scholarly journals Gold-Catalyzed Complementary Nitroalkyne Internal Redox Process: A DFT Study

2021 ◽  
Vol 9 ◽  
Author(s):  
K. Vipin Raj ◽  
Pawan S. Dhote ◽  
Kumar Vanka ◽  
Chepuri V. Ramana
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Gold Catalysis ◽  
Redox Process ◽  
Biologically Active ◽  
Dft Study ◽  
Relative Stabilities ◽  
Wide Range ◽  
Theoretical Investigations ◽  
Synthetic Methodologies

Gold-catalysis, in this century, is one of the most emerging and promising new areas of research in organic synthesis. During the last two decades, a wide range of distinct synthetic methodologies have been unveiled employing homogeneous gold catalysis and aptly applied in the synthesis of numerous natural products and biologically active molecules. Among these, the reactions involving α-oxo gold carbene/α-imino gold carbene intermediates are of contemporary interest, in view of their synthetic potential and also due to the need to understand the bonding involved in these complexes. In this manuscript, we document the theoretical investigations on the regio-selectivity dependence of substitution on the gold-catalyzed cycloisomerization of o-nitroarylalkyne derivatives. We have also studied the relative stabilities of α-oxo gold carbene intermediates.

scholarly journals Synthetic Strategies in the Preparation of Phenanthridinones

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5560
Author(s):  
Rajeshwar Reddy Aleti ◽  
Alexey A. Festa ◽  
Leonid G. Voskressensky ◽  
Erik V. Van der Eycken
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Coupling Reactions ◽  
Structural Importance ◽  
Wide Range ◽  
Biaryl Coupling ◽  
Synthetic Methodologies

Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, N-aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions.

Copper-catalyzed N-arylation of pyrroles: An overview

2021 ◽  
Author(s):  
Kalathingal Nasreen Hisana ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-Arylated pyrroles have a wide range of applications in pharmaceuticals, agrochemical industry and organic synthesis. They are intermediates for the formation of many biologically active compounds and natural products. Over...

scholarly journals Guanidine Motif in Biologically Active Peptides

2014 ◽  
Vol 67 (7) ◽  
pp. 965 ◽  
Author(s):  
Juan V. Alegre-Requena ◽  
Eugenia Marqués-López ◽  
Raquel P. Herrera
Keyword(s):  
Hydrogen Bond ◽  
Natural Products ◽  
Organic Synthesis ◽  
Biologically Active ◽  
Metal Salts ◽  
Structural Motif ◽  
Active Peptides ◽  
The Past ◽  
Wide Range ◽  
Biologically Active Peptides

In the past decade, guanidines have attracted attention as valuable hydrogen bond-based catalysts while they have long been considered as organic superbases with a broad scope of synthetic applicability. Their easy modification has also expanded their capacity to form complexes with a wide range of metal salts as effective metal scavengers. All these attractive aspects have promoted a huge growth in the field of organic synthesis involving guanidines and examples of such reactions have been collected in numerous reviews and some books. Moreover, this structural motif is also present in a large number of natural products and biologically active compounds that exhibit appealing properties and play important roles in medicinal chemistry. In this highlight, we will only cover the synthesis and properties of biologically active guanidine-containing peptides reported in the past 3 years.

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

scholarly journals A REVIEW ON THE SYNTHETIC METHODOLOGIES OF CHROMONES

2018 ◽  
Vol 11 (12) ◽  
pp. 9 ◽  
Author(s):  
Mahathy Vanguru ◽  
Ramchander Merugu ◽  
Swetha Garimella ◽  
Laxminarayana E
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
Biological Applications ◽  
Essential Component ◽  
Wide Range ◽  
Synthetic Methodologies ◽  
New Compounds

Chromones group of compounds and their derivatives form the essential component of pharmacophores in many biologically active molecules. They exhibit a wide range of biological activities such as antibiotic, antitumor, antiviral, antioxidant, antipsychotic, and antihypoxic activities. These applications have stimulated a continuous search for the synthesis of new compounds in this field and are being extensively investigated. The various methodologies so far reported for the synthesis of these compounds with the compounds biological applications are discussed in this communication

scholarly journals Recent Advances in the Synthesis of Isothiocyanates Using Elemental Sulfur

Catalysts ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1081
Author(s):  
András Gy. Németh ◽  
Péter Ábrányi-Balogh
Keyword(s):  
Natural Products ◽  
Best Practices ◽  
Organic Synthesis ◽  
Elemental Sulfur ◽  
Biologically Active ◽  
Primary Amines ◽  
Pharmaceutical Ingredients ◽  
Recent Developments ◽  
In Situ Generation

Isothiocyanates (ITCs) are biologically active molecules found in several natural products and pharmaceutical ingredients. Moreover, due to their high and versatile reactivity, they are widely used as intermediates in organic synthesis. This review considers the best practices for the synthesis of ITCs using elemental sulfur, highlighting recent developments. First, we summarize the in situ generation of thiocarbonyl surrogates followed by their transformation in the presence of primary amines leading to ITCs. Second, carbenes and amines afford isocyanides, and the further reaction of this species with sulfur readily generates ITCs under thermal, catalytic or basic conditions. Additionally, we also reveal that in the catalyst-free reaction of isocyanides and sulfur, two—until this time overlooked and not investigated—different mechanistic pathways exist.

3,4-Dihydroisocoumarins, Interesting Natural Products: Isolation, Organic Syntheses and Biological Activities

2019 ◽  
Vol 16 (1) ◽  
pp. 112-129 ◽  
Author(s):  
Aurelio Ortiz ◽  
Miriam Castro ◽  
Estibaliz Sansinenea
Keyword(s):  
Natural Products ◽  
Biological Activities ◽  
Natural Compounds ◽  
Biologically Active ◽  
Bacterial Strains ◽  
Drug Candidates ◽  
Heterocyclic Molecules ◽  
Naturally Occurring ◽  
Wide Range ◽  
Different Sources

Background:3,4-dihydroisocoumarins are an important small group belonging to the class of naturally occurring lactones isolated from different bacterial strains, molds, lichens, and plants. The structures of these natural compounds show various types of substitution in their basic skeleton and this variability influences deeply their biological activities. These lactones are structural subunits of several natural products and serve as useful intermediates in the synthesis of different heterocyclic molecules, which exhibit a wide range of biological activities, such as anti-inflammatory, antiplasmodial, antifungal, antimicrobial, antiangiogenic and antitumoral activities, among others. Their syntheses have attracted attention of many researchers reporting many synthetic strategies to achieve 3,4-dihydroisocoumarins and other related structures. </P><P> Objective: In this context, the isolation of these natural compounds from different sources, their syntheses and biological activities are reviewed, adding the most recent advances and related developments.Conclusion:This review aims to encourage further work on the isolation and synthesis of this class of natural products. It would be beneficial for synthetic as well as the medicinal chemists to design selective, optimized dihydroisocoumarin derivatives as potential drug candidates, since dihydroisocoumarin scaffolds have significant utility in the development of therapeutically relevant and biologically active compounds.

scholarly journals Tale of Breslow Intermediate, a Central Player in N-Heterocyclic Carbene Organocatalysis: Then and Now

2021 ◽  
Author(s):  
Raghavan B. Sunoj ◽  
Monika Pareek ◽  
Yernaidu Reddi
Keyword(s):  
Natural Products ◽  
Heterocyclic Carbenes ◽  
Biologically Active Compounds ◽  
Biologically Active ◽  
Active Compounds ◽  
Wide Range

N-heterocyclic carbenes (NHCs) belong to the popular family of organocatalysts used in a wide range of reactions, including that for the synthesis of complex natural products and biologically active compounds....

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