scholarly journals Functional Hydrogel Dressings for Treatment of Burn Wounds

2021 ◽  
Vol 9 ◽  
Author(s):  
Wentao Shu ◽  
Yinan Wang ◽  
Xi Zhang ◽  
Chaoyang Li ◽  
Hanxiang Le ◽  
...  
Keyword(s):  
Wound Healing ◽  
Treatment Strategies ◽  
Skin Substitutes ◽  
Clinical Value ◽  
Burn Treatment ◽  
Clinical Issue ◽  
Burn Wounds ◽  
Wound Debridement ◽  
Accelerate Wound Healing

The therapy of burns is a challenging clinical issue. Burns are long-term injuries, and numerous patients suffer from chronic pain. Burn treatment includes management, infection control, wound debridement and escharotomy, dressing coverage, skin transplantation, and the use of skin substitutes. The future of advanced care of burn wounds lies in the development of “active dressings”. Hydrogel dressings have been employed universally to accelerate wound healing based on their unique properties to overcome the limitations of existing treatment methods. This review briefly introduces the advantages of hydrogel dressings and discusses the development of new hydrogel dressings for wound healing along with skin regeneration. Further, the treatment strategies for burns, ranging from external to clinical, are reviewed, and the functional classifications of hydrogel dressings along with their clinical value for burns are discussed.

scholarly journals Bacterial Autofluorescence Digital Imaging Guides Treatment in Stage 4 Pelvic Pressure Injuries: A Preliminary Case Series

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 839
Author(s):  
James B. Stiehl
Keyword(s):  
Wound Healing ◽  
Digital Imaging ◽  
Bacterial Contamination ◽  
Long Term Care ◽  
Treatment Strategies ◽  
Autofluorescence Imaging ◽  
Term Care ◽  
Stage 4 ◽  
Pelvic Pressure

Pelvic pressure injuries in long-term care facilities are at high risk for undetected infection and complications from bacterial contamination and stalling of wound healing. Contemporary wound healing methods must address this problem with mechanical debridement, wound irrigation, and balanced dressings that reduce bacterial burden to enable the normal healing process. This study evaluated the impact of bacterial autofluorescence imaging to indicate wound bacterial contamination and guide treatment for severe stage 4 pelvic pressure injuries. A handheld digital imaging system was used to perform bacterial autofluorescence imaging in darkness on five elderly, high-risk, long-term care patients with advanced stage 4 pelvic pressure injuries who were being treated for significant bacterial contamination. The prescient findings of bacterial autofluorescence imaging instigated treatment strategies and enabled close monitoring of the treatment efficacy to ameliorate the bacterial contamination. Wound sepsis recurrence, adequate wound cleansing, and diagnosis of underlying periprosthetic total joint infection were confirmed with autofluorescence imaging showing regions of high bacterial load. By providing objective information at the point of care, imaging improved understanding of the bacterial infections and guided treatment strategies.

Polymer-Based Nanotherapeutics for Burn Wounds

2021 ◽  
Vol 22 ◽  
Author(s):  
Rewati Raman Ujjwal ◽  
Awesh Yadav ◽  
Shourya Tripathi ◽  
S.T.V. Sai Krishna
Keyword(s):  
Wound Healing ◽  
Research Effort ◽  
Synthetic Polymers ◽  
Wound Dressings ◽  
High Porosity ◽  
Natural Polymers ◽  
Burn Wound ◽  
Burn Treatment ◽  
Mortality And Morbidity ◽  
Burn Wounds

: Burn wounds are complex and intricate injuries that have become a common cause of trauma leading to significant mortality and morbidity every year. Dressings are applied to burn wounds with the aim of promoting wound healing, preventing burn infection and restoring skin function. The dressing protects the injury and contributes to recovery of dermal and epidermal tissues. Polymer-based nanotherapeutics are increasingly being exploited as burn wound dressings. Natural polymers such as cellulose, chitin, alginate, collagen, gelatin and synthetic polymers like poly (lactic-co-glycolic acid), polycaprolactone, polyethylene glycol, and polyvinyl alcohol are being obtained as nanofibers by nanotechnological approaches like electrospinning and have shown wound healing and re-epithelialization properties. Their biocompatibility, biodegradability, sound mechanical properties and unique structures provide optimal microenvironment for cell proliferation, differentiation, and migration contributing to burn wound healing. The polymeric nanofibers mimic collagen fibers present in extracellular matrix and their high porosity and surface area to volume ratio enable increased interaction and sustained release of therapeutics at the site of thermal injury. This review is an attempt to compile all recent advances in the use of polymer-based nanotherapeutics for burn wounds. The various natural and synthetic polymers used have been discussed comprehensively and approaches being employed have been reported. With immense research effort that is currently being invested in this field and development of proper characterization and regulatory framework, future progress in burn treatment is expected to occur. Moreover, appropriate preclinical and clinical research will provide evidence for the great potential that polymer-based nanotherapeutics hold in the management of burn wounds.

Biology of chronic wounds and new treatment strategies

2014 ◽  
Vol 29 (1_suppl) ◽  
pp. 165-167 ◽  
Author(s):  
Catherine van Montfrans ◽  
Myrte Stok ◽  
Maud Geerkens
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Treatment Strategies ◽  
Skin Substitutes ◽  
Related Factors ◽  
Impaired Wound Healing ◽  
Healing Tissue ◽  
Biologic Process ◽  
Matrix Components ◽  
New Treatment

Impaired wound healing is the result of the interplay between patient-related factors, wound-related factors, skill and knowledge of the healthcare professional and resources and treatment-related factors. The study of wound-related factors learns us that healing is a very complex biologic process. Both ‘seed’ (differentiated and stem cells) and ‘soil’ (e.g. cytokines/chemokines, growth factors, matrix components) are essential for effective wound healing. Tissue engineering for chronic wounds has the potential to improve healing by providing an ‘ideal’ combination of cells and their local microenviroment. In this contribution we discuss new treatment strategies to improve wound-related factors by biomaterials, skin substitutes and stem cell-based therapies.

671 Burn Wound Healing Effect of Bromelain-loaded Chitosan Nanofibers

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S192-S192
Author(s):  
Fatemeh Kalalinia ◽  
Nafise Aamiri ◽  
Samaneh Bayat ◽  
Jebrail Movaffagh ◽  
Maryam Hahsemi
Keyword(s):  
Wound Healing ◽  
Proteolytic Enzymes ◽  
Dermal Fibroblasts ◽  
Ananas Comosus ◽  
Burn Wound ◽  
Burn Treatment ◽  
Burn Wounds ◽  
Healing Effect ◽  
Burn Wound Healing

Abstract Introduction Bromelain is a mixture of proteolytic enzymes present in all tissues of pineapple (Ananas comosus). It is known as an efficient debriding agent in burn treatment and has been shown to effectively and selectively debride burn eschar. In this study, the efficiency of bromelain-loaded chitosan nanofibers for burn wounds repair was investigated in animal model. Methods Chitosan nanofibers containing bromelain were prepared by electrospinning method. The physicochemical characteristics of the synthetized nanofibers, release profile and activity of bromelain loaded in nanofibers were evaluated. The burn healing effect of bromelain-loaded nanofibers were studied in the induced burn wounds in rats for 21 days. The efficacy of treatment was assessed by evaluating changes in wound closer and histological analysis at different time point. Results Successful electrospinning of bromelain-loaded chitosan nanofibers resulted in uniform and bead-less nanofibers which released bromelain up to 48h. The formulation kept bromelain enzyme activity after 6-month storage at 4 °C and did not show any cytotoxicity on human dermal fibroblasts. Moreover, in vivo study in a rat burn model confirmed the safety and efficacy of applying bromelain loaded nanofibers in burn wound healing when a significant improve in wound closer was observed in bromelain loaded group and histopathological studies showed more effects on re-epithelialization, debridement and more reduction of necrosis compared to chitosan alone. Conclusions Together, these results suggest that bromelain chitosan nanofiber possesses great wound healing activity and could be considered as an effective natural topical burn wound healing treatment.

scholarly journals Early results of negative pressure wound therapy in treatment of chronic wounds

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S A Maaty ◽  
S M Gerges ◽  
A A El-desoki ◽  
M M Khalil
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Chronic Wounds ◽  
Armed Forces ◽  
Wound Therapy ◽  
Wound Debridement ◽  
Accelerate Wound Healing ◽  
Early Results ◽  
Stimulation Of

Abstract Background Chronic wounds may affect only the epidermis and dermis, or they may affect tissues all the way to the fascia. Chronic wounds seem to be detained in one or more of the phases of wound healing. For example, chronic wounds often remain in the inflammatory stage for too long. Aim of the work to assess the effect of negative pressure wound therapy in management of chronic wound. Patients and Methods This is prospective study was conducted on 30 Egyptian volunteers participated; they were 20 males and 10 females, between the age of 18 and 70 years. This study was conducted from July 2017 to July 2018 at Ain shams university specialized hospitals and Alexandria armed forces hospital. Results VAC therapy, together with periodical surgical wound debridement and specific antibiotic therapy, could be helpful to promote and accelerate wound healing of foot lesions after restoration of an adequate distal blood flow through surgical revascularization or angioplasty. Conclusion Negative-pressure wound therapy (NPWT) devices are designed to apply controlled suction to a wound bed at continuous or intermittent pressure settings to stimulate wound closure. Negative pressure can result in numerous alterations in the wound environment, including removal of excess exudate containing high concentrations of proteases and inflammatory cytokines, stimulation of senescent cells, mobilization of macrophages, and stimulation of angiogenesis.

Multidisciplinary Evidence to Treat Bilingual Individuals with Aphasia

2008 ◽  
Vol 15 (3) ◽  
pp. 66-72 ◽  
Author(s):  
José G. Centeno
Keyword(s):  
Stroke Rehabilitation ◽  
Culturally Diverse ◽  
Treatment Strategies ◽  
The United States ◽  
Intervention Strategies ◽  
Steady Increase ◽  
Clinical Procedures ◽  
Bilingual Speakers ◽  
Aphasic Clients

Abstract The steady increase in linguistic and cultural diversity in the country, including the number of bilingual speakers, has been predicted to continue. Minorities are expected to be the majority by 2042. Strokes, the third leading cause of death and the leading cause of long-term disability in the U.S., are quite prevalent in racial and ethnic minorities, so population estimates underscore the imperative need to develop valid clinical procedures to serve the predicted increase in linguistically and culturally diverse bilingual adults with aphasia in post-stroke rehabilitation. Bilingualism is a complex phenomenon that interconnects culture, cognition, and language; thus, as aphasia is a social phenomenon, treatment of bilingual aphasic persons would benefit from conceptual frameworks that exploit the culture-cognition-language interaction in ways that maximize both linguistic and communicative improvement leading to social re-adaptation. This paper discusses a multidisciplinary evidence-based approach to develop ecologically-valid treatment strategies for bilingual aphasic individuals. Content aims to spark practitioners' interest to explore conceptually broad intervention strategies beyond strictly linguistic domains that would facilitate linguistic gains, communicative interactions, and social functioning. This paper largely emphasizes Spanish-English individuals in the United States. Practitioners, however, are advised to adapt the proposed principles to the unique backgrounds of other bilingual aphasic clients.

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