scholarly journals Meibomian Gland Morphology Changes After Cataract Surgery: A Contra-Lateral Eye Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Pingjun Chang ◽  
Shuyi Qian ◽  
Zhizi Xu ◽  
Feng Huang ◽  
Yinying Zhao ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Meibomian Gland ◽  
Control Group ◽  
Study Group ◽  
Image Analyzer ◽  
Lateral Eye ◽  
Age Related ◽  
Length Width ◽  
Tear Meniscus Height ◽  
Morphology Changes

Purpose: To evaluate the morphology changes of meibomian glands (MGs) after cataract surgery.Setting: Hangzhou Branch of the Eye Hospital of Wenzhou Medical University, Zhejiang, China.Methods: In this contra-lateral eye study, 40 patients received unilateral cataract surgery for age-related cataract. All the patients underwent the evaluation of non-invasive break-up time (NIBUT) and lower tear meniscus height (TMH) before the surgery and 6 months post-operatively. The MGs were evaluated via ImageJ and Meibomian Gland Bio-image Analyzer. MG dropout, length, width, area, gland diameter deformation index (DI), and gland signal index (SI) were recorded.Results: MG length, width, area, DI, and SI were significantly decreased after cataract surgery in the study group (operated eyes, P < 0.001, P = 0.003, P < 0.001, P = 0.001, and P < 0.001, respectively) and showed no significant changes in the control group (non-operated eyes) (all P > 0.05). MG loss increased more in the study group (P = 0.030), and the changes in TMH and NIBUT were not significantly different between the two eyes (both P > 0.05).Conclusion: Cataract surgery aggravated meibomian gland morphology, such as MG loss, MG length, width, area, and SI, and produced no change in NIBUT and TMH at 6 months post-operatively.

Impression cytology and meibomian glands in conjunctivochalasis

2021 ◽  
pp. 112067212110087
Author(s):  
Ersin Muhafiz ◽  
Erdinç Bozkurt ◽  
Remzi Erten
Keyword(s):  
Dropout Rate ◽  
Meibomian Gland ◽  
Control Group ◽  
Study Group ◽  
Impression Cytology ◽  
Schirmer Test ◽  
Significant Difference ◽  
Meibomian Glands ◽  
And Control ◽  
Margin Cytology

Purpose: To evaluate the tear parameters, meibomian glands and lid margin and tarsal conjunctival impression cytology in patients with conjunctivochalasis (CCH). Methods: The study included 57 patients diagnosed with CCH and 35 healthy volunteers. Tear break-up time (TBUT) was measured and Schirmer test was performed. Meibomian gland morphologies, dropout rates, and meiboscores were evaluated using meibography. Finally, impression cytology samples were taken by pressing the impression filters on the lower lid margin and lower tarsal conjunctiva. The samples were evaluated according to the Nelson grading system. Results: Schirmer test was longer and TBUT was shorter in the study group ( p = 0.035 and p < 0.001, respectively). The median of meibomian gland dropout rate was 33.45% (Interquartile range [IQR]; 23.17%–49.75%) and 18.80% (IQR; 12.35%–26.50%) in the study and control groups, respectively ( p < 0.001). There was no significant difference in terms of lid-margin cytology between the two groups ( p = 0.481). In tarsal conjunctiva cytology, the median value of Nelson grade of the study group was 2 (IQR; 1–2) and that of the control group was 1 (IQR; 1–2) ( p = 0.040). When Nelson grade-2 and above was accepted as the pathological limit, it was found that 27.5% of the study group and 15.2% of the control group showed pathological findings ( p = 0.204). Conclusions: In patients with CCH, damage occurs in the tarsal conjunctiva with the effects of redundant conjunctival folds. In these patients, atrophy occurs in the meibomian glands and tear stability is impaired. Therefore, CCH should not be overlooked in clinical practice.

scholarly journals The elevated risk of sight-threatening cataract in diabetes with retinopathy: a retrospective population-based cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chan-Wei Nien ◽  
Chia-Yi Lee ◽  
Hung-Chi Chen ◽  
Shih-Chun Chao ◽  
Hung-Jui Hsu ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Multivariable Analysis ◽  
Population Based ◽  
Cumulative Probability ◽  
Control Group ◽  
Study Group ◽  
Research Database ◽  
Proportional Hazard ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Regression

Abstract Background The effect of diabetic retinopathy (DR) on the development of sight-threatening cataracts was assessed using the National Health Insurance Research Database of Taiwan. Methods Patients diagnosed with diabetes mellitus (DM) and DR were enrolled in the study group. Age- and sex-matched DM individuals without DR and patients without DM served as the DM control group and non-DM control group, respectively, both with 1:4 ratios. The outcome was set as the performance of cataract surgery. Cox proportional hazard regression was used to calculate the adjusted hazard ratio (aHR) of DR considering multiple factors underlying cataract formation. Results A total of 3297 DR patients, 13,188 DM control patients and 13,188 non-DM control subjects were enrolled. The study group included 919 events of sight-threatening cataracts (27.87%), the DM control group included 1108 events (8.40%), and the non-DM control group included 957 events (7.26%). A multivariable analysis indicated that the study group presented a higher aHR of cataract surgery (2.93, 95% CI: 2.60–3.30) and a higher cumulative probability of cataract surgery than both the DM control and non-DM control groups (both log rank P < 0.001). In addition, both the proliferative DR (3.90, 95% CI: 3.42–4.45) and nonproliferative DR (2.35, 95% CI: 2.08–2.65) subgroups showed a higher aHR of cataract surgery than the DM control group. Conclusion The presence of DR increases the risk of sight-threatening cataracts that warrant surgery, and the effect is prominent among patients with both proliferative DR and nonproliferative DR.

scholarly journals Video-Assisted Informed Consent for Cataract Surgery: A Randomized Controlled Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yuehong Zhang ◽  
Xiangcai Ruan ◽  
Haoying Tang ◽  
Weizhong Yang ◽  
Zhuanhua Xian ◽  
...  
Keyword(s):  
Informed Consent ◽  
Cataract Surgery ◽  
Positive Impact ◽  
Controlled Trial ◽  
Consent Process ◽  
Chinese Patients ◽  
Control Group ◽  
Video Assisted ◽  
Age Related ◽  
Video Group

Purpose. To investigate whether adding video assistance to traditional verbal informed consent advisement improved satisfaction among cataract surgery patients. Methods. This trial enrolled 80 Chinese patients with age-related cataracts scheduled to undergo unilateral phacoemulsification surgery. Patients were randomized into two groups: the video group watched video explaining cataract-related consent information and rewatched specific segments of the video at their own discretion, before receiving traditional verbal consent advisement; the control group did not watch the video. Outcomes included patient satisfaction, refusal to consent, time to complete the consent process, and comprehension measured by a ten-item questionnaire. Results. All 80 enrolled patients signed informed consent forms. Compared with the control group, members of the video group exhibited greater satisfaction (65% versus 86%, p=0.035) and required less time to complete the consent process (12.3±6.7 min versus 5.6±5.4 min, p<0.001), while also evincing levels of comprehension commensurate with those reported for patients who did not watch the video (accuracy rate, 77.5% versus 80.2%, p=0.386). Conclusion. The video-assisted informed consent process had a positive impact on patients’ cataract surgery experiences. Additional research is needed to optimize patients’ comprehension of the video.

scholarly journals Association between relative telomere length and a genetic variant of SIRT1 gene and age-related macular degeneration

2021 ◽  
Vol 21 (3) ◽  
pp. 143-146
Author(s):  
L.K. Moshetova ◽  
◽  
O.P. Dmitrenko ◽  
O.I. Abramova ◽  
N.S. Karpova ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Telomere Length ◽  
Genetic Variant ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Study Group ◽  
Relative Telomere Length ◽  
Age Related ◽  
Buccal Epithelial Cells ◽  
Sirt1 Gene

One of the most important factors predisposing to the development of age-related macular degeneration (AMD) is aging. Telomeres are important for aging by maintaining genome stability. Aim: to identify the association between relative telomere length of buccal epithelial cells and SIRT1 rs12778366 genetic variation and late AMD. Patients and Methods: 100 patients (200 eyes) were enrolled, i.e., 50 patients with AMD (AREDS category 4) and 50 patients without AMD. Genomic DNA isolated from buccal epithelial cells by phenol-chloroform extraction was used. Genotyping of SIRT1 rs12778366 polymorphic locus was performed by TaqMan® real-time PCR. Telomere length was measured by real-time PCR as described earlier [Cawthon, 2002] using specific primers. Relative telomere length was assessed by the relative telomere to single-copy gene (T/S) ratio. Results: the rate of allele C was 25% in the study group and 14% in the control group (p=0.049). The rate of heterozygotic TC genotype was twice higher in the study group compared to the control group (p=0.045). In heterozygotic carriers of the allele C of the SIRT1 rs12778366 gene, the risk of AMD is 2.048- and 2.425-times higher in сodominant and dominant inheritance pattern, respectively. In patients with late AMD, there are more short telomeres (64% vs. 48% in the control group, р=0.0002). Conclusions: further studies of a polymorphic SIRT1 gene locus in the association with telomere length in a larger sample are required. In the future, these molecular markers can be applied to predict the individual course of AMD and to implement preventive measures. Keywords: age-related macular degeneration, relative telomere length, rs12778366, SIRT1 gene, age-related diseases, buccal epithelium, genetic testing. For citation: Moshetova L.K., Dmitrenko O.P., Abramova O.I. et al. Association between relative telomere length and a genetic variant of SIRT gene and age-related macular degeneration. Russian Journal of Clinical Ophthalmology. 2021;21(3):143–146 (in Russ.). DOI: 10.32364/2311- 7729-2021-21-3-143-146.

scholarly journals Addressing the specificities of contusion cataract surgery in adults

2020 ◽  
Vol 20 (4) ◽  
pp. 187-190
Author(s):  
N.V. Kutukova ◽  
◽  
A. Yu. Kutukov ◽  
V.V. Brzheskiy ◽  
◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Surgical Procedures ◽  
Clinical Course ◽  
Clinical Signs ◽  
Control Group ◽  
Study Group ◽  
Surgical Performance ◽  
Lens Subluxation ◽  
Capsular Tension Ring ◽  
Complicated Cataract

im: to assess the clinical course and surgical procedures for contusion cataracts.Patients and Methods: 50 patients with a contusion cataract who underwent surgical treatment in 2008–2018 were included in the study group. 50 patients with a complicated cataract, either along with glaucoma (n=25) or diabetic cataract (n=25), were included in the control group. All patients were examined and treated in the same manner (i.e., eye exam was performed at admission, before the surgery, on postoperative days 1–3, and 1, 3, and 6 months after the surgery).Results: unilateral cataracts were revealed in the study group and bilateral cataracts were revealed in the control group. More than two-third of study group patients and only 14% of controls have the clinical signs of subluxated lens. In the study group, lens opacities were polymorphic. In the control group, nuclear opacities occurred in 30%, cortical opacities in 32%, and mixed opacities in 38%. In the course of surgical procedures, previously undiagnosed mild lens subluxation was identified in 12% of study group patients and less than 6% of controls. The total rate of zonular insufficiency in the study group was twice as much as in the control group. Additional devices (i.e., iris and capsular retractors, capsular tension rings etc.) were used in 46% of study group patients and 20% of control group patients. Visual acuity more than 12/20 was reported in 86% of study group patients and only 32% of control group patients.Conclusions: the clinical course and surgical performance of contusion cataracts should be considered when examining and operating these patients. Occult minimal lens subluxation is also important. Keywords: complicated cataract, traumatic cataract, contusion cataract, lens subluxation, iris capsular retractor, capsular tension ring, surgical specificities.For citation: Kutukova N.V., Kutukov A.Yu., Brzheskiy V.V. Addressing the specificities of contusion cataract surgery in adults. Russian Journal of Clinical Ophthalmology. 2020;20(4):187–190. DOI: 10.32364/2311-7729-2020-20-4-187-190.

Increased levels of circulating CD34+ cells in neovascular age-related macular degeneration: relation with clinical and OCT features

2018 ◽  
Vol 28 (1) ◽  
pp. 80-86
Author(s):  
Caner Kara ◽  
Pınar Ç. Özdal ◽  
Emrullah Beyazyıldız ◽  
Nurgül E. Özcan ◽  
Mehmet Y. Teke ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Age Related ◽  
Significant Difference ◽  
And Control

Purpose: To investigate the levels of circulating CD34+ stem cells in patients with neovascular type age-related macular degeneration (AMD) and its relation with clinical and optical coherence tomography (OCT) findings. Methods: The study consisted of 55 patients: 28 patients (18 male and 10 female) with neovascular type AMD as a study group and 27 patients (12 male and 15 female) scheduled for cataract surgery as a control group. The level of CD34+ stem cells was measured by flow cytometry. Demographic and clinical data were recorded. Results: The mean ages of patients in the study and control groups were 71 ± 8 and 68 ± 6 years, respectively. There was no statistically significant difference in terms of age, sex, or systemic disease association between study and control groups. However, smoking status was significantly higher in the study group (67.9% vs 37.0%; p = 0.02). Stem cell levels were significantly higher in the study group (1.5 ± 0.9 vs 0.5 ± 0.3; p<0.001), but there was no relation between stem cell levels and clinical and OCT findings. Conclusions: Increased circulating CD34+ stem cell levels were observed in patients with choroidal neovascular membrane associated with AMD, but no significant relation was found between cell levels and clinical and OCT findings.

scholarly journals The Effect of Brimonidine 0.15% on the Development of Bulbar Redness Following Femtosecond Laser Assisted Cataract Surgery

2021 ◽  
Vol 4 (1) ◽  
pp. 227-232
Author(s):  
Felicia Tai ◽  
Nistha Jaki ◽  
Sohel Somani ◽  
Hannah Chiu ◽  
Eric Tam
Keyword(s):  
Femtosecond Laser ◽  
Cataract Surgery ◽  
Intraoperative Complications ◽  
Final Analysis ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Eye Drops ◽  
Subconjunctival Hemorrhage ◽  
Student’S T

Purpose: To assess the effect of brimonidine tartrate 0.15% on reducing subconjunctival hemorrhage, measured with a bulbar redness score, following femtosecond laser assisted cataract surgery (FLACS). Patients and Methods: A prospective, masked randomized controlled study was done using single-blinded simple randomization. All FLACS cases completed between June and August 2019 were included except those on anticoagulation or with prior conjunctival surgery. All operated eyes received usual preoperative eye drops, while Study group received added brimonidine. Exclusion criteria included >1 vacuum attempt during FLACS and any intraoperative complications. All subjects received Bulbar Redness (BR) Score and Analyzed Area (AA) imaging by Oculus 5M Keratograph preoperatively and postoperatively. AA including non-conjunctival structures, <25mm2, or postoperative AA values >10% different from preoperative values were excluded from final analysis. Absolute values and differences between mean postoperative and preoperative BR and AA were compared using Student’s t-test. Results: 62 eyes (Study group=25, Control group=37) of 56 patients were randomized and included for analysis. Baseline demographic comparison between the two groups were similar. Preoperative BR score in the Study group trended higher (1.62) than Control (1.40, p=0.07), while postoperative BR score remained similar between groups (p=0.70). Difference in postoperative and preoperative BR score was significantly larger in the study group (-0.21±0.56) than controls (+0.06±0.43, p=0.036). Conclusions: The use of preoperative brimonidine in FLACS reduces the amount of postoperative subconjunctival hemorrhage following FLACS, as observed by reduced bulbar redness. Oculus 5M BR scoring has potential to be used as an objective method of quantifying subconjunctival hemorrhage after ophthalmic surgeries and procedures.

scholarly journals Tear Film Osmolarity of the Eye after Cataract Surgery. Summary of the Doctoral Thesis

2021 ◽  
Author(s):  
◽  
Ēriks Elksnis ◽  
Keyword(s):  
Cataract Surgery ◽  
Postoperative Period ◽  
Ocular Surface ◽  
Tear Film ◽  
Visual Outcome ◽  
Early Postoperative Period ◽  
University Hospital ◽  
Control Group ◽  
Study Group ◽  
Significant Difference

Almost every cataract surgeon has encountered a situation during the postoperative period when, even though, the primary goal – improvement of visual acuity – has been achieved, yet the patient felt frustrated because of subjective discomfort in the operated eye. Sometimes this issue is more disturbing for the patient than the hope for a perfect visual outcome. Although it has been established that the ocular surface is affected during the postoperative period, there is still no generally accepted opinion about the changes in tear osmolarity after cataract surgery despite several studies dedicated to evaluation of these changes. The present study was designed to elucidate the effect of cataract surgery on the characteristic feature of ocular surface homeostasis – tear film osmolarity in the early postoperative period. Aim. The aim of the study was to evaluate the changes in tear film osmolarity after a cataract surgery in a healthy ocular surface. Methods. For this purpose two examination groups were formed. The study group included voluntary patients undergoing cataract surgery not having any complaints about subjective symptoms typical of dry eye disease. In order to correspond to the criteria of healthy ocular surface, the study group excludes the following types of patients and conditions: contact lens wearers, patients with diabetes, pseudoexfoliation, pterygia and eye drop users. The eye that has not undergone the surgery was classified as the control group. This single–center, prospective study was held at Ophthalmology department of Pauls Stradins Clinical university hospital. All cataract surgeries were done by the same surgeon. The tear osmolarity tests were evaluated with TearLab Osmolarity System (TearLab Corporation, San Diego, CA, the USA) before surgery, in the next morning, one week and one month after the surgery. Results. No statistically significant difference was observed between the groups before operation when comparing the mean tear osmolarity – in the study group it was 296.87 mOsm/L, and in the control group it was 297.27 mOsm/L (p = 0.84). The tear osmolarity results changed significantly during early postoperative period in the study group (p < 0.001), while in non–operated eye no significant tear film osmolarity changes were observed (p = 0.86). Significant changes were recognized on the next day after the surgery – the tears became hypoosmolar (< 275 mOsm/L). One week later the tear osmolarity increased significantly, and the tears became hyperosmolar (312.64 mOsm/L). Over the course of one month, the test values for the study and control groups equalized (297.87 in the study group and 298.93 in the control group (p = 0.66)), when compared to preoperative tear osmolarity results. Conclusion. The results achieved lead towards a more detailed understanding of the changes in the ocular surface homeostasis after a cataract surgery. The obtained data indicate that tear osmolarity changes considerably during the first postoperative month after a cataract surgery. Also, there is a huge difference in measurements between operated and non–operated eye on the next day and one week after the surgery. One month after the surgery tear osmolarity returns to preoperative test results, and there is no difference determined between the eyes.

scholarly journals Correlation of Binocular Refractive Errors and Calculation of Intraocular Lens Power for the Second Eye

2020 ◽  
Author(s):  
Pengcheng Zhang ◽  
Yuhuan Yang ◽  
Hong Yan ◽  
Jie Zhang ◽  
Weijia Yan
Keyword(s):  
Cataract Surgery ◽  
Intraocular Lens ◽  
Refractive Error ◽  
Control Group ◽  
Refractive Errors ◽  
Age Related ◽  
Department Of Ophthalmology ◽  
Group A ◽  
Iol Power ◽  
Lens Power

Abstract Background: How to reduce the refractive error has always been a tricky problem. The aim of this study was to verify the correlation between binocular refractive errors (RE) after sequential cataract surgery and explore the individualized calculation method of intraocular lens (IOL) for the second eye.Methods: This is a prospective study. One hundred eighty-eight affected eyes of 94 age-related cataract patients with sequential cataract surgery from the Department of Ophthalmology, Tangdu Hospital, china, were recruited. Complete case data of 94 patients were included for correlation analysis of binocular RE. Thereafter, data of patients with RE values greater than 0.50 diopter (D) in the first eyes were extracted and divided randomly into two groups- Group A and B. As the adjustment group, in group A we modified the IOL power for the second eyes according to 50% of the RE of the first eye, and group B was the control group without modify. The mean absolute refractive error (MARE) values of the second eyes were evaluated one month after surgery.Results: The correlation coefficient of binocular RE after sequential cataract surgery was 0.760 (P < 0.001). After the IOL power of the second eyes were adjusted, the MARE of the second eyes was 0.57±0.41 D while MARE of the first eyes was 1.18±0.85 D, and the difference was statistically significant (P<0.001).Conclusions: Binocular REs were correlated positively after sequential cataract surgery. The RE of the second eye can be reduced by adjusting the IOL power based on 50% of the postoperative RE of the first eye.

scholarly journals Phacoemulsification after Trabeculectomy in Uveitis Associated with Vogt-Koyanagi-Harada Disease: Intermediate-Term Visual Outcome, IOP Control and Trabeculectomy Survival

2021 ◽  
Author(s):  
Faisal A. Almobarak ◽  
Ali Alharbi ◽  
Ibrahim Aljadaan ◽  
Hasan Aldhibi
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Cataract Surgery ◽  
Visual Outcome ◽  
Pressure Control ◽  
Control Group ◽  
Study Group ◽  
Safe Procedure ◽  
Patient Counselling ◽  
And Control

Abstract PurposeTo evaluate the visual outcome, intraocular pressure control and survival of trabeculectomy after phacoemulsification in eyes with prior trabeculectomy in uveitis associated with Vogt-Koyanagi-Harada disease (VKH).DesignRetrospective comparative study.MethodsEyes with uveitic glaucoma associated with VKH who underwent mitomycin C (MMC)-enhanced trabeculectomy were included. Eyes were divided into two groups: the first study group included eyes that later underwent cataract surgery in the form of phacoemulsification, and the second control group included eyes that did not have cataract surgery. The main outcome measures were changes in the visual acuity, intraocular pressure (IOP), the number of antiglaucoma medications, IOP control and trabeculectomy survival. ResultsThere were no significant differences in the final visual acuity (0.78 (±0.9) and 0.92 (±1.1), p=0.80)) nor IOP (14.21 mmHg (±5.8) and 12.16 mmHg (±6.1), p=0.29), but there was a difference in the antiglaucoma medications (1.58 (±1.5) and 0.53 (±1.0), p=0.02) between the study and control group, respectively. There was no difference in the overall trabeculectomy survival (p=0.381, Log Rank), but more eyes in the study group converted to qualified success after phacoemulsification and required more medications to control the IOP.ConclusionPhacoemulsification after trabeculectomy seems to be a safe procedure in eyes with combined vision threatening complications of VKH, although the visual improvement was limited. Nevertheless, more medications were required to control the IOP, thereby affecting IOP control; but such medication did not affect trabeculectomy survival. Therefore, patient counselling before surgery is essential.

Sign in / Sign up

Export Citation Format

Share Document