scholarly journals The updates on Middle East Respiratory Syndrome coronavirus (MERS-CoV) epidemiology, pathogenesis, viral genome and currently available drugs

2016 ◽  
Vol 3 (2) ◽  
pp. 10-18 ◽  
Author(s):  
Surender Singh Jadav ◽  
Narayana Murthy Ganta ◽  
Anoop Kumar ◽  
Nirnoy Dan ◽  
Neha Padma Mohanty
Keyword(s):  
Middle East ◽  
Viral Genome ◽  
Development Process ◽  
Middle East Respiratory Syndrome ◽  
Respiratory Disorder ◽  
The Novel ◽  
Asian Countries ◽  
Epidemic Outbreak ◽  
The Family ◽  
Novel Coronavirus

The Middle East Respiratory Syndrome (MERS) is caused by the novel coronavirus belongs to the family Betacoronaviridae was first identified in Saudi Arabia during 2012. The first epidemic outbreak of the MERS-CoV has been started reporting in the South Korea and other Asian Countries. The disease was transmitted to humans to humans from the Middle East to other countries through travelling history. The MERS-CoV is responsible for the lower acute and severe respiratory disorder causes the shortness of breath along with fever and cough. The treatment for the disease is purely symptomatic and vaccination is not existed. In the present work we are tried to compile the epidemiology, pathogenesis, viral genome and currently available drugs. At the last the promising approaches for the drug design and development process has been presented.

scholarly journals Does the novel coronavirus 2019 like heart more than the other family members of coronaviruses?

2020 ◽  
Vol 12 (2) ◽  
pp. 156-157
Author(s):  
Mohammad Mostafa Ansari Ramandi ◽  
Mohammadreza Baay ◽  
Nasim Naderi
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Family Members ◽  
Middle East Respiratory Syndrome ◽  
The Other ◽  
The Novel ◽  
The World ◽  
Future Challenges ◽  
Novel Coronavirus ◽  
Coronavirus Infections

The disaster due to the novel coronavirus disease 2019 (COVID-19) around the world has made investigators enthusiastic about working on different aspects of COVID-19. However, although the pandemic of COVID-19 has not yet ended, it seems that COVID-19 compared to the other coronavirus infections (the Middle East Respiratory Syndrome [MERS] and Severe Acute Respiratory Syndrome [SARS]) is more likely to target the heart. Comparing the previous presentations of the coronavirus family and the recent cardiovascular manifestations of COVID-19 can also help in predicting possible future challenges and taking measures to tackle these issues.

scholarly journals Extension and Advisory Services during Lockdown due to COVID-19: Efforts by KVK in Barmer District of Rajasthan

2020 ◽  
Vol 35 (1-2) ◽  
Author(s):  
Pradeep Pagaria ◽  
L. R. Choudhary ◽  
Haridayal Choudhary ◽  
Ganga Ram ◽  
Turfan Khan
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Common Cold ◽  
Large Family ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
Advisory Services ◽  
The Common ◽  
Novel Coronavirus

Coronavirus outbreak was first reported in Wuhan, China on 31 December, 2019. Coronavirus (CoV) is a large family of viruses that causes illness. It ranges from the common cold to more severe diseases like Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). The novel coronavirus is a new strain of virus that has not been identified in human so far.

scholarly journals The necessity for carnivore experimentation in predicting the next zoonotic disease epidemic

2022 ◽  
pp. 1-3
Author(s):  
Freeha Anjum ◽  
Hillary Hale
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Infectious Diseases ◽  
Novel Species ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
The Public ◽  
Bodily Fluids ◽  
Novel Coronavirus ◽  
Human Infections

Zoonoses are human infections or diseases caused by disease spillover from vertebrate animals to people [1]. Spillover is the movement of pathogens from their normal host to a novel species [2]; this can occur through bodily fluids, bites, food, water, or contact with surfaces where infected animals have travelled [3]. Although some zoonoses remain established within populations and primarily affect only one person per spillover (classified as enzootic zoonoses—e.g., rabies), others can be transmitted between people and result in localized, or even global outbreaks [4]. Zoonoses account for over 60% of infectious diseases in humans [4] and can be caused by viruses, parasites, bacteria, or fungi. Of these, viral zoonoses prove to be of greatest detriment to the public on a widespread scale, as they are responsible for numerous epidemics and pandemics, including severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the novel coronavirus (COVID-19) [5-7]. Research has also been conducted on different taxonomic orders of species, such as Carnivora — placental animals which obtain nutrients from flesh — and their viral spillover risk [11].

scholarly journals COVID-19 Pandemic Between Severity Facts and Prophylaxis

2021 ◽  
Vol 16 (11) ◽  
pp. 1934578X2110412
Author(s):  
Hui Liu ◽  
Wenxia Zhu ◽  
Yilin Wu ◽  
Caini Jiang ◽  
Lili Huo ◽  
...  
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Infectious Virus ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
Healthy Nutrition ◽  
The World ◽  
Seasonal Flu ◽  
Novel Coronavirus ◽  
Nutrition Habits

Before COVID-19, many viruses have infected humans, so what caused COVID-19 to be considered as a pandemic? COVID-19 belongs to the coronavirus family that includes severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS). This family has caused a large number of deaths all over the world. How risky is the novel coronavirus? People and their careers were disrupted, and many businesses all over the world are now closed. From here, it seems to us that this virus is something that can make people feel afraid. In this article, we will try to understand the severity of this virus, and then disclose the available ways to confront it and ways that might improve the ability to face it, either now or in the future. Upon comparing COVID-19 with seasonal flu, we have found that COVID-19 is about 10 times more deadly, although it is not the most infectious virus. In this review, we will discuss how healthy nutrition and lifestyle may help to prevent and treat diseases, and especially COVID-19. We will focus on how to follow healthy nutrition habits and lifestyles to stop the dangers of COVID-19.

COVID -19 infection: Epidemiology, Virology, Clinical Features, Diagnosis and Pharmacological Treatment

2021 ◽  
Vol 27 ◽  
Author(s):  
Avneet Kaur ◽  
Vijay Bhalla ◽  
Mohammed Salahuddin ◽  
Syed Obaidur Rahman ◽  
Faheem Hyder Pottoo
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Features ◽  
Pharmacological Treatment ◽  
Middle East Respiratory Syndrome ◽  
Present Review ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
Potential Therapeutics

Abstract:: Coronavirus was first discovered during the year 1930 and since then vrious coronaviruses like HKU1, MERS-CoV , NL63 and SARS-CoV-2 had been found to infect humans. The COVID-19 pandemic caused by SARS-CoV-2 is spreading at an alarming rate thereby created health emergency around the world. SARS-CoV2 is reportedly to be originated from wet animal market of Wuhan, China. Since then the world is searching for effective way to manage and treat the COVID-19 infection. The infections has already multiplied with several folds compared to the number of person infected by Middle East Respiratory Syndrome Coronavirus and Severe Acute Respiratory Syndrome. In order to fill the gap of knowledge about this virus, several evidences are required to control it so more lives could be saved. The present review is based on the publicly available literature in order to explore the knowledge regarding epidemiology, virology, diagnosis, clinical features, pharmacological and therapeutic ways to treat the novel coronavirus. This can be helpful in offering novel insights and potential therapeutics in fighting this disease.

Hypothesis: Designation of Liposomal Scavenger System for Fighting against 2019-nCoV

2021 ◽  
Vol 21 ◽  
Author(s):  
Nooshin Bagherani ◽  
Bruce R. Smoller
Keyword(s):  
Septic Shock ◽  
Immune System ◽  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Effective Treatment ◽  
Organ Failure ◽  
Severe Pneumonia ◽  
Middle East Respiratory Syndrome ◽  
The Family ◽  
Novel Coronavirus

: 2019 novel coronavirus (2019-nCoV), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 virus, is a member of the family Coronaviridae, which is responsible for the current pandemic of disease COVID-19. It is the seventh member of the family Coronaviridae, which infects humans, after 229E, OC43, NL63, HKU1, SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Fever, dry cough and severe pneumonia are seen as common symptoms at the early stages of COVID-19. Some cases progress to acute respiratory stress syndrome, septic shock, organ failure, and death. The development of an effective treatment or vaccination for treating or preventing this lethal condition is an urgent need in order to fight this crisis. Up to now, some effective vaccines with different efficacy profiles have been introduced. Herein, we have theoretically designed a scavenger system for gathering 2019-nCoVs, breaking them, and re-introducing them to the immune system.

scholarly journals Coronaviruses – a new old menace

2021 ◽  
Author(s):  
Anna Golke ◽  
Karolina Piekarska ◽  
Tomasz Dzieciątkowski
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Systems ◽  
Middle East Respiratory Syndrome ◽  
Control Measures ◽  
The Novel ◽  
Global Impact ◽  
Infection Control Measures ◽  
The World ◽  
Novel Coronavirus

current pandemic caused by novel coronavirus SARS-CoV-2 pandemic has been described as a global health emergency. The outbreak of this virus has raised a number of questions: what exactly is SARS-CoV-2? How transmissible the novel coronavirus is? How severely affected are patients infected with SARS-CoV-2? What are the risk factors for COVID-19? What are the differences between this novel coronavirus and other coronaviruses? To answer these questions, a comparative study of three pathogenic coronaviruses that primarily invade the human respiratory system and may cause death, namely, severe acute respiratory syndrome (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Middle East respiratory syndrome coronavirus (MERS-CoV). This review describes the source of origin, transmission, and pathogenicity of these viruses. Prevention of SARS-CoV-2 spreading entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The novel coronavirus spreads faster than its two predecessors – the SARS-CoV-1 and MERS-CoV – but has lower fatality rate. The global impact of this new pandemic is still uncertain, but it is a challenge to healthcare systems around the world.

A Review of the Virology of SARS-CoV-2

2020 ◽  
Vol 7 (1) ◽  
pp. 69-77
Author(s):  
Aldonna Maria Susngi ◽  
◽  
Clara Ermine Sawian
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Causative Agent ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
Highly Pathogenic ◽  
Key Features

The novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of Coronavirus disease 2019 (COVID-19) is a β-coronavirus, which also includes the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome Coronavirus (MERS-CoV). Emerging in December 2019 from Wuhan, China, it has spread worldwide resulting in a pandemic that has not ended till date. This review highlights some of the key features of the virology of SARS-CoV-2.

scholarly journals Impact of COVID-19 on community health: A systematic review of a population of 82 million

2020 ◽  
Vol 9 (1) ◽  
pp. 4-11
Author(s):  
Brijesh Sathian ◽  
Mohammad Asim ◽  
Ahammed Mekkodathil ◽  
Edwin R. Van Teijlingen ◽  
Supram Hosuru Subramanya ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Community Health ◽  
South Asian ◽  
Personal Hygiene ◽  
The Novel ◽  
Asian Countries ◽  
Current Systematic Review ◽  
Novel Coronavirus ◽  
The Impact

The novel coronavirus disease 2019 (COVID-19) outbreak, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is exponentially spreading across the globe. As there is paucity of published literature, the influence of COVID-19 on community health remains unclear. Therefore, we aimed to conduct a systematic review of the literature on the impact of COVID-19 on community health. The current systematic review was performed utilizing electronic databases, i.e., PubMed, MEDLINE, and EMBASE. We searched for the keywords "COVID-19" AND "community health" between January 1, 2020, until May 10, 2020. Although, limited evidence is available regarding quarantine to prevent COVID‐19, most studies considered quarantine as an essential public health measure to minimize rate of infection and mortality. Under these circumstances, people should focus on maintaining personal hygiene, proper nutrition, and extreme social distancing to reduce the risk of COVID-19. Besides, that there is a need to provide professional psychological support to reduce mental ill-health. We have highlighted two different public health approaches in South Asian countries, namely Nepal and India.

scholarly journals Middle East Respiratory Syndrome Coronavirus (MERS CoV): An Emerging Pathogen

2014 ◽  
Vol 14 (2) ◽  
pp. 156-163
Author(s):  
H A M Nazmul Ahasan ◽  
Aparna Das ◽  
Mostofa Kamal Chowdhury ◽  
Baharul Minnat
Keyword(s):  
Saudi Arabia ◽  
Middle East ◽  
Health And Safety ◽  
The Elderly ◽  
Economic Consequences ◽  
Middle East Respiratory Syndrome ◽  
Severe Illness ◽  
Health Security ◽  
Single Positive ◽  
Novel Coronavirus

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus (nCoV) first reported on 24 September 2012 on ProMED-mail by Egyptian virologist Dr. Ali Mohamed Zaki in Jeddah, Saudi Arabia. He isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old male patient with acute pneumonia and acute renal failure. MERS-CoV is the sixth new type of coronavirus like SARS (but still distinct from it and from the common-cold coronavirus). Until 23 May 2013, MERS-CoV had frequently been referred to as a SARS-like virus, or simply the novel coronavirus, and colloquially on messageboards as “Saudi SARS”. These respiratory viruses are an emerging threat to global health security and have led to worldwide epidemics with substantial morbidity, mortality, and economic consequences. Currently confirmatory testing requires molecular diagnostics including either a positive PCR on at least two specific genomic targets or a single positive target with sequencing on a second. However, the interim recommendations for laboratory testing for MERS-CoV should be consulted for the most recent standard for laboratory confirmation. Hajj and Umrah draws some of the largest crowds in the world, and the large crowds bring some health and safety risks. The virus can spread from person to person when people are touching or very near each other, so pilgrims in crowds may be at risk. Symptoms of MERS include fever, cough, and shortness of breath. Most people infected with MERS have had severe illness and pneumonia, and about half of them have died. If anyone develops a fever and cough or difficulty in breathing within 14 days after returning from trip, must seek medical care. The Embassy of Saudi Arabia recommends that the following groups should postpone their plans for Hajj and Umrah in 2013: the elderly, the terminally ill, pregnant women, and children.DOI: http://dx.doi.org/10.3329/jom.v14i2.19634 J Medicine 2013, 14(2): 156-163

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