scholarly journals Geographical Variations in Host Predisposition to COVID-19 Related Anosmia, Ageusia, and Neurological Syndromes

2021 ◽  
Vol 8 ◽  
Author(s):  
A Aravin Kumar ◽  
Sean Wei Yee Lee ◽  
Christine Lock ◽  
Nicole CH Keong
Keyword(s):  
Case Series ◽  
Genotypic Differences ◽  
The Novel ◽  
Asian Countries ◽  
Geographical Variations ◽  
Subjective Testing ◽  
Taste Disorders ◽  
Different Populations ◽  
Novel Coronavirus ◽  
Global Health Challenge

The novel coronavirus disease (COVID-19), has become the most critical global health challenge in recent history. With SARS-CoV-2 infection, there was an unexpectedly high and specific prevalence of olfactory and taste disorders (OTDs). These high rates of hyposmia and hypogeusia, initially reported as up to 89% in European case series, led to the global inclusion of loss of taste and/or smell as a distinctive feature of COVID-19. However, there is emerging evidence that there are striking differences in the rates of OTDs in East Asian countries where the disease first emerged, as compared to Western countries (15.8 vs. 60.9%, p-value < 0.01). This may be driven by either variations in SARS-CoV-2 subtypes presenting to different global populations or genotypic differences in hosts which alter the predisposition of these different populations to the neuroinvasiveness of SARS-CoV-2. We also found that rates of OTDs were significantly higher in objective testing for OTDs as compared to subjective testing (73.6 vs. 60.8%, p-value = 0.03), which is the methodology employed by most studies. Concurrently, it has also become evident that racial minorities across geographically disparate world populations suffer from disproportionately higher rates of COVID-19 infection and mortality. In this mini review, we aim to delineate and explore the varying rates of olfactory and taste disorders amongst COVID-19 patients, by focusing on their underlying geographical, testing, ethnic and socioeconomic differences. We examine the current literature for evidence of differences in the olfactory and gustatory manifestations of COVID-19 and discuss current pathophysiological hypotheses for such differences.

scholarly journals Management challenges in patients with comorbid COVID-19 associated delirium and serious mental illness – A case series

2021 ◽  
pp. 009121742098597
Author(s):  
Saba Syed ◽  
Michael Couse ◽  
Rashi Ojha
Keyword(s):  
Mental Illness ◽  
Serious Mental Illness ◽  
Healthcare Providers ◽  
Case Series ◽  
Retrospective Chart Review ◽  
Active Management ◽  
The Novel ◽  
Psychiatric Facility ◽  
Medical Teams ◽  
Novel Coronavirus

Background There is still a lot unknown about the novel Coronavirus Disease 19 (COVID-19) and its effects in humans. This pandemic has posed several challenging clinical situations to healthcare providers. Objective We hope to highlight the distinctive challenges that COVID-19 presents in patients with serious mental illness and what steps primary medical teams can take to co-manage these patients with the psychiatry consultants. Methods We present a retrospective chart review of four patients who were on psychotropic polypharmacy and admitted to our hospital from the same long-term psychiatric facility with COVID-19 delirium and other associated medical complications. Results We illustrate how the primary medical teams and psychiatrists collaborated in clinical diagnosis, treatment, and management. Conclusions Patients with serious mental illness and COVID-19 infection require active collaboration between primary medical teams and psychiatrists for diagnostic clarification, reduction of psychotropic polypharmacy to avoid adverse effects and drug-drug interactions, prevention of psychiatric decompensation, and active management of agitation while balancing staff and patient safety concerns.

scholarly journals Impact of COVID-19 on community health: A systematic review of a population of 82 million

2020 ◽  
Vol 9 (1) ◽  
pp. 4-11
Author(s):  
Brijesh Sathian ◽  
Mohammad Asim ◽  
Ahammed Mekkodathil ◽  
Edwin R. Van Teijlingen ◽  
Supram Hosuru Subramanya ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Community Health ◽  
South Asian ◽  
Personal Hygiene ◽  
The Novel ◽  
Asian Countries ◽  
Current Systematic Review ◽  
Novel Coronavirus ◽  
The Impact

The novel coronavirus disease 2019 (COVID-19) outbreak, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is exponentially spreading across the globe. As there is paucity of published literature, the influence of COVID-19 on community health remains unclear. Therefore, we aimed to conduct a systematic review of the literature on the impact of COVID-19 on community health. The current systematic review was performed utilizing electronic databases, i.e., PubMed, MEDLINE, and EMBASE. We searched for the keywords "COVID-19" AND "community health" between January 1, 2020, until May 10, 2020. Although, limited evidence is available regarding quarantine to prevent COVID‐19, most studies considered quarantine as an essential public health measure to minimize rate of infection and mortality. Under these circumstances, people should focus on maintaining personal hygiene, proper nutrition, and extreme social distancing to reduce the risk of COVID-19. Besides, that there is a need to provide professional psychological support to reduce mental ill-health. We have highlighted two different public health approaches in South Asian countries, namely Nepal and India.

scholarly journals A Second Pandemic: Mental Health Spillover From the Novel Coronavirus (COVID-19)

2020 ◽  
Vol 26 (4) ◽  
pp. 340-343 ◽  
Author(s):  
Kristen R. Choi ◽  
MarySue V. Heilemann ◽  
Alex Fauer ◽  
Meredith Mead
Keyword(s):  
Public Health ◽  
Mental Health ◽  
Health Systems ◽  
Nurse Leaders ◽  
The Novel ◽  
Public Health Response ◽  
Health Response ◽  
Mental Wellness ◽  
Novel Coronavirus ◽  
Global Health Challenge

The novel coronavirus (COVID-19) pandemic has created an unprecedented global health challenge. There is risk that the outbreak will create a “second pandemic” of mental health crises in health systems and communities. Thus, a comprehensive public health response to the pandemic must include (a) attention to the psychological aspects of hospitalization for patients, families, and staff affected by COVID-19; (b) planning for emergency and acute psychiatric patient care if hospitals become overwhelmed with COVID-19 patients; and (c) innovations for providing mental health care in communities while social distancing is required and health system resources are strained. Nurses and nurse leaders must anticipate these mental health challenges, assist with preparedness in health systems and communities, and advocate for a coordinated response to promote mental wellness and resilience.

scholarly journals Situation analysis of novel Coronavirus (2019-nCoV) cases in Nepal

2020 ◽  
Vol 1 (1) ◽  
pp. 9-14
Author(s):  
Kiran Paudel ◽  
Prashamsa Bhandari ◽  
Yadav Prasad Joshi
Keyword(s):  
South Asian ◽  
Case Fatality ◽  
Cumulative Number ◽  
The Novel ◽  
Asian Countries ◽  
Primary Case ◽  
The Status ◽  
Exponential Trend ◽  
Using Data ◽  
Novel Coronavirus

The Novel Coronavirus (2019-nCoV) is currently a major threat to global health in an unprecedented manner. The global pandemic of COVID-19 has affected 215 countries and territories including Nepal. Until 1st June 2020, altogether 1,811 COVID-19 positive cases were diagnosed using RT-PCR. This study aimed to analyze the status of COVID-19 cases in Nepal and South Asian countries. A retrospective study from 23rd January to 1st June 2020 was conducted using data of the Ministry of Home Affairs, Nepal and Worldometer homepages. The primary case records during the pre and post lockdown periods were examined. Spatial distribution was observed. An exponential trend line was plotted and COVID-19 situation in South Asian countries was assessed. Of 1,811 COVID-19 cases, the highest number (38.3%) was reported in Province 2. Out of 77 districts, 59 were affected. In Fifty-eight districts, primary cases appeared during the lockdown period. The cumulative number of COVID-19 cases showed the exponential pattern of distribution in Nepal. In South Asian countries, India had the highest number of cases and case fatality rate (CFR). There were no cases of CFR in Bhutan. The Novel Coronavirus emergence in Nepal has become a serious challenge to the various sectors including public health. The emergence of primary cases even in the lockdown period needs a detailed study in the future.

scholarly journals Emergence of the first manic episode in recovered COVID-19 patients: A case series from Egypt

2021 ◽  
Author(s):  
Hayam M. Elgohary ◽  
Mohammad G. Sehlo ◽  
Usama M. Youssef ◽  
Mohamed Abdelghani
Keyword(s):  
Neuropsychiatric Symptoms ◽  
Gastrointestinal Symptoms ◽  
Case Series ◽  
Manic Episode ◽  
Behavioral Changes ◽  
Future Research ◽  
The Novel ◽  
Manic Symptoms ◽  
Global Pandemic ◽  
Novel Coronavirus

Abstract Objective In December 2019, the novel coronavirus (COVID-19) infection was first reported in Wuhan city, China, which had rapidly spread as a global pandemic. This infection was commonly presented by respiratory and /or gastrointestinal symptoms. However, it is still unclear whether COVID-19 infection could be associated with central nervous system (CNS) damage which would result in development of neuropsychiatric symptoms. Method A total of five cases of suddenly emerged manic episodes during the pandemic of COVID-19 were extensively described. We presented the symptoms and described the diagnosis, clinical course, and treatment of each case. Results All patients had positive findings of ribonucleic acid (RNA) tests for COVID-19 in specimens of their sputum. The patients later developed manic symptoms during and after the recovering period of their illness. Conclusions The case series of newly emerged manic symptoms associated with COVID-19 infection highlights the essential need for evaluation of mental health status and would contribute to our understanding of the potential risk of CNS affection by COVID-19 infection. The limited number of cases would limit the generalizability of association. Future research should investigate the behavioral changes accompanying and following COVID-19 infection.

scholarly journals Respiratory Viral Co-infection with Novel Coronavirus in Children: A Case Series

2020 ◽  
Author(s):  
Emily Hertzberg ◽  
C. Anthoney Lim ◽  
Erick Eiting ◽  
Steven Yung ◽  
Jeranil Nunez ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Case Series ◽  
Respiratory Viruses ◽  
World Health ◽  
Clinical Implications ◽  
The Novel ◽  
Global Pandemic ◽  
Surgical Evaluation ◽  
Novel Coronavirus ◽  
Health Organization

Abstract Background:The novel coronavirus, COVID-19 was identified in January 2020 initially in Wuhan, China but quickly spread worldwide and was declared a global pandemic by the World Health Organization on March 11, 2020. There are more than 185 countries impacted and the numbers of cases and deaths continues to rise. The rate of coinfections with COVID-19 in children and the clinical implications are unknown.Case Presentation:We describe the clinical presentation and course of three patients with COVID-19 and coinfections with other common respiratory viruses. Two cases were diagnosed with COVID-19 as well as rhinovirus/enterovirus and the third case was COVID-19 and pertussis. Each case had a unique presentations and hospital courses including an emergency room discharge, urgent surgical evaluation and an intensive care unit admission.Conclusions:This is the first US-based case report to discuss coinfections with COVID-19 and other respiratory viruses. Decisions regarding diagnosis and management of children in the setting of the current pandemic should account for the possibility of coinfections. We also highlight publish health challenged resulting from children with the novel coronavirus.

scholarly journals The updates on Middle East Respiratory Syndrome coronavirus (MERS-CoV) epidemiology, pathogenesis, viral genome and currently available drugs

2016 ◽  
Vol 3 (2) ◽  
pp. 10-18 ◽  
Author(s):  
Surender Singh Jadav ◽  
Narayana Murthy Ganta ◽  
Anoop Kumar ◽  
Nirnoy Dan ◽  
Neha Padma Mohanty
Keyword(s):  
Middle East ◽  
Viral Genome ◽  
Development Process ◽  
Middle East Respiratory Syndrome ◽  
Respiratory Disorder ◽  
The Novel ◽  
Asian Countries ◽  
Epidemic Outbreak ◽  
The Family ◽  
Novel Coronavirus

The Middle East Respiratory Syndrome (MERS) is caused by the novel coronavirus belongs to the family Betacoronaviridae was first identified in Saudi Arabia during 2012. The first epidemic outbreak of the MERS-CoV has been started reporting in the South Korea and other Asian Countries. The disease was transmitted to humans to humans from the Middle East to other countries through travelling history. The MERS-CoV is responsible for the lower acute and severe respiratory disorder causes the shortness of breath along with fever and cough. The treatment for the disease is purely symptomatic and vaccination is not existed. In the present work we are tried to compile the epidemiology, pathogenesis, viral genome and currently available drugs. At the last the promising approaches for the drug design and development process has been presented.

scholarly journals Co-infection of SARS-CoV-2 with Chlamydia or Mycoplasma pneumoniae: a case series and review of the literature

2020 ◽  
Author(s):  
Alessandra Oliva ◽  
Guido Siccardi ◽  
Ambra Migliarini ◽  
Francesca Cancelli ◽  
Martina Carnevalini ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Chlamydia Pneumoniae ◽  
Present Report ◽  
Case Series ◽  
Respiratory Pathogens ◽  
The Novel ◽  
Global Pandemic ◽  
Large Teaching Hospital ◽  
Atypical Pathogens ◽  
Novel Coronavirus

Abstract The novel coronavirus SARS-CoV-2 has spread all over the world causing a global pandemic and representing a great medical challenge. Nowadays, there is limited knowledge on the rate of co-infections with other respiratory pathogens, with viral co-infection being the most representative agents. Co-infection with Mycoplasma pneumoniae has been described both in adults and pediatrics whereas only 2 cases of Chlamydia pneumoniae have been reported in a large US study so far. In the present report, we describe a series of 7 patients where co-infection with C. pneumoniae (n=5) or M. pneumoniae (n=2) and SARS-CoV-2 was detected in a large teaching hospital in Rome. An extensive review of the updated literature regarding the co-infection between SARS-CoV-2 and these atypical pathogens is also performed.

scholarly journals Risk Communication in Asian Countries: COVID-19 Discourse on Twitter (Preprint)

2020 ◽  
Author(s):  
Sungkyu Park ◽  
Sungwon Han ◽  
Jeongwook Kim ◽  
Mir Majid Molaie ◽  
Hoang Dieu Vu ◽  
...  
Keyword(s):  
Social Media ◽  
Natural Language Processing ◽  
Natural Language ◽  
Risk Communication ◽  
Language Processing ◽  
World Health ◽  
The Novel ◽  
Asian Countries ◽  
Public Attention ◽  
Novel Coronavirus

BACKGROUND The novel coronavirus disease (hereafter COVID-19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused a global pandemic. During this time, a plethora of information regarding COVID-19 containing both false information (misinformation) and accurate information circulated on social media. The World Health Organization has declared a need to fight not only the pandemic but also the infodemic (a portmanteau of information and pandemic). In this context, it is critical to analyze the quality and veracity of information shared on social media and the evolution of discussions on major topics regarding COVID-19. OBJECTIVE This research characterizes risk communication patterns by analyzing public discourse on the novel coronavirus in four Asian countries that suffered outbreaks of varying degrees of severity: South Korea, Iran, Vietnam, and India. METHODS We collect tweets on COVID-19 posted from the four Asian countries from the start of their respective COVID-19 outbreaks in January until March 2020. We consult with locals and utilize relevant keywords from the local languages, following each country's tweet conventions. We then utilize a natural language processing (NLP) method to learn topics in an unsupervised fashion automatically. Finally, we qualitatively label the extracted topics to comprehend their semantic meanings. RESULTS We find that the official phases of the epidemic, as announced by the governments of the studied countries, do not align well with the online attention paid to COVID-19. Motivated by this misalignment, we develop a new natural language processing method to identify the transitions in topic phases and compare the identified topics across the four Asian countries. We examine the time lag between social media attention and confirmed patient counts. We confirm an inverse relationship between the tweet count and topic diversity. CONCLUSIONS Through the current research, we observe similarities and differences in the social media discourse on the pandemic in different Asian countries. We observe that once the daily tweet count hits its peak, the successive tweet count trend tends to decrease for all countries. This phenomenon aligns with the dynamics of the issue-attention cycle, an existing construct from communication theory conceptualizing how an issue rises and falls from public attention. Little work has been performed to identify topics in online risk communication by collectively considering temporal tweet trends in different countries. In this regard, if a critical piece of misinformation can be detected at an early stage in one country, it can be reported to prevent the spread of misinformation in other countries. Therefore, this work can help social media services, social media communicators, journalists, policymakers, and medical professionals fight the infodemic on a global scale. CLINICALTRIAL N/A

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