scholarly journals Cognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Gao ◽  
Xue Shen ◽  
Randy Ko ◽  
Cong Huang ◽  
Changbing Shen
Keyword(s):  
Drug Development ◽  
Skin Disease ◽  
Cognitive Process ◽  
Normal Population ◽  
Genetic Associations ◽  
Inflammatory Skin Disease ◽  
Novel Therapy ◽  
The Past ◽  
Genetic Components ◽  
The World

Psoriasis (PsO) is a chronic inflammatory skin disease that affects approximately 2% of the population all over the world. Comorbidities of PsO have increasingly garnered more interest in the past decades. Compared with the normal population, the incidences of comorbidities are higher among patients with PsO. In the last 20 years, researchers have focused on studying the genetic components of PsO, and genetic associations between PsO and its comorbidities were elucidated. This review provides an in-depth understanding and summarization of the connection between PsO and its comorbidities from the perspectives of epidemiology and genetics. Further understanding of PsO and its comorbidities will promote research on the pathogenesis, drug development, novel therapy methods, and personalized and precision treatment of PsO and its comorbidities.

Extra-articular manifestations: psoriasis

2016 ◽  
Author(s):  
Wolf-Henning Boehncke ◽  
Dafna D. Gladman
Keyword(s):  
Psoriatic Arthritis ◽  
Skin Disease ◽  
Genetic Research ◽  
Skin Lesions ◽  
World Health ◽  
Current Status ◽  
Inflammatory Skin Disease ◽  
Psychosocial Burden ◽  
The World ◽  
Underlying Pathogenesis

Psoriasis is a chronic, recurrent inflammatory skin disease, affecting about 2% of the world’s population. In 2014, the World Health Organization’s member states adopted a resolution on psoriasis, recognizing it as ‘a chronic, non-communicable, painful, disfiguring, and disabling disease for which there is no cure’. The resolution acknowledges the psychosocial burden of the disease and that many people with psoriasis suffer due to lack of awareness and access to sufficient treatment. Psoriasis is a multifaceted disease including not only a variety of skin lesions, but also joint manifestations and comorbidities. This chapter focuses on the clinical features of psoriasis of the skin and its underlying pathogenesis, taking into account the current status of genetic research in the field. It also describes psoriatic arthritis, as well as the association of psoriasis with spondyloarthritis.

A basic introduction to image processing using NIH-Image as a model

1994 ◽  
Vol 52 ◽  
pp. 392-393
Author(s):  
John Mansfield
Keyword(s):  
Image Processing ◽  
Digital Image ◽  
Image Acquisition ◽  
Digital Instrument ◽  
Novice User ◽  
Nih Image ◽  
The Past ◽  
Digital World ◽  
The World ◽  
Instrument Control

Advances in camera technology and digital instrument control have meant that in modern microscopy, the image that was, in the past, typically recorded on a piece of film is now recorded directly into a computer. The transfer of the analog image seen in the microscope to the digitized picture in the computer does not mean, however, that the problems associated with recording images, analyzing them, and preparing them for publication, have all miraculously been solved. The steps involved in the recording an image to film remain largely intact in the digital world. The image is recorded, prepared for measurement in some way, analyzed, and then prepared for presentation.Digital image acquisition schemes are largely the realm of the microscope manufacturers, however, there are also a multitude of “homemade” acquisition systems in microscope laboratories around the world. It is not the mission of this tutorial to deal with the various acquisition systems, but rather to introduce the novice user to rudimentary image processing and measurement.

Changes in CD44 isoform expression during inflammatory skin disease

1997 ◽  
Vol 22 (03) ◽  
pp. 128-133
Author(s):  
A.J. HARRIS ◽  
D. DEAN ◽  
S. BURGE ◽  
F. WOJNAROWSKA
Keyword(s):  
Skin Disease ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin ◽  
Isoform Expression

On the Symbolism of Rain in A Farewell to Arms

2018 ◽  
Keyword(s):  
Research Tool ◽  
The Past ◽  
The World ◽  
Farewell To Arms

This paper critically analyzes the symbolic use of rain in A Farewell to Arms (1929). The researcher has applied the Sapir-Whorf Hypothesis as a research tool for the analysis of the text. This hypothesis argues that the languages spoken by a person determine how one observes this world and that the peculiarities encoded in each language are all different from one another. It affirms that speakers of different languages reflect the world in pretty different ways. Hemingway’s symbolic use of rain in A Farewell to Arms (1929) is denotative, connotative, and ironical. The narrator and protagonist, Frederick Henry symbolically embodies his own perceptions about the world around him. He time and again talks about rain when something embarrassing is about to ensue like disease, injury, arrest, retreat, defeat, escape, and even death. Secondly, Hemingway has connotatively used rain as a cleansing agent for washing the past memories out of his mind. Finally, the author has ironically used rain as a symbol when Henry insists on his love with Catherine Barkley while the latter being afraid of the rain finds herself dead in it.

Profilometry. Using Corneo-scleral topography for scleral lens fitting

The Eye ◽  
2019 ◽  
Vol 21 (128) ◽  
pp. 19-22
Author(s):  
Gregory DeNaeyer
Keyword(s):  
Ocular Surface ◽  
World Wide ◽  
Contact Lenses ◽  
The Past ◽  
The World ◽  
The Future ◽  
The Way

The world-wide use of scleral contact lenses has dramatically increased over the past 10 year and has changed the way that we manage patients with corneal irregularity. Successfully fitting them can be challenging especially for eyes that have significant asymmetries of the cornea or sclera. The future of scleral lens fitting is utilizing corneo-scleral topography to accurately measure the anterior ocular surface and then using software to design lenses that identically match the scleral surface and evenly vault the cornea. This process allows the practitioner to efficiently fit a customized scleral lens that successfully provides the patient with comfortable wear and improved vision.

Aftershocks

2017 ◽  
Author(s):  
Seva Gunitsky
Keyword(s):  
Twentieth Century ◽  
Regime Change ◽  
International System ◽  
Political Legitimacy ◽  
Great Powers ◽  
Past Century ◽  
The Past ◽  
Sudden Rise ◽  
The World ◽  
National Borders

Over the past century, democracy spread around the world in turbulent bursts of change, sweeping across national borders in dramatic cascades of revolution and reform. This book offers a new global-oriented explanation for this wavelike spread and retreat—not only of democracy but also of its twentieth-century rivals, fascism, and communism. The book argues that waves of regime change are driven by the aftermath of cataclysmic disruptions to the international system. These hegemonic shocks, marked by the sudden rise and fall of great powers, have been essential and often-neglected drivers of domestic transformations. Though rare and fleeting, they not only repeatedly alter the global hierarchy of powerful states but also create unique and powerful opportunities for sweeping national reforms—by triggering military impositions, swiftly changing the incentives of domestic actors, or transforming the basis of political legitimacy itself. As a result, the evolution of modern regimes cannot be fully understood without examining the consequences of clashes between great powers, which repeatedly—and often unsuccessfully—sought to cajole, inspire, and intimidate other states into joining their camps.

The Tyranny of the Ideal

2018 ◽  
Author(s):  
Gerald Gaus
Keyword(s):  
Political Philosophy ◽  
Moral Life ◽  
Moral Inquiry ◽  
Open Society ◽  
The Past ◽  
Theories Of Justice ◽  
The World ◽  
Diverse Society ◽  
Just Society ◽  
The Ideal

This book lays out a vision for how we should theorize about justice in a diverse society. It shows how free and equal people, faced with intractable struggles and irreconcilable conflicts, might share a common moral life shaped by a just framework. The book argues that if we are to take diversity seriously and if moral inquiry is sincere about shaping the world, then the pursuit of idealized and perfect theories of justice—essentially, the entire production of theories of justice that has dominated political philosophy for the past forty years—needs to change. Drawing on recent work in social science and philosophy, the book points to an important paradox: only those in a heterogeneous society—with its various religious, moral, and political perspectives—have a reasonable hope of understanding what an ideally just society would be like. However, due to its very nature, this world could never be collectively devoted to any single ideal. The book defends the moral constitution of this pluralistic, open society, where the very clash and disagreement of ideals spurs all to better understand what their personal ideals of justice happen to be. Presenting an original framework for how we should think about morality, this book rigorously analyzes a theory of ideal justice more suitable for contemporary times.

Development of Dermatological Skin Disease Detection and Classification based on Wavelet and ANN

2018 ◽  
Vol 8 (5) ◽  
pp. 10
Author(s):  
Revati Kadu ◽  
U. A. Belorkar
Keyword(s):  
Neural Network ◽  
Artificial Neural Network ◽  
Skin Disease ◽  
Skin Diseases ◽  
Screening Method ◽  
Phase Detection ◽  
Statistical Measures ◽  
The World ◽  
Artificial Neural ◽  
Wavelet Techniques

One of the most common and augmenting health problems in the world are related to skin. The most  unpredictable and one of the most difficult entities to automatically detect and evaluate is the human skin disease because of complexities of texture, tone, presence of hair and other distinctive features. Many cases of skin diseases in the world have triggered a need to develop an effective automated screening method for detection and diagnosis of the area of disease. Therefore the objective of this work is to develop a new technique for automated detection and analysis of the skin disease images based on color and texture information for skin disease screening. In this paper, system is proposed which detects the skin diseases using Wavelet Techniques and Artificial Neural Network. This paper presents a wavelet-based texture analysis method for classification of five types of skin diseases. The method applies tree-structured wavelet transform on different color channels of red, green and blue dermoscopy images, and employs various statistical measures and ratios on wavelet coefficients. In all 99 unique features are extracted from the image. By using Artificial Neural Network, the system successfully detects different types of dermatological skin diseases. It consists of mainly three phases image processing, training phase, detection  and classification phase.

History of Tour de France from the Geographical Point of View

2013 ◽  
Vol 22 (3-4) ◽  
pp. 255-277 ◽  
Author(s):  
Vladimír Bačík ◽  
Michal Klobučník
Keyword(s):  
Point Of View ◽  
The Past ◽  
Advanced Technologies ◽  
The World ◽  
Spatial Dimensions ◽  
Tour De France ◽  
Wide Circle ◽  
History Of ◽  
Expert Community ◽  
Geographical Point

Abstract The Tour de France, a three week bicycle race has a unique place in the world of sports. The 100th edition of the event took place in 2013. In the past of 110 years of its history, people noticed unique stories and duels in particular periods, celebrities that became legends that the world of sports will never forget. Also many places where the races unfolded made history in the Tour de France. In this article we tried to point out the spatial context of this event using advanced technologies for distribution of historical facts over the Internet. The Introduction briefly displays the attendance of a particular stage based on a regional point of view. The main topic deals with selected historical aspects of difficult ascents which every year decide the winner of Tour de France, and also attract fans from all over the world. In the final stage of the research, the distribution of results on the website available to a wide circle of fans of this sports event played a very significant part (www.tdfrance.eu). Using advanced methods and procedures we have tried to capture the historical and spatial dimensions of Tour de France in its general form and thus offering a new view of this unique sports event not only to the expert community, but for the general public as well.

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