Case control study of hormone replacement therapy (HRT) and breast cancer in Japanese women

10012 Background: Some prospective studies in US and UK (represented by Women’s Health Initiative and Million Women Study) show that HRT use may increase the risk of breast cancer. However, it is unclear whether or not this perspective is applicable to Japanese women, due to several factors such as the difference in incidence of breast cancer, difference in HRT prevalence, which are to be concerned in this study. To investigate the relationship between HRT use and breast cancer, a case-control study was conducted in Japan. Methods: We sent self-administered questionnaire to 4,500 cases who have a previous history of confirmed histological breast cancer and 4,500 controls who were selected according to the inclusion criteria. All the subjects were between age 45 and 69 at the time of enrollment. Among these subjects, 3,434 in case group and 2,427 in control group sent back their questionnaire (total 5,861). The datacenter was run in Kitasato Univ. and the statistical analysis was performed using SAS (version 9.1). Control was selected by considering the screening record for GI disease and respiratory disorders, with no previous history of breast cancer, gynecological and hormonal disease at the time of screening. We asked about past history of exposure to the factors supposed to be breast cancer-causing; previous or current use of HRT, age at diagnosis, academic background, BMI, lifestyle habits, age of menarche, birth history, history of breast feeding, family history, use of contraceptive agents and menopausal status. Results: As the main analysis result, 164 (5.0%) out of 3,316 cases and 253 (7.4%) out of 2355 controls had used HRT (Odds ratio 0.432 [95% CI 0.352–0.530]. Conclusions: The result of this study shows that HRT users were less likely to develop breast cancer than never users. However, in this study, there was a difference in the observation period for the past use of HRT between cases and controls. Considering the transition of HRT prevalence in Japan, there may be a possibility that this difference can be a cause of a serious bias for the main analysis result. Further sensitivity analyses are needed to evaluate the robustness of the findings and this point is under consideration. No significant financial relationships to disclose.

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An evaluation of the risk factors of breast cancer in women in Ilam Province: a case–control study based on hospital

Breast Cancer Management ◽

10.2217/bmt-2020-0026 ◽

2020 ◽

pp. BMT49

Author(s):

Shoboo Rahmati ◽

Milad Azami ◽

Zahra Jaafari ◽

Nasrin Pouratar ◽

Khairollah Asodollahi

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Case Control Study ◽

Menopausal Status ◽

Oral Contraceptive Pill ◽

Disease Status ◽

Case Control ◽

Case Group ◽

History Of ◽

Control Study

Aims: The present study aimed to identify the most associated risk factors of breast cancer in Ilam province in 2015–2016. Materials & methods: In this case–control study, the case group consisted of 50 women with breast cancer with a definitive diagnosis from date 23 September 2015 to 22 September 2016. The two groups were group matched in terms of age. Data were collected through interviews and medical records. Results: According to the results, there was a significant relationship between the disease status and variables of family history, history of irregular menstrual cycles, history of breastfeeding, menopausal status, history of oral contraceptive pill consumption, BMI, menarche and number of pregnancies (p < 0.05). Conclusion: Regarding decisive risk factors of breast cancer, more studies with larger sample sizes that take into account more risk factors are necessary.

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Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case–control study

Cancer Causes & Control ◽

10.1007/s10552-013-0181-5 ◽

2013 ◽

Vol 24 (5) ◽

pp. 1033-1044 ◽

Cited By ~ 15

Author(s):

Masaaki Kawai ◽

Yoichiro Kakugawa ◽

Yoshikazu Nishino ◽

Yohei Hamanaka ◽

Noriaki Ohuchi ◽

...

Keyword(s):

Breast Cancer ◽

Physical Activity ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Hormone Receptor ◽

Case Control Study ◽

Menopausal Status ◽

Case Control ◽

Japanese Women ◽

Control Study

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Risk factors associated with early childhood caries – a case control study

Revista Odonto Ciência ◽

10.15448/198-6523.2016.2.21496 ◽

2016 ◽

Vol 31 (2) ◽

pp. 83

Author(s):

Marina De Deus Moura Lima ◽

Zacarias Soares Brito-Neto ◽

Heylane Oliveira Amaral ◽

Cacilda Castelo Branco Lima ◽

Marcoeli Silva de Moura ◽

...

Keyword(s):

Risk Factors ◽

Early Childhood ◽

Early Childhood Caries ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Factors Associated ◽

History Of ◽

Control Study ◽

Childhood Caries

Objective: The aim of this study was to determine the risk factors associated with early childhood caries (ECC).Methods: It was an observational retrospective case-control study. The case group consisted of all patients diagnosed with ECC in the records of an active program of maternal and child care. The control group was composed of an equal number of children, matched for gender and age, who attended the program and did not have ECC. The process of data collection consisted of completing a pre-established schedule to analyse variables related to the mother/caregiver and child.Statisticalanalysis was performed using the chi-squared and odds ratio (OR), with alpha (α) = 0.05.Results: History of caries in the mother (OR=2.61; CI 95%=1.45-4.67) and father (OR=1.72; CI 95%=1.02-2.89) were key determinants in the child being diagnosed with ECC.Conclusions: The risk factors associated with ECC were the following: no oral hygiene acceptance, nocturnal feeding duration of more than 16 months, a daily intake of sugar greater than 4 times a day, a Baume type II maxillary arch, fewer than 3 consultations with the program, and a history of decay in the parents.

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Determinants of pregnancy-induced hypertension on maternal and foetal outcomes in Hossana town administration, Hadiya zone, Southern Ethiopia: Unmatched case-control study

PLoS ONE ◽

10.1371/journal.pone.0250548 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0250548

Author(s):

Getachew Ossabo Babore ◽

Tsegaye Gebre Aregago ◽

Tadesse Lelago Ermolo ◽

Mangistu Handiso Nunemo ◽

Teshome Tesfaye Habebo

Keyword(s):

Case Control Study ◽

Previous History ◽

Educational Status ◽

Case Control ◽

Health Facilities ◽

Sub Saharan Africa ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

History Of ◽

Control Study

Background Globally, 292,982 women die due to the complications of pregnancy and childbirth per year, out of those deaths 85% occurs in Sub Saharan Africa. In Ethiopia, pre-eclampsia accounts for 11% of direct maternal deaths. Objective To determine maternal and foetal outcomes of pregnancy-induced hypertension among women who gave birth at health facilities in Hossana town administration. Methods Institutional based unmatched case-control study was conducted among women, who gave birth at health facilities from May 20 to October 30, 2018. By using Epi-Info version 7; 207 sample size was estimated, for each case two controls were selected. Two health facilities were selected using a simple random sampling method. Sample sizes for each facility were allocated proportionally. All cleaned & coded data were entered into Epi-info version 3.5.1 and analysis was carried out using SPSS version 20. Multivariate analysis was performed to determine predictors of pregnancy-induced hypertension at a p-value of <0.05. Result Women between 18 to 41 years old had participated in the study with the mean age of 26.00(SD ±4.42), and 25.87(SD ±5.02) for cases and controls respectively. Out of participants 21(30.4%) among cases and 21(15.2%) among controls had developed at least one complication following delivery. 12 (17.4%) and 8 (5.7%) foetal deaths were found in cases and controls groups respectively whereas 15.6% from cases and 3.6% from controls groups women gave birth to the foetus with intra-uterine growth retardation. Women gravidity AOR = 0.32 [95% CI (0.12 0.86)], Previous history of pregnancy-induced hypertension AOR = 22.50 [95% CI (14.95 16.52)] and educational status AOR = 0.32[95% CI (0.12, 0.85)] were identified as predictor of pregnancy-induced hypertension. Conclusion Women with a previous history of pregnancy-induced hypertension had increased risk of developing pregnancy-induced hypertension, whilst ≥ 3 previous pregnancies and informal educational status decrease odds of developing pregnancy-induced hypertension.

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Risk of neurodegenerative dementia in asthma patients: a nested case–control study using a national sample cohort

BMJ Open ◽

10.1136/bmjopen-2019-030227 ◽

2019 ◽

Vol 9 (10) ◽

pp. e030227 ◽

Cited By ~ 1

Author(s):

So Young Kim ◽

Chanyang Min ◽

Dong Jun Oh ◽

Hyo Geun Choi

Keyword(s):

Case Control Study ◽

Previous History ◽

National Sample ◽

Case Control ◽

Region Of Residence ◽

Neurodegenerative Dementia ◽

Icd 10 ◽

History Of ◽

Nested Case Control ◽

Control Study

ObjectivesThis study investigated the risk of neurodegenerative dementia following asthma.DesignA nested case–control studySettingThe ≥60-year-old population was selected from the Korean Health Insurance Review and Assessment Service – National Sample Cohort from 2002 to 2013.Participants and interventionsThe 11 442 dementia cases were matched with 45 768 control cases for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Asthma was classified using International Classification of Disease-10 (ICD-10) codes (J45 and J46) and medication history. Dementia was identified based on ICD-10 codes (G30 and F00).Primary and secondary outcome measuresThe ORs of a previous history of asthma in patients with dementia were analysed using conditional logistic regression analysis stratified for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Subgroup analysis was performed according to age and sex.ResultsOverall, 22.6% (2587/11 442) and 22.3% (10 229/45 768) of the cases in the dementia and control groups, respectively, had a previous history of asthma. The OR for asthma in the dementia group was not higher than that in the control group (adjusted OR=0.97, 95% CI 0.92 to 1.02, p=0.207). All age and sex subgroups demonstrated consistent results.ConclusionsAsthma was not related to an increased risk of dementia.

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Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Nutrients ◽

10.3390/nu11081871 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1871 ◽

Cited By ~ 1

Author(s):

Jordana Carolina Marques Godinho-Mota ◽

Larissa Vaz Gonçalves ◽

Joao Felipe Mota ◽

Leonardo Ribeiro Soares ◽

Raquel Machado Schincaglia ◽

...

Keyword(s):

Breast Cancer ◽

Alcohol Consumption ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Sedentary Behavior ◽

Case Control Study ◽

Menopausal Status ◽

Case Control ◽

Alcoholic Beverages ◽

Control Study

Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.

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