(s):  
Arban Uka ◽  
Albana Ndreu Halili ◽  
Xhoena Polisi ◽  
Ali O. Topal ◽  
Gent Imeraj ◽  
...  
Keyword(s):  
Image Analysis ◽  
Point Of Care ◽  
Cell Interaction ◽  
Specific Pattern ◽  
Point Of Care Testing ◽  
New Techniques ◽  
Future Directions ◽  
Sensing Platforms ◽  
Brightfield Microscopy ◽  
Characteristics Of Image

Medical imaging is a growing field that has stemmed from the need to conduct noninvasive diagnosis, monitoring, and analysis of biological systems. With the developments and advances in the medical field and the new techniques that are used in the intervention of diseases, very soon the prevalence of implanted biomedical devices will be even more significant. The implanted materials in a biological system are used in diverse fields, which require lengthy evaluation and validation processes. However, currently the evaluation of the toxicity of biomaterials has not been fully automated yet. Moreover, image analysis is an integral part of biomaterial research, but it is not within the core capacities of a significant portion of biomaterial scientists, which results in the use of predominantly ready-made tools. The detailed image analysis can be conducted once all the relevant parameters including the inherent characteristics of image acquisition techniques are considered. Herein, we cover the currently used image analysis-based techniques for assessment of biomaterial/cell interaction with a specific focus on unstained brightfield microscopy acquired mostly in but not limited to microfluidic systems, which serve as multiparametric sensing platforms for noninvasive experimental measurements. We present the major imaging acquisition techniques that enable point-of-care testing when incorporated with microfluidic cells, discuss the constraints enforced by the geometry of the system and the material that is analyzed, and the challenges that rise in the image analysis when unstained cell imaging is employed. Emerging techniques such as utilization of machine learning and cell-specific pattern recognition algorithms and potential future directions are discussed. Automation and optimization of biomaterial assessment can facilitate the discovery of novel biomaterials together with making the validation of biomedical innovations cheaper and faster.

The current state of the legislative implementation of criminal law policy

2020 ◽  
pp. 111-118
Author(s):  
Oleksandr Ostrohliad
Keyword(s):  
Law Enforcement ◽  
Criminal Code ◽  
Practical Significance ◽  
New Approach ◽  
Public Discussion ◽  
Current State ◽  
Criminal Offenses ◽  
Legal Technology ◽  
Logical Semantic

Purpose. The aim of the work is to consider the novelties of the legislative work, which provide for the concept and classification of criminal offenses in accordance with the current edition of the Criminal Code of Ukraine and the draft of the new Code developed by the working group and put up for public discussion. Point out the gaps in the current legislation and the need to revise individual rules of the project in this aspect. The methodology. The methodology includes a comprehensive analysis and generalization of the available scientific and theoretical material and the formulation of appropriate conclusions and recommendations. During the research, the following methods of scientific knowledge were used: terminological, logical-semantic, system-structural, logical-normative, comparative-historical. Results In the course of the study, it was determined that despite the fact that the amendments to the Criminal Code of Ukraine came into force in July of this year, their perfection, in terms of legal technology, raises many objections. On the basis of a comparative study, it was determined that the Draft Criminal Code of Ukraine needs further revision taking into account the opinions of experts in the process of public discussion. Originality. In the course of the study, it was established that the classification of criminal offenses proposed in the new edition of the Criminal Code of Ukraine does not stand up to criticism, since other elements of the classification appear in subsequent articles, which are not covered by the existing one. The draft Code, using a qualitatively new approach to this issue, retains the elements of the previous classification and has no practical significance in law enforcement. Practical significance. The results of the study can be used in law-making activities to improve the norms of the current Criminal Code, to classify criminal offenses, as well as to further improve the draft Criminal Code of Ukraine.

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