scholarly journals The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration:In VitroStudies

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Ofra Ziv-Polat ◽  
Abraham Shahar ◽  
Itay Levy ◽  
Hadas Skaat ◽  
Sara Neuman ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Iron Oxide Nanoparticles ◽  
Neurotrophic Factors ◽  
Biological Effects ◽  
Oxide Nanoparticles ◽  
Neural Repair ◽  
Long Acting

Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basic fibroblast growth factor (FGF-2). Comparative stability studies of free versus conjugated factors revealed that the conjugated neurotrophic factors were significantly more stable in tissue cultures and in medium at 37°C. The biological effects of free versus conjugated neurotrophic factors were examined on organotypic dorsal root ganglion (DRG) cultures performed in NVR-Gel, composed mainly of hyaluronic acid and laminin. Results revealed that the conjugated neurotrophic factors enhanced early nerve fiber sprouting compared to the corresponding free factors. The most meaningful result was that conjugated-GDNF, accelerated the onset and progression of myelin significantly earlier than the free GDNF and the other free and conjugated factors. This is probably due to the beneficial and long-acting effect that the stabilized conjugated-GDNF had on neurons and Schwann cells. These conclusive results make NVR-Gel enriched with conjugated-GDNF, a desirable scaffold for the reconstruction of severed peripheral nerve.

scholarly journals Role of hydration and micellar shielding in tuning the structure of single crystalline iron oxide nanoparticles for designer applications

Nano Select ◽  
2021 ◽  
Author(s):  
Ramis Arbi ◽  
Amr Ibrahim ◽  
Liora Goldring‐Vandergeest ◽  
Kunyu Liang ◽  
Greg Hanta ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Single Crystalline

Preparation of epidermal growth factor (EGF) conjugated iron oxide nanoparticles and their internalization into colon cancer cells

2010 ◽  
Vol 322 (15) ◽  
pp. 2244-2250 ◽  
Author(s):  
Mar Creixell ◽  
Adriana P. Herrera ◽  
Vanessa Ayala ◽  
Magda Latorre-Esteves ◽  
Marianela Pérez-Torres ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Iron Oxide ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Colon Cancer Cells ◽  
Epidermal Growth

Iron Oxide Nanoparticles as Imaging and Therapeutic Agents for Atherosclerosis

2020 ◽  
Vol 46 (05) ◽  
pp. 553-562
Author(s):  
Joshua Talev ◽  
Jagat Rakesh Kanwar
Keyword(s):  
Iron Oxide ◽  
Cardiovascular Diseases ◽  
Iron Oxide Nanoparticles ◽  
Imaging Techniques ◽  
Therapeutic Agents ◽  
Oxide Nanoparticles ◽  
Future Prospects ◽  
Wide Range ◽  
Theranostic Applications

AbstractAtherosclerosis is the major cause of cardiovascular diseases and is the leading cause of mortality worldwide. Iron oxide nanoparticles have emerged as potential diagnostic and therapeutic agents for a wide range of conditions. To date, the theranostic applications of iron oxide nanoparticles have been studied mainly in cancer, but atherosclerosis has not received the same attention. Therefore, it appears appropriate to review the current and future applications of iron oxide nanoparticles for the diagnosis and therapy of atherosclerosis. This review will first discuss current imaging techniques for the diagnosis of atherosclerosis as well as their limitations. It will then discuss the role of nanotechnology for molecular imaging of atherosclerosis and the benefits of this approach as well as reviewing current developments in the field including single, bi-, and tri-modal imaging. Next, it will discuss the role of nanotechnology for therapies of atherosclerosis with a focus on nanotheranostics, concluding with a look at the challenges faced by nanoparticle-based imaging and therapy of atherosclerosis as well as a look at future prospects.

Size-tunable synthesis of iron oxide nanocrystals by continuous seed-mediated growth: role of alkylamine species in the stepwise thermal decomposition of iron(ii) oxalate

2021 ◽  
Author(s):  
Ryosuke Nozawa ◽  
Takashi Naka ◽  
Masato Kurihara ◽  
Takanari Togashi
Keyword(s):  
Thermal Decomposition ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Small Volume ◽  
Oxide Nanoparticles ◽  
Seed Mediated

Size of monodisperse iron oxide nanoparticles are turned via continuous seed mediated growth via stepwise thermal decomposition of iron(ii) oxalate in small volume alkylamine mixture.

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