scholarly journals DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhaoxi Zhang ◽  
Juan Wang ◽  
Jiameng Liu
Keyword(s):  
Abc Transporters ◽  
Vital Role ◽  
Biological Research ◽  
Atp Binding ◽  
Convolutional Network ◽  
Average Accuracy ◽  
Novel Method ◽  
Transport Of Macromolecules ◽  
Amino Acid Alphabet ◽  
Atp Binding Cassette

ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules. Therefore, the identification of ABC transporters is of great significance for the biological research. This paper will introduce a novel method called DeepRTCP. DeepRTCP uses the deep convolutional neural network and a feature combined of reduced amino acid alphabet based tripeptide composition and PSSM to recognize ABC transporters. We constructed a dataset named ABC_2020. It contains the latest ABC transporters downloaded from Uniprot. We performed 10-fold cross-validation on DeepRTCP, and the average accuracy of DeepRTCP was 95.96%. Compared with the start-of-the-art method for predicting ABC transporters, DeepRTCP improved the accuracy by 9.29%. It is anticipated that DeepRTCP can be used as an effective ABC transporter classifier which provides a reliable guidance for the research of ABC transporters.

ATP binding cassette transporters and cancer: revisiting their controversial role

2021 ◽  
Author(s):  
Parul Sharma ◽  
Navneet Singh ◽  
Siddharth Sharma
Keyword(s):  
Multidrug Resistance ◽  
Abc Transporters ◽  
Vital Role ◽  
Atp Binding ◽  
Toxic Compounds ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette Transporters ◽  
Oncology Treatment ◽  
Abc Transporter Genes ◽  
Atp Binding Cassette

The expression of ATP-binding cassette transporter (ABC transporters) has been reported in various tissues such as the lung, liver, kidney, brain and intestine. These proteins account for the efflux of different compounds and metabolites across the membrane, thus decreasing the concentration of the toxic compounds. ABC transporter genes play a vital role in the development of multidrug resistance, which is the main obstacle that hinders the success of chemotherapy. Preclinical and clinical trials have investigated the probability of overcoming drug-associated resistance and substantial toxicities. The focus has been put on several strategies to overcome multidrug resistance. These strategies include the development of modulators that can modulate ABC transporters. This knowledge can be translated for clinical oncology treatment in the future.

Growth Promotion and Increased ATP-Binding Cassette Transporters Expression by Liraglutide in Triple Negative Breast Cancer Cell Line MDA-MB-231

Drug Research ◽  
2021 ◽  
Author(s):  
Amir Shadboorestan ◽  
Parastoo Tarighi ◽  
Mahsa Koosha ◽  
Homa Faghihi ◽  
Mohammad Hossein Ghahremani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Triple Negative Breast Cancer ◽  
Abc Transporters ◽  
Triple Negative ◽  
Epithelial Mesenchymal Transition ◽  
Growth Promotion ◽  
Atp Binding ◽  
Mesenchymal Transition ◽  
Atp Binding Cassette

Background Glucagon-like petide-1 (GLP-1) agonists such as liraglutide are widely employed in type 2 diabetes due to their glucose reducing properties and small risk of hypoglycemia. Recently, it has been shown that GLP-1agonists can inhibit breast cancer cells growth. Nonetheless, concerns are remained about liraglutide tumor promoting effects as stated by population studies. Material and Methods We evaluated the effects liraglutide on proliferation of MDA-MB-231 cells by MTT assay and then ATP-binding cassette (ABC) transporters expressions assessed by Real time PCR. Statistical comparisons were made using one-way analysis of variance followed by a post hoc Dunnett test. Results Here, we report that liraglutide can stimulate the growth of highly invasive triple negative cell line MDA-MB-231; which can be attributed to AMPK-dependent epithelial-mesenchymal transition (EMT) happening in MDA-MB-231 context. Toxicity effects were only observed with concentrations far above the serum liraglutide concentration. ATP-binding cassette (ABC) transporters expressions were upregulated, indicating the possible drug resistance and increased EMT. Conclusion In conclusion, these results suggest that liraglutide should be used with caution in patients who are suffering or have the personal history of triple negative breast cancer. However, more detailed studies are required to deepen understanding of liraglutide consequences in triple negative breast cancer. ▶Graphical Abstract.

scholarly journals Correction to: ATP binding cassette (ABC) transporters: expression and clinical value in glioblastoma

2018 ◽  
Vol 138 (3) ◽  
pp. 487-487
Author(s):  
Antonin Dréan ◽  
Shai Rosenberg ◽  
François-Xavier Lejeune ◽  
Larissa Goli ◽  
Aravindan Arun Nadaradjane ◽  
...  
Keyword(s):  
Abc Transporters ◽  
Atp Binding ◽  
Clinical Value ◽  
Atp Binding Cassette

scholarly journals Expression of some ATP-binding cassette transporters in acute myeloid leukemia

2017 ◽  
Vol 9 (4) ◽  
Author(s):  
Antonella Maria Salvia ◽  
Flavia Cuviello ◽  
Sabrina Coluzzi ◽  
Roberta Nuccorini ◽  
Immacolata Attolico ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Abc Transporters ◽  
Healthy Subjects ◽  
Myeloid Leukemia ◽  
Resistance Mechanisms ◽  
Atp Binding ◽  
Atp Binding Cassette Transporters ◽  
Acute Myeloid ◽  
Atp Binding Cassette

Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.

scholarly journals Stickleback embryos use ATP-binding cassette transporters as a buffer against exposure to maternally derived cortisol

2016 ◽  
Vol 283 (1826) ◽  
pp. 20152838 ◽  
Author(s):  
Ryan T. Paitz ◽  
Syed Abbas Bukhari ◽  
Alison M. Bell
Keyword(s):  
Abc Transporters ◽  
Gasterosteus Aculeatus ◽  
Transcriptional Response ◽  
Threespine Stickleback ◽  
Egg Laying ◽  
Atp Binding ◽  
Active Efflux ◽  
Atp Binding Cassette Transporters ◽  
Stress Influences ◽  
Atp Binding Cassette

Offspring from females that experience stressful conditions during reproduction often exhibit altered phenotypes and many of these effects are thought to arise owing to increased exposure to maternal glucocorticoids. While embryos of placental vertebrates are known to regulate exposure to maternal glucocorticoids via placental steroid metabolism, much less is known about how and whether egg-laying vertebrates can control their steroid environment during embryonic development. We tested the hypothesis that threespine stickleback ( Gasterosteus aculeatus ) embryos can regulate exposure to maternal steroids via active efflux of maternal steroids from the egg. Embryos rapidly (within 72 h) cleared intact steroids, but blocking ATP-binding cassette (ABC) transporters inhibited cortisol clearance. Remarkably, this efflux of cortisol was sufficient to prevent a transcriptional response of embryos to exogenous cortisol. Taken together, these findings suggest that, much like their placental counterparts, developing fish embryos can actively regulate their exposure to maternal cortisol. These findings highlight the fact that even in egg-laying vertebrates, the realized exposure to maternal steroids is mediated by both maternal and embryonic processes and this has important implications for understanding how maternal stress influences offspring development.

scholarly journals Two B-type ATP-binding cassette (ABC) transporters localize to the plasma membrane in Thalictrum minus

2015 ◽  
Vol 32 (3) ◽  
pp. 243-247 ◽  
Author(s):  
Nobukazu Shitan ◽  
Kazuyoshi Terasaka ◽  
Hirobumi Yamamoto ◽  
Fumihiko Sato ◽  
Kazufumi Yazaki
Keyword(s):  
Plasma Membrane ◽  
Abc Transporters ◽  
Atp Binding ◽  
Thalictrum Minus ◽  
Atp Binding Cassette
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