Circulating Biomarkers and Cardiac Structure and Function in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) increases the risk for abnormalities of the cardiac structure and function, which may lead to heart failure (HF). Studying the association between circulating biomarkers and echocardiographic parameters is important to screen patients with RA with a higher risk of cardiac dysfunction.Aim: To study the association between circulating biomarkers and echocardiographic parameters in patients with RA.Methods: Echocardiography was performed in 355 patients with RA from RA Porto cohort and the associations between echocardiographic characteristics and 94 circulating biomarkers were assessed. These associations were also assessed in the Metabolic Road to Diastolic Heart Failure (MEDIA-DHF) [392 patients with HF with preserved ejection fraction (HFpEF)] and the Suivi Temporaire Annuel Non-Invasif de la Santé des Lorrains Assurés Sociaux (STANISLAS) (1,672 healthy population) cohorts.Results: In the RA Porto cohort, mean age was 58 ± 13 years, 23% were males and mean RA duration was 12 ± 10 years. After adjustment and multiple testing correction, left ventricular mass index (LVMi), left atrial volume index (LAVi), and E/e′ were independently associated with biomarkers reflecting inflammation [i.e., bone morphogenetic protein 9 (BMP9), pentraxin-related protein 3 (PTX3), tumor necrosis factor receptor superfamily member 11a (TNFRSF11A)], extracellular matrix remodeling [i.e., placental growth factor (PGF)], congestion [i.e., N-terminal pro-brain natriuretic peptide (NT-proBNP), adrenomedullin (ADM)], and myocardial injury (e.g., troponin). Greater LVMi [hazard ratio (HR) (95% CI) per 1 g/m2 = 1.03 (1.02–1.04), p < 0.001], LAVi [HR (95% CI) per 1 ml/m2 = 1.03 (1.01–1.06), p < 0.001], and E/e′ [HR (95% CI) per 1 = 1.08 (1.04–1.13), p < 0.001] were associated with higher rates of cardiovascular events. These associations were externally replicated in patients with HFpEF and asymptomatic individuals.Conclusion: Circulating biomarkers reflecting inflammation, extracellular matrix remodeling, congestion, and myocardial injury were associated with underlying alterations of cardiac structure and function. Biomarkers might be used for the screening of cardiac alterations in patients with RA.

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Cardiac structure and function in monozygotic twin pairs discordant for physical fitness

Journal of Applied Physiology ◽

10.1152/japplphysiol.00107.2005 ◽

2005 ◽

Vol 99 (2) ◽

pp. 535-541 ◽

Cited By ~ 12

Author(s):

Jarna C. Hannukainen ◽

Urho M. Kujala ◽

Jyri Toikka ◽

Olli J. Heinonen ◽

Jukka Kapanen ◽

...

Keyword(s):

Physical Activity ◽

Monozygotic Twins ◽

Monozygotic Twin ◽

Left Ventricular ◽

Structure And Function ◽

Cardiac Structure ◽

Cross Sectional ◽

Echocardiographic Parameters ◽

Cardiac Structure And Function ◽

And Function

Cross-sectional studies in athletes and untrained subjects suggest that exercise training induces adaptations in cardiac structure and function. However, the role of genetic variation on the results has largely been ignored in these studies. The purpose of this study was to investigate the effects of long-term volitionally increased physical activity on electrocardiographic and echocardiographic parameters in male monozygotic twin pairs discordant for physical activity and fitness. On the basis of the mailed questionnaires, a telephone interview, and the inclusion criteria, 12 pairs of young adult male monozygotic twins were recruited from a Finnish twin cohort. All subjects completed a maximal oxygen uptake (V̇o2 max) test and electrocardiography and echocardiography studies. Nine pairs had at least 9% difference in V̇o2 max and were selected for further analysis and for a second echocardiography study. Twins were divided into the more (MAG) and less active group (LAG), according to their V̇o2 max. On average, MAG had 18% higher V̇o2 max compared with LAG. In electrocardiography, MAG had 29% ( P = 0.02) higher Cornell voltage and 37% ( P = 0.01) higher right-side hypertrophy index. In echocardiography, no significant differences were observed between the groups, and left ventricular mass index was only 7% ( P = 0.16) higher in MAG. These results show that the volitionally increased physical activity that has led to an 18% increase in cardiorespiratory fitness induces greater changes in electro- than echocardiographic parameters. Electrocardiographic changes were suggestive of left ventricular hypertrophy, and echocardiography showed a similar but statistically nonsignificant trend.

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A longitudinal study of cardiac structure and function using echocardiography in patients undergoing peritoneal dialysis

BMC Nephrology ◽

10.1186/s12882-021-02535-3 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Yunyun Zhu ◽

Difei Zhang ◽

Xiaoxuan Hu ◽

Hui Liu ◽

Yuan Xu ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Mortality Risk ◽

Structure And Function ◽

Cardiac Structure ◽

Clinical Trial Registry ◽

Cox Models ◽

All Cause Mortality ◽

Echocardiographic Parameters ◽

Cardiac Structure And Function ◽

And Function

Abstract Background Peritoneal dialysis (PD) can be associated with abnormal cardiac structure and function and increased mortality risk. Therefore, in this study, we analyzed the cardiac structure and function dynamic changes using echocardiography during the first 2 years of PD therapy. We also assessed its associations with all-cause mortality risk after 2 years of follow-up. Methods End-stage renal disease (ESRD) patients that have started PD from 2011 to 2017, and had echocardiography at baseline and years 1 and 2, were included in this study. Echocardiographic parameters were compared between baseline and year 2. Multivariable Cox models were used to estimate the association between echocardiographic parameters changes and all-cause mortality risk. Results We finally enrolled 72 PD patients in this study. The mean right ventricular diameter (RVD) increased from baseline (18.31 mm) to year 1 (18.75 mm) and year 2 (19.65 mm). We also observed a significant decrease in cardiac output (CO) between baseline and year 2. Additionally, a slight decrease trend in ejection fraction (EF) was observed. Finally, every 1 % increase in RVD was associated with a 68.2 % higher mortality risk after dialysis (HR, 1.682; 95 % CI, 1.017–2.783). Conclusions Our results demonstrated a susceptibility for deteriorated right cardiac structure and function during the first 2 years of PD treatment. Also, higher all-cause mortality risk was observed after 2 years of PD. Altogether, these results highlighted the need for additional focus on regular echocardiographic examinations during long-term PD management. Trial registration The PD-CRISC cohort, registered with the Chinese Clinical Trial Registry (ChiCTR1900023565).

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An exploratory investigation of echocardiographic parameters and the effects of posture on cardiac structure and function in the Livingstone's fruit bat (Pteropus livingstonii )

Veterinary Radiology & Ultrasound ◽

10.1111/vru.12539 ◽

2017 ◽

Vol 59 (1) ◽

pp. 89-97

Author(s):

Aimee L. Drane ◽

Robert Shave ◽

Andrew Routh ◽

Alberto Barbon

Keyword(s):

Structure And Function ◽

Cardiac Structure ◽

Fruit Bat ◽

Exploratory Investigation ◽

Echocardiographic Parameters ◽

Cardiac Structure And Function ◽

And Function

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IMPACT OF MYOCARDIAL VIABILITY ON ECHOCARDIOGRAPHIC PARAMETERS OF CARDIAC STRUCTURE AND FUNCTION IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY. A REPORT FROM THE STICH TRIAL

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(10)61192-8 ◽

2010 ◽

Vol 55 (10) ◽

pp. A127.E1191

Author(s):

Federico M. Asch ◽

Thomas A. Holly ◽

Lilin She ◽

Gerald Maurer ◽

Jacek Myc ◽

...

Keyword(s):

Myocardial Viability ◽

Ischemic Cardiomyopathy ◽

Structure And Function ◽

Cardiac Structure ◽

Echocardiographic Parameters ◽

Cardiac Structure And Function ◽

Stich Trial ◽

And Function

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Five-year changes in cardiac structure and function in patients with rheumatoid arthritis compared with the general population

International Journal of Cardiology ◽

10.1016/j.ijcard.2017.03.108 ◽

2017 ◽

Vol 240 ◽

pp. 379-385 ◽

Cited By ~ 17

Author(s):

John M. Davis ◽

Grace Lin ◽

Jae K. Oh ◽

Cynthia S. Crowson ◽

Sara J. Achenbach ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

General Population ◽

Structure And Function ◽

Cardiac Structure ◽

Cardiac Structure And Function ◽

And Function

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P3569The effect of percutaneous renal revascularization upon cardiac structure and function in patients with significant atherosclerotic renal artery stenosis

European Heart Journal ◽

10.1093/eurheartj/ehz745.0431 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

D O Geavlete ◽

C Beladan ◽

D Deleanu ◽

M R Zaharia ◽

O Tautu ◽

...

Keyword(s):

Renal Artery ◽

Solitary Kidney ◽

Study Groups ◽

Structure And Function ◽

Cardiac Structure ◽

Renal Revascularization ◽

Echocardiographic Parameters ◽

Cardiac Geometry ◽

Cardiac Structure And Function ◽

And Function

Abstract Introduction Different consequences concerning the cardiac function and structure in patients with renal artery stenosis (RAS) and completely different patterns of activation of the renin-angiotensin-aldosteron system were reported, depending on RAS severity. These changes might have an impact upon the outcomes after renal revascularization. Purpose The study was aimed to analyze the effect of renal stenting upon echocardiographic parameters of cardiac structure and function in the studied population and by comparison between 3 different RAS-profile patients. Methods A total of 78 hypertensive patients diagnosed by renal angiography with significant RAS (>70%) were prospectively enrolled, thus subsequently resulting in 3 groups (34-unilateral RAS, 28-bilateral RAS, 14-RAS in a solitary kidney). Clinical, laboratory and echocardiographic parameters (left ventricular (LV) dimensions, LV mass index (LVMI), relative wall thickness (RWT), type of cardiac geometry, systolic and diastolic function, LV filling pressures) were assessed before renal stenting and 12 months after the procedure. The evolution of renal function was based on the glomerular filtration rate (eGFRCKD-EPI). Blood pressure evolution after revascularization was defined as cured, controlled, improved or stationary. Results Similar baseline characteristics were found for the 3 study groups regarding demographics, cardiovascular risk factors, baseline LV diameters, RWT and LVMI (p>0.05), although higher values of echocardiographic parameters were observed in solitary kidney RAS patients. Only 9.6% of all cases had normal geometry, the majority of the patients presenting concentric hypertrophy (58.9%) of similar proportions in the defined groups. Analyzing variations of echocardiographic parameters before and 12 months after stenting confirmed significant changes in all structural parameters (LV walls dimensions, LVMI, RWT, p<0.05), with significant differences between the 3 study groups. The most favorable evolution after revascularization was observed in bilateral-RAS patients (significant decreased cardiac mass, p=0.018), while RAS in a solitary kidney was associated with non-significant changes of the analyzed parameters. The evaluation of cardiac geometry evolution 12 month after renal stenting showed a stationary cardiac remodeling profile (p>0.05). Conclusions The current analysis showed favorable outcomes after renal angioplasty with stent in RAS patients with regard to structural changes of the LV (regression of LVMI, RWT). However, the impact of these beneficial changes did not have the magnitude for producing a significant effect upon cardiac geometry one year after renal revascularization.

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