scholarly journals Biomedical Applications of Supramolecular Materials in the Controllable Delivery of Steroids

2021 ◽  
Vol 8 ◽  
Author(s):  
Yun Hao ◽  
Feiyi Zhang ◽  
Shanshan Mo ◽  
Jinming Zhao ◽  
Xiangdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Electrostatic Interactions ◽  
Adrenal Glands ◽  
Hydrophobic Interactions ◽  
Inflammatory Diseases ◽  
Supramolecular System ◽  
Supramolecular Materials ◽  
Chronic Inflammatory Diseases ◽  
Delivery Platform

Glucocorticoids are a class of steroid hormones secreted from the adrenal glands. The strong anti-inflammatory effects make it be one of the most popular and versatile drugs available to treat chronic inflammatory diseases. Additionally, supramolecular materials have been widely exploited in drug delivery, due to their biocompatibility, tunability, and predictability. Thus, steroid-based supramolecular materials and the release of steroids have been applied in the treatment of inflammatory diseases. This mini-review summarized recent advances in supramolecular materials loaded with glucocorticoid drugs in terms of hydrophobic interactions, electrostatic interactions, hydrogen bonding, and π-π stackings. We also discussed and prospected the application of the glucocorticoid drugs-based supramolecular system on chronic rhinosinusitis, multifactorial inflammatory disease of the nasal and paranasal sinuses mucosal membranes. Overall, supramolecular materials can provide an alternative to traditional materials as a novel delivery platform in clinical practice.

scholarly journals Protein-Based Nanohydrogels for Bioactive Delivery

2021 ◽  
Vol 9 ◽  
Author(s):  
Subhash Chander ◽  
Giriraj T. Kulkarni ◽  
Neerupma Dhiman ◽  
Harsha Kharkwal
Keyword(s):  
Drug Delivery ◽  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Biological Fluids ◽  
Three Dimensional ◽  
Covalent Bond ◽  
Ionic Concentration ◽  
Covalent Bonds ◽  
Encapsulation Process ◽  
Insightful Analysis

Hydrogels possess a unique three-dimensional, cross-linked network of polymers capable of absorbing large amounts of water and biological fluids without dissolving. Nanohydrogels (NGs) or nanogels are composed of diverse types of polymers of synthetic or natural origin. Their combination is bound by a chemical covalent bond or is physically cross-linked with non-covalent bonds like electrostatic interactions, hydrophobic interactions, and hydrogen bonding. Its remarkable ability to absorb water or other fluids is mainly attributed to hydrophilic groups like hydroxyl, amide, and sulphate, etc. Natural biomolecules such as protein- or peptide-based nanohydrogels are an important category of hydrogels which possess high biocompatibility and metabolic degradability. The preparation of protein nanohydrogels and the subsequent encapsulation process generally involve use of environment friendly solvents and can be fabricated using different proteins, such as fibroins, albumin, collagen, elastin, gelatin, and lipoprotein, etc. involving emulsion, electrospray, and desolvation methods to name a few. Nanohydrogels are excellent biomaterials with broad applications in the areas of regenerative medicine, tissue engineering, and drug delivery due to certain advantages like biodegradability, biocompatibility, tunable mechanical strength, molecular binding abilities, and customizable responses to certain stimuli like ionic concentration, pH, and temperature. The present review aims to provide an insightful analysis of protein/peptide nanohydrogels including their preparation, biophysiochemical aspects, and applications in diverse disciplines like in drug delivery, immunotherapy, intracellular delivery, nutraceutical delivery, cell adhesion, and wound dressing. Naturally occurring structural proteins that are being explored in protein nanohydrogels, along with their unique properties, are also discussed briefly. Further, the review also covers the advantages, limitations, overview of clinical potential, toxicity aspects, stability issues, and future perspectives of protein nanohydrogels.

Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy

2016 ◽  
Vol 4 (29) ◽  
pp. 5046-5058 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Yongli Wang ◽  
Wenjing Zhao ◽  
Fangqin Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Anticancer Therapy ◽  
Effective Strategy ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Delivery Platform

We introduce a simple and effective strategy to design a promising drug delivery platform for improving the biomedical applications of smart nanodiamond carriers.

scholarly journals Synergistical Use of Electrostatic and Hydrophobic Interactions for the Synthesis of a New Class of Multifunctional Nanohybrids: Plasmonic Magneto-Liposomes

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1623 ◽  
Author(s):  
Gabriela Fabiola Știufiuc ◽  
Ștefan Nițică ◽  
Valentin Toma ◽  
Cristian Iacoviță ◽  
Dietrich Zahn ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Raman Spectroscopy ◽  
Controlled Release ◽  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Superparamagnetic Iron Oxide ◽  
Surface Enhanced Raman Spectroscopy ◽  
New Class

By carefully controlling the electrostatic interactions between cationic liposomes, which already incorporate magnetic nanoparticles in the bilayers, and anionic gold nanoparticles, a new class of versatile multifunctional nanohybrids (plasmonic magneto-liposomes) that could have a major impact in drug delivery and controlled release applications has been synthesized. The experimental results confirmed the successful synthesis of hydrophobic superparamagnetic iron oxide nanoparticles (SPIONs) and polyethylene glycol functionalized (PEGylated) gold nanoparticles (AuNPs). The SPIONs were incorporated in the liposomal lipidic bilayers, thus promoting the formation of cationic magnetoliposomes. Different concentrations of SPIONs were loaded in the membrane. The cationic magnetoliposomes were decorated with anionic PEGylated gold nanoparticles using electrostatic interactions. The successful incorporation of SPIONs together with the modifications they generate in the bilayer were analyzed using Raman spectroscopy. The plasmonic properties of the multifunctional nanohybrids were investigated using UV-Vis absorption and (surface-enhanced) Raman spectroscopy. Their hyperthermic properties were recorded at different frequencies and magnetic field intensities. After the synthesis, the nanosystems were extensively characterized in order to properly evaluate their potential use in drug delivery applications and controlled release as a result of the interaction with an external stimulus, such as an NIR laser or alternating magnetic field.

Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

scholarly journals Hyaluronic Acid Nanoparticles as Nanomedicine for Treatment of Inflammatory Diseases

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 931 ◽  
Author(s):  
N.Vijayakameswara Rao ◽  
Jun Gi Rho ◽  
Wooram Um ◽  
Pramod Kumar EK ◽  
Van Quy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Biomedical Applications ◽  
Therapeutic Agent ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Biological Functions ◽  
Wide Range ◽  
Diagnostic Agents ◽  
Long Acting

Owing to their unique biological functions, hyaluronic acid (HA) and its derivatives have been explored extensively for biomedical applications such as tissue engineering, drug delivery, and molecular imaging. In particular, self-assembled HA nanoparticles (HA-NPs) have been used widely as target-specific and long-acting nanocarriers for the delivery of a wide range of therapeutic or diagnostic agents. Recently, it has been demonstrated that empty HA-NPs without bearing any therapeutic agent can be used therapeutically for the treatment of inflammatory diseases via modulating inflammatory responses. In this review, we aim to provide an overview of the significant achievements in this field and highlight the potential of HA-NPs for the treatment of inflammatory diseases.

scholarly journals Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self-Assembly for Potential Biomedical Applications

2020 ◽  
Author(s):  
Sarah michel ◽  
Alice Kilner ◽  
Jean-Charles Eloi ◽  
Sarah E rogers ◽  
Wuge H. Briscoe ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Hydrophobic Interactions ◽  
Gelation Mechanism ◽  
Swelling Behaviour ◽  
Assembly Mechanism ◽  
Significant Toxicity ◽  
Chitosan Hydrogels

<p><br></p><p> Access to biocompatible self-assembled gels and microgels is of great interests for a variety of biological applications from tissue engineering to drug delivery. Here, the facile synthesis of supramolecular hydrogels of norbornene (nb)-functionalised chitosan (CS-nb) via UV-triggered self-assembly in the presence of Irgacure 2959 (IRG) is reported. The <i>in vitro </i>stable hydrogels are injectable and showed pH-responsive swelling behaviour, while their structure and mechanical properties could be tuned by tailoring the stereochemistry of the norbornene derivative (e.g. <i>endo</i>- or -<i>exo</i>). Interestingly, unlike other nb-type hydrogels, the gels possess nanopores within their structure, which might lead to potential drug delivery applications. A gelation mechanism was proposed based on hydrophobic interactions following the combination of IRG on norbornene, as supported by 1H NMR. This self-assembly mechanism was used to access microgels of size 100-150 nm which could be further functionalised and showed no significant toxicity to human dermofibroblast cells. </p>

scholarly journals MATERIALS SELECTION FOR PRODUCTION OF MICROSPHERES PROTECTING LACTOFERRIN UNDER ACID CONDITIONS

2016 ◽  
pp. 92-102 ◽  
Author(s):  
Marina Novoselova ◽  
Marina Novoselova ◽  
Alexander Prosekov ◽  
Alexander Prosekov
Keyword(s):  
Tannic Acid ◽  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Inflammatory Diseases ◽  
Adsorbed Layer ◽  
Multifunctional Protein ◽  
Acidic Conditions ◽  
Selection For ◽  
The Stability ◽  
Subsequent Layer

Lactoferrin is a multifunctional protein of the transferrin family, which can be found in the human and other mammals milk. On the basis of many biological functions of lactoferrin, researchers have considered various possibilities of its application in health care, in the prevention and treatment of infectious and inflammatory diseases. However, lactoferrin is exposed to pepsin degradation in the gastrointestinal tract, decreasing its bioactivity after oral administration. In this regard, appropriate delivery system of lactoferrin, which ensures its delivery intact to the receptors in the small intestine requires. In this study, the different compositions of the capsules in combination with tannic acid, formed mainly by hydrogen and hydrophobic interactions were showed. Its stability toward acidic conditions (0.1 M HCl) was investigated. Complexes with polyelectrolytes (and its pairs): PSS/PAH, Parg as the first adsorbed layer on CaCO3 particles formed by electrostatic interactions were presented. As the results, the adsorption of these polyelectrolytes led to greater stability of the obtained capsules. Bovine serum albumin and tannic acid, in particular with the use of poly-L-arginine as the first layer, increasing the stability of the obtained microspheres were selected as the most promising materials for the microcapsules synthesis. The changes in the morphology of [BSA/TA] and Parg [BSA/TA] capsules depending on the various number of bilayers (from 3 to 6) were analyzes. The thickness of capsule was increased on 1-2 nm by applying each subsequent layer. It was noted BSA/TA capsules looked thinner than Parg [BSA/TA] capsules with the same number of bilayers.

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