scholarly journals Complications of Pregnancy and the Risk of Developing Endometrial or Ovarian Cancer: A Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yang Liu ◽  
Xingyu Chen ◽  
Jiayi Sheng ◽  
Xinyi Sun ◽  
George Qiaoqi Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Endometrial Cancer ◽  
Case Control Study ◽  
Gynecological Cancer ◽  
Case Control ◽  
Control Group ◽  
Age At First Birth ◽  
Increased Risk ◽  
History Of ◽  
Control Study

BackgroundThe association of complications of pregnancy and the risk of developing gynecological cancer is controversial with the limited study. In this study, we investigated the association of preeclampsia, or gestational diabetes mellitus (GDM), or large for gestational age (LGA), or intrauterine growth restriction (IUGR) and the risk of endometrial or ovarian cancer.MethodsIn this case-control study, 189 women with endometrial cancer and 119 women with ovarian cancer were included. 342 women without gynecological cancers were randomly selected as a control group. Data on the history of pregnancy and age at diagnosis of gynecological cancer as well as the use of intrauterine devices (IUDs) were collected.ResultsWomen with a history of preeclampsia or IUGR did not have an increased risk of developing endometrial or ovarian cancer. While women with a history of GDM or with the delivery of LGA infant increased the risk of developing endometrial cancer but not ovarian cancer. The odds of women with a history of GDM or with the delivery of LGA infant developing endometrial cancer was 2.691 (95% CI: 1.548, 4.3635, p=0.0003), or 6.383 (95% CI: 2.812, 13.68, p<0.0001) respectively, compared to the controls. The odds ratio of women who did not use IUDs developing ovarian cancer was 1.606 (95% CI: 1.057, 2.434), compared to the controls. There was no association of age at first birth and developing endometrial or ovarian cancer.ConclusionOur observational data suggested that GDM and delivery of an LGA infant are associated with an increased risk of endometrial cancer.

Laparoscopy compared with laparotomy for comprehensive surgical staging of early ovarian cancer: Results of a retrospective multicenter case-control study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 6067-6067
Author(s):  
Julia Caroline Radosa ◽  
Marc P Radosa ◽  
Pauline Mertke ◽  
Marie-Luise Hugo ◽  
Christoph Georg Radosa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Surgical Staging ◽  
Control Group ◽  
Increased Risk ◽  
Duration Of Surgery ◽  
Early Ovarian Cancer ◽  
Control Study

6067 Background: The objective of this study was to compare laparoscopy and laparotomy for comprehensive surgical staging of early ovarian cancer in terms of efficacy and oncologic safety. Methods: Patients who had laparoscopic staging for early stage (I/II) ovarian cancer between 01/2000 and 10/2018 at the participating sites (Gynecologic comprehensive cancer centers with respective expertise in minimal invasive surgery) were included in this retrospective case-control study. The control group consisted of all patients treated via laparotomy during the study period. Clinical data were abstracted from medical record and recent follow up information were obtained. Comparisons were made between patients regarding surgical parameters and oncologic outcome and multivariate models were used to identify factors independently associated with disease recurrence. Results: Among 313 patients, staging was performed via laparoscopy in 208 (66 %) patients and via laparotomy in 105 (34 %) patients. Patients staged laparoscopically were younger (median 52 (15-86) vs. 59 (17-92) vears, p≤0.01) and had a lower BMI (24.4 (16.5-46.8) vs. 26 (15.5-53.8), p≤0.01). Regarding surgical parameters, duration of surgery was longer (291 (159-778) vs. 277 (159-690) minutes, p≤0.01), postoperative hospitalization was shorter (7 (0-27) vs. 9 (0-92) days, p≤0.01) and postoperative complications were lower in the laparoscopy group. On univariate analysis there were no differences in rates of tumor stage according to FIGO, intraoperative rupture of ovarian cysts (14 % vs. 13 %, p=0.87), number of lymph nodes removed (24 (0-89) vs. 22 (0-96), p=0.81) or any recurrence of disease (14 % vs. 16 %, p=0.52). At a median follow-up of 46 months (0-227), there were no differences in DFS and OS by surgical technique (5yr DFS 82 % (SE 0.04) vs. 83 % (SE 0.05), p=0.43; OS 91 % (SE 0.03) vs. 87 % (SE 0.04), p=0.87). On multivariate analysis route of surgery was not associated with an increased risk of recurrence. Conclusions: According to this preliminary analysis, laparoscopic surgical staging in patients with early ovarian cancer seems to be adequate and safe, but a longer follow-up and prospective data are needed to enhance evidence on oncologic outcomes.

scholarly journals Risk of meningioma associated with exposure of hormonal contraception. A case control study

2018 ◽  
Vol 26 (1) ◽  
pp. 36
Author(s):  
Joni Wahyuhadi ◽  
Dini Heryani ◽  
Hari Basuki
Keyword(s):  
Contraceptive Use ◽  
Case Control Study ◽  
Hormonal Contraception ◽  
Hormonal Contraceptive ◽  
Case Control ◽  
Control Group ◽  
Contraceptive Pills ◽  
Increased Risk ◽  
History Of ◽  
Control Study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use >10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

scholarly journals Association of CCL5 rs2107538, and CCL2 rs3760396 Gene Pol-ymorphisms with the Risk of Cardiovascular Disease

2021 ◽  
Author(s):  
Naser Mohtavinejad ◽  
Alireza Nakhaee ◽  
Honey Harati ◽  
Nazila Gholipour ◽  
Yavar Mahmoodzade
Keyword(s):  
Haplotype Analysis ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Large Sample Size ◽  
Increased Risk ◽  
History Of ◽  
Cc Chemokines ◽  
Pcr Method ◽  
Control Study

Background: Chemokines are proinflammatory cytokines that play key roles in development of cardiovascular diseases (CVD). Chemokine-induced recruitment of peripheral leucocytes to tissues is a crucial step in the CVD progression. CC chemokines ligand 5, 2 (CCL5 and CCL2), have been characterized as emerging inflammatory biomarkers of atherosclerotic CVD. The aim of this study was to find out whether genetic polymorphisms of CCL5 -403 G>A (rs2107538) and CCL2 –927 G>C, (rs3760396) were associated with the risk of CVD. Methods: In this case-control study, 500 Iranian individuals including 250 CVD patients and 250 healthy subjects as the control group participated in 2017. Genotyping of CCL5 -403 G>A and CCL2 –927 G>C polymorphisms were executed using Tetra-ARMS PCR method. Results: At genotypic level both CCL5 -403 G>A and CCL2 –927 G>C polymorphisms were not associated with the risk of CVD (P>0.05), even after adjustment by age, sex, race, and history of hypertension, DM and smoking. However, the CCL2 –927 C allele was associated with an increased risk of CVD (OR=1.42, P=0.050) with a higher prevalence in CVD patient than in controls (17% vs. 12%). Moreover, the haplotype analysis revealed that CCL5/CCL2 haplotype (G/C) was a risk factor for CVD (OR=2.13, P=0.001), and that carriers of this haplotype were at 2.13-fold higher risk of CVD than subjects with G/G haplotype. Conclusion: CCL2 –927 C variant and CCL5/CCL2 haplotype (G/C) were associated with susceptibility to CVD, and were risk factors for CVD in our population but more studies with large sample size are recommended.

scholarly journals Risk of meningioma associated with exposure of hormonal contraception. A case control study

2018 ◽  
Vol 26 (1) ◽  
pp. 36
Author(s):  
Joni Wahyuhadi ◽  
Dini Heryani ◽  
Hari Basuki Basuki
Keyword(s):  
Contraceptive Use ◽  
Case Control Study ◽  
Hormonal Contraception ◽  
Hormonal Contraceptive ◽  
Case Control ◽  
Control Group ◽  
Contraceptive Pills ◽  
Increased Risk ◽  
History Of ◽  
Control Study

Objective: To identify the effect of hormonal contraceptive exposure to the occurrence of meningioma.Materials and Methods: This study, conducted in 2016, was a case-control study by collecting a group of cases comprising all patients diagnosed histopathologically with meningioma in 2012-2013 and treated in dr. Soetomo Hospital, Surabaya, Indonesia. Medical record data were analyzed and compared to control group of patients diagnosed with non-meningioma who underwent contrast head ct scan and direct interviews. We obtained 101 cases and 101 controls. Data were analyzed using univariate logistic regression test.Results: Based on the history of hormonal contraceptive use, patients who had history of hormonal contraceptive use had 12.31 times higher risk (p=0.000). In this study, those who had contraceptive injections for one month and used contraceptive pills had a meningioma risk lower than those who used injectables 3 months. Patients who used hormonal contraception more than 10 years had an increased risk for meningioma as much as 18.216 times (p=0.000). Histopathologically, we found a non-significant association between history of hormonal contraceptive use and the distribution of histopathology, but based on descriptive data showed it was found that the most histopatological meningioma was of the transitional type in cases group.Conclusion: There is a significant association between hormonal contraceptive use, the type of injectable hormonal contraception for 3 months, the duration of hormonal contraceptive use >10 years, and no significant association between meningioma grade and the history of hormonal contraception exposure.

scholarly journals Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Mariantonietta Pisaturo ◽  
Federica Calò ◽  
Antonio Russo ◽  
Clarissa Camaioni ◽  
Agnese Giaccone ◽  
...  
Keyword(s):  
Case Control Study ◽  
Severe Disease ◽  
Signs And Symptoms ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Moderate Disease ◽  
Increased Risk ◽  
History Of ◽  
Control Study

BackgroundThe aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia.Patients and MethodsIn a multicenter, observational, 1:2 matched case-control study all 23 patients with a history of dementia, hospitalized with a diagnosis of SARS-CoV-2 infection from February 28th 2020 to January 31st 2021 were enrolled. For each Case, 2 patients without dementia observed in the same period study, pair matched for gender, age (±5 years), PaO2/FiO2 (P/F) ratio at admission (<200, or >200), number of comorbidities (±1; excluding dementia) were chosen (Control group).ResultsThe majority of patients were males (60.9% of Cases and Controls) and very elderly [median age 82 years (IQR: 75.5–85) in the Cases and 80 (IQR: 75.5–83.75) in the Controls]. The prevalence of co-pathologies was very high: all the Cases and 43 (93.5%) Controls showed a Charlson comorbidity index of at least 2. During hospitalization the patients in the Case group less frequently had a moderate disease of COVID-19 (35 vs. 67.4%, p = 0.02), more frequently a severe disease (48 vs. 22%, p = 0.03) and more frequently died (48 vs. 22%, p = 0.03). Moreover, during coronavirus disease 2019 (COVID-19), 14 (60.8%) patients in the Case group and 1 (2.1%; p < 0.000) in the Control group showed signs and symptoms of delirium.ConclusionPatients with dementia are vulnerable and have an increased risk of a severe disease and death when infected with COVID-19.

Risk factors for basal cell carcinoma: Results from the case-control study

Open Medicine ◽  
2010 ◽  
Vol 5 (6) ◽  
pp. 666-673 ◽  
Author(s):  
Slavenka Janković ◽  
Nataša Maksimović ◽  
Janko Janković ◽  
Milena Ražnatović ◽  
Jelena Marinković ◽  
...  
Keyword(s):  
Risk Factors ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Increased Risk ◽  
History Of ◽  
Control Study

AbstractThe aim of the present case-control study was to assess the risk factors for Basal cell carcinoma (BCC) in the Montenegrin population. The study group was comprised of 100 consecutive patients with a diagnosis of BCC, while the control group consisted of patients who did not present skin cancer and who were individually matched to the cases by sex and age. The increased risk for BCC was associated with: the presence of nevi (odds ratio [OR] = 3.77; 95% confidence interval [CI] = 1.12–12.73), type of skin concerning to burn rather than to tan after repeated sun exposure in childhood or adolescence (OR = 3.14; 95% CI = 1.59–6.18), the skin reaction to burn after two or more hours of sunlight during childhood or adolescence (OR = 4.53; 95% CI = 2.37–8.63), the number of severe and painful sunburns during their lifetime(OR = 3.52; 95% CI = 1.68–7.38), outdoor work during the summer-time (OR = 2.73; 95% CI = 1.00–7.45), occupational exposure to chemicals (OR = 17.89; 95% CI = 2.82–113.52), history of eczema (OR = 4.17; 95% CI = 1.53–11.39), and history of previous BCC (OR = 3.86; 95% CI = 1.40–10.65). Our study confirms the role of environmental and constitutional factors in development of BCC.

scholarly journals Risk factors associated with early childhood caries – a case control study

2016 ◽  
Vol 31 (2) ◽  
pp. 83
Author(s):  
Marina De Deus Moura Lima ◽  
Zacarias Soares Brito-Neto ◽  
Heylane Oliveira Amaral ◽  
Cacilda Castelo Branco Lima ◽  
Marcoeli Silva de Moura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Factors Associated ◽  
History Of ◽  
Control Study ◽  
Childhood Caries

Objective: The aim of this study was to determine the risk factors associated with early childhood caries (ECC).Methods: It was an observational retrospective case-control study. The case group consisted of all patients diagnosed with ECC in the records of an active program of maternal and child care. The control group was composed of an equal number of children, matched for gender and age, who attended the program and did not have ECC. The process of data collection consisted of completing a pre-established schedule to analyse variables related to the mother/caregiver and child.Statisticalanalysis was performed using the chi-squared and odds ratio (OR), with alpha (α) = 0.05.Results: History of caries in the mother (OR=2.61; CI 95%=1.45-4.67) and father (OR=1.72; CI 95%=1.02-2.89) were key determinants in the child being diagnosed with ECC.Conclusions: The risk factors associated with ECC were the following: no oral hygiene acceptance, nocturnal feeding duration of more than 16 months, a daily intake of sugar greater than 4 times a day, a Baume type II maxillary arch, fewer than 3 consultations with the program, and a history of decay in the parents.

scholarly journals Suicide in Psychiatric Inpatients— A Case–Control Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Eberhard A. Deisenhammer ◽  
Elisa-Marie Behrndt-Bauer ◽  
Georg Kemmler ◽  
Christian Haring ◽  
Carl Miller
Keyword(s):  
Logistic Regression ◽  
Hospital Stay ◽  
Attempted Suicide ◽  
Case Control Study ◽  
Psychiatric Inpatients ◽  
Case Control ◽  
Increased Risk ◽  
Inpatient Suicide ◽  
History Of ◽  
Control Study

Objective: Psychiatric inpatients constitute a population at considerably increased risk for suicide. Identifying those at imminent risk is still a challenging task for hospital staff. This retrospective case–control study focused on clinical risk factors related to the course of the hospital stay.Method: Inpatient suicide cases were identified by linking the Tyrol Suicide Register with the registers of three psychiatric hospitals in the state. Control subjects were patients who had also been hospitalized in the respective psychiatric unit but had not died by suicide. Matching variables included sex, age, hospital, diagnosis, and admission date. The study period comprised 7 years. Data were analyzed by the appropriate two-sample tests and by logistic regression.Results: A total of 30 inpatient suicide cases and 54 control patients were included. A number of factors differentiated cases from controls; after correction for multiple testing, the following retained significance: history of aborted suicide, history of attempted suicide, history of any suicidal behavior/threats, suicidal ideation continuing during hospitalization, no development of prospective plans, no improvement of mood during the hospital stay, and leaving ward without giving notice. Logistic regression identified the latter three variables and history of attempted suicide as highly significant predictors of inpatient suicide.Conclusions: Preventive measures during hospitalization include thorough assessment of suicidal features, an emphasis on the development of future perspectives, and a review of hospital regulations for patients who want to leave the ward.

Inflammatory potential of diet and risk for hepatocellular cancer in a case–control study from Italy

2015 ◽  
Vol 115 (2) ◽  
pp. 324-331 ◽  
Author(s):  
Nitin Shivappa ◽  
James R. Hébert ◽  
Jerry Polesel ◽  
Antonella Zucchetto ◽  
Anna Crispo ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Case Control Study ◽  
Hepatocellular Cancer ◽  
Serum Markers ◽  
Case Control ◽  
Logistic Regression Models ◽  
Inflammatory Index ◽  
Increased Risk ◽  
History Of ◽  
Control Study

AbstractInflammation and diet have been suggested to be important risk factors for hepatocellular cancer (HCC). This Italian multicentre hospital-based case–control study conducted between 1999 and 2002 and including 185 cases with incident, histologically confirmed HCC, and 404 controls hospitalised for acute non-neoplastic diseases provided an opportunity to investigate the association between HCC and the dietary inflammatory index (DII). The DII was computed on the basis of dietary intake assessed 2 years before the date of interview by a validated sixty-three-item FFQ. Logistic regression models were used to estimate OR adjusted for age, sex, study centre, education, BMI, smoking, physical activity, serum markers of hepatitis B and C infection and energy intake. Energy adjustment for DII was performed using the residual method. Participants in the highest tertile of DII scores (i.e. with a more pro-inflammatory diet) had a higher risk for HCC (ORtertile 3 v, 1 2·43; 95 % CI 1·27, 4·68; Ptrend=0·03). When stratified by the presence or absence of hepatitis B/C infection and sex, DII was strongly associated with HCC in hepatitis B- and C-negative participants (ORtertile 3 v. 1 4·18; 95 % CI 1·53, 11·39; Ptrend=0·02) and among males (ORtertile 3 v. 1 3·60; 95 % CI 1·65, 7·87; Ptrend=0·001). These results indicate that a pro-inflammatory diet is associated with increased risk for HCC, in those without a history of hepatitis B/C infection and among males.

Case control study of hormone replacement therapy (HRT) and breast cancer in Japanese women

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10012-10012
Author(s):  
M. Takeuchi ◽  
T. Saeki ◽  
M. Sano ◽  
H. Sonoo ◽  
H. Honjo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Menopausal Status ◽  
Previous History ◽  
Case Control ◽  
Japanese Women ◽  
Sensitivity Analyses ◽  
Control Group ◽  
History Of ◽  
Control Study

10012 Background: Some prospective studies in US and UK (represented by Women’s Health Initiative and Million Women Study) show that HRT use may increase the risk of breast cancer. However, it is unclear whether or not this perspective is applicable to Japanese women, due to several factors such as the difference in incidence of breast cancer, difference in HRT prevalence, which are to be concerned in this study. To investigate the relationship between HRT use and breast cancer, a case-control study was conducted in Japan. Methods: We sent self-administered questionnaire to 4,500 cases who have a previous history of confirmed histological breast cancer and 4,500 controls who were selected according to the inclusion criteria. All the subjects were between age 45 and 69 at the time of enrollment. Among these subjects, 3,434 in case group and 2,427 in control group sent back their questionnaire (total 5,861). The datacenter was run in Kitasato Univ. and the statistical analysis was performed using SAS (version 9.1). Control was selected by considering the screening record for GI disease and respiratory disorders, with no previous history of breast cancer, gynecological and hormonal disease at the time of screening. We asked about past history of exposure to the factors supposed to be breast cancer-causing; previous or current use of HRT, age at diagnosis, academic background, BMI, lifestyle habits, age of menarche, birth history, history of breast feeding, family history, use of contraceptive agents and menopausal status. Results: As the main analysis result, 164 (5.0%) out of 3,316 cases and 253 (7.4%) out of 2355 controls had used HRT (Odds ratio 0.432 [95% CI 0.352–0.530]. Conclusions: The result of this study shows that HRT users were less likely to develop breast cancer than never users. However, in this study, there was a difference in the observation period for the past use of HRT between cases and controls. Considering the transition of HRT prevalence in Japan, there may be a possibility that this difference can be a cause of a serious bias for the main analysis result. Further sensitivity analyses are needed to evaluate the robustness of the findings and this point is under consideration. No significant financial relationships to disclose.

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