Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies

Introduction: Vitamin D deficiency has become quite prevalent and is known to cause a great many diseases. Numerous studies have investigated the association between vitamin D deficiency and gestational diabetes, and the results are somewhat contradictory. The present study deals with the relationship between the vitamin D deficiency and gestational diabetes. Methods: Two researchers made use of MeSH, Scopus, PubMed database, Science Direct, the Cochrane Library, the Web of Science, CINAHL, and Google Scholar search engines to identify qualified studies and articles carried out and published before August 2017 and reported the risk of gestational diabetes developing as a result of vitamin D deficiency. The association between the two conditions was measured using odds ratios (ORs) with 95% confidence intervals (CIs). Funnel plots, Egger’s, and Begg’s tests were also used to assess publication bias. All analysis was done by STATA (version 11.2). Results: Twenty-nine eligible studies with a total of 14,497 participants were included in the final analysis. Overall, maternal vitamin D insufficiency was significantly associated with a greater risk of gestational diabetes (OR = 1.15; 95% CI, 1.00-1.30; p<0.001). Serum 25OHD was significantly lower in participants with gestational diabetes mellitus than in those with natural glucose tolerance (−29.7 nmol/L, 95% CI, −36.6 to −22.8; p=0.000). Conclusion: According to the current meta-analysis results, vitamin D deficiency is correlated with the risk of gestational diabetes development.

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The Role of Vitamin D in the Development of Diabetes Post Gestational Diabetes Mellitus: A Systematic Literature Review

Nutrients ◽

10.3390/nu12061733 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1733

Author(s):

Amélie Keller ◽

Carmen Varela Vazquez ◽

Rojina Dangol ◽

Peter Damm ◽

Berit Lilienthal Heitmann ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Literature Review ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Systematic Literature Review ◽

Observational Studies ◽

Vitamin D Supplementation ◽

Diabetes Development ◽

High Degree

Women diagnosed with gestational diabetes mellitus (GDM) are more likely to later develop diabetes. Evidence from some previous reviews suggests that low vitamin D status during pregnancy increases the risk of developing GDM, but whether vitamin D during pregnancy also influences the risk of diabetes post GDM is less well studied. Thus, the aim of this systematic literature review was to summarize the current available literature on that topic. This review considered observational studies and randomized controlled trials (RCTs). Five databases were searched. The risk of bias of the included studies was assessed. A total of six studies were included: three observational studies and three RCTs. Findings were inconsistent across the six included studies. However, when considering RCTs only, the findings more strongly suggested that vitamin D supplementation during and after pregnancy did not have an influence on markers of diabetes development or diabetes development post GDM. This systematic review highlights inconsistent findings on the associations between vitamin D supplementation or concentration during and after pregnancy and markers of diabetes development or diabetes development post GDM; and although results from randomized interventional studies more strongly suggested no associations, the conclusion holds a high degree of uncertainty.

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Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20170551 ◽

2017 ◽

Vol 6 (3) ◽

pp. 890 ◽

Cited By ~ 1

Author(s):

Ankita Kumari ◽

Shaila Mitra ◽

Harish C Tiwari ◽

Reena Srivastav

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Health Concern ◽

Control Group ◽

The Impact

Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

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The association between gestational diabetes mellitus and cancer in women: A systematic review and meta-analysis of observational studies

Diabetes & Metabolism ◽

10.1016/j.diabet.2020.02.003 ◽

2020 ◽

Vol 46 (6) ◽

pp. 461-471 ◽

Cited By ~ 1

Author(s):

Y. Wang ◽

P. Yan ◽

T. Fu ◽

J. Yuan ◽

G. Yang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Observational Studies ◽

Meta Analysis

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Vitamin D deficiency in gestational diabetes mellitus and the role of the placenta

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2013.08.015 ◽

2013 ◽

Vol 209 (6) ◽

pp. 560.e1-560.e8 ◽

Cited By ~ 24

Author(s):

Geum Joon Cho ◽

Soon-Cheol Hong ◽

Min-Jeong Oh ◽

Hai-Joong Kim

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency

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Relationship between mean platelet volume and vitamin D deficiency in gestational diabetes mellitus

Archives of Endocrinology and Metabolism ◽

10.1590/2359-3997000000063 ◽

2015 ◽

Vol 59 (5) ◽

pp. 448-454 ◽

Cited By ~ 3

Author(s):

Esra Bahar Gur ◽

Muammer Karadeniz ◽

Mine Genc ◽

Fatma Eskicioglu ◽

Murat Yalcin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Mean Platelet Volume ◽

Platelet Volume

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Vitamin D status and risk factors among pregnancy of shanghai in China

10.21203/rs.3.rs-244871/v1 ◽

2021 ◽

Author(s):

chun yang ◽

Jing Wu ◽

Sheng Ge ◽

Wenguang Sun

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Vitamin D ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Vitamin D Deficiency ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Vitamin D Status

Abstract Background This study was to assess vitamin D nutritional status and risk factors among pregnancy of shanghai in China. Methods A cross-sectional study conducted in the Sixth Affiliated People’s Hospital of Shanghai Jiao Tong University. All pregnancy was measured for plasma vitamin D, total blood cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL) or very-low-density lipoprotein (VLDL) cholesterol and triglycerides, and completed OGTTs test. Age, height, and weight variables came from their electronic medical records. Criteria for vitamin D status were: <12 ng/ml: severe deficiency; 12–19 ng/ml: deficiency; 20–29 ng/ml: insufficiency; 30–50 ng/ml: normal; and > 50 ng/ml (particularly > 60 ng/ml): possibly leading to adverse effects. Vitamin D was measured from December 2016 to April 2017. Results Our study included 953 pregnant women. The mean vitamin D level of pregnancy was 16.06 (range 10.90 to 20.60) ng/ml,and severe vitamin D deficiency was 31.79%(303); vitamin D deficiency was 40.71 %(388); vitamin D insufficiency was 25.08%(239); normal vitamin D was 2.42%(23). Vitamin D deficiency risk factors were age over 30, parity over 2, overweight, obese, gestational diabetes mellitus, and hyperglycemia. Conclusions It is a high prevalence of vitamin D deficiency of Chinese pregnancy in shanghai. Aging more than 30 years, the parity of more than 2, overweight and obesity, gestational diabetes mellitus and hyperglycemia are risk factors for vitamin D deficiency. Public health strategies should focus on the population of pregnancy in shanghai in China.

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