scholarly journals Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture Models

2020 ◽  
Vol 8 ◽  
Author(s):  
Stefan Hauser ◽  
Stefanie Schuster ◽  
Elena Heuten ◽  
Philip Höflinger ◽  
Jakob Admard ◽  
...  
Keyword(s):  
Cell Culture ◽  
Motor Neuron ◽  
Human Cell ◽  
Transcriptional Profiling ◽  
Human Cell Culture ◽  
Motor Neuron Disorder ◽  
Culture Models ◽  
Cell Culture Models

Metabolism of the neurotoxic amino acid β-N-methylamino-L-alanine in human cell culture models

Toxicon ◽  
2019 ◽  
Vol 168 ◽  
pp. 131-139 ◽  
Author(s):  
Simoné Downing ◽  
Rianita Van Onselen ◽  
Gabré Kemp ◽  
Timothy Grant Downing
Keyword(s):  
Cell Culture ◽  
Amino Acid ◽  
Human Cell ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Barrier functions and paracellular integrity in human cell culture models of the proximal respiratory unit

2009 ◽  
Vol 72 (2) ◽  
pp. 339-349 ◽  
Author(s):  
Christine Pohl ◽  
M. Iris Hermanns ◽  
Chiara Uboldi ◽  
Michaela Bock ◽  
Sabine Fuchs ◽  
...  
Keyword(s):  
Cell Culture ◽  
Human Cell ◽  
Human Cell Culture ◽  
Barrier Functions ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8556 ◽  
Author(s):  
Jose F. Abisambra ◽  
Tina Fiorelli ◽  
Jaya Padmanabhan ◽  
Peter Neame ◽  
Inge Wefes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Culture ◽  
Human Cell ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

Drug delivery to the inflamed intestinal mucosa - targeting technologies and human cell culture models for better therapies of IBD

2021 ◽  
pp. 113828
Author(s):  
Hartwig Olga ◽  
A. Shetab Boushehri Maryam ◽  
S. Shalaby Karim ◽  
Loretz Brigitta ◽  
Lamprecht Alf ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Culture ◽  
Intestinal Mucosa ◽  
Human Cell ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

PAW19 Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease

2010 ◽  
Vol 81 (11) ◽  
pp. e29-e29
Author(s):  
C. Carroll ◽  
G. J. Williams ◽  
N. H. Chadborn ◽  
C. O. Hanemann ◽  
J. P. Zajicek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Human Cell ◽  
Regulatory Gene ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease

2011 ◽  
Vol 59 (1) ◽  
pp. 73-80 ◽  
Author(s):  
C.B. Carroll ◽  
M.-L. Zeissler ◽  
N. Chadborn ◽  
K. Gibson ◽  
G. Williams ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Human Cell ◽  
Regulatory Gene ◽  
Human Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals Transcriptional profiling of radiation damage and preventive treatments in a 3-dimensional (3D) human cell culture model of oral mucositis

Genomics Data ◽  
2015 ◽  
Vol 6 ◽  
pp. 40-43 ◽  
Author(s):  
Maria P. Lambros ◽  
Michael K. DeSalvo ◽  
Jonathan Moreno ◽  
Hari Chandana Mulamalla ◽  
Lavanya Kondapalli
Keyword(s):  
Cell Culture ◽  
Radiation Damage ◽  
Oral Mucositis ◽  
Human Cell ◽  
Transcriptional Profiling ◽  
Cell Culture Model ◽  
Human Cell Culture ◽  
3 Dimensional ◽  
Culture Model

scholarly journals Opportunities for organoids as new models of aging

2017 ◽  
Vol 217 (1) ◽  
pp. 39-50 ◽  
Author(s):  
Jennifer L. Hu ◽  
Michael E. Todhunter ◽  
Mark A. LaBarge ◽  
Zev J. Gartner
Keyword(s):  
Cell Culture ◽  
Animal Studies ◽  
Model Organisms ◽  
Human Tissues ◽  
Human Cell Culture ◽  
Aging Research ◽  
New Models ◽  
Culture Models ◽  
Biology Of Aging ◽  
Cell Culture Models

The biology of aging is challenging to study, particularly in humans. As a result, model organisms are used to approximate the physiological context of aging in humans. However, the best model organisms remain expensive and time-consuming to use. More importantly, they may not reflect directly on the process of aging in people. Human cell culture provides an alternative, but many functional signs of aging occur at the level of tissues rather than cells and are therefore not readily apparent in traditional cell culture models. Organoids have the potential to effectively balance between the strengths and weaknesses of traditional models of aging. They have sufficient complexity to capture relevant signs of aging at the molecular, cellular, and tissue levels, while presenting an experimentally tractable alternative to animal studies. Organoid systems have been developed to model many human tissues and diseases. Here we provide a perspective on the potential for organoids to serve as models for aging and describe how current organoid techniques could be applied to aging research.

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