scholarly journals Imaging Features by Machine Learning for Quantification of Optic Disc Changes and Impact on Choroidal Thickness in Young Myopic Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Dandan Sun ◽  
Yuchen Du ◽  
Qiuying Chen ◽  
Luyao Ye ◽  
Huai Chen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Disc ◽  
Torsion Angle ◽  
Choroidal Thickness ◽  
Imaging Features ◽  
Lasso Regression ◽  
Test Set ◽  
Swept Source ◽  
Negatively Associated ◽  
Fundus Photographs

Purpose: To construct quantifiable models of imaging features by machine learning describing early changes of optic disc and peripapillary region, and to explore their performance as early indicators for choroidal thickness (ChT) in young myopic patients.Methods: Eight hundred and ninety six subjects were enrolled. Imaging features were extracted from fundus photographs. Macular ChT (mChT) and peripapillary ChT (pChT) were measured on swept-source optical coherence tomography scans. All participants were divided randomly into training (70%) and test (30%) sets. Imaging features correlated with ChT were selected by LASSO regression and combined into new indicators of optic disc (IODs) for mChT (IOD_mChT) and for pChT (IOD_pChT) by multivariate regression models in the training set. The performance of IODs was evaluated in the test set.Results: A significant correlation between IOD_mChT and mChT (r = 0.650, R2 = 0.423, P < 0.001) was found in the test set. IOD_mChT was negatively associated with axial length (AL) (r = −0.562, P < 0.001) and peripapillary atrophy (PPA) area (r = −0.738, P < 0.001) and positively associated with ovality index (r = 0.503, P < 0.001) and torsion angle (r = 0.242, P < 0.001) in the test set. Every 1 × 10 μm decrease in IOD_mChT was associated with an 8.87 μm decrease in mChT. A significant correlation between IOD_pChT and pChT (r = 0.576, R2 = 0.331, P < 0.001) was found in the test set. IOD_pChT was negatively associated with AL (r = −0.478, P < 0.001) and PPA area (r = −0.651, P < 0.001) and positively associated with ovality index (r = 0.285, P < 0.001) and torsion angle (r = 0.180, P < 0.001) in the test set. Every 1 × 10 μm decrease in IOD_pChT was associated with a 9.64 μm decrease in pChT.Conclusions: The study introduced a machine learning approach to acquire imaging information of early changes of optic disc and peripapillary region and constructed quantitative models significantly correlated with choroidal thickness. The objective models from fundus photographs represented a new approach that offset limitations of human annotation and could be applied in other areas of fundus diseases.

scholarly journals Characteristics of Fundal Changes in Fundus Tessellation in Young Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Hanyi Lyu ◽  
Qiuying Chen ◽  
Guangyi Hu ◽  
Ya Shi ◽  
Luyao Ye ◽  
...  
Keyword(s):  
Young Adults ◽  
Choroidal Thickness ◽  
Anterior Segment ◽  
Population Based ◽  
Cross Sectional ◽  
Swept Source ◽  
Lower Body Weight ◽  
Parapapillary Atrophy ◽  
Fundus Photographs ◽  
Body Weight Index

Purpose: To explore the characteristics and associated factors of fundus tessellation, especially the alternation of choroidal thickness among different degrees of tessellated fundus in young adults.Design: Cross-sectional, population-based study.Methods: A total of 796 students were included in the study and underwent comprehensive ophthalmic examinations, including anterior segment examinations and swept-source optical coherence tomography (OCT) measurements. The degree of tessellated fundus was assessed by fundus photographs applying an early treatment of diabetic retinopathy study grid to evaluate the location of fundus tessellation and then divided into five groups. The topographic variation and factors, tilted disc ratio, parapapillary atrophy (PPA), retinal thickness (ReT), choroidal thickness (ChT), and subfoveal scleral thickness (SST) related to tessellated fundus were analyzed.Results: Compared to normal fundus, tessellated fundus had a lower spherical equivalent (SE) (p < 0.0001), worse best-corrected visual acuity (BCVA)(p = 0.043), longer axial length (AL) (p < 0.0001), thinner retina (p < 0.0001), thinner (p < 0.0001) choroid, and thinner sclera in center fovea (p = 0.0035). Among all subfields of macular and peripapillary regions, center fovea and macula-papillary region showed the most significant decrease in choroidal thickness. The proportion of fundus tessellation significantly increased with lower body weight index (BMI) (p = 0.0067), longer AL (p < 0.0001), larger PPA(p = 0.0058), thinner choroid (p < 0.0001), and thinner sclera (p < 0.0001).Conclusions: Eyes showed more severe myopic morphological alternation with the increasement of proportion of fundus tessellation to the center fovea, including a significant decrease in both choroid and scleral thickness. Choroidal thinning may progress most rapidly in the macula-papillary region as fundus tessellation approaches to the center fovea.

scholarly journals Choroidal thickness measurements around the optic disc in healthy subjects using Swept-Source optical coherence device

2017 ◽  
Vol 95 ◽  
Author(s):  
M.  Ciprés Alastuey ◽  
E.  García Martín ◽  
M.P.  Bambó Rubio ◽  
E.  Vilades Palomar ◽  
M.J.  Rodrigo Sanjuan ◽  
...  
Keyword(s):  
Optic Disc ◽  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Swept Source ◽  
Thickness Measurements

Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography

2019 ◽  
Vol 103 (11) ◽  
pp. 1584-1589 ◽  
Author(s):  
Jay C Wang ◽  
Inês Laíns ◽  
Patrick Oellers ◽  
Ivana K Kim ◽  
Joan W Miller ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Fundus Photography ◽  
Imaging Features ◽  
Optical Coherence ◽  
Swept Source ◽  
Macular Telangiectasia ◽  
Macular Telangiectasia Type 2 ◽  
And Control

PurposeTo investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).MethodsProspective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were used for statistical analysis.ResultsThirty-nine eyes of 20 patients with MacTel2 and 29 eyes of 15 control patients were included. Average CT and perifoveal temporal CT did not differ significantly between eyes with MacTel2 and control eyes (p≥0.350), when accounting for confounding factors. Overall and temporal CVD also did not significantly differ between the two groups (p≥0.490).ConclusionCT and CVD did not significantly differ between MacTel2 and control eyes in this study using SS-OCT. Even though MacTel2 may include abnormalities involving the choroid, these are likely minor in comparison to the predominant retinal changes.

scholarly journals Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuchen Du ◽  
Qiuying Chen ◽  
Ying Fan ◽  
Jianfeng Zhu ◽  
Jiangnan He ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Disc ◽  
Early Stage ◽  
Image Features ◽  
Pathologic Myopia ◽  
High Risk Population ◽  
Imaging Features ◽  
Chorioretinal Atrophy ◽  
Disc Region ◽  
Myopic Maculopathy

Abstract Background Myopic maculopathy (MM) is the most serious and irreversible complication of pathologic myopia, which is a major cause of visual impairment and blindness. Clinic proposed limited number of factors related to MM. To explore additional features strongly related with MM from optic disc region, we employ a machine learning based radiomics analysis method, which could explore and quantify more hidden or imperceptible MM-related features to the naked eyes and contribute to a more comprehensive understanding of MM and therefore may assist to distinguish the high-risk population in an early stage. Methods A total of 457 eyes (313 patients) were enrolled and were divided into severe MM group and without severe MM group. Radiomics analysis was applied to depict features significantly correlated with severe MM from optic disc region. Receiver Operating Characteristic were used to evaluate these features’ performance of classifying severe MM. Results Eight new MM-related image features were discovered from the optic disc region, which described the shapes, textural patterns and intensity distributions of optic disc region. Compared with clinically reported MM-related features, these newly discovered features exhibited better abilities on severe MM classification. And the mean values of most features were markedly changed between patients with peripapillary diffuse chorioretinal atrophy (PDCA) and macular diffuse chorioretinal atrophy (MDCA). Conclusions Machine learning and radiomics method are useful tools for mining more MM-related features from the optic disc region, by which complex or even hidden MM-related features can be discovered and decoded. In this paper, eight new MM-related image features were found, which would be useful for further quantitative study of MM-progression. As a nontrivial byproduct, marked changes between PDCA and MDCA was discovered by both new image features and clinic features.

scholarly journals Multimodal Segmentation of Optic Disc and Cup From SD-OCT and Color Fundus Photographs Using a Machine-Learning Graph-Based Approach

2015 ◽  
Vol 34 (9) ◽  
pp. 1854-1866 ◽  
Author(s):  
Mohammad Saleh Miri ◽  
Michael D. Abramoff ◽  
Kyungmoo Lee ◽  
Meindert Niemeijer ◽  
Jui-Kai Wang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Disc ◽  
Fundus Photographs ◽  
Sd Oct

scholarly journals Phacoemulsification Induced Changes of Choroidal Thickness in Eyes with Age-Related Macular Degeneration

Medicina ◽  
2020 ◽  
Vol 56 (5) ◽  
pp. 252
Author(s):  
Gailė Gudauskienė ◽  
Ieva Povilaitytė ◽  
Eglė Šepetauskienė ◽  
Dalia Žaliūnienė
Keyword(s):  
Macular Degeneration ◽  
Choroidal Thickness ◽  
Late Onset ◽  
Intraoperative Complications ◽  
Age Related Macular Degeneration ◽  
Swept Source ◽  
Negatively Associated ◽  
Time Points ◽  
Postoperative Changes ◽  
Age Related

Background and Objectives: Patients with cataract and age-related macular degeneration (AMD) may safely undergo cataract phacoemulsification to enhance visual acuity. Although it has not been proven that cataract surgery can cause AMD progression, different phacoemulsification effects are observed not only on retinal but also on choroidal tissues. The purpose of this study was to evaluate the effect of phacoemulsification on the choroidal thickness (CT) in eyes with and without AMD. Materials and Methods: In 32 eyes of 32 patients with senile cataract (No-AMD group) and in 32 eyes of 32 patients with cataract and dry AMD (AMD group), who had phacoemulsification without intraoperative complications and intraocular lens implantation, foveal retinal thickness (FRT) and CT were evaluated three times: at 1–2 post meridiem preoperatively, then 1 month and 3 months postoperatively, using 1050 nm swept source-optical coherence tomography (Topcon, Tokyo, Japan). Results: In both groups, a significant increase in FRT was observed after one month and a decrease after three months without reaching the baseline. One month after surgery, a sectorial CT increase was apparent in all sectors in both groups. A negative association between CT and age was disclosed in the No-AMD group almost for all regions at all time points. Furthermore, CT was significantly negatively associated with axial length (AL) in all sectors at all time points in the AMD group. Conclusion: Uneventful phacoemulsification may induce changes in the posterior eye segment. An increase in CT and FRT was observed in both groups one month after the surgery. However, three months after surgery, CT changes were different in both groups, while FRT decreased in both groups. CT changes negatively associated with age in the No-AMD group and with AL in the AMD eyes. These postoperative changes in the choroid and retina may not only lead to the late-onset pseudophakic cystoid macular edema but also to progression of AMD.

scholarly journals Retinal and Choroidal Changes in Children with Moderate-to-High Hyperopia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yu Qian ◽  
Yingyan Ma ◽  
Qiurong Lin ◽  
Zhaoyu Xiang ◽  
Jun Qiang ◽  
...  
Keyword(s):  
Optic Disc ◽  
Axial Length ◽  
Choroidal Thickness ◽  
Cross Sectional Study ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Swept Source ◽  
Uncorrected Visual Acuity ◽  
Spherical Equivalent Refraction ◽  
High Hyperopia

Purpose. This study aimed to investigate the characteristics of retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, and choroidal thickness in children with moderate-to-high hyperopia (MHH). Methods. This was a cross-sectional study that enrolled 53 children with MHH and 53 emmetropic children. Subjects with a spherical equivalent refraction (SER) of +4.0 D or higher were included in the MHH group, and subjects with SER between −1.0 D and +1.0 D were included in the emmetropic group. Ophthalmic examinations, including uncorrected visual acuity, cycloplegic refraction, slit-lamp examination, axial length, and swept-source optical coherence tomography (SS-OCT; DRI OCT Triton-1, Topcon, Tokyo, Japan), were performed. Results. The RNFL and GCL in the temporal and inferior quadrants in 1–3 mm of the macular fovea were thinner in the MHH group than in the emmetropic group (all P < 0.05 ). The MHH group also had a thicker choroidal thickness in all regions (all P < 0.05 ). The SER was independently correlated with the average choroidal thickness in the optic disc and fovea (coefficient = 4.853, P < 0.001 for the optic disc; coefficient = 5.523, P = 0.004 for the fovea), while axial length was negatively correlated with choroidal thickness (coefficient = −12.649, P < 0.001 ). Axial length was positively associated with RNFL and GCL thickness in the temporal quadrant in 1–3 mm of the macular fovea (coefficient = 0.966, P = 0.007 for RNFL and coefficient = 1.476, P = 0.011 for the macular fovea). Conclusion. Compared with emmetropic children, MMH children had greater choroidal thickness. The characteristics of the RNFL and GCL thickness in MMH children were different from those in emmetropic children.

scholarly journals Correction to: Automatic identification of myopic maculopathy related imaging features in optic disc region via machine learning methods

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuchen Du ◽  
Qiuying Chen ◽  
Ying Fan ◽  
Jianfeng Zhu ◽  
Jiangnan He ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Disc ◽  
Automatic Identification ◽  
Imaging Features ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Disc Region ◽  
Myopic Maculopathy

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Decreased choroidal and scleral thicknesses in highly myopic eyes with posterior staphyloma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Un Chul Park ◽  
Eun Kyoung Lee ◽  
Bo Hee Kim ◽  
Baek-Lok Oh
Keyword(s):  
Choroidal Thickness ◽  
Structural Changes ◽  
Meta Analysis ◽  
Cross Sectional Study ◽  
Pathologic Myopia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Swept Source ◽  
Posterior Staphyloma ◽  
Myopic Maculopathy

AbstractIn this cross-sectional study, we investigated choroidal thickness (CT) and scleral thickness (ST) in highly myopic eyes and their associations with ocular factors. Patients underwent widefield swept-source optical coherence tomography (OCT) to measure the CT and ST at the subfovea and 3000 μm superior, inferior, temporal, and nasal to the fovea and macular curvature. A total of 237 eyes (154 patients) were included. At all five measurement points, thinner CTs and STs were associated with longer axial lengths (r = − 0.548 to − 0.357, all P < 0.001) and greater macular curvatures (r = − 0.542 to − 0.305, all P < 0.001). The CT and ST were significantly thinner in eyes with posterior staphyloma than in those without at all measurement points (all P ≤ 0.006) but did not differ between eyes with the wide macular and narrow macular type of staphyloma. Eyes with myopic maculopathy of category ≥ 3 according to the International Meta-Analysis for Pathologic Myopia classification had significantly thinner CTs and STs than those with category ≤ 2 (all P ≤ 0.005). In highly myopic eyes, a decrease in the CT and ST was more pronounced in eyes with more structural changes, such as longer axial length, steeper macular curvature, and the presence of posterior staphyloma.

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