scholarly journals In vitro Targetability Validation of Peptide-Functionalized Mesoporous Silica Nanoparticles in the Presence of Serum Proteins

2020 ◽  
Vol 8 ◽  
Author(s):  
Valeriy M. Paramonov ◽  
Melanie Gerstenberg ◽  
Cecilia Sahlgren ◽  
Mika Lindén ◽  
Adolfo Rivero-Müller
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Serum Proteins ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica

scholarly journals In vitro speciation of molybdenum in human biological samples based on thiol functionalized mesoporous silica nanoparticles and hexyl-methylimidazolium tris-pentafluoroethyl-trifluorophosphate

2020 ◽  
Vol 3 (03) ◽  
pp. 54-64
Author(s):  
Roya Ashori ◽  
Seyed Alireza Hajiseyed Mirzahosseini
Keyword(s):  
Ionic Liquid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biological Samples ◽  
Solid Phase ◽  
Mesoporous Silica Nanoparticles ◽  
Electrothermal Atomic Absorption Spectrometry ◽  
Serum Samples ◽  
Functionalized Mesoporous Silica

Molybdenum (Mo) ions enter to human body from the diet or drinking waters and have a potentially toxic effect on humans. The thiol-functionalized mesoporous silica nanoparticles (HS-MSNPs) were used for determination and speciation of Mo (II, VI) in human biological samples by dispersive ionic liquid-micro-solid phase extraction (DIL-μ-SPE) coupled to electrothermal atomic absorption spectrometry (ET-AAS). Firstly, the mixture of HS-MSNPs (15 mg), the hydrophobic ionic liquid (1-Hexyl-3-methylimidazolium tris(pentafluoroethyl) trifluorophosphate; [HMIM][T(PFE)PF3]) and acetone injected into 10 mL of human blood and serum samples. After shaking for 5 min, the Mo(II) and Mo(VI) ions were extracted with the thiol group of MSNPs at pH 6 and 2, respectively, and collected through IL at the bottom of the conical tube by centrifuging. Then, the MO(II,VI) ions were back-extracted from HS-MSNPs with elent based on changing pH, and remained solutions were determined by ET-AAS after dilution with DW up to 0.5 mL, separately.

scholarly journals In vitro Studies of Functionalized Mesoporous Silica Nanoparticles for Photodynamic Therapy

2009 ◽  
Vol 21 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Hsiung-Lin Tu ◽  
Yu-Shen Lin ◽  
Hsia-Yu Lin ◽  
Yann Hung ◽  
Leu-Wei Lo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Studies ◽  
Functionalized Mesoporous Silica

scholarly journals Amine-Functionalized Mesoporous Silica Nanoparticles: A New Nanoantibiotic for Bone Infection Treatment

2018 ◽  
Vol 4 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Daniel Pedraza ◽  
Jaime Díez ◽  
Isabel-Izquierdo-Barba ◽  
Montserrat Colilla ◽  
María Vallet-Regí
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Chemical Properties ◽  
Bone Infection ◽  
Bacterial Biofilm ◽  
Functionalized Mesoporous Silica ◽  
Infection Treatment ◽  
Antimicrobial Effectiveness

Abstract This manuscript reports an effective new alternative for the management of bone infection by the development of an antibiotic nanocarrier able to penetrate bacterial biofilm, thus enhancing antimicrobial effectiveness. This nanosystem, also denoted as “nanoantibiotic”, consists in mesoporous silica nanoparticles (MSNs) loaded with an antimicrobial agent (levofloxacin, LEVO) and externally functionalized with N-(2-aminoethyl)-3- aminopropyltrimethoxysilane (DAMO) as targeting agent. This amine functionalization provides MSNs of positive charges, which improves the affinity towards the negatively charged bacteria wall and biofilm. Physical and chemical properties of the nanoantibiotic were studied using different characterization techniques, including Xray diffraction (XRD), transmission electron microscopy (TEM), N2 adsorption porosimetry, elemental chemical analysis, dynamic light scattering (DLS), zeta (ζ)-potential and solid-state nuclear magnetic resonance (NMR). “In vial” LEVO release profiles and the in vitro antimicrobial effectiveness of the different released doses were investigated. The efficacy of the nanoantibiotic against a S. aureus biofilm was also determined, showing the practically total destruction of the biofilm due to the high penetration ability of the developed nanosystem. These findings open up promising expectations in the field of bone infection treatment.

Co-Delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy

2016 ◽  
Vol 13 (7) ◽  
pp. 1176-1182 ◽  
Author(s):  
Mohammad Yahya Hanafi-Bojd ◽  
Mahmoud Reza Jaafari ◽  
Navid Ramezanian ◽  
Khalil Abnous ◽  
Bizhan Malaekeh-Nikouei
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Efficacy ◽  
Functionalized Mesoporous Silica

scholarly journals Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3337
Author(s):  
Sara Hooshmand ◽  
Sahar Mollazadeh ◽  
Negar Akrami ◽  
Mehrnoosh Ghanad ◽  
Ahmed El-Fiqi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Skin Regeneration ◽  
Bioactive Molecules ◽  
Wound Management ◽  
Bioactive Glasses ◽  
Wide Range

Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. The main merits of these porous substances can be summarized as their excellent biocompatibility and the ability of loading and delivering a wide range of both hydrophobic and hydrophilic bioactive molecules and chemicals. In addition, doping with inorganic elements (e.g., Cu, Ga, and Ta) into MSNs and MBGs structure is a feasible and practical approach to prepare customized materials for improved skin regeneration. Nowadays, MSNs and MBGs could be utilized in the concept of targeted therapy of skin malignancies (e.g., melanoma) by grafting of specific ligands. Since potential effects of various parameters including the chemical composition, particle size/morphology, textural properties, and surface chemistry should be comprehensively determined via cellular in vitro and in vivo assays, it seems still too early to draw a conclusion on ultimate efficacy of MSNs and MBGs in skin regeneration. In this regard, there are some concerns over the final fate of MSNs and MBGs in the wound site plus optimal dosages for achieving the best outcomes that deserve careful investigation in the future.

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