scholarly journals Iron Oxide Nanoparticles in Bioimaging – An Immune Perspective

2021 ◽  
Vol 12 ◽  
Author(s):  
Mark Geppert ◽  
Martin Himly
Keyword(s):  
Immune System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biological Effects ◽  
Tumor Therapy ◽  
Short Review ◽  
Oxide Nanoparticles ◽  
Human Immune System ◽  
Potential Applications ◽  
Immunological Effects

Iron oxide nanoparticles (IONPs) bear big hopes in nanomedicine due to their (potential) applications in tumor therapy, drug delivery or bioimaging. However, as foreign entities, such particles may be recognized by the immune system and, thus, lead to inflammation, hypersensitivity or anaphylactic shock. In addition, an overload with iron is known to cause oxidative stress. In this short review, we summarize the biological effects of such particles with a major focus on IONP-formulations used for bioimaging purposes and their effects on the human immune system. We conclude that especially the characteristics of the particles (size, shape, surface charge, coating, etc.) as well as the presence of bystander substances, such as bacterial endotoxin are important factors determining the resulting biological and immunological effects of IONPs. Further studies are needed in order to establish clear structure-activity relationships.

Magnetic iron oxide nanoparticles encapsulating horseradish peroxidase (HRP): synthesis, characterization and carrier for the generation of free radicals for potential applications in cancer therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 111099-111108 ◽  
Author(s):  
Nikesh Gupta ◽  
Chetna Gupta ◽  
Sandeep Sharma ◽  
Brijesh Rathi ◽  
Rakesh Kumar Sharma ◽  
...  
Keyword(s):  
Free Radicals ◽  
Iron Oxide ◽  
Horseradish Peroxidase ◽  
Iron Oxide Nanoparticles ◽  
Average Diameter ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Cancerous Cell ◽  
Potential Applications ◽  
20 Nm

We report synthesis of iron oxide nanoparticles encapsulating HRP. The average diameter of the particles was around 20 nm. HRP has been used to convert IAA to a toxic oxidized product and its toxic effect has been seen on cancerous cell lines.

scholarly journals Labeling mesenchymal cells with DMSA-coated gold and iron oxide nanoparticles: assessment of biocompatibility and potential applications

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Luisa H. A. Silva ◽  
Jaqueline R. da Silva ◽  
Guilherme A. Ferreira ◽  
Renata C. Silva ◽  
Emilia C. D. Lima ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Mesenchymal Cells ◽  
Oxide Nanoparticles ◽  
Potential Applications

scholarly journals Multifunctional Silver Nanoparticles: Synthesis and Applications

2021 ◽  
Author(s):  
Nguyen Hoang Nam
Keyword(s):  
Silver Nanoparticles ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Silica Matrix ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
The Core ◽  
Methods Of Synthesis ◽  
Potential Applications

Multifunctional silver nanoparticles have attracted widely due to their potential applications. Based on the properties of individual silver nanoparticles, such as plasmonic and antibacterial properties, silver nanoparticles can become multifunctional by surface modifications with various surfactants or they can be combined in core-shell and composite structures with the magnetic nanoparticles to form bifunctional nanoparticles. After reviewing the methods of synthesis and applications of silver nanoparticles, the chapter describes the synthesis and the properties of the new types of multifunctional silver nanomaterials based on the plasmonic behaviors of silver nanoparticles and the iron oxide Fe3O4 superparamagnetic nanoparticles. One type is a simple combination of silver nanoparticles and iron oxide nanoparticles in a silica matrix Fe3O4/Ag-4ATP@SiO2. Other types are the core-shell structured nanoparticles, where Fe3O4 nanoparticles play as the core and silver nanoparticles are the outer shell, so-called Fe3O4@SiO2-Ag and Fe3O4-Ag. In the Fe3O4@SiO2-Ag, silver nanoparticles are reduced on the surface of silica-coated magnetic core, while in Fe3O4-Ag, silver nanoparticles are directly reduced on the amino groups functionalized on the surface of magnetic nanoparticles without coating with silica. Both of types of the multifunctional silver nanoparticles show the plasmonic and magnetic properties similar as the individual silver and iron oxide nanoparticles. Finally, some applications of those multifunctional silver nanoparticles will be discussed.

scholarly journals The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration:In VitroStudies

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ofra Ziv-Polat ◽  
Abraham Shahar ◽  
Itay Levy ◽  
Hadas Skaat ◽  
Sara Neuman ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Iron Oxide Nanoparticles ◽  
Neurotrophic Factors ◽  
Biological Effects ◽  
Oxide Nanoparticles ◽  
Neural Repair ◽  
Long Acting

Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basic fibroblast growth factor (FGF-2). Comparative stability studies of free versus conjugated factors revealed that the conjugated neurotrophic factors were significantly more stable in tissue cultures and in medium at 37°C. The biological effects of free versus conjugated neurotrophic factors were examined on organotypic dorsal root ganglion (DRG) cultures performed in NVR-Gel, composed mainly of hyaluronic acid and laminin. Results revealed that the conjugated neurotrophic factors enhanced early nerve fiber sprouting compared to the corresponding free factors. The most meaningful result was that conjugated-GDNF, accelerated the onset and progression of myelin significantly earlier than the free GDNF and the other free and conjugated factors. This is probably due to the beneficial and long-acting effect that the stabilized conjugated-GDNF had on neurons and Schwann cells. These conclusive results make NVR-Gel enriched with conjugated-GDNF, a desirable scaffold for the reconstruction of severed peripheral nerve.

scholarly journals Controllable Kerr and Raman-Kerr frequency combs in functionalized microsphere resonators

Nanophotonics ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 2321-2329 ◽  
Author(s):  
Song Zhu ◽  
Lei Shi ◽  
Linhao Ren ◽  
Yanjing Zhao ◽  
Bo Jiang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Tuning Range ◽  
Frequency Comb ◽  
Oxide Nanoparticles ◽  
Optical Frequency ◽  
Frequency Combs ◽  
Wavelength Division ◽  
Potential Applications ◽  
Control Light

AbstractOptical frequency comb (OFC) based on the whispering-gallery-mode microresonator has various potential applications in fundamental and applied areas. Once the solid microresonator is fabricated, its structure parameters are generally unchanged. Therefore, realizing the tunability of the microresonator OFC is an important precondition for many applications. In this work, we proposed and demonstrated the tunable Kerr and Raman-Kerr frequency combs using the ultrahigh-quality-factor (Q) functionalized silica microsphere resonators, which are coated with iron oxide nanoparticles on their end surfaces. The functionalized microsphere resonator possesses Q factors over 108 and large all-optical tunability due to the excellent photothermal performance of the iron oxide nanoparticles. We realized a Kerr frequency comb with an ultralow threshold of 0.42 mW and a comb line tuning range of 0.8 nm by feeding the control light into the hybrid microsphere resonator through its fiber stem. Furthermore, in order to broaden the comb span, we realized a Raman-Kerr frequency comb with a span of about 164 nm. Meanwhile, we also obtained a comb line tuning range of 2.67 nm for the Raman-Kerr frequency comb. This work could find potential applications in wavelength-division multiplexed coherent communications and optical frequency synthesis.

scholarly journals Immunotherapy for cancer: effects of iron oxide nanoparticles on polarization of tumor-associated macrophages

Nanomedicine ◽  
2021 ◽  
Author(s):  
Camila Sales Nascimento ◽  
Érica Alessandra Rocha Alves ◽  
Celso Pinto de Melo ◽  
Rodrigo Corrêa-Oliveira ◽  
Carlos Eduardo Calzavara-Silva
Keyword(s):  
Immune System ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Iron Metabolism ◽  
Therapeutic Strategy ◽  
Macrophage Polarization ◽  
Metabolic Reprogramming ◽  
Oxide Nanoparticles ◽  
Tumor Associated Macrophages ◽  
Fight Against Cancer

Cancer immunotherapy is the most promising trend in oncology, focusing on helping or activating the patient's immune system to identify and fight against cancer. In the last decade, interest in metabolic reprogramming of tumor-associated macrophages from M2-like phenotype (promoting tumor progression) to M1-like phenotypes (suppressing tumor growth) as a therapeutic strategy against cancer has increased considerably. Iron metabolism has been standing out as a target for the reprogramming of tumor-associated macrophages to M1-like phenotype with therapeutic purposes against cancer. Due to the importance of the iron levels in macrophage polarization states, iron oxide nanoparticles can be used to change the activation state of tumor-associated macrophages for a tumor suppressor phenotype and as an anti-tumor strategy.

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