scholarly journals Shunt Overdrainage: Reappraisal of the Syndrome and Proposal for an Integrative Model

2021 ◽  
Vol 10 (16) ◽  
pp. 3620
Author(s):  
Bienvenido Ros ◽  
Sara Iglesias ◽  
Jorge Linares ◽  
Laura Cerro ◽  
Julia Casado ◽  
...  
Keyword(s):  
Individual Case ◽  
Integrative Model ◽  
Review Of The Literature ◽  
Management Options ◽  
Pathophysiological Mechanisms ◽  
Treatment Concepts ◽  
Craniocerebral Disproportion ◽  
Insight Into ◽  
Cranial Expansion

Although shunt overdrainage is a well-known complication in hydrocephalus management, the problem has been underestimated. Current literature suggests that the topic requires more examination. An insight into this condition is limited by a lack of universally agreed-upon diagnostic criteria, heterogeneity of published series, the multitude of different management options and misunderstanding of relationships among pathophysiological mechanisms involved. We carried out a review of the literature on clinical, radiological, intracranial pressure (ICP), pathophysiological and treatment concepts to finally propose an integrative model. Active prophylaxis and management are proposed according to this model based on determination of pathophysiological mechanisms and predisposing factors behind each individual case. As pathophysiology is progressively multifactorial, prevention of siphoning with gravitational valves or antisiphon devices is mandatory to avoid or minimize further complications. Shunt optimization or transferal and neuroendoscopy may be recommended when ventricular collapse and cerebrospinal fluid isolation appear. Cranial expansion may be useful in congenital or acquired craniocerebral disproportion and shunting the subarachnoid space in communicating venous hydrocephalus and idiopathic intracranial hypertension.

scholarly journals “Rust stain”: a rare mark in firearm suicide—a case report and review of the literature

2021 ◽  
Author(s):  
Luca Tomassini ◽  
Daniele Paolini ◽  
Anna Maria Manta ◽  
Edoardo Bottoni ◽  
Costantino Ciallella
Keyword(s):  
Case Report ◽  
Medical Examiner ◽  
Experimental Setting ◽  
Review Of The Literature ◽  
Histological Findings ◽  
Porcine Skin ◽  
Manner Of Death ◽  
Prolonged Contact ◽  
Firearm Suicide

AbstractRust stains are marks left by firearms in case of prolonged contact with the cutaneous surfaces. These peculiar signs along with other well-documented findings can guide the medical examiner in the determination of the manner of death, especially in case of firearm suicide. This paper presents the case of a 33-year-old male soldier who committed suicide by using a short-barreled weapon, whose trigger remained in contact with the first finger of his right hand, leading to the formation of a rust stain that perfectly reproduced its design. The forensic examination of the scene, the external cadaveric inspection, and the autopsy are described. For the evaluation of the histological findings typical of rust spots, the authors decided to replicate the phenomenon in an experimental setting using porcine skin. In order to provide an exhaustive overview on the formation and the features of rust stains, a review of the forensic literature concerning this rare mark was performed.

An insight into the determination of size and number concentration of silver nanoparticles in blood using single particle ICP-MS (spICP-MS): Feasibility of application to samples relevant to in vivo toxicology studies

2021 ◽  
Author(s):  
Isabel Abad-Álvaro ◽  
Diego Leite ◽  
Dorota Bartczak ◽  
Susana Cuello ◽  
Beatriz Gomez-Gomez ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Single Particle ◽  
Number Concentration ◽  
Biological Matrices ◽  
Icp Ms ◽  
Toxicological Studies ◽  
Insight Into

Toxicological studies concerning nanomaterials in complex biological matrices usually require a carefully designed workflow that involves handling, transportation and preparation of a large number of samples without affecting the nanoparticle...

scholarly journals Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study

2021 ◽  
Author(s):  
Olga Wronikowska ◽  
Maria Zykubek ◽  
Agnieszka Michalak ◽  
Anna Pankowska ◽  
Paulina Kozioł ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Interdisciplinary Approach ◽  
Nmda Antagonist ◽  
Exchange Chromatography ◽  
Resonance Spectroscopy ◽  
Monoamine Transporters ◽  
Ex Vivo Study ◽  
Insight Into

AbstractMephedrone is a widely used drug of abuse, exerting its effects by interacting with monoamine transporters. Although this mechanism has been widely studied heretofore, little is known about the involvement of glutamatergic transmission in mephedrone effects. In this study, we comprehensively evaluated glutamatergic involvement in rewarding effects of mephedrone using an interdisciplinary approach including (1) behavioural study on effects of memantine (non-selective NMDA antagonist) on expression of mephedrone-induced conditioned place preference (CPP) in rats; (2) evaluation of glutamate concentrations in the hippocampus of rats following 6 days of mephedrone administration, using in vivo magnetic resonance spectroscopy (MRS); and (3) determination of glutamate levels in the hippocampus of rats treated with mephedrone and subjected to MRS, using ion-exchange chromatography. In the presented research, we confirmed priorly reported mephedrone-induced rewarding effects in the CPP paradigm and showed that memantine (5 mg/kg) was able to reverse the expression of this effect. MRS study showed that subchronic mephedrone administration increased glutamate level in the hippocampus when measured in vivo 24 h (5 mg/kg, 10 mg/kg and 20 mg/kg) and 2 weeks (5 mg/kg and 20 mg/kg) after last injection. Ex vivo chromatographic analysis did not show significant changes in hippocampal glutamate concentrations; however, it showed similar results as obtained in the MRS study proving its validity. Taken together, the presented study provides new insight into glutamatergic involvement in rewarding properties of mephedrone.

scholarly journals Prediction of Dead Oil Viscosity: Machine Learning vs. Classical Correlations

Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 930
Author(s):  
Fahimeh Hadavimoghaddam ◽  
Mehdi Ostadhassan ◽  
Ehsan Heidaryan ◽  
Mohammad Ali Sadri ◽  
Inna Chapanova ◽  
...  
Keyword(s):  
Machine Learning ◽  
Viscosity Data ◽  
Oil Viscosity ◽  
Pvt Data ◽  
Proposed Model ◽  
Wide Range ◽  
Engineering Problems ◽  
Functional Forms ◽  
Insight Into

Dead oil viscosity is a critical parameter to solve numerous reservoir engineering problems and one of the most unreliable properties to predict with classical black oil correlations. Determination of dead oil viscosity by experiments is expensive and time-consuming, which means developing an accurate and quick prediction model is required. This paper implements six machine learning models: random forest (RF), lightgbm, XGBoost, multilayer perceptron (MLP) neural network, stochastic real-valued (SRV) and SuperLearner to predict dead oil viscosity. More than 2000 pressure–volume–temperature (PVT) data were used for developing and testing these models. A huge range of viscosity data were used, from light intermediate to heavy oil. In this study, we give insight into the performance of different functional forms that have been used in the literature to formulate dead oil viscosity. The results show that the functional form f(γAPI,T), has the best performance, and additional correlating parameters might be unnecessary. Furthermore, SuperLearner outperformed other machine learning (ML) algorithms as well as common correlations that are based on the metric analysis. The SuperLearner model can potentially replace the empirical models for viscosity predictions on a wide range of viscosities (any oil type). Ultimately, the proposed model is capable of simulating the true physical trend of the dead oil viscosity with variations of oil API gravity, temperature and shear rate.

Systematic Approach to Measuring ILI Tool Performance

2014 ◽  
Author(s):  
Sean Keane ◽  
Karmun Cheng ◽  
Kaitlyn Korol
Keyword(s):  
Performance Measurement ◽  
Performance Measures ◽  
New Technologies ◽  
Efficient Reduction ◽  
Tool Performance ◽  
Typical Performance ◽  
Substantial Investment ◽  
Integrity Management ◽  
Insight Into

In-line inspection (ILI) tools play an important role within integrity management and substantial investment is made to continuously advance performance of the existing technologies and, where necessary, to develop new technologies. Performance measurement is typically focused for the purpose of understanding the measured performance in relation to the ILI vendor specification and for the determination of residual uncertainty regarding pipeline integrity. These performance measures may not provide the necessary insight into what type of investment into a technology is necessary to further reduce residual uncertainty regarding pipeline integrity, and beyond that, what investment, as an operator, results in an effective and efficient reduction in uncertainty. The paper proposes a reliability based approach for investigating uncertainty associated with ultrasonic crack ILI technology for the purpose of identifying efficient investment into the technology that results in an effective and measurable improvement. Typical performance measures and novel performance measurement methods are presented and reviewed with respect to what information they can provide to assist in investment decisions. Finally, general observations are made regarding Enbridge’s experience using ultrasonic crack ILI technology and areas currently being investigated.

scholarly journals RESEARCH INTO THE METHODS OF ANALYSING THE PRODUCTIVITY INDICATORS OF TRANSPORT TERMINALS

Transport ◽  
2009 ◽  
Vol 24 (3) ◽  
pp. 192-199 ◽  
Author(s):  
Ilona Jaržemskienė
Keyword(s):  
Comparative Analysis ◽  
Functional Dependence ◽  
Data Envelopment ◽  
Analysis Method ◽  
Accurate Evaluation ◽  
Feasible Alternative ◽  
Productivity Indicators ◽  
Insight Into ◽  
Regressive Analysis

The measurement of terminal productivity is the issue of extreme importance to both terminal owners and management and customers. As the sector of transport is highly intensive in terms of investments into the infrastructure, the productivity of a terminal may play a crucial role in competing with other terminals. Productivity is defined in terms of inputs and output. The majority of the available studies, wherein this issue is addressed, are generally focused on the determination of functional dependence between inputs and output using the method of regressive analysis. The present article provides an insight into the Data Envelopment Analysis method as a tool for measuring productivity. This technique enables a rather accurate evaluation of terminal productivity by means of comparative analysis, which, in fact, appears to be the only feasible alternative in cases where statistic data required for performing regressive analysis is lacking.

scholarly journals Channel noise in nerve membranes and lipid bilayers

1975 ◽  
Vol 8 (4) ◽  
pp. 451-506 ◽  
Author(s):  
F Conti ◽  
E. Wanke
Keyword(s):  
Brownian Motion ◽  
Lipid Bilayers ◽  
Fluctuation Phenomena ◽  
Channel Noise ◽  
Fluctuation Analysis ◽  
Electronic Charge ◽  
Basic Principles ◽  
Avogadro’S Number ◽  
Insight Into

The basic principles underlying fluctuation phenomena in thermodynamics have long been understood (for reviews see Kubo, 1957; Kubo, Matsuo & Kazuhiro 1973 Lax, 1960). Classical examples of how fluctuation analysis can provide an insight into the corpuscular nature of matter are the determination of Avogadro's number according to Einstein's theory of Brownian motion (see, e.g. Uhlenbeck & Ornstein, 1930; Kac, 1947) and the evaluation of the electronic charge from the shot noise in vacuum tubes (see Van der Ziel, 1970).

FITNESS CLUBS FACING COVID-19 LOCKDOWN

2020 ◽  
Vol 21 (specjalny) ◽  
pp. 159-172
Author(s):  
Marcin Komańda
Keyword(s):  
Business Model ◽  
The State ◽  
Electronic Business ◽  
Sources Of Information ◽  
Review Of The Literature ◽  
Fitness Clubs ◽  
Fitness Industry ◽  
Model Components ◽  
Financial Issues ◽  
Insight Into

The establishment of the state of epidemic in Poland in March 2020 caused significant difficulties in accessing certain services or a total ban on their rendering. The fitness industry faced the inability to provide activity. This extraordinary situation forced entities in the fitness industry (including fitness clubs) to face a number of challenges related to surviving the closing period. These include, first of all, financial issues, the development of electronic business model components, as well as thinking about the conditions of running business after lifting the ban. The aim of the paper is to analyse the actions taken by the Polish fitness clubs during the lockdown period (13/03/2020-06/06/2020) caused by the coronavirus pandemic (COVID-19). It covers recognizing the thinking of these clubs about the possibilities of acting despite these restrictions, as well as immediately after lifting restrictions on the service activities of this industry. The method of analysing the situation of the industry was based on two sources of information: a review of the literature and industry reports on the situation before the lockdown and media information presenting its state during the lockdown. The combination of information from both sources gave a unique insight into the justifications of the activities announced and undertaken by the Polish fitness club industry.

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