scholarly journals Gut Microbiome and Metabolome Were Altered and Strongly Associated With Platelet Count in Adult Patients With Primary Immune Thrombocytopenia

2020 ◽  
Vol 11 ◽  
Author(s):  
Xuewu Zhang ◽  
Silan Gu ◽  
Liangshun You ◽  
Yu Xu ◽  
De Zhou ◽  
...  
Keyword(s):  
Platelet Count ◽  
Gut Microbiome ◽  
Immune Thrombocytopenia ◽  
Adult Patients ◽  
Primary Immune Thrombocytopenia

scholarly journals Management of Adult Patients with Primary Immune Thrombocytopenia (ITP) in Clinical Practice: A Consensus Approach of the Spanish ITP Expert Group

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
M. Eva Mingot-Castellano ◽  
M. Teresa Álvarez Román ◽  
Luis Fernando Fernández Fuertes ◽  
Tomás José González-López ◽  
José María Guinea de Castro ◽  
...  
Keyword(s):  
Platelet Count ◽  
Clinical Practice ◽  
Immune Thrombocytopenia ◽  
Adult Patients ◽  
Severe Bleeding ◽  
Clinical Practices ◽  
Questionnaire Response ◽  
Diagnosis And Management ◽  
Asymptomatic Patients ◽  
Primary Immune Thrombocytopenia

Background and Objective. Diagnosis and management of primary immune thrombocytopenia (ITP) have changed dramatically in the last decade. The aim of the study was to obtain information about the opinion of the Spanish ITP Group (GEPTI) members regarding the best clinical practices for diagnosis and management of adult patients with ITP. Materials and Methods. A two-round Delphi method was carried out by sending to 129 experts a 90-item questionnaire developed by 11 specialists, with a 4-point Likert scale (“never,” “sometimes,” “frequently,” and “always”) for the assessment of responses. Results. Forty out of the 129 experts participated in the survey (participation rate 30.2%) and 39 completed the questionnaire (response rate 97.5%). Salient consensus points included the following: the need to indicate workup studies from a sustained platelet count < 100 x 109/L in the absence of a clear etiology; bone marrow aspiration in elderly patients with suspected ITP; beginning treatment in asymptomatic patients with a platelet count < 20 x 109/L; not exceeding 6-7 weeks of corticosteroid therapy; switching from corticosteroids to one thrombopoietin receptor agonist (TRA); switching to other TRA or other options as combinations of them with immunosuppressive drugs in case of failure; how to reduce tapering TRA; treating patients with symptomatic persistent ITP and platelet count > 20 x 109/L; and considering mucosal or severe bleeding as a basic criterion for hospital admission. Conclusions. The present consensus document provides a reference framework for the management of patients with ITP in clinical practice.

NK cell compartment in the peripheral blood and spleen in adult patients with primary immune thrombocytopenia

2017 ◽  
Vol 177 ◽  
pp. 18-28 ◽  
Author(s):  
M. Ebbo ◽  
S. Audonnet ◽  
A. Grados ◽  
L. Benarous ◽  
M. Mahevas ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Immune Thrombocytopenia ◽  
Nk Cell ◽  
Adult Patients ◽  
Cell Compartment ◽  
Primary Immune Thrombocytopenia

Low-dose rituximab in adult patients with primary immune thrombocytopenia

2010 ◽  
Vol 85 (4) ◽  
pp. 329-334 ◽  
Author(s):  
Francesco Zaja ◽  
Nicola Vianelli ◽  
Stefano Volpetti ◽  
Marta Lisa Battista ◽  
Marzia Defina ◽  
...  
Keyword(s):  
Immune Thrombocytopenia ◽  
Low Dose ◽  
Adult Patients ◽  
Primary Immune Thrombocytopenia

How I Manage cyclic thrombocytopenia

Blood ◽  
2020 ◽  
Author(s):  
Paul A Kyrle ◽  
Sabine Eichinger
Keyword(s):  
Platelet Count ◽  
Immune Thrombocytopenia ◽  
Hematological Malignancies ◽  
Severe Bleeding ◽  
Typical Pattern ◽  
Periodic Fluctuation ◽  
Thrombopoietin Receptor ◽  
Primary Immune Thrombocytopenia ◽  
Platelet Count Monitoring ◽  
Mucocutaneous Bleeding

Cyclic thrombocytopenia (CTP) is a rare disease, which is characterized by periodic fluctuation of the platelet count. The pathogenesis of CTP is unknown and most likely heterogeneous. Patients with CTP are almost always misdiagnosed as having primary immune thrombocytopenia (ITP). The interval between ITP and CTP diagnosis can be many years. CTP patients often receive ITP-specific therapies including corticosteroids, thrombopoietin receptor agonists, rituximab and splenectomy which are followed by a transient increase in platelet count that is wrongly attributed to treatment effect with inevitable "relapse". CTP can be diagnosed by frequent platelet count monitoring which reveals a typical pattern of periodic platelet cycling. An early diagnosis of CTP will prevent these patients from being exposed to possibly harmful therapies. The bleeding phenotype is usually mild and consists of mucocutaneous bleeding at the time when the platelet count is at its nadir. Severe bleeding from other sites can occur but is rare. Some patients respond to cyclosporine A or to danazol, but most patients do not respond to any therapy. CTP can be associated with hematological malignancies or disorders of the thyroid gland. Nevertheless, spontaneous remissions can occur, even after many years.

Sign in / Sign up

Export Citation Format

Share Document