scholarly journals The genetic mechanisms of the influence of the light regime on the lifespan of Drosophila melanogaster

2013 ◽  
Vol 3 ◽  
Author(s):  
O. A. Shostal ◽  
A. A. Moskalev
Keyword(s):  
Drosophila Melanogaster ◽  
Light Regime ◽  
Genetic Mechanisms

scholarly journals Combining metabolomics and experimental evolution reveals key mechanisms underlying longevity differences in laboratory evolved Drosophila melanogaster populations

2021 ◽  
Author(s):  
Mark Phillips ◽  
Kenneth R. Arnold ◽  
Zer Vue ◽  
Heather Beasley ◽  
Edgar Garza Lopez ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Carbohydrate Metabolism ◽  
Experimental Evolution ◽  
Statistical Power ◽  
Accelerated Aging ◽  
Experimental System ◽  
Tca Cycle ◽  
Dna And Rna ◽  
Metabolomic Data ◽  
Genetic Mechanisms

Experimental evolution with Drosophila melanogaster has been used extensively for decades to study aging and longevity. In recent years, the addition of DNA and RNA sequencing to this framework has allowed researchers to leverage the statistical power inherent to experimental evolution study the genetic basis of longevity itself. Here we incorporated metabolomic data into to this framework to generate even deeper insights into the physiological and genetic mechanisms underlying longevity differences in three groups of experimentally evolved D. melanogaster populations with different aging and longevity patterns. Our metabolomic analysis found that aging alters mitochondrial metabolism through increased consumption of NAD+ and increased usage of the TCA cycle. Combining our genomic and metabolomic data produced a list of biologically relevant candidate genes. Among these candidates, we found significant enrichment for genes and pathways associated with neurological development and function, and carbohydrate metabolism. While we do not explicitly find enrichment for aging canonical genes, neurological dysregulation and carbohydrate metabolism are both known to be associated with accelerated aging and reduced longevity. Taken together, our results in total provide very plausible genetic mechanisms for what might be driving longevity differences in this experimental system. More broadly, our findings demonstrate the value of combining multiple types of omic data with experimental evolution when attempting to dissect mechanisms underlying complex and highly polygenic traits like aging.

scholarly journals THE ROLE OF TRANSCRIPTION FACTORS DFOXO, DSIR2 AND HSP70 IN LIFESPAN ALTERATION OF DROSOPHILA MELANOGASTER IN DIFFERENT LIGHT CONDITIONS

2010 ◽  
Vol 8 (3) ◽  
pp. 67-80 ◽  
Author(s):  
Aleksey A Moskalev ◽  
Olga A Malysheva
Keyword(s):  
Drosophila Melanogaster ◽  
Transcription Factors ◽  
Stress Response ◽  
Life Span ◽  
Light Regime ◽  
Light Conditions ◽  
Wild Type ◽  
Stress Response Genes ◽  
Significant Difference

It was investigated the role of stress-response genes (dFOXO, dSir2, Hsp70) in regulation of life span of Drosophila in response to light regime alteration. It was revealed the FOXO-dependant mechanism of lifespan increasing at darkness conditions. The distance of lifespan of FOXO homozygous mutants at different light conditions were absent 3 times from 4 times. It was shown, that homozygotes with deletion of dSir2 have more significant difference between lifespan at standard light and darkness conditions with comparing to wild type and heterozygous strain. The same tendency was also detected the in the strains with Hsp70 deletions. It was produced the evidences of two mechanisms of light regime influence on lifespan: metabolism intensification at light conditions and neuroendocrine-determinated lifespan increasing at darkness conditions.

MULTIPLE GENETIC MECHANISMS FOR THE EVOLUTION OF SENESCENCE IN DROSOPHILA MELANOGASTER

Evolution ◽  
1988 ◽  
Vol 42 (4) ◽  
pp. 708-716 ◽  
Author(s):  
P. M. Service ◽  
E. W. Hutchinson ◽  
M. R. Rose
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Mechanisms

Multiple Genetic Mechanisms for the Evolution of Senescence in Drosophila melanogaster

Evolution ◽  
1988 ◽  
Vol 42 (4) ◽  
pp. 708 ◽  
Author(s):  
P. M. Service ◽  
E. W. Hutchinson ◽  
M. R. Rose
Keyword(s):  
Drosophila Melanogaster ◽  
Genetic Mechanisms

scholarly journals Drosophila as a Model System to Study Cell Signaling in Organ Regeneration

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Sara Ahmed-de-Prado ◽  
Antonio Baonza
Keyword(s):  
Drosophila Melanogaster ◽  
Signaling Pathways ◽  
Cell Fate ◽  
Cellular Responses ◽  
Model System ◽  
Signaling Networks ◽  
Cellular Processes ◽  
Organ Regeneration ◽  
Ability To Regenerate ◽  
Genetic Mechanisms

Regeneration is a fascinating phenomenon that allows organisms to replace or repair damaged organs or tissues. This ability occurs to varying extents among metazoans. The rebuilding of the damaged structure depends on regenerative proliferation that must be accompanied by proper cell fate respecification and patterning. These cellular processes are regulated by the action of different signaling pathways that are activated in response to the damage. The imaginal discs of Drosophila melanogaster have the ability to regenerate and have been extensively used as a model system to study regeneration. Drosophila provides an opportunity to use powerful genetic tools to address fundamental problems about the genetic mechanisms involved in organ regeneration. Different studies in Drosophila have helped to elucidate the genes and signaling pathways that initiate regeneration, promote regenerative growth, and induce cell fate respecification. Here we review the signaling networks involved in regulating the variety of cellular responses that are required for discs regeneration.

scholarly journals Identification of Genes Controlling Malpighian Tubule and Other Epithelial Morphogenesis in Drosophila melanogaster

Genetics ◽  
1999 ◽  
Vol 151 (2) ◽  
pp. 685-695
Author(s):  
Xuejun Liu ◽  
István Kiss ◽  
Judith A Lengyel
Keyword(s):  
Drosophila Melanogaster ◽  
Uric Acid ◽  
Malpighian Tubule ◽  
Model System ◽  
Epithelial Morphogenesis ◽  
Phenotypic Analysis ◽  
Genetic Pathway ◽  
Novel Gene ◽  
Genetic Mechanisms

Abstract The Drosophila Malpighian tubule is a model system for studying genetic mechanisms that control epithelial morphogenesis. From a screen of 1800 second chromosome lethal lines, by observing uric acid deposits in unfixed inviable embryos, we identified five previously described genes (barr, fas, flb, raw, and thr) and one novel gene, walrus (wal), that affect Malpighian tubule morphogenesis. Phenotypic analysis of these mutant embryos allows us to place these genes, along with other previously described genes, into a genetic pathway that controls Malpighian tubule development. Specifically, wal affects evagination of the Malpighian tubule buds, fas and thr affect bud extension, and barr, flb, raw, and thr affect tubule elongation. In addition, these genes were found to have different effects on development of other epithelial structures, such as foregut and hindgut morphogenesis. Finally, from the same screen, we identified a second novel gene, drumstick, that affects only foregut and hindgut morphogenesis.

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