scholarly journals Case Report: Pansclerotic Morphea-Clinical Features, Differential Diagnoses and Modern Treatment Concepts

2021 ◽  
Vol 12 ◽  
Author(s):  
Sarah Ventéjou ◽  
Agnes Schwieger-Briel ◽  
Rebecca Nicolai ◽  
Stephanie Christen-Zaech ◽  
Caroline Schnider ◽  
...  
Keyword(s):  
Differential Diagnoses ◽  
Localized Scleroderma ◽  
Case Review ◽  
Review Of The Literature ◽  
Good Clinical Response ◽  
Skin Changes ◽  
Superficial Skin ◽  
Systemic Glucocorticoids ◽  
Treatment Concepts ◽  
Promising Treatment

Pansclerotic morphea (PSM) is a rare skin disease characterized by progressive stiffening of the skin with or without the typical superficial skin changes usually seen in morphea (localized scleroderma). Standard therapy, consisting of a combination of systemic glucocorticoids and methotrexate or mycophenolate mofetil, does rarely stop disease progression, which may lead to severe cutaneous sclerosis and secondary contractures. Little is known about the efficacy of newer biologicals such as abatacept, a fusion protein antibody against CTLA-4, or tocilizumab, a fully humanized IL-6R antibody, in the treatment of this pathology. We present the case of an 8 years old girl with an unusual, progressive stiffening of the skin, which was eventually diagnosed as pansclerotic morphea. A treatment with systemic glucocorticoids and methotrexate combined with tocilizumab led to a good clinical response within 2 months after initiation. In this paper, we discuss differential diagnoses to be considered and this new promising treatment option based on a case review of the literature.

Tuberculosis amigdalina con foco pulmonar activo en un paciente VHI. A Propósito de un Caso.

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Alex Lara Jácome ◽  
Luis Mogrovejo Freire ◽  
Guillermo Freire Castro ◽  
Rosaura Bravo Pita ◽  
Omar Barragán Cabezas ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Clinical Manifestations ◽  
Morbidity And Mortality ◽  
Differential Diagnoses ◽  
Hiv Positive ◽  
Review Of The Literature ◽  
Detailed Review ◽  
Primary Tuberculosis ◽  
The World ◽  
Pulmonary Focus

Tuberculosis is one of the most serious infectious problems in the world, it represents one of the main causes of global morbidity and mortality. Primary tuberculosis of the oral cavity and oropharynx is quite rare. In this article, we describe a case of a 38-year-old woman who has been HIV positive for two years with a diagnosis of tonsillar tuberculosis with an active pulmonary focus. Clinical manifestations, difficulty of diagnosis, differential diagnoses are considered. A detailed review of the literature on tonsillar tuberculosis is also included. Palabras claves: amígdala, tuberculosis, VHI

scholarly journals Localized scleroderma progressing to systemic disease. case report and review of the literature

1993 ◽  
Vol 36 (3) ◽  
pp. 410-415 ◽  
Author(s):  
Nina Birdi ◽  
Ronald M. Laxer ◽  
Paul Thorner ◽  
Marvin J. Fritzler ◽  
Earl D. Silverman
Keyword(s):  
Case Report ◽  
Systemic Disease ◽  
Localized Scleroderma ◽  
Review Of The Literature ◽  
Disease Case

scholarly journals Dedifferentiated Melanoma: A Diagnostic Histological Pitfall! Review of the Literature with Case Presentation

2021 ◽  
Vol 8 (4) ◽  
pp. 494-501
Author(s):  
Gerardo Cazzato ◽  
Lucia Lospalluti ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Paolo Romita ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Clinical Outcome ◽  
Differential Diagnoses ◽  
Review Of The Literature ◽  
Therapeutic Approaches ◽  
Case Presentation ◽  
Diagnostic Difficulties ◽  
Genetic Signatures ◽  
Morphological Patterns

Dedifferentiated melanoma is a particular form of malignant melanoma with a progressive worsening of the patient’s clinical outcome. It is well known that melanoma can assume different histo-morphological patterns, to which specific genetic signatures correspond, sometimes but not always. In this review we address the diagnostic difficulties in correctly recognizing this entity, discuss the major differential diagnoses of interest to the dermatopathologist, and conduct a review of the literature with particular attention and emphasis on the latest molecular discoveries regarding the dedifferentiation/undifferentiation mechanism and more advanced therapeutic approaches.

scholarly journals Shunt Overdrainage: Reappraisal of the Syndrome and Proposal for an Integrative Model

2021 ◽  
Vol 10 (16) ◽  
pp. 3620
Author(s):  
Bienvenido Ros ◽  
Sara Iglesias ◽  
Jorge Linares ◽  
Laura Cerro ◽  
Julia Casado ◽  
...  
Keyword(s):  
Individual Case ◽  
Integrative Model ◽  
Review Of The Literature ◽  
Management Options ◽  
Pathophysiological Mechanisms ◽  
Treatment Concepts ◽  
Craniocerebral Disproportion ◽  
Insight Into ◽  
Cranial Expansion

Although shunt overdrainage is a well-known complication in hydrocephalus management, the problem has been underestimated. Current literature suggests that the topic requires more examination. An insight into this condition is limited by a lack of universally agreed-upon diagnostic criteria, heterogeneity of published series, the multitude of different management options and misunderstanding of relationships among pathophysiological mechanisms involved. We carried out a review of the literature on clinical, radiological, intracranial pressure (ICP), pathophysiological and treatment concepts to finally propose an integrative model. Active prophylaxis and management are proposed according to this model based on determination of pathophysiological mechanisms and predisposing factors behind each individual case. As pathophysiology is progressively multifactorial, prevention of siphoning with gravitational valves or antisiphon devices is mandatory to avoid or minimize further complications. Shunt optimization or transferal and neuroendoscopy may be recommended when ventricular collapse and cerebrospinal fluid isolation appear. Cranial expansion may be useful in congenital or acquired craniocerebral disproportion and shunting the subarachnoid space in communicating venous hydrocephalus and idiopathic intracranial hypertension.

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