A U-Shaped Relationship Between Selenium Concentrations and All-Cause or Cardiovascular Mortality in Patients With Hypertension

Background: Given the antioxidant activity of selenium, it has been reported benefits for blood pressure control and hypertension prevention, but few studies have investigated the association between serum selenium with mortality in hypertensive population.Methods: All participants with hypertension aged ≥18 years at baseline were recruited from the National Health and Nutritional Examination Surveys (NHANES) 2003–2004, and followed for mortality through December 31, 2015. Subjects were categorized by quartiles of serum selenium (Q1: ≤124 μg/L, Q2: 125–135 μg/L, Q3: 136–147 μg/L, Q4: ≥148 μg/L). Multivariate Cox regression were implemented to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Restricted cubic spline analysis and two-piecewise linear regression were used to evaluate the relationship of serum selenium with mortality. Survival curves were used to depict cause-specific mortalities.Results: A total of 929 participants (52.53% were male) were eligible for the current study with the average age of 63.10 ± 12.59 years. There were 307 deaths occurred including 56 cardiovascular death events during the mean follow-up time of 121.05 ± 40.85 months. A U-shaped association was observed between serum selenium and all-cause or cardiovascular mortality. In fully adjusted model, comparisons among quartiles revealed that risks of all-cause [HR (95%CI), 0.57 (0.39–0.81)] and cardiovascular death [HR (95%CI), 0.33 (0.13–0.86)] were lower in Q3. The nadir mortality of all-cause and cardiovascular was occurred at the serum selenium level of 136 μg/L and 130 μg/L, respectively.Conclusion: Serum selenium concentration showed a U-shaped association with all-cause and cardiovascular mortality.

Download Full-text

The association between serum selenium concentration and prognosis in patients with heart failure in a Chinese population

Scientific Reports ◽

10.1038/s41598-021-93873-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Zhiliang Zhang ◽

Chao Chang ◽

Yuxin Zhang ◽

Zhiyong Chai ◽

Jinbei Li ◽

...

Keyword(s):

Heart Failure ◽

Chinese Population ◽

Selenium Concentration ◽

Chinese Patients ◽

Serum Selenium ◽

Increased Risk ◽

Patients With Heart Failure ◽

All Cause Mortality ◽

Serum Selenium Concentration ◽

Baseline Information

AbstractWhether Selenium (Se) deficiency relates with adverse prognosis in Chinese patients with heart failure (HF) is still unknown. This study aimed to investigate the association of serum Se level and the outcomes of patients with HF in a Chinese population. Patients with HF and serum Se examination were retrospectively included. Baseline information were collected at patient’s first admission. The primary and secondary outcomes were all-cause mortality and rehospitalization for HF during follow-up, respectively. The study participants were divided into quartiles according to their serum Se concentrations. The Cox proportional hazard models were adopted to estimate the association of serum Se levels with observed outcomes. A total of 411 patients with HF with a mean age of 62.5 years were included. The mean serum level of Se was 68.3 ± 27.7 µg/L. There was nonsignificant difference of baseline characterizes between the four quartile groups. In comparison with patients in the highest quartile, those with the lowest quartile (17.40–44.35 µg/L) were associated with increased risk of all-cause mortality [adjusted hazard ratios (95% CI) 2.32 (1.43–3.77); Ptrend = 0.001]. Our study suggested that a lower serum Se level was significantly associated with increased risk of all-cause mortality in patients with HF.

Download Full-text

Low serum selenium concentration in patients with colonic adenomatous polyps

Clinical Nutrition ◽

10.1016/0261-5614(93)90286-d ◽

1993 ◽

Vol 12 ◽

pp. 46

Author(s):

F. Fernández-Bañares ◽

M. Esteve ◽

M.D. Mingorance ◽

A. Abad-Lacruz ◽

E. Cabré ◽

...

Keyword(s):

Selenium Concentration ◽

Adenomatous Polyps ◽

Serum Selenium ◽

Serum Selenium Concentration ◽

Low Serum

Download Full-text

Serum selenium concentration is associated with metabolic factors in the elderly: a cross-sectional study

Nutrition & Metabolism ◽

10.1186/1743-7075-7-38 ◽

2010 ◽

Vol 7 (1) ◽

pp. 38 ◽

Cited By ~ 32

Author(s):

Kuen-Cheh Yang ◽

Long-Teng Lee ◽

Yow-Shan Lee ◽

Hui-Ying Huang ◽

Ching-Yu Chen ◽

...

Keyword(s):

Selenium Concentration ◽

The Elderly ◽

Cross Sectional Study ◽

Serum Selenium ◽

Sectional Study ◽

Metabolic Factors ◽

Cross Sectional ◽

Serum Selenium Concentration

Download Full-text

The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality

European Journal of Preventive Cardiology ◽

10.1177/2047487318804618 ◽

2018 ◽

Vol 26 (2) ◽

pp. 199-207 ◽

Cited By ~ 11

Author(s):

Esko Salokari ◽

Jari A Laukkanen ◽

Terho Lehtimaki ◽

Sudhir Kurl ◽

Setor Kunutsor ◽

...

Keyword(s):

Exercise Capacity ◽

Exercise Testing ◽

Cardiovascular Mortality ◽

Cox Regression ◽

Cardiovascular Death ◽

Bicycle Exercise ◽

Metabolic Equivalents ◽

Ergometer Exercise ◽

Duke Treadmill Score

Background The Duke treadmill score, a widely used treadmill testing tool, is a weighted index combining exercise time or capacity, maximum ST-segment deviation and exercise-induced angina. No previous studies have investigated whether the Duke treadmill score and its individual components based on bicycle exercise testing predict cardiovascular death. Design Two populations with a standard bicycle testing were used: 3936 patients referred for exercise testing (2371 men, age 56 ± 13 years) from the Finnish Cardiovascular Study (FINCAVAS) and a population-based sample of 2683 men (age 53 ± 5.1 years) from the Kuopio Ischaemic Heart Disease study (KIHD). Methods Cox regression was applied for risk prediction with cardiovascular mortality as the primary endpoint. Results In FINCAVAS, during a median 6.3-year (interquartile range (IQR) 4.5–8.2) follow-up period, 180 patients (4.6%) experienced cardiovascular mortality. In KIHD, 562 patients (21.0%) died from cardiovascular causes during the median follow-up of 24.1 (IQR 18.0–26.2) years. The Duke treadmill score was associated with cardiovascular mortality in both populations (FINCAVAS, adjusted hazard ratio (HR) 3.15 for highest vs. lowest Duke treadmill score tertile, 95% confidence interval (CI) 1.83–5.42, P < 0.001; KIHD, adjusted HR 1.71, 95% CI 1.34–2.18, P < 0.001). However, after progressive adjustment for the Duke treadmill score components, the score was not associated with cardiovascular mortality in either study population, as exercise capacity in metabolic equivalents of task was the dominant harbinger of poor prognosis. Conclusions The Duke treadmill score is associated with cardiovascular mortality among patients who have undergone bicycle exercise testing, but metabolic equivalents of task, a component of the Duke treadmill score, proved to be a superior predictor.

Download Full-text

The Evaluation of Serum Selenium Concentration in Children with Febrile Convulsion

journal of ilam university of medical sciences ◽

10.18869/acadpub.sjimu.24.4.95 ◽

2016 ◽

Vol 24 (4) ◽

pp. 95-103

Author(s):

Nooshin Taghizadegan ◽

Sima Afsharnezhad ◽

Hossein Abbaspour ◽

◽

...

Keyword(s):

Selenium Concentration ◽

Febrile Convulsion ◽

Serum Selenium ◽

Serum Selenium Concentration

Download Full-text

Abstract TP431: Association of Systolic Blood Pressure and Cardiovascularrisk According to Hemoglobin Concentration

Stroke ◽

10.1161/str.51.suppl_1.tp431 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Jun Young Chang ◽

Se Young Jang ◽

Sun-uck Kwon

Keyword(s):

Blood Pressure ◽

Cardiovascular Risk ◽

Systolic Blood Pressure ◽

Cox Regression ◽

Hemoglobin Concentration ◽

Cardiovascular Death ◽

Normal Range ◽

Cox Regression Analysis ◽

Hazard Ratios ◽

Hb Concentration

Introduction: We evaluated whether the optimal cutoff of blood pressure to reduce cardiovascular risk is different according to hemoglobin (Hb) concentration and its changing pattern using the National Health Insurance Service-Health Screening Cohort. Methods: The study population consisted of individuals who underwent both 2002-2003 and 2004-2005 health examinations. Individuals who were diagnosed with cardiovascular disease or who died before index date of 1 January 2006 were excluded. The primary outcome of the study was the association between systolic blood pressure (SBP) and MACE (composite of myocardial infarction, stroke, and cardiovascular death) according to Hb concentration. Hazard ratios (HR) were calculated using Cox regression analysis adjusted for age and sex. Results: A total of 290573 were included in the analysis. During the follow up period from 1 January 2006 to 31 December 2013, a total of 18292 experienced MACE. There was a significant interaction between SBP and Hb concentration with regard to cardiovascular diseases (p for interaction= 0.07). Among the subjects with Hb <10, a significant increment of MACE was observed when SBP ≥140 mmHg. HR for MACE increased when SBP ≥130mmHg among the subjects with 10≤ Hb <11 and 11≤ Hb <12. HR for MACE increased when SBP ≥ 120 mmHg among the subjects with 12≤ Hb <13, 13≤ Hb <15, and 15≤ Hb. Cardiovascular risk was the lowest in SBP below 120mmHg and cut off value for increasing cardiovascular risk was 120 mmHg or above in subjects who maintain normal range of hemoglobin level and whose hemoglobin concentration changed from anemia to normal range. However, individuals who maintain anemic state and whose hemoglobin concentration changed from normal range to anemia, SBP threshold for increasing cardiovascular risk was equal or above 130 mmHg . Conclusion: The threshold of SBP which increases cardiovascular risk may be different according to the hemoglobin concentration and change pattern of hemoglobin.

Download Full-text

Total antioxidant status reduction conditioned by a serum selenium concentration decrease as a mechanism of the ultrasonographically measured brachial artery dilatation impairment in patients with arterial hypertension

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2020.103332 ◽

2020 ◽

Vol 75 ◽

pp. 103332

Author(s):

Paweł Gać ◽

Dominika Urbanik ◽

Natalia Pawlas ◽

Małgorzata Poręba ◽

Helena Martynowicz ◽

...

Keyword(s):

Arterial Hypertension ◽

Brachial Artery ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Selenium Concentration ◽

Serum Selenium ◽

Total Antioxidant ◽

Serum Selenium Concentration

Download Full-text

Injectable organic and inorganic selenium in dairy cows – Effects on milk, blood and somatic cell count levels

Onderstepoort Journal of Veterinary Research ◽

10.4102/ojvr.v86i1.1664 ◽

2019 ◽

Vol 86 (1) ◽

Author(s):

Gert M. Ferreira ◽

Inge-Marie Petzer

Keyword(s):

Dairy Cows ◽

Somatic Cell ◽

Cell Count ◽

Negative Correlation ◽

Somatic Cell Count ◽

Selenium Concentration ◽

Trace Minerals ◽

Serum Selenium ◽

Inorganic Selenium ◽

Serum Selenium Concentration

Mastitis is the most costly disease of dairy cows. A pro-active approach includes insuring adequate levels of selective trace minerals. The aim of this study was to determine the effect of two different commercially available, injectable selenium products, (sodium) Na-selenite (inorganic) and (selenium) Se-methionine (organic), on milk composition and on serum and milk selenium concentrations in high-yielding Holstein cows on total mix ration. Sixty multiparous cows were randomly selected into three groups of 20, one control group and two groups supplemented with injectable trace minerals. Blood and milk samples were collected over a period of 60 days. No specific change was indicated in milk yield, lactose, milk urea nitrogen (MUN) and milk pH levels compared with baseline values. The Se-methionine supplemented group showed a numerical increase in total milk protein percentage. In the group injected with Se-methionine, a negative correlation was present for the initial 72 hours between serum selenium concentration and somatic cell count (SCC) and a highly significant (p 0.001) increase in milk selenium concentration for the initial 24 hours. Serum selenium concentration of Se-methionine-supplemented cows was however not significantly changed. Injection of Na-selenite led to a 60-day initial increase in serum selenium concentration above baseline levels and a significant milk selenium concentration on day 1 but to a negative correlation between serum selenium concentration and SCC. Differences in serum and milk selenium concentrations followed with the use of organic and inorganic selenium injectables. Injectable Na-selenite, as selenium, can be of important value for cattle farmers if supplemented on strategically physiological periods to improve production, reproduction and immunity.

Download Full-text