The characteristic of the component body composition of athletes involved in game-based and cyclic kinds of sports

Objective: to determine a component body composition of students specializing in volleyball and athletics and to conduct a comparative analysis of the results.Materials and methods: the study was conducted at the Department of physical training and sports at the Yaroslavl State Medical University of the Ministry of Health of the Russian Federation. The study included students from different groups of physical training: volleyball (10 men and 10 women), athletics (10 women) (experimental groups), and first­year students that attended physical training classes (14 men and 16 women) (control group).Results: significant differences were revealed between the anthropometric measurements in the experimental groups of the studied women and between the results of anthropometric measurements in the female volleyball players, female athletes, and students from the control group. Significant differences were revealed in the component body composition of the studied women from the experimental and control groups. The analysis of the results of anthropometric measurements in the experimental and control groups of men did not reveal any significant differences between the parameters. Bioimpedancemetry revealed significant differences in the composition of the internal milieu of volleyball players in comparison with the control group.Conclusions: 1. differences were revealed in the component composition of the body of female athletes involved in game­based and cyclic kinds of sport as well as in the parameters of bio­impedance of female volleyball players and the control group. Female volleyball players had higher parameters of total body fluids, intracellular and extracellular fluids, fat­free, fat, and active cell mass in comparison with female light athletes and the control group. The differences in the obtained results were more significant in the experimental groups. 2. Bio­impendance analysis of men showed significant differences in the component body composition of volleyball players in comparison with untrained students. The parameters of total body fluids, fat­free, fat, and active cell mass in sportsmen exceeded the same parameters in the control group. 3. Differences were established in the anthropometric parameters depending on the sport­oriented specialization of female students. Female volleyball players had higher values of mass, length, body weight index, and body surface area, the circumferences of the pelvis, thighs, and wrists in comparison with the results obtained in female light athletes. Similar differences were revealed in the anthropometric parameters of female volleyball players and students from the control group. Significantly lower values of the body weight index, circumference of the chest and pelvis of female athletes were registered in comparison with students from the control group. Male volleyball players did not have significant differences in the anthropometric parameters. They tended to have an increase in the body mass, length and surface area of the body, circumference of the chest, thighs, and wrists.

PEMODELAN KASUS GIZI BURUK PADA BALITA DI PROVINSI BALI TAHUN 2018 MENGGUNAKAN REGRESI SPLINE

Malnutrition associated with an unusual condition of the patient's nutritional status because the body weight index and age are not suitable, where body weight should be positively correlated with age. According to data from the Bali Health Department, malnutrition cases found in 2016 is 3,4% while in 2017 it founded 3,8%. This research uses spIine regression with malnutrition cases of children under 5 years old in Bali Province. To compare basis truncated spIine and B-SpIine, this study using the minimum value of Generalized Cross Validation (GCV) and Mean Square Error (MSE) of each basis. B-SpIine quadratic modeI with four knots is the best model.

Custom Shoe Sole Design and Modeling Toward 3D Printing

This study introduces a design procedure for improving an individual’s footwear comfort with body weight index and activity requirements by customized three-dimensional (3D)-printed shoe midsole lattice structure. This method guides the selection of customized 3D-printed fabrications incorporating both physical and geometrical properties that meet user demands. The analysis of the lattice effects on minimizing the stress on plantar pressure was performed by initially creating various shoe midsole lattice structures designed. An appropriate common 3D printable material was selected along with validating its viscoelastic properties using finite element analysis. The lattice structure designs were analyzed under various loading conditions to investigate the suitability of the method in fabricating a customized 3D-printed shoe midsole based on the individual’s specifications using a single material with minimum cost, time, and material use.

Factors associated with atherosclerotic plaque echogenicity in patients aged 40-64 with carotid atherosclerosis

Aim To identify clinical and laboratory indexes related with the atherosclerotic plaque (ASP) echogenicity based on results of the analysis of grey-scale median (GSM) in patients aged 40–64 years.Material and methods The study included patients aged 40–64 years with carotid atherosclerosis. The carotid duplex scanning was performed for all patients. The GSM analysis of obtained images was performed with the Adobe Photoshop CS6 software.Results Atherosclerotic cardiovascular diseases were found in 31 (21.4 %) patients. Correlation analysis determined inverse interrelationships between GSM and the body weight index (BWI) (r=–0.359; p<0.0001), waist circumference (r=–0.357; p<0.0001), and levels of uric acid (r=–0.244; p=0.021) and glucose (r=–0.205; p=0.032). According to the regression, statistically significant correlations remained between GSM and BWI as well as the waist circumference after the adjustment for sex and age.Conclusion In patients with carotid atherosclerosis aged 40–64 years, the decrease in ASP GSM was associated with increases in BWI and waist circumference.

Nutrition Assessment and Adverse Outcomes in Hospitalized Patients with Tuberculosis

Background: Malnutrition in patients with tuberculosis (TB) is associated with poor outcomes. This study assessed the validity of the patient-generated subjective global assessment (PG-SGA) in adult TB patients and examined the association of the PG-SGA score with adverse outcomes. Methods: This is a retrospective chart review study compared with the well-nourished and malnourished TB patients. The nutritional status was determined using the PG-SGA for adult patients (n = 128). Clinical outcomes included liver injury and mortality. Adverse outcomes included hepatitis during anti-tuberculosis therapy. Results: By comparing nutritional status using global assessment, well-nourished patients had a significantly higher body weight index (p = 0.002), a lower PG-SGA score (p < 0.001), and lower diabetic rate (p = 0.029). Malnourishment was a risk factor (p = 0.022) for liver injury and fatal outcomes (p < 0.001). A higher PG-SGA score was a risk factor for liver injury (p = 0.002) and an independent risk factor for fatal outcomes (p = 0.031). ROC analysis for outcome prediction showed that a PG-SGA score of 5.5 points yielded the most appropriate sensitivity (61.5%) and specificity (64.7%). Conclusion: Both global assessment and the total PG-SGA score were related to tuberculosis outcome and liver injury during anti-TB treatment.

PROPHYLACTIC EFFECT OF COENZYME Q10 ON GROSS PARAMETERS OF RAT TESTIS EXPOSED TO MOSQUITO COIL SMOKE INHALATION

Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito coil smoke alone showed significantly less weight gain (p<0.001)), testicular weight (p<0.001), volume (p<0.001), and relative tissue body weight index (p<0.001) as compared to control group. Rats administered Coenzyme Q10 along with mosquito coil smoke exposure exhibited significantly higher weight gain (p<0.001), testicular weight (p<0.001), volume (p<0.001) and relative tissue body weight index (p<0.001) as compared to rats exposed to mosquito coil smoke alone. Conclusion: Long-term inhalation of allethrin-based mosquito coil smoke caused testicular atrophy among rats, as evident by reduced testicular weight, volume and relative tissue body weight index. Whereas, prophylactic oral administration of Coenzyme......................

Characteristics of Fundal Changes in Fundus Tessellation in Young Adults

Purpose: To explore the characteristics and associated factors of fundus tessellation, especially the alternation of choroidal thickness among different degrees of tessellated fundus in young adults.Design: Cross-sectional, population-based study.Methods: A total of 796 students were included in the study and underwent comprehensive ophthalmic examinations, including anterior segment examinations and swept-source optical coherence tomography (OCT) measurements. The degree of tessellated fundus was assessed by fundus photographs applying an early treatment of diabetic retinopathy study grid to evaluate the location of fundus tessellation and then divided into five groups. The topographic variation and factors, tilted disc ratio, parapapillary atrophy (PPA), retinal thickness (ReT), choroidal thickness (ChT), and subfoveal scleral thickness (SST) related to tessellated fundus were analyzed.Results: Compared to normal fundus, tessellated fundus had a lower spherical equivalent (SE) (p &lt; 0.0001), worse best-corrected visual acuity (BCVA)(p = 0.043), longer axial length (AL) (p &lt; 0.0001), thinner retina (p &lt; 0.0001), thinner (p &lt; 0.0001) choroid, and thinner sclera in center fovea (p = 0.0035). Among all subfields of macular and peripapillary regions, center fovea and macula-papillary region showed the most significant decrease in choroidal thickness. The proportion of fundus tessellation significantly increased with lower body weight index (BMI) (p = 0.0067), longer AL (p &lt; 0.0001), larger PPA(p = 0.0058), thinner choroid (p &lt; 0.0001), and thinner sclera (p &lt; 0.0001).Conclusions: Eyes showed more severe myopic morphological alternation with the increasement of proportion of fundus tessellation to the center fovea, including a significant decrease in both choroid and scleral thickness. Choroidal thinning may progress most rapidly in the macula-papillary region as fundus tessellation approaches to the center fovea.

Efficacy and immunogenicity of different BCG doses in BALB/c and CB6F1 mice when challenged with H37Rv or Beijing HN878

In this study, 2 strains of mice (BALB/c and CB6F1) were vaccinated with a range of Bacille Calmette-Guérin (BCG) Danish doses from 3×105 to 30 CFU/mouse, followed by either immunogenicity evaluation or aerosol infection with Mycobacterium tuberculosis (a laboratory strain H37Rv or West-Beijing HN878 strain). The results indicated that both strains of mice when infected with HN878 exhibited significant protection in their lungs with BCG doses at 3×105 – 3000 CFU (BALB/c) and 3×105-300 CFU (CB6F1). Whereas, both strains of mice when infected with H37Rv, significant protection was seen in BCG doses at 3×105 - 300 CFU. Immunological evaluation revealed interesting results; i) both strains of mice demonstrated a significant increase in the frequencies of BCG-specific IFNγ+ IL2+ TNFα+ CD4 T cells in the BCG doses at 3×105 – 3000 CFU (BALB/c) and 3×105 - 300 CFU (CB6F1); ii) secretion of IL2 and IFNγ were correlated with the bacterial burden in the lungs of HN878 infected CB6F1 mice. The study demonstrated a BCG dose at 3000 CFU (an equivalent single human dose in the mice by body weight index) is protective in both strains of mice and the use of a virulent clinical isolate in testing new tuberculosis vaccine/advancing research is recommended.

Levels of keratinocyteand fibroblast-derived chemokines in skin cells isolated from abdominoplasty surgical materials from patients with normal weight and obesity

Цель работы - определение уровня хемокинов, ассоциированных с фибробластами и кератиноцитами, в клетках кожи, выделеных из операционного материала при абдоминопластике у пациенток с нормальной массой тела и ожирением. Методика. Для исследования использовали фрагменты кожи пациенток с нормальной массой тела и ожирением. Степень ожирения оценивали по индексу массы тела (ИМТ) согласно международным критериям. ИМТ, принятый в исследовании за норму, составлял 19,8±1,7 кг/м2, для пациенток с ожирением - 38,3±4,1 кг/м2. Клетки выделяли путем ферментативной обработки коллагеназой II. Проводили иммунотипирование клеток моноклональными антителами меченными флуоресцентными красителями. Использовали антитела к хемокинам семейства CXCL (R&D systems) и CCL (Boeringer Ingelheim, Германия). Меченные флуоресцентными красителями иммунотипированные клетки анализировали на проточном цитометре FACSCalibur (Becton Dickinson, США) по программе SimulSet. Статистический анализ проводили по программе ANOVA. Результаты. Были проанализированы хемокины семейства CCL и CXCL, секретируемые кератиноцитами и фибробластами кожи. Показано, что в коже пациенток с ожирением повышен процент клеток, экспрссирующих рецепторы CXCR3, CXCR4, CCR3, CCR10, регулирующие секрецию хемокинов кератиноцитами и фибробластами кожи. При ожирении в клетках кожи повышен уровень хемокинов CXCL8, CXCL9, CXCL10, CXCL13, CCL24 и CCL27, имеющих отношение к развитию и поддержанию воспалительного процесса в коже, а уровень хемокинов CCL17, CCL22, CCL28 снижен, что указывает на нарушение хемокиновой и цитокиновой регуляции при ожирении и является основой для развития послеоперационных осложнений при абдоминопластике. Заключение. Полученные данные указывают на нарушение хемокиновой регуляции при ожирении, что способствует развитию послеоперационных осложнений при абдоминопластике. The aim of the study was to compare chemokine expression in skin cells obtained from patients with normal body weight and obesity after abdominoplasty. Methods. Obesity was determined by body weight index (normal, 19.8±1.7 kg/m2; obesity, 38.3±4.1 kg/m2). Only skin without subcutaneous fat was isolated from surgical material. The skin cells obtained from surgical material were stained with monoclonal antibodies to chemokines. Fluorescence of proteins and receptors was analyzed by flow cytometry. Statistical analysis was performed with ANOVA. Results. Keratinocyte- and fibroblast-derived chemokines of the CCL and CXCL families were analyzed. Percentage of cells expressing CXCR3, CXCR4, CCR3, and CCR10 receptors (regulators of chemokine secretion by keratinocytes and skin fibroblasts) was increased in the skin of obese patients. Expression of the pro-inflammatory chemokines, CXCL8, CXCL9, CXCL10, CXCL13, CCL24, and CCL27, was increased in skin cells from obese patients. Obesity was associated with reduced expression of the chemokines CCL17, CCL22, and CCL28 in skin cells. Conclusion. Chemokine regulation is disturbed in obesity, which may underlie the development of complications after abdominal surgery.