scholarly journals A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus

2021 ◽  
Vol 9 ◽  
Author(s):  
Diana Pereira ◽  
Inês Sequeira
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
The Body ◽  
Tissue Formation ◽  
Epithelial Stem Cells ◽  
Cell Behaviour ◽  
Phenotypic Differences ◽  
Epithelial Tissues ◽  
Minimal Scarring ◽  
Stem And Progenitor Cells

Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability for renewal and regeneration. This ability is crucial for survival as epithelia are essential to provide the ultimate barrier against the external environment, protecting the underlying tissues. Tissue stem and progenitor cells are responsible for self-renewal and repair during homeostasis and following injury. Upon wounding, epithelial tissues undergo different phases of haemostasis, inflammation, proliferation and remodelling, often resulting in fibrosis and scarring. In this review, we explore the phenotypic differences between the skin, the oesophagus and the oral mucosa. We discuss the plasticity of these epithelial stem cells and contribution of different fibroblast subpopulations for tissue regeneration and wound healing. While these epithelial tissues share global mechanisms of stem cell behaviour for tissue renewal and regeneration, the oral mucosa is known for its outstanding healing potential with minimal scarring. We aim to provide an updated review of recent studies that combined cell therapy with bioengineering exporting the unique scarless properties of the oral mucosa to improve skin and oesophageal wound healing and to reduce fibrotic tissue formation. These advances open new avenues toward the ultimate goal of achieving scarless wound healing.

Dose schedule of Rasa Aushadhis

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Jambla Neha ◽  
Saroch Vikas ◽  
Johar Smita
Keyword(s):  
Particle Size ◽  
Oral Mucosa ◽  
Small Particle ◽  
Dose Schedule ◽  
The Body ◽  
Small Particle Size ◽  
Inherent Property ◽  
Ayurvedic Drugs ◽  
Modern Era

Rasashastra deals with the Rasa Aushadhis, the drugs of metallic and mineral origin. Mercury is used in most of the Rasaaushadhis. The toxicity of Mineral and metallic preparations are reduced to such an extent by various procedures of Shodhana, Marana etc. that Mercury converts its inherent property of toxicity into medicinal property. Rasa Aushadhis works quickly on the body because due to their small particle size, their absorption starts from the oral mucosa itself. The action of drugs depends largely upon the Anupana i.e. the vehicle for the drug. Rasacharayas have mentioned various Rasa preparations like Bhasmas, Parpati, Pottali, Manduras, Karpooras etc. along with their doses, dose schedule and Anupana / Sahapana etc. The principles of Rasaaushadhis when correlated in modern era are found to be scientifically accurate. We may say that Rasacharyas had already mastered the science of nanotechnology, purification, action of metabolic catalysts, biotransformation and preservation of medicines. The Ayurvedic drugs can be harmful for our body when not administered in proper dosage as per mentioned in classic literatures.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

scholarly journals Overexpression of the Oral Mucosa-Specific microRNA-31 Promotes Skin Wound Closure

2019 ◽  
Vol 20 (15) ◽  
pp. 3679 ◽  
Author(s):  
Lin Chen ◽  
Alyne Simões ◽  
Zujian Chen ◽  
Yan Zhao ◽  
Xinming Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Wound Closure ◽  
Expression Patterns ◽  
Skin Wound ◽  
Skin Wound Healing ◽  
Specific Expression ◽  
Keratinocyte Proliferation

Wounds within the oral mucosa are known to heal more rapidly than skin wounds. Recent studies suggest that differences in the microRNAome profiles may underlie the exceptional healing that occurs in oral mucosa. Here, we test whether skin wound-healing can be accelerating by increasing the levels of oral mucosa-specific microRNAs. A panel of 57 differentially expressed high expresser microRNAs were identified based on our previously published miR-seq dataset of paired skin and oral mucosal wound-healing [Sci. Rep. (2019) 9:7160]. These microRNAs were further grouped into 5 clusters based on their expression patterns, and their differential expression was confirmed by TaqMan-based quantification of LCM-captured epithelial cells from the wound edges. Of these 5 clusters, Cluster IV (consisting of 8 microRNAs, including miR-31) is most intriguing due to its tissue-specific expression pattern and temporal changes during wound-healing. The in vitro functional assays show that ectopic transfection of miR-31 consistently enhanced keratinocyte proliferation and migration. In vivo, miR-31 mimic treatment led to a statistically significant acceleration of wound closure. Our results demonstrate that wound-healing can be enhanced in skin through the overexpression of microRNAs that are highly expressed in the privileged healing response of the oral mucosa.

scholarly journals Surgical Strategies to Promote Cutaneous Healing

2021 ◽  
Vol 9 (2) ◽  
pp. 45
Author(s):  
Ines Maria Niederstätter ◽  
Jennifer Lynn Schiefer ◽  
Paul Christian Fuchs
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Chronic Wounds ◽  
Treatment Algorithm ◽  
Surgical Site Infections ◽  
Repair Process ◽  
Suture Technique ◽  
The Body ◽  
Wound Debridement ◽  
Reconstructive Ladder

Usually, cutaneous wound healing does not get impeded and processes uneventfully, reaching wound closure easily. The goal of this repair process is to restore the integrity of the body surface by creating a resilient and stable scar. Surgical practice and strategies have an impact on the course of wound healing and the later appearance of the scar. By considering elementary surgical principles, such as the appropriate suture material, suture technique, and timing, optimal conditions for wound healing can be created. Wounds can be differentiated into clean wounds, clean–contaminated wounds, contaminated, and infected/dirty wounds, based on the degree of colonization or infection. Furthermore, a distinction is made between acute and chronic wounds. The latter are wounds that persist for longer than 4–6 weeks. Care should be taken to avoid surgical site infections in the management of wounds by maintaining sterile working conditions, using antimicrobial working techniques, and implementing the principles of preoperative antibiotics. Successful wound closure is influenced by wound debridement. Wound debridement removes necrotic tissue, senescent and non-migratory cells, bacteria, and foreign bodies that impede wound healing. Additionally, the reconstructive ladder is a viable and partially overlapping treatment algorithm in plastic surgery to achieve successful wound closure.

Fabrication of gelatin/sodium alginate-poly (3-hydroxybutyric acid) bilayer electrospun biosheet as wound healing material in nursing care on pediatric fracture surgery

2020 ◽  
pp. 152808372097634
Author(s):  
Daiqi Jiang ◽  
Zaiju Tong ◽  
Lingjun Peng ◽  
Lingzhi Zhang ◽  
Qianzi Ruan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Sodium Alginate ◽  
Wound Closure ◽  
Skin Wound ◽  
Tissue Formation ◽  
Hydroxybutyric Acid ◽  
Physiochemical Properties ◽  
Pediatric Fracture ◽  
Fracture Surgery

Novel the bilayered electrospun biosheet with rapid cell mimiciking and proliferative efficacy will be suitable for wound healing application. The optimized concentration of gelatin (G) and sodium alginate (A) biosheet with nanofibrous Poly (3-hydroxybutyric acid) (P) as a bilayered elctrospun matrix through electrospinning. The engineered GAP bilayered biosheet involves tissue formation at extra cellular matrix (ECM) which further characterized its function in vitro and invivo. Here we fabricated GAP which exhibit better physiochemical properties, biological and mechanical properties with superior prosomes it enhance air passable at skin wounds. The Bilayered biosheet matrix possess better biocompatibility, cell adherence, fructuous and cell to cell interactions evaluated using cell lines. Furthermore, GAP bilayered matrix regulates growth factors to attain maximum wound closure efficiency during invivo. Thus, the fabricated GAP electrospun biosheet would be a possible wound dressing for skin wound applications.

scholarly journals Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamed Nosrati ◽  
Reza Aramideh Khouy ◽  
Ali Nosrati ◽  
Mohammad Khodaei ◽  
Mehdi Banitalebi-Dehkordi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
The Body ◽  
Key Factors ◽  
Potential Applications ◽  
Nanocomposite Scaffolds

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

The Effects of Oral Mucosa-Derived Heterotopic Fibroblasts on Cutaneous Wound Healing

2021 ◽  
Author(s):  
Billur Sezgin ◽  
Sedat Tatar ◽  
Sercin Karahuseyinoglu ◽  
Gizem Nur Sahin ◽  
Yagmur Ergun ◽  
...  
Keyword(s):  
Wound Healing ◽  
Oral Mucosa ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

The Effect of a Hydrocolloid Dressing on Second Intention Wound Healing in Cats

2018 ◽  
Vol 54 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Vassiliki Tsioli ◽  
Pagona G. Gouletsou ◽  
Apostolos D. Galatos ◽  
Dimitra Psalla ◽  
Antonios Lymperis ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
The Other ◽  
Skin Wounds ◽  
Tissue Formation ◽  
Dorsal Midline ◽  
Granulation Tissue Formation ◽  
Hydrocolloid Dressing ◽  
Thickness Skin ◽  
The Right

ABSTRACT The objective of the present study was to evaluate the effect of a hydrocolloid dressing on second intention wound healing in cats. Two full-thickness skin wounds, measuring 2 × 2 cm, were created on both sides of the dorsal midline of 10 cats; bilaterally, one randomly selected wound was bandaged with a hydrocolloid dressing and the second one (control) with a semiocclusive pad. Subjective clinical evaluation of granulation tissue formation, of the quantity and nature of wound exudate, and planimetry were performed on the right-side wounds, and histological examination on the left. No significant differences in subjective clinical evaluation or in planimetry were observed between the hydrocolloid-treated wounds and controls. Most wounds had serous or absence of exudate (41.25% and 25%, respectively), whereas purulent exudate was observed in 7.5% of wounds. Edema was significantly increased in the hydrocolloid-treated wounds compared with controls on day 7 but no significant differences in the other histological variables were observed.

Dental Trauma Caused by Screws in Internal Fixation of Mandibular Osteotomies in the Dog

1992 ◽  
Vol 05 (03) ◽  
pp. 104-108 ◽  
Author(s):  
A. J. Ligthelm ◽  
F. J. M. Verstraete
Keyword(s):  
Internal Fixation ◽  
Oral Mucosa ◽  
Postoperative Period ◽  
Periodontal Ligament ◽  
Dental Trauma ◽  
Mandibular Fracture ◽  
Fracture Repair ◽  
The Body ◽  
Mandibular Osteotomy

SummaryIn a canine mandibular osteotomy model, the extent and nature of dental trauma resulting from internal fixation by means of a plate and screws was investigated. The plate was positioned relatively dorsally on the buccal aspect of the body of the mandible, for maximum biomechanical advantage. After a three-month period, dental trauma was evaluated clinically and histologically. Erosion of the oral mucosa overlying the plate occurred in 10 out of 15 dogs. Dental roots were damaged by 61% of the screws. A variety of lesions involving the periodontal ligament, dentine, cementum, pulp, and periapical tissue were noted. It is concluded that this method of fixation can not be recommended for mandibular fracture repair in the dog.The effects of plating osteotomies of canine mandibles are described and evaluated following a three-month postoperative period.

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