scholarly journals Maternal Smoking During Pregnancy Induces Persistent Epigenetic Changes Into Adolescence, Independent of Postnatal Smoke Exposure and Is Associated With Cardiometabolic Risk

2019 ◽  
Vol 10 ◽  
Author(s):  
Sebastian Rauschert ◽  
Phillip E. Melton ◽  
Graham Burdge ◽  
Jeffrey M. Craig ◽  
Keith M. Godfrey ◽  
...  
Keyword(s):  
Maternal Smoking ◽  
Cardiometabolic Risk ◽  
Smoke Exposure ◽  
Epigenetic Changes ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy

scholarly journals Tobacco smoke exposure in early life and adolescence in relation to lung function

2018 ◽  
Vol 51 (6) ◽  
pp. 1702111 ◽  
Author(s):  
Jesse D. Thacher ◽  
Erica S. Schultz ◽  
Jenny Hallberg ◽  
Ulrika Hellberg ◽  
Inger Kull ◽  
...  
Keyword(s):  
Lung Function ◽  
Tobacco Smoke ◽  
Maternal Smoking ◽  
Airway Resistance ◽  
Adolescent Smoking ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy ◽  
The Impact

Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years.The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295).Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of −1.1% (95% CI −2.0 to −0.2%). IOS demonstrated greater resistance at 5–20 Hz (R5–20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of −0.9% (95% CI −1.8 to −0.1%) and increased resistance of 6.5 Pa·L–1·s (95% CI 0.7 to 12.2 Pa·L–1·s) in R5–20. Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using ≥12 ng·mL−1 as a cut-off for adolescent smoking.Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.

scholarly journals Maternal smoking during pregnancy affects adult onset of asthma in offspring: a follow up from birth to age 46 years

2020 ◽  
Vol 55 (6) ◽  
pp. 1901857 ◽  
Author(s):  
Sanna Toppila-Salmi ◽  
Annika T. Luukkainen ◽  
Baizhuang Xu ◽  
Jussi Lampi ◽  
Juha Auvinen ◽  
...  
Keyword(s):  
Cumulative Incidence ◽  
Maternal Smoking ◽  
Forced Expiratory Volume ◽  
Smoke Exposure ◽  
P Value ◽  
Adult Onset ◽  
Long Term Effects ◽  
Smoking During Pregnancy ◽  
Respiratory Problems ◽  
Maternal Smoking During Pregnancy

RationaleEnvironmental tobacco smoke (ETS) exposure increases asthma risk in children. There is limited knowledge of prenatal ETS for adult-onset asthma.ObjectivesTo determine the association between prenatal ETS and adult onset asthma.Measurements and main resultsThe questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by 31 years of age, who were included in the Northern Finland Birth Cohort 1966 Study was used. The association of maternal smoking during the last 3 months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring was studied using adjusted multivariate regression analyses. The cumulative incidence of physician-diagnosed asthma between the ages of 31 and 46 years was 5.1% among men and 8.8% among women. Gestational smoke exposure was associated with adult-onset asthma among offspring (adjusted OR 1.54, 95% CI 1.04–2.29), namely among offspring who reported either past non-diagnosed asthma (OR 9.63, 95% CI 2.28–40.67) or past cough with wheeze (3.21, 95% CI 1.71–6.05). A significant association was detected between gestational smoke exposure and the offspring's forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio at 31 years of age. In offspring with the haplotype rs11702779-AA of RUNX1, gestational smoke exposure was associated with adult-onset asthma (5.53, 95% CI 2.11–14.52, adjusted p-value for interaction 0.10).ConclusionMaternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between the ages of 31 and 46 years. The association was accentuated in offspring who at age 31, reported having past respiratory problems and/or who had haplotype rs11702779-AA. A reduction in FEV1/FVC ratio was also observed at age 31 years in offspring with gestational smoke exposure. These results could reflect the early vulnerability of offspring's airways to ETS and its putative long-term effects.

scholarly journals Are Suboptimal in utero Conditions Associated with Obesity and Cardiometabolic Risk Factors in Caucasian children?

2020 ◽  
Author(s):  
Soraya Saidj ◽  
Melanie Henderson ◽  
Stephanie-May Ruchat ◽  
Gilles Paradis ◽  
Andraea Van Hulst ◽  
...  
Keyword(s):  
Risk Factors ◽  
Waist Circumference ◽  
Maternal Smoking ◽  
Cardiometabolic Risk ◽  
In Utero ◽  
Cardiometabolic Risk Factors ◽  
Smoking During Pregnancy ◽  
High Waist Circumference ◽  
Hypertensive Disorders ◽  
Maternal Smoking During Pregnancy

AbstractObjectiveTo explore the association between in utero exposure to suboptimal gestational factors (SGF;gestational diabetes mellitus, hypertensive disorders during pregnancy, maternal smoking during pregnancy), childhood obesity, and cardiometabolic risk factors.MethodsData were obtained from the “ QUebec Adiposity and Lifestyle InvesTigation in Youth” longitudinal study (QUALITY) composed of 630 Caucasian children recruited at age 8–10 (first visit V1; n=619) and followed-up 2 years later (V2; n=557). Simple logistic regression models were used.ResultsIn the cohort, maternal smoking during pregnancy was associated with higher odds of obesity (OR1=2.00, 95% CI 1.25-3.20, OR2=2.29, 95% IC 1.26-4.16) at both visit and with high waist circumference (OR1=1.96, 95% IC 1.24-3.1) at V1. Hypertensive disorders during pregnancy were associated with higher odds of obesity (OR1=2.37, 95% CI 1.17-4.80) at visit 1. Joint exposure to SGF was associated with higher odds of high waist circumference (OR1=1.42, 95% CI 1.06-1.91) at V1, obesity (OR2= 1.63, 95% IC 1.153-2.32) at V2 and low level of HDL (OR2=1.45, 95% IC 1.04-2.03) at V2. Analysis’ stratification by sex revealed that boys were more adversely affected by exposure to combined SGF while girls were more affected by exposure to maternal smoking during pregnancy.ConclusionIn utero exposure to an independent or combined SGF is associated with adverse adipose and cardiometabolic profiles in children, with sex specificities.

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